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  1. Article ; Online: Role of plant homeodomain finger protein 8 in P19 embryonic carcinoma cells revealed by genome editing and specific inhibitor.

    Doi, Shusuke / Suzuki, Takayoshi / Soeda, Shuhei / Miyata, Naoki / Inazu, Tetsuya

    Biochemistry and biophysics reports

    2024  Volume 38, Page(s) 101670

    Abstract: Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation and ... ...

    Abstract Plant homeodomain finger protein 8 (PHF8) is a histone demethylase that regulates the expression of various genes. PHF8 targets repressor histone markers and activates gene expression. Although PHF8 has been involved in X-linked mental retardation and certain types of cancers, the role of PHF8 remains largely unknown, and its relevance to the pathogenesis of these diseases is also uncertain. In the present study, we aimed to clarify the cellular function of PHF8 in P19 cells using
    Language English
    Publishing date 2024-03-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2831046-9
    ISSN 2405-5808 ; 2405-5808
    ISSN (online) 2405-5808
    ISSN 2405-5808
    DOI 10.1016/j.bbrep.2024.101670
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  2. Article ; Online: Nickel-Catalyzed Exhaustive Hydrodefluorination of Perfluoroalkyl Arenes.

    Doi, Ryohei / Yasuda, Masashi / Kajita, Naoki / Koh, Kenta / Ogoshi, Sensuke

    Journal of the American Chemical Society

    2023  Volume 145, Issue 20, Page(s) 11449–11456

    Abstract: Perfluoroalkyl compounds are persistent environmental pollutants due to their strong C( ... ...

    Abstract Perfluoroalkyl compounds are persistent environmental pollutants due to their strong C(sp
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c03471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Quantifying the direct and indirect effects of sika deer (Cervus nippon) on the prevalence of infection with Rickettsia in questing Haemaphysalis megaspinosa: A field experimental study.

    Matsuyama, Hiroyuki / Doi, Kandai / Agetsuma, Naoki / Suzuki, Maki

    Ticks and tick-borne diseases

    2023  Volume 14, Issue 5, Page(s) 102201

    Abstract: Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of ... ...

    Abstract Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of Rickettsia infection in questing H. megaspinosa. As sika deer decrease vegetation cover and height and thereby indirectly cause changes in the abundance of other hosts, including reservoirs of Rickettsia, the prevalence of Rickettsia infection in questing ticks can also change. We investigated these possible effects of deer on the prevalence of infection with Rickettsia in questing ticks in a field experiment in which deer density was manipulated at three fenced sites: a deer enclosure (Deer-enclosed site); a deer enclosure where deer had been present until 2015 and only indirect effects remained (Indirect effect site); and a deer exclosure in place since 2004 (Deer-exclosed site). Density of questing nymphs and the prevalence of infection with Rickettsia sp. 1 in questing nymphs at each site were compared from 2018 to 2020. The nymph density at the Deer-exclosed site did not significantly differ from that at the Indirect effect site, suggesting that the deer herbivory did not affect the nymph density by reducing vegetation and increasing the abundance of other host mammals. However, the prevalence of infection with Rickettsia sp. 1 in questing nymphs was higher at the Deer-exclosed site than at the Deer-enclosed site, possibly because ticks utilized alternative hosts when deer were absent. The difference in Rickettsia sp. 1 prevalence between the Indirect effect and Deer-exclosed sites was comparable to that between the Indirect effect and Deer-enclosed sites, indicating that the indirect effects of deer were as strong as the direct effects. Examining the indirect effects of ecosystem engineers in the study of tick-borne diseases may be more important than previously recognized.
    MeSH term(s) Animals ; Rickettsia ; Ecosystem ; Prevalence ; Deer/microbiology ; Ixodidae ; Ticks ; Rickettsia Infections/epidemiology ; Nymph ; Ixodes/microbiology
    Language English
    Publishing date 2023-05-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102201
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  4. Article ; Online: Biomechanical gait analysis and rehabilitation in a traumatic hallux deficit patient: a case report.

    Doi, Naoki / Pataky, Todd / Tateuchi, Hiroshige / Nagai-Tanima, Momoko / Aoyama, Tomoki

    Journal of medical case reports

    2024  Volume 18, Issue 1, Page(s) 105

    Abstract: Background: The hallux plays a crucial role in maintaining standing balance and facilitating forward and backward movements during gait.: Case presentation: A 21-year-old Japanese patient, suffering from a traumatic hallux deficit with only a portion ...

