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  1. Article: Crosstalk between bone and muscle in chronic kidney disease.

    Wong, Limy / McMahon, Lawrence P

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1146868

    Abstract: With increasing life expectancy, the related disorders of bone loss, metabolic dysregulation and sarcopenia have become major health threats to the elderly. Each of these conditions is prevalent in patients with chronic kidney disease (CKD), particularly ...

    Abstract With increasing life expectancy, the related disorders of bone loss, metabolic dysregulation and sarcopenia have become major health threats to the elderly. Each of these conditions is prevalent in patients with chronic kidney disease (CKD), particularly in more advanced stages. Our current understanding of the bone-muscle interaction is beyond mechanical coupling, where bone and muscle have been identified as interrelated secretory organs, and regulation of both bone and muscle metabolism occurs through osteokines and myokines
    MeSH term(s) Humans ; Aged ; Muscle, Skeletal/metabolism ; Sarcopenia/etiology ; Sarcopenia/metabolism ; Bone and Bones ; Cell Physiological Phenomena ; Bone Diseases, Metabolic/metabolism
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1146868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: MiR-423-5p as Optimal Endogenous Control for Quantification of Circulating MicroRNAs in Patients With CKD.

    Wong, Limy / Tsang, Yung Shing / Kenny, Rachel / Lyburn, Matthew / McMahon, Lawrence P

    Kidney international reports

    2023  Volume 8, Issue 10, Page(s) 2150–2152

    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.07.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: De novo PLA2R positive membranous nephropathy following BNT162b2 mRNA COVID-19 vaccine.

    Paxton, Lisa / McMahon, Lawrence / Wong, Limy

    Internal medicine journal

    2022  Volume 52, Issue 12, Page(s) 2191–2192

    MeSH term(s) Humans ; Glomerulonephritis, Membranous ; BNT162 Vaccine ; RNA, Messenger ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Autoantibodies ; Receptors, Phospholipase A2
    Chemical Substances BNT162 Vaccine ; RNA, Messenger ; COVID-19 Vaccines ; Autoantibodies ; Receptors, Phospholipase A2
    Language English
    Publishing date 2022-10-20
    Publishing country Australia
    Document type Letter
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15915
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    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  4. Article ; Online: Sarcopenia and Frailty: Challenges in Mainstream Nephrology Practice.

    Wong, Limy / Duque, Gustavo / McMahon, Lawrence P

    Kidney international reports

    2021  Volume 6, Issue 10, Page(s) 2554–2564

    Abstract: Sarcopenia and frailty are prevalent in the chronic kidney disease (CKD) population. Sarcopenia is characterised by the loss of muscle mass and function, while frailty is defined as a multi-system impairment associated with increased vulnerability to ... ...

    Abstract Sarcopenia and frailty are prevalent in the chronic kidney disease (CKD) population. Sarcopenia is characterised by the loss of muscle mass and function, while frailty is defined as a multi-system impairment associated with increased vulnerability to stressors. There is substantial overlap between the 2 conditions, particularly with regards to physical aspects: low grip strength, gait speed and low muscle mass. Both sarcopenia and frailty have been associated with a wide range of adverse health outcomes. Although there is no recommended pharmacological treatment as yet, it is widely accepted that exercise training and nutritional supplementation are the key interventions to maintain skeletal muscle mass and strength. This review aims to present a comprehensive overview of sarcopenia and frailty in patients with CKD.
    Language English
    Publishing date 2021-06-12
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.05.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Nephritis and Hearing Loss-Not All Roads Lead to Alport Syndrome.

    Wong, Limy / Huang, Louis L / Nedeljkovic, Marija / Irish, Ashley / McMahon, Lawrence P

    Kidney international reports

    2021  Volume 6, Issue 11, Page(s) 2922–2925

    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Case Reports
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.08.003
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  6. Article ; Online: Low muscle mass and early hospital readmission post-kidney transplantation.

    Wong, Limy / Kent, Annette B / Lee, Darren / Roberts, Matthew A / McMahon, Lawrence P

    International urology and nephrology

    2022  Volume 54, Issue 8, Page(s) 1977–1986

    Abstract: Purpose: Patients exhibiting features of frailty and sarcopenia increasingly are presenting for kidney transplantation (KT) assessment. Sarcopenia, when ascertained by radiological measures, is associated with a higher transplant waiting list mortality; ...

    Abstract Purpose: Patients exhibiting features of frailty and sarcopenia increasingly are presenting for kidney transplantation (KT) assessment. Sarcopenia, when ascertained by radiological measures, is associated with a higher transplant waiting list mortality; but studies on post-operative outcomes are lacking. We aimed to determine the clinical significance of low muscle mass in chronic kidney disease (CKD) patients subsequently receiving KT.
    Methods: We retrospectively analyzed 63 patients with Stage 4-5 CKD who, between 2012 and 2020, had undergone abdominal computed tomography (CT) scanning up to 2 years before KT. The degree of skeletal muscle loss was assessed using the total cross-sectional skeletal muscle area at the third lumbar vertebral level (L3). Cox proportional-hazards regression and Frailty models were used to identify risk factors for early hospital readmission post KT.
    Results: Thirty-four patients (54%) displayed low muscle mass, which was independently associated with a lower serum creatinine and phosphate, lower body mass index, lower mean muscle attenuation of the L3 cross-sectional area, and higher serum parathyroid hormone (for all p < 0.05). Deceased donor transplant recipients (n = 45) with low muscle mass demonstrated greater hospital readmissions within 30 days of KT [adjusted hazard ratio (HR) = 4.24, 95% CI 1.40-12.90, p = 0.01].
    Conclusion: Low muscle mass is highly prevalent in the pre-transplant CKD population and is associated with increased hospital readmission in the early post-transplant period.
    MeSH term(s) Frailty/complications ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/adverse effects ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Patient Readmission ; Retrospective Studies ; Risk Factors ; Sarcopenia/diagnostic imaging ; Sarcopenia/epidemiology
    Language English
    Publishing date 2022-01-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-021-03085-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 733: Show issues Location:
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  7. Article ; Online: Treatment dilemma-bilateral renal artery aneurysms.

    Wong, Limy / Kok, Li Teng / Kok, Hong Kuan / Lee, Michael J

    Kidney international

    2017  Volume 92, Issue 3, Page(s) 774

    MeSH term(s) Adult ; Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Aneurysm/therapy ; Computed Tomography Angiography ; Conservative Treatment ; Female ; Humans ; Kidney/blood supply ; Marfan Syndrome/complications ; Renal Artery/diagnostic imaging ; Renal Artery/pathology
    Language English
    Publishing date 2017-08-14
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2017.03.017
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    Zs.A 797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Getting the balance right: adverse events of therapy in anti-neutrophil cytoplasm antibody vasculitis.

    Wong, Limy / Harper, Lorraine / Little, Mark A

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2015  Volume 30 Suppl 1, Page(s) i164–70

    Abstract: Antineutrophil cytoplasm antibody associated systemic vasculitides (AASV) have traditionally been managed with a combination of cyclophosphamide and glucocorticoids during the induction phase, followed by azathioprine in the maintenance phase. Whilst ... ...

    Abstract Antineutrophil cytoplasm antibody associated systemic vasculitides (AASV) have traditionally been managed with a combination of cyclophosphamide and glucocorticoids during the induction phase, followed by azathioprine in the maintenance phase. Whilst these therapies have markedly improved the prognosis in AASV, treatment related adverse events remain a major challenge and include complications such as infection, glucocorticoid related side effects, malignancy, cardiovascular disease, infertility and death. Newer biologic therapies have been shown to demonstrate equivalent efficacy as cyclophosphamide for remission but the hoped for reduction in adverse events has yet to be realised. More recent efforts have been focused on refining existing therapeutic regimens and strategies, tailoring individual treatment to disease severity, patient age and kidney function to derive maximum treatment efficacy while minimising treatment toxicity. In particular, current interventional trials are targeting a reduction in corticosteroid exposure in an effort to make induction and maintenance regimens safer.
    MeSH term(s) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Drug-Related Side Effects and Adverse Reactions/diagnosis ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Glucocorticoids/adverse effects ; Humans ; Immunosuppressive Agents/adverse effects ; Prognosis ; Severity of Illness Index
    Chemical Substances Glucocorticoids ; Immunosuppressive Agents
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfu406
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  9. Article ; Online: FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human.

    Espéli, Marion / Bashford-Rogers, Rachael / Sowerby, John M / Alouche, Nagham / Wong, Limy / Denton, Alice E / Linterman, Michelle A / Smith, Kenneth G C

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 1970

    Abstract: Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated with ... ...

    Abstract Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated with autoimmune disease, yet its impact on specific B cell tolerance checkpoints is unknown. Here we show that reduced expression of FcγRIIb enhances the deletion and anergy of autoreactive immature B cells, but in contrast promotes autoreactive B cell expansion in the germinal center and serum autoantibody production, even in response to exogenous, non-self antigens. Our data thus show that FcγRIIb has opposing effects on pre-immune and post-immune tolerance checkpoints, and suggest that B cell tolerance requires the control of bystander germinal center B cells with low or no affinity for the immunizing antigen.
    MeSH term(s) Algorithms ; Animals ; B-Lymphocytes/immunology ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Enzyme-Linked Immunosorbent Assay ; Female ; Flow Cytometry ; Germinal Center ; Humans ; Immune Tolerance/immunology ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Male ; Mice ; Receptors, IgG/genetics ; Receptors, IgG/metabolism ; Software
    Chemical Substances Receptors, IgG
    Language English
    Publishing date 2019-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-09434-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Kidney transplant outcomes in familial C3 glomerulopathy.

    Wong, Limy / Moran, Sarah / Lavin, Peter J / Dorman, Anthony M / Conlon, Peter J

    Clinical kidney journal

    2016  Volume 9, Issue 3, Page(s) 403–407

    Abstract: C3 glomerulopathy, a newly designated entity, is characterized by glomerular disease associated with dysregulation of the alternative complement pathway and is a rare cause of end-stage kidney disease. Overall disease characteristics that include ... ...

    Abstract C3 glomerulopathy, a newly designated entity, is characterized by glomerular disease associated with dysregulation of the alternative complement pathway and is a rare cause of end-stage kidney disease. Overall disease characteristics that include clinical presentation, laboratory assessment, histopathology and genetic background have only been unravelled in recent years and have led to the development of anti-complement therapies targeting different levels of the alternative pathway. We describe the long-term outcomes following kidney transplantation in an Irish family with familial C3 glomerulopathy due to a hybrid CFHR3-1 gene.
    Language English
    Publishing date 2016-04-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfw020
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