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  1. Article ; Online: Review and future directions for PIMS-TS (MIS-C).

    Roarty, Cathal / Waterfield, Thomas

    Archives of disease in childhood

    2022  Volume 108, Issue 4, Page(s) e2

    MeSH term(s) Humans ; Systemic Inflammatory Response Syndrome ; COVID-19
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 524-1
    ISSN 1468-2044 ; 0003-9888 ; 1359-2998
    ISSN (online) 1468-2044
    ISSN 0003-9888 ; 1359-2998
    DOI 10.1136/archdischild-2021-323143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.106: Show issues Location:
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    Zs.MA 3: Show issues

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  2. Article ; Online: Kinetics and seroprevalence of SARS-CoV-2 antibodies in children.

    Roarty, Cathal / Tonry, Claire / McFetridge, Lisa / Mitchell, Hannah / Watson, Chris / Waterfield, Thomas

    The Lancet. Infectious diseases

    2020  Volume 21, Issue 6, Page(s) e143

    MeSH term(s) Adolescent ; Antibodies, Viral/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; Child ; Child, Preschool ; Humans ; Immunoglobulin G/blood ; Kinetics ; SARS-CoV-2/immunology ; Seroepidemiologic Studies ; United Kingdom/epidemiology
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2020-11-19
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30884-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5743: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Study protocol: Medium throughput proteomic characterization of children with PIMS-TS, and identification of candidate diagnostic biomarkers.

    Roarty, Cathal / Mills, Clare / Tonry, Claire / Cosgrove, Peter / Norman-Bruce, Hannah / Groves, Helen / Watson, Chris / Waterfield, Thomas

    medRxiv

    Abstract: SARS-CoV-2 infection in children results in a wide range of clinical outcomes. Paediatric Multisystem Inflammatory syndrome temporally associated with COVID-19(PIMS-TS) occurs weeks after a SARS-CoV-2 infection, and results in severe illness. This ... ...

    Abstract SARS-CoV-2 infection in children results in a wide range of clinical outcomes. Paediatric Multisystem Inflammatory syndrome temporally associated with COVID-19(PIMS-TS) occurs weeks after a SARS-CoV-2 infection, and results in severe illness. This protocol describes a study to fully characterize the circulating proteome of children who have PIMS-TS, the proteome of healthy children who have previously been infected with SARS-CoV-2 and the proteome of febrile children with a confirmed invasive infection. Orthogonal proteomic techniques will be utilized to provide a deep proteomic characterization
    Keywords covid19
    Language English
    Publishing date 2022-12-28
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.12.27.22283890
    Database COVID19

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  4. Article ; Online: Study protocol: Medium throughput, deep proteomic characterization of children with PIMS-TS, and identification of candidate diagnostic biomarkers

    Roarty, Cathal / Mills, Clare / Tonry, Claire / Cosgrove, Peter / Norman-Bruce, Hannah / Groves, Helen / Watson, Chris / Waterfