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Article: Kilonovae.

Metzger, Brian D

2019 Volume 23, Issue 1, Page(s) 1

Abstract: The coalescence of double neutron star (NS-NS) and black hole (BH)-NS binaries are prime sources of gravitational waves (GW) for Advanced LIGO/Virgo and future ground-based detectors. Neutron-rich matter released from such events undergoes rapid neutron ... ...

Abstract	The coalescence of double neutron star (NS-NS) and black hole (BH)-NS binaries are prime sources of gravitational waves (GW) for Advanced LIGO/Virgo and future ground-based detectors. Neutron-rich matter released from such events undergoes rapid neutron capture (
Language	English
Publishing date	2019-12-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1416143-6
ISSN	1433-8351
ISSN	1433-8351
DOI	10.1007/s41114-019-0024-0
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Article: Kilonovae.

Metzger, Brian D

Living reviews in relativity

2017 Volume 20, Issue 1, Page(s) 3

Abstract: The mergers of double neutron star (NS-NS) and black hole (BH)-NS binaries are promising gravitational wave (GW) sources for Advanced LIGO and future GW detectors. The neutron-rich ejecta from such merger events undergoes rapid neutron capture ( ...

Abstract	The mergers of double neutron star (NS-NS) and black hole (BH)-NS binaries are promising gravitational wave (GW) sources for Advanced LIGO and future GW detectors. The neutron-rich ejecta from such merger events undergoes rapid neutron capture (
Language	English
Publishing date	2017-05-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1433-8351
ISSN	1433-8351
DOI	10.1007/s41114-017-0006-z
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Article ; Online: Rapid restitution of contractile dysfunction by synthetic copolymers in dystrophin-deficient single live skeletal muscle fibers.

Hahn, Dongwoo / Quick, Joseph D / Thompson, Brian R / Crabtree, Adelyn / Hackel, Benjamin J / Bates, Frank S / Metzger, Joseph M

Skeletal muscle

2023 Volume 13, Issue 1, Page(s) 9

Abstract: Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop severe skeletal muscle weakness, degeneration, and ... ...

Abstract	Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop severe skeletal muscle weakness, degeneration, and early death. We tested here amphiphilic synthetic membrane stabilizers in mdx skeletal muscle fibers (flexor digitorum brevis; FDB) to determine their effectiveness in restoring contractile function in dystrophin-deficient live skeletal muscle fibers. After isolating FDB fibers via enzymatic digestion and trituration from thirty-three adult male mice (9 C57BL10, 24 mdx), these were plated on a laminin-coated coverslip and treated with poloxamer 188 (P188; PEO
MeSH term(s)	Male ; Animals ; Mice ; Dystrophin/metabolism ; Mice, Inbred mdx ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Muscle Contraction ; Muscular Dystrophy, Duchenne/metabolism
Chemical Substances	Dystrophin
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2595637-1
ISSN	2044-5040 ; 2044-5040
ISSN (online)	2044-5040
ISSN	2044-5040
DOI	10.1186/s13395-023-00318-y
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Article ; Online: Collapsars as a major source of r-process elements.

Siegel, Daniel M / Barnes, Jennifer / Metzger, Brian D

Nature

2019 Volume 569, Issue 7755, Page(s) 241–244

Abstract: The production of elements by rapid neutron capture (r-process) in neutron-star mergers is expected theoretically and is supported by multimessenger ... ...

Abstract	The production of elements by rapid neutron capture (r-process) in neutron-star mergers is expected theoretically and is supported by multimessenger observations
Language	English
Publishing date	2019-05-08
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-019-1136-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Three-Dimensional General-Relativistic Magnetohydrodynamic Simulations of Remnant Accretion Disks from Neutron Star Mergers: Outflows and r-Process Nucleosynthesis.

Siegel, Daniel M / Metzger, Brian D

Physical review letters

2017 Volume 119, Issue 23, Page(s) 231102

Abstract: The merger of binary neutron stars, or of a neutron star and a stellar-mass black hole, can result in the formation of a massive rotating torus around a spinning black hole. In addition to providing collimating media for γ-ray burst jets, unbound ... ...

Abstract	The merger of binary neutron stars, or of a neutron star and a stellar-mass black hole, can result in the formation of a massive rotating torus around a spinning black hole. In addition to providing collimating media for γ-ray burst jets, unbound outflows from these disks are an important source of mass ejection and rapid neutron capture (r-process) nucleosynthesis. We present the first three-dimensional general-relativistic magnetohydrodynamic (GRMHD) simulations of neutrino-cooled accretion disks in neutron star mergers, including a realistic equation of state valid at low densities and temperatures, self-consistent evolution of the electron fraction, and neutrino cooling through an approximate leakage scheme. After initial magnetic field amplification by magnetic winding, we witness the vigorous onset of turbulence driven by the magnetorotational instability (MRI). The disk quickly reaches a balance between heating from MRI-driven turbulence and neutrino cooling, which regulates the midplane electron fraction to a low equilibrium value Y_{e}≈0.1. Over the 380-ms duration of the simulation, we find that a fraction ≈20% of the initial torus mass is unbound in powerful outflows with asymptotic velocities v≈0.1c and electron fractions Y_{e}≈0.1-0.25. Postprocessing the outflows through a nuclear reaction network shows the production of a robust second- and third-peak r process. Though broadly consistent with the results of previous axisymmetric hydrodynamical simulations, extrapolation of our results to late times suggests that the total ejecta mass from GRMHD disks is significantly higher. Our results provide strong evidence that postmerger disk outflows are an important site for the r process.
Language	English
Publishing date	2017-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.119.231102
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Article ; Online: Sarcomere integrated biosensor detects myofilament-activating ligands in real time during twitch contractions in live cardiac muscle.

Vetter, Anthony D / Martin, Ashley A / Thompson, Brian R / Thomas, David D / Metzger, Joseph M

Journal of molecular and cellular cardiology

2020 Volume 147, Page(s) 49–61

Abstract: The sarcomere is the functional unit of cardiac muscle, essential for normal heart function. To date, it has not been possible to study, in real time, thin filament-based activation dynamics in live cardiac muscle. We report here results from a cardiac ... ...

Abstract	The sarcomere is the functional unit of cardiac muscle, essential for normal heart function. To date, it has not been possible to study, in real time, thin filament-based activation dynamics in live cardiac muscle. We report here results from a cardiac troponin C (TnC) FRET-based biosensor integrated into the cardiac sarcomere via stoichiometric replacement of endogenous TnC. The TnC biosensor provides, for the first time, evidence of multiple thin filament activating ligands, including troponin I interfacing with TnC and cycling myosin, during a cardiac twitch. Results show that the TnC FRET biosensor transient significantly precedes that of peak twitch force. Using small molecules and genetic modifiers known to alter sarcomere activation, independently of the intracellular Ca
MeSH term(s)	Animals ; Biosensing Techniques ; Female ; Ligands ; Male ; Mice, Inbred C57BL ; Mutation/genetics ; Myocardial Contraction/physiology ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Myofibrils/metabolism ; Myosins/metabolism ; Rats, Sprague-Dawley ; Sarcomeres/metabolism ; Troponin C/metabolism ; Troponin I/metabolism
Chemical Substances	Ligands ; Troponin C ; Troponin I ; Myosins (EC 3.6.4.1)
Language	English
Publishing date	2020-08-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2020.07.012
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Zs.A 426: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Direct Uranium Isotopic Analysis of Swipe Surfaces by Microextraction-ICP-MS.

Manard, Benjamin T / Rogers, Kayron T / Ticknor, Brian W / Metzger, Shalina C / Zirakparvar, N Alex / Roach, Benjamin D / Bostick, Debra A / Hexel, Cole R

Analytical chemistry

2021 Volume 93, Issue 32, Page(s) 11133–11139

Abstract: The ability to directly measure uranium isotope ratios on environmental swipes has been achieved through a solution-based microextraction process and represents a significant advancement toward the development of a rapid method to analyze international ... ...

Abstract	The ability to directly measure uranium isotope ratios on environmental swipes has been achieved through a solution-based microextraction process and represents a significant advancement toward the development of a rapid method to analyze international nuclear safeguard samples. Here, a microextraction probe is lowered and sealed onto the swipe surface, and analytes within the sampling site (∼8 mm
MeSH term(s)	Isotopes ; Mass Spectrometry ; Uranium/analysis
Chemical Substances	Isotopes ; Uranium (4OC371KSTK)
Language	English
Publishing date	2021-07-08
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.1c01569
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Zs.A 4033: Show issues

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Article ; Online: Sustained Mechanical Aspiration Thrombectomy for High Thrombus Burden Coronary Vessel Occlusion: The Multicenter CHEETAH Study.

Mathews, S Jay / Parikh, Sahil A / Wu, Willis / Metzger, D Christopher / Chambers, Jeffrey W / Ghali, Magdi G H / Sumners, Michael James / Kolski, Brian C / Pinto, Duane S / Dohad, Suhail

Circulation. Cardiovascular interventions

2023 Volume 16, Issue 2, Page(s) e012433

Abstract: Background: Poor myocardial reperfusion due to distal embolization and microvascular obstruction after percutaneous coronary intervention is associated with increased risk of morbidity and mortality. Prior trials have not shown a clear benefit of ... ...

Abstract	Background: Poor myocardial reperfusion due to distal embolization and microvascular obstruction after percutaneous coronary intervention is associated with increased risk of morbidity and mortality. Prior trials have not shown a clear benefit of routine manual aspiration thrombectomy. Sustained mechanical aspiration may mitigate this risk and improve outcomes. The objective of this study is to evaluate sustained mechanical aspiration thrombectomy before percutaneous coronary intervention in high thrombus burden acute coronary syndrome patients. Methods: This prospective study evaluated the Indigo CAT RX Aspiration System (Penumbra Inc, Alameda CA) for sustained mechanical aspiration thrombectomy before percutaneous coronary intervention at 25 hospitals across the USA. Adults presenting within 12 hours of symptom onset with high thrombus burden and target lesion(s) located in a native coronary artery were eligible. The primary end point was a composite of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, or new or worsening New York Heart Association class IV heart failure within 30 days. Secondary end points included Thrombolysis in Myocardial Infarction thrombus grade, Thrombolysis in Myocardial Infarction flow, myocardial blush grade, stroke, and device-related serious adverse events. Results: From August 2019 through December 2020, a total of 400 patients were enrolled (mean age 60.4 years, 76.25% male). The primary composite end point rate was 3.60% (14/389 [95% CI, 2.0-6.0%]). Rate of stroke within 30 days was 0.77%. Final rates of Thrombolysis in Myocardial Infarction thrombus grade 0, Thrombolysis in Myocardial Infarction flow 3, and myocardial blush grade 3 were 99.50%, 97.50%, and 99.75%, respectively. No device-related serious adverse events occurred. Conclusions: Sustained mechanical aspiration before percutaneous coronary intervention in high thrombus burden acute coronary syndrome patients was safe and was associated with high rates of thrombus removal, flow restoration, and normal myocardial perfusion on final angiography.
MeSH term(s)	Male ; Animals ; Female ; Coronary Vessels/diagnostic imaging ; Acinonyx ; Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/therapy ; Acute Coronary Syndrome/complications ; Suction ; Prospective Studies ; Treatment Outcome ; Thrombosis/etiology ; Thrombectomy/adverse effects ; Myocardial Infarction ; Percutaneous Coronary Intervention/adverse effects ; Coronary Occlusion/etiology ; Stroke/etiology ; Coronary Thrombosis/diagnostic imaging ; Coronary Thrombosis/therapy ; Coronary Angiography
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2450797-0
ISSN	1941-7632 ; 1941-7640
ISSN (online)	1941-7632
ISSN	1941-7640
DOI	10.1161/CIRCINTERVENTIONS.122.012433
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Zs.A 6746: Show issues

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Article ; Online: Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species.