    Abstract Background: The hallux plays a crucial role in maintaining standing balance and facilitating forward and backward movements during gait.
    Case presentation: A 21-year-old Japanese patient, suffering from a traumatic hallux deficit with only a portion of the basal phalanx intact, underwent rehabilitation treatment. The thenar area exhibited instability, leading to impaired balance and walking difficulties. Biomechanical assessment revealed the need for a rehabilitation strategy for the foot, as well as the knee, hip, and trunk. A rehabilitation protocol was designed to enhance medial foot loading during walking and standing, including balance and trunk strength training. After a 12-week rehabilitation period, the patient's gait showed significant improvement. Specifically, the load response and single-support phases of the gait cycle on the affected side increased from 46.9% to 49.3%, while the pre-swing phase decreased from 14.6% to 11.6%. The vertical component of the ground reaction force rose from 599.8 to 647.5 N. The enhanced stability from balance training and increased muscle strength contributed to the patient's improved walking and balance.
    Conclusion: A patient with a traumatic hallux deficit underwent conservative treatment through strategic rehabilitation according to biomechanical assessment. This case report underscores the value of biomechanical gait analysis in the conservative management of similar conditions.
    MeSH term(s) Humans ; Young Adult ; Adult ; Hallux ; Gait Analysis ; Lower Extremity ; Foot ; Medicine ; Walking
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-024-04444-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Predictive factors for malignant neoplasms veiled in deep neck infections.

    Sato, Mitsuo P / Otsuki, Naoki / Kimura, Takayuki / Doi, Katsumi

    Acta oto-laryngologica

    2022  Volume 142, Issue 2, Page(s) 202–205

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Head ; Hospitalization ; Humans ; Neck/pathology ; Neoplasms/pathology ; Retrospective Studies
    Language English
    Publishing date 2022-02-03
    Publishing country England
    Document type Journal Article
    ISSN 1651-2251
    ISSN (online) 1651-2251
    DOI 10.1080/00016489.2022.2030880
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs 105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The Metabolic Regulation of Amino Acid Synthesis Counteracts Reactive Nitrogen Stress via

    Amahisa, Madoka / Tsukagoshi, Madoka / Kadooka, Chihiro / Masuo, Shunsuke / Takeshita, Norio / Doi, Yuki / Takagi, Hiroshi / Takaya, Naoki

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 1

    Abstract: Nitric oxide (NO) is a natural reactive nitrogen species (RNS) that alters proteins, DNA, and lipids and damages biological activities. Although microorganisms respond to and detoxify NO, the regulation of the cellular metabolic mechanisms that cause ... ...

    Abstract Nitric oxide (NO) is a natural reactive nitrogen species (RNS) that alters proteins, DNA, and lipids and damages biological activities. Although microorganisms respond to and detoxify NO, the regulation of the cellular metabolic mechanisms that cause cells to tolerate RNS toxicity is not completely understood. We found that the proline and arginine auxotrophic
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10010058
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  7. Article ; Online: Quantifying the direct and indirect effects of sika deer (Cervus nippon) on the prevalence of infection with Rickettsia in questing Haemaphysalis megaspinosa: A field experimental study

    Matsuyama, Hiroyuki / Doi, Kandai / Agetsuma, Naoki / Suzuki, Maki

    Ticks and Tick-borne Diseases. 2023 Sept., v. 14, no. 5 p.102201-

    2023  

    Abstract: Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of ... ...

    Abstract Sika deer (Cervus nippon) are important hosts for all life stages of Haemaphysalis megaspinosa, a suspected Rickettsia vector. Because some Rickettsia are unlikely to be amplified by deer in Japan, the presence of deer may decrease the prevalence of Rickettsia infection in questing H. megaspinosa. As sika deer decrease vegetation cover and height and thereby indirectly cause changes in the abundance of other hosts, including reservoirs of Rickettsia, the prevalence of Rickettsia infection in questing ticks can also change. We investigated these possible effects of deer on the prevalence of infection with Rickettsia in questing ticks in a field experiment in which deer density was manipulated at three fenced sites: a deer enclosure (Deer-enclosed site); a deer enclosure where deer had been present until 2015 and only indirect effects remained (Indirect effect site); and a deer exclosure in place since 2004 (Deer-exclosed site). Density of questing nymphs and the prevalence of infection with Rickettsia sp. 1 in questing nymphs at each site were compared from 2018 to 2020. The nymph density at the Deer-exclosed site did not significantly differ from that at the Indirect effect site, suggesting that the deer herbivory did not affect the nymph density by reducing vegetation and increasing the abundance of other host mammals. However, the prevalence of infection with Rickettsia sp. 1 in questing nymphs was higher at the Deer-exclosed site than at the Deer-enclosed site, possibly because ticks utilized alternative hosts when deer were absent. The difference in Rickettsia sp. 1 prevalence between the Indirect effect and Deer-exclosed sites was comparable to that between the Indirect effect and Deer-enclosed sites, indicating that the indirect effects of deer were as strong as the direct effects. Examining the indirect effects of ecosystem engineers in the study of tick-borne diseases may be more important than previously recognized.
    Keywords Cervus nippon ; Haemaphysalis ; Japan ; Rickettsia ; deer ; ecosystems ; field experimentation ; herbivores ; vegetation cover ; Tick-borne diseases ; Ecosystem engineer ; Large mammalian herbivores ; Disease ecology ; Spotted fever
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier GmbH
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2541872-5
    ISSN 1877-9603 ; 1877-959X
    ISSN (online) 1877-9603
    ISSN 1877-959X
    DOI 10.1016/j.ttbdis.2023.102201
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Diagnostic utility of cytology in a patient with Epstein-Barr virus-positive mucocutaneous ulcer in palatine tonsils: A case report.

