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Book ; Online: Table 2. Percentage of palynomorphs found in each sample through Longling section, supplementary data to: Xu, Jing-Xian; Ferguson, David-Kay; Li, Cheng-Sen; Wang, Yu-Fei; Du, Nai-Qiu (2004): Climatic and ecological implications of Late Pliocene Palynoflora from Longling, Yunnan, China. Quaternary International, 117(1), 91-103

Xu, Jing-Xian / Du, Nai-Qiu / Ferguson, David-Kay / Li, Cheng-Sen / Wang, Yu-Fei

2004

Abstract: The Longling Coal Mine (W. Yunnan) is situated in an area of substantial geotectonic activity. Its Late Pliocene palynoflora is of considerable interest, since the area represents a centre of biodiversity. Eighty-two palynomorphs belonging to 61 families ...

Abstract	The Longling Coal Mine (W. Yunnan) is situated in an area of substantial geotectonic activity. Its Late Pliocene palynoflora is of considerable interest, since the area represents a centre of biodiversity. Eighty-two palynomorphs belonging to 61 families were recovered from the lignite. The palynoflora is dominated by angiosperms (68.3%), with ferns (24.4%), gymnosperms (4.9%) and algae (2.4%). Comparisons indicate that most of the palynoflora was derived from the Montane Humid Evergreen Broad-leaved Forest, with lesser contributions from the Tsuga dumosa Forest and Evergreen Coniferous Broad-leaved Mixed Forest, as well as the Montane Mossy Evergreen Broad-leaved Forest. This indicates that the Late Pliocene climate was cooler than that of the present. In the course of the accumulation of the lignite, the climate underwent five major phases of warming and cooling.
Language	English
Dates of publication	2004-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.1016/S1040-6182(03)00119-8
DOI	10.1594/PANGAEA.695903
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Serum secreted phosphoprotein 1 level is associated with plaque vulnerability in patients with coronary artery disease.

Huang, Ke / Chen, Shuai / Yu, Lin-Jun / Wu, Zhi-Ming / Chen, Qiu-Jing / Wang, Xiao-Qun / Li, Fei-Fei / Liu, Jing-Meng / Wang, Yi-Xuan / Mao, Lin-Shuang / Shen, Wei-Feng / Zhang, Rui-Yan / Shen, Ying / Lu, Lin / Dai, Yang / Ding, Feng-Hua

Frontiers in immunology

2024 Volume 15, Page(s) 1285813

Abstract: Background: Vulnerable plaque was associated with recurrent cardiovascular events. This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease.: Methods: To reveal the phenotype-associated ... ...

Abstract	Background: Vulnerable plaque was associated with recurrent cardiovascular events. This study was designed to explore predictive biomarkers of vulnerable plaque in patients with coronary artery disease. Methods: To reveal the phenotype-associated cell type in the development of vulnerable plaque and to identify hub gene for pathological process, we combined single-cell RNA and bulk RNA sequencing datasets of human atherosclerotic plaques using Single-Cell Identification of Subpopulations with Bulk Sample Phenotype Correlation (Scissor) and Weighted gene co-expression network analysis (WGCNA). We also validated our results in an independent cohort of patients by using intravascular ultrasound during coronary angiography. Results: Macrophages were found to be strongly correlated with plaque vulnerability while vascular smooth muscle cell (VSMC), fibrochondrocyte (FC) and intermediate cell state (ICS) clusters were negatively associated with unstable plaque. Weighted gene co-expression network analysis showed that Secreted Phosphoprotein 1 (SPP1) in the turquoise module was highly correlated with both the gene module and the clinical traits. In a total of 593 patients, serum levels of SPP1 were significantly higher in patients with vulnerable plaques than those with stable plaque (113.21 [73.65 - 147.70] ng/ml versus 71.08 [20.64 - 135.68] ng/ml; Conclusion: Elevated serum SPP1 levels confer an increased risk for plaque vulnerability in patients with coronary artery disease.
MeSH term(s)	Humans ; Biomarkers ; Coronary Angiography ; Coronary Artery Disease ; Osteopontin/genetics ; Plaque, Atherosclerotic/pathology
Chemical Substances	Biomarkers ; Osteopontin (106441-73-0) ; SPP1 protein, human
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1285813
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer

Qu, Ye-Min / Chen, Ai / Zhao, Xue / Wang, Zan / Guo, Dong / Shao, Shu-Li / Tao, Yuan-Yong / Li, Qiu-Jing / Wang, Ming-Yi / Ma, Wan-Shan

Mol Biol Rep. 2023 Feb., v. 50, no. 2 p.1517-1531

2023

Abstract: BACKGROUND: Gastric cancer is heterogeneous cancer and the causes of this disease are complex. New diagnostic and therapeutic targets are urgently needed to explore. Huntingtin-associated protein 1 (HAP1) is directly related to Huntington’s disease (HD). ...