Metzger, Brian P H / Wittkopp, Patricia J / Coolon, Joseph D

Genome biology and evolution

2017 Volume 9, Issue 4, Page(s) 843–854

Abstract: Heritable changes in gene expression are important contributors to phenotypic differences within and between species and are caused by mutations in cis-regulatory elements and trans-regulatory factors. Although previous work has suggested that cis- ... ...

Abstract	Heritable changes in gene expression are important contributors to phenotypic differences within and between species and are caused by mutations in cis-regulatory elements and trans-regulatory factors. Although previous work has suggested that cis-regulatory differences preferentially accumulate with time, technical restrictions to closely related species and limited comparisons have made this observation difficult to test. To address this problem, we used allele-specific RNA-seq data from Saccharomyces species and hybrids to expand both the evolutionary timescale and number of species in which the evolution of regulatory divergence has been investigated. We find that as sequence divergence increases, cis-regulatory differences do indeed become the dominant type of regulatory difference between species, ultimately becoming a better predictor of expression divergence than trans-regulatory divergence. When both cis- and trans-regulatory differences accumulate for the same gene, they more often have effects in opposite directions than in the same direction, indicating widespread compensatory changes underlying the evolution of gene expression. The frequency of compensatory changes within and between species and the magnitude of effect for the underlying cis- and trans-regulatory differences suggests that compensatory changes accumulate primarily due to selection against divergence in gene expression as a result of weak stabilizing selection on gene expression levels. These results show that cis-regulatory differences and compensatory changes in regulation play increasingly important roles in the evolution of gene expression as time increases.
MeSH term(s)	Alleles ; Evolution, Molecular ; Gene Expression Regulation, Fungal ; Genetic Variation ; Regulatory Sequences, Nucleic Acid/genetics ; Saccharomyces/genetics ; Species Specificity
Language	English
Publishing date	2017-04-01
Publishing country	England
Document type	Journal Article
ISSN	1759-6653
ISSN (online)	1759-6653
DOI	10.1093/gbe/evx035
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Article ; Online: Direct isotopic analysis of solid uranium particulates on cotton swipes by microextraction-ICP-MS.

Bradley, Veronica C / Spano, Tyler L / Metzger, Shalina C / Ticknor, Brian W / Dunlap, Daniel R / Zirakparvar, N Alex / Roach, Benjamin D / Hexel, Cole R / Manard, Benjamin T

Analytica chimica acta

2022 Volume 1209, Page(s) 339836

Abstract: Direct isotope ratio analysis of solid uranium particulates on cotton swipes was achieved using a solution-based microextraction technique, coupled to a quadrupole inductively coupled plasma - mass spectrometer (ICP-MS). This microextraction-ICP-MS ... ...

Abstract	Direct isotope ratio analysis of solid uranium particulates on cotton swipes was achieved using a solution-based microextraction technique, coupled to a quadrupole inductively coupled plasma - mass spectrometer (ICP-MS). This microextraction-ICP-MS methodology provides rapid isotopic analysis which could be applicable to nuclear safeguards measurements. Particulates of uranyl nitrate hexahydrate (UO
MeSH term(s)	Isotopes ; Mass Spectrometry/methods ; Textiles ; Uranium/analysis ; Uranium Compounds
Chemical Substances	Isotopes ; Uranium Compounds ; Uranium (4OC371KSTK)
Language	English
Publishing date	2022-04-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1483436-4
ISSN	1873-4324 ; 0003-2670
ISSN (online)	1873-4324
ISSN	0003-2670
DOI	10.1016/j.aca.2022.339836
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