    Doi, Mieko / Hamada, Mei / Ishizawa, Keisuke / Fushimi, Naoki / Kase, Yasuhiro / Ikezono, Tetsuo / Tamaru, Jun-Ichi / Yamada, Taketo

    Diagnostic cytopathology

    2024  

    Abstract: Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, ... ...

    Abstract Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, dysphagia, and oral pain. His medical history included rheumatoid arthritis that had been treated with methotrexate. Clinically, peritonsillar abscess was suspected, but since neoplastic lesions, including malignant lymphoma (ML), could not be excluded, a series of cytohistological examination was attempted. Despite some alarming findings (e.g., frequent mitoses), fine-needle aspiration and touch imprint cytology consistently revealed a heterogeneous population of lymphoid and plasmacytoid cells with mild nuclear atypia. The final diagnosis of EBVMCU was established based on the permanent histologic specimen; however, retrospectively, cytology was more representative of the benign nature of the lesion than histology, helping a great deal to differentiate it from ML. Cytology can be a useful tool for the correct diagnosis of EBVMCU.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632710-2
    ISSN 1097-0339 ; 8755-1039
    ISSN (online) 1097-0339
    ISSN 8755-1039
    DOI 10.1002/dc.25309
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2117: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Detailed analysis of recurrent sites after wedge resection for primary hepatocellular carcinoma considering the potential usefulness of anatomic resection: a retrospective cohort study.

    Hokuto, Daisuke / Yasuda, Satoshi / Kamitani, Naoki / Matsuo, Yasuko / Doi, Shunsuke / Sho, Masayuki

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 29

    Abstract: Purpose: We investigated the detailed recurrent sites after wedge liver resection for primary hepatocellular carcinoma (HCC).: Methods: We retrospectively reviewed 278 patients with primary HCC who underwent curative liver resection between 2000 and ... ...

    Abstract Purpose: We investigated the detailed recurrent sites after wedge liver resection for primary hepatocellular carcinoma (HCC).
    Methods: We retrospectively reviewed 278 patients with primary HCC who underwent curative liver resection between 2000 and 2016. Recurrent sites were divided into four groups: around the initial HCC (segmental recurrence), within the same section as the primary HCC (sectional recurrence), within the same lobe as the primary HCC (lobar recurrence), and contralateral or extrahepatic recurrence (extra recurrence).
    Results: Recurrence was observed in 101 of 147 patients who underwent wedge resection. At first recurrence, segmental recurrence was observed in 18 patients (17.8%), while 28 patients (27.7%) were with sectional recurrence and 48 patients (47.5%) were with lobar recurrence. However, the cumulative recurrent sites of each patient showed extra recurrence in 53 patients (52.5%) at initial recurrence, 79 patients (78.2%) until the second recurrence, 89 patients (88.1%) until the third recurrence, 94 patients (93.0%) until the fourth, and 96 patients (95.0%) until the fifth recurrence.
    Conclusion: Some intrahepatic recurrence after wedge resection might have been avoided if anatomic resection had been performed instead. However, the number of contralateral or extrahepatic recurrences increased with the number of recurrences.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Retrospective Studies ; Neoplasm Recurrence, Local/surgery ; Neoplasm Recurrence, Local/pathology ; Hepatectomy ; Recurrence
    Language English
    Publishing date 2023-01-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-02775-x
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    Uk I Zs.10: Show issues Location:
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  10. Article ; Online: Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma

    Machiko Kai / Hayato Hikita / Maesaka Kazuki / Yuki Tahata / Kazuma Shinkai / Akira Doi / Kazuyoshi Ohkawa / Masanori Miyazaki / Hisashi Ishida / Kengo Matsumoto / Yasutoshi Nozaki / Takayuki Yakushijin / Ryotaro Sakamori / Akira Kaneko / Sadaharu Iio / Takatoshi Nawa / Naruyasu Kakita / Naoki Morishita / Naoki Hiramatsu /
    Takeo Usui / Kazuho Imanaka / Yoshinori Doi / Mitsuru Sakakibara / Yuichi Yoshida / Tsugiko Oze / Takahiro Kodama / Tomohide Tatsumi / Tetsuo Takehara

    PLoS ONE, Vol 19, Iss

    A multicenter prospective observational study

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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