Abstract	BACKGROUND: Gastric cancer is heterogeneous cancer and the causes of this disease are complex. New diagnostic and therapeutic targets are urgently needed to explore. Huntingtin-associated protein 1 (HAP1) is directly related to Huntington’s disease (HD). However, patients with Huntington’s disease have a lower incidence of cancer. Therefore, we are committed to studying the correlation between HAP1 and gastric carcinogenesis and development. METHODS AND RESULTS: Immunohistochemical staining, western blot analysis, and RT-qPCR were conducted to explore the localization and expression of HAP1 in gastric cancer. To study the biological significance of HAP1, we overexpressed HAP1 in both MKN28 and AGS cell lines by lentivirus infection. To explore the role of HAP1 in cell proliferation, the cells counting assay, EdU incorporation assay, and colony formation assay were carried out. We performed the wound healing assay and transwell assay to study the cell migration and invasion. To further investigate whether HAP1 could regulate gastric cancer cell death during glucose deprivation, Annexin V-FITC/PI staining was performed. In our study, we elucidated that HAP1 was downregulated in gastric cancer. What’s more, overexpressing HAP1 inhibited cell proliferation, cell migration and invasion, and triggered apoptosis during glucose deprivation. More importantly, the antitumor properties and mechanisms of HAP1 have been elucidated further in gastric cancer. CONCLUSIONS: Taken together, the available evidence implies that HAP1 may serve as a potential tumor suppressor, making it a significant target in preventing and treating gastric cancer. This research provides a theoretical basis for the early diagnosis, clinical targeted therapy, and prognosis evaluation of gastric cancer.
Keywords	Western blotting ; apoptosis ; carcinogenesis ; cell movement ; cell proliferation ; early diagnosis ; glucose ; immunohistochemistry ; neoplasm cells ; prognosis ; stomach neoplasms ; therapeutics
Language	English
Dates of publication	2023-02
Size	p. 1517-1531.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-022-08090-w
Database	NAL-Catalogue (AGRICOLA)

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Article: Comparative Metabolomic Analysis of the Nutritional Aspects from Ten Cultivars of the Strawberry Fruit.

Wang, Xinlu / Wu, Linxia / Qiu, Jing / Qian, Yongzhong / Wang, Meng

Foods (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Strawberry ( ...

Abstract	Strawberry (
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12061153
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Article: Dietary 25-Hydroxycholecalciferol Supplementation as a Vitamin D

Gao, Shan / Qiu, Kai / Zheng, Junjie / Zhang, Haijun / Wang, Jing / Qi, Xiaolong / Wu, Shugeng

Animals : an open access journal from MDPI

2024 Volume 14, Issue 6

Abstract: This study aimed to investigate whether a dietary 25- ... ...

Abstract	This study aimed to investigate whether a dietary 25-OHD
Language	English
Publishing date	2024-03-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14060878
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Article ; Online: PI3Kδ inhibition alleviates the brain injury during cerebral ischemia reperfusion via suppressing pericyte contraction in a TNF-α dependent manner.

Qiu, Jing / Wang, Yi-Han / Wang, Xiu-Ming / Chen, Hui-Sheng

Experimental neurology

2024 Volume 375, Page(s) 114728

Abstract: The pericytes (PCs) surrounding capillaries are vital regulators of capillary constriction. Persistent PC contraction results in the increased capillary constriction, therefore leading to the impaired cerebral blood flow (CBF) recovery after reperfusion ... ...

Abstract	The pericytes (PCs) surrounding capillaries are vital regulators of capillary constriction. Persistent PC contraction results in the increased capillary constriction, therefore leading to the impaired cerebral blood flow (CBF) recovery after reperfusion and worsening the clinical outcomes in stroke patients. However, the potential determinants of PC functions during ischemia/reperfusion are poorly understood. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta (PIK3CD/PI3Kδ) is a crucial factor involved with neuronflammation during ischemic stroke. PI3Kδ has shown the expression in PCs, while its effect on PC functions has not been explored yet. In this study, a rodent ischemia/reperfusion model was established in C57BL/6 mice via transient middle cerebral artery occlusion and reperfusion (MCAO/R). The PI3Kδ expression in ischemic penumbra was remarkably upregulated following MCAO/R induction. PI3Kδ inhibitor CAL-101 improved the CBF recovery, ischemic brain injury, and suppressed capillary constriction in MCAO/R mice. Besides, the production of tumor necrosis factor alpha (TNF-α), an inducer for tissue injury, and the expression of transient receptor potential vanilloid type 2 (TRPV2), a channel protein permitting calcium (Ca
MeSH term(s)	Animals ; Humans ; Mice ; Brain Injuries ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/metabolism ; Ischemic Stroke ; Mice, Inbred C57BL ; Pericytes/metabolism ; Reperfusion ; Reperfusion Injury/metabolism ; Tumor Necrosis Factor-alpha
Chemical Substances	Tumor Necrosis Factor-alpha ; Pik3cd protein, mouse (EC 2.7.1.137)
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2024.114728
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Article ; Online: An Er

Zhao, Chunli / Gao, Yuan / Song, Tiantian / Wang, Jing / Qiu, Jianbei

The journal of physical chemistry letters

2023 Volume 14, Issue 40, Page(s) 9011–9018

Abstract: Lanthanide ions are widely used as dopants for halide perovskites for their broad energy level coverage from the visible to near-infrared (NIR) range. In this work, ... ...

Abstract	Lanthanide ions are widely used as dopants for halide perovskites for their broad energy level coverage from the visible to near-infrared (NIR) range. In this work, Cs
Language	English
Publishing date	2023-10-02
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c02321
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Article ; Online: Alterations of the amplitude of low-frequency fluctuation induced by repetitive transcranial magnetic stimulation combined with antidepressants treatment for major depressive disorder.

Qiu, Jing / Gu, Weiguo / Zhang, Yuan / Wang, Lei / Shen, Junkang

Psychiatry research. Neuroimaging

2024 Volume 340, Page(s) 111792

Abstract: We investigated the neuroimaging changes and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants in major depressive disorder (MDD) patients. We scanned 35 patients with MDD and 27 healthy controls (HC) ... ...

Abstract	We investigated the neuroimaging changes and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants in major depressive disorder (MDD) patients. We scanned 35 patients with MDD and 27 healthy controls (HC) with resting-state functional magnetic resonance imaging (fMRI) before and after treatment. We analyzed amplitude of low-frequency fluctuation (ALFF) and the correlation with clinical variables. The rate of significant efficacy after treatment was higher in the combination treatment group than in the antidepressant group, although not statistically significant. At baseline, ALFF increased in the left middle temporal, brain stem, and left cerebellum and decreased in the right anterior cingulate (ACC), right orbital frontal cortex (OFC), and right caudate. ALFF increased in the left fusiform and decreased in the right lingual gyrus, left middle occipital gyrus, and left superior occipital gyrus after antidepressants. ALFF increased in the right ACC, right OFC, and right rectus after combination treatment. ALFF changes in the right ACC/OFC were negatively correlated with HAMD changes. After treatment, abnormal activity in some brain regions normalized, but these regions differed between the two treatment groups. rTMS combined with antidepressants therapy may improve MDD symptoms by improving neuronal activity levels in the right ACC and right OFC.
MeSH term(s)	Humans ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/drug therapy ; Transcranial Magnetic Stimulation ; Brain Mapping ; Magnetic Resonance Imaging/methods ; Antidepressive Agents/therapeutic use
Chemical Substances	Antidepressive Agents
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7506 ; 1872-7123 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7506 ; 1872-7123
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.pscychresns.2024.111792
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Article ; Online: Convolutional neural network-based measurement of crown-implant ratio for implant-supported prostheses.

Zhang, Jin-Ping / Wang, Ze-Hui / Zhang, Juan / Qiu, Jing

The Journal of prosthetic dentistry

2024

Abstract: Statement of problem: Research has revealed that the crown-implant ratio (CIR) is a critical variable influencing the long-term stability of implant-supported prostheses in the oral cavity. Nevertheless, inefficient manual measurement and varied ... ...

Abstract	Statement of problem: Research has revealed that the crown-implant ratio (CIR) is a critical variable influencing the long-term stability of implant-supported prostheses in the oral cavity. Nevertheless, inefficient manual measurement and varied measurement methods have caused significant inconvenience in both clinical and scientific work. Purpose: This study aimed to develop an automated system for detecting the CIR of implant-supported prostheses from radiographs, with the objective of enhancing the efficiency of radiograph interpretation for dentists. Material and methods: The method for measuring the CIR of implant-supported prostheses was based on convolutional neural networks (CNNs) and was designed to recognize implant-supported prostheses and identify key points around it. The experiment used the You Only Look Once version 4 (Yolov4) to locate the implant-supported prosthesis using a rectangular frame. Subsequently, two CNNs were used to identify key points. The first CNN determined the general position of the feature points, while the second CNN finetuned the output of the first network to precisely locate the key points. The network underwent testing on a self-built dataset, and the anatomic CIR and clinical CIR were obtained simultaneously through the vertical distance method. Key point accuracy was validated through Normalized Error (NE) values, and a set of data was selected to compare machine and manual measurement results. For statistical analysis, the paired t test was applied (α=.05). Results: A dataset comprising 1106 images was constructed. The integration of multiple networks demonstrated satisfactory recognition of implant-supported prostheses and their surrounding key points. The average NE value for key points indicated a high level of accuracy. Statistical studies confirmed no significant difference in the crown-implant ratio between machine and manual measurement results (P>.05). Conclusions: Machine learning proved effective in identifying implant-supported prostheses and detecting their crown-implant ratios. If applied as a clinical tool for analyzing radiographs, this research can assist dentists in efficiently and accurately obtaining crown-implant ratio results.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	218157-5
ISSN	1097-6841 ; 0022-3913
ISSN (online)	1097-6841
ISSN	0022-3913
DOI	10.1016/j.prosdent.2024.01.007
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Article: Efficacy and tolerability of zuranolone in patients with depression: a meta-analysis of randomized controlled trials.

Qiu, Youjia / Tao, Yuchen / Duan, Aojie / Wei, Xingzhou / Wang, Menghan / Xie, Minjia / Chen, Zhouqing / Shang, Jing / Wang, Zhong

Frontiers in pharmacology

2024 Volume 14, Page(s) 1334694

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1334694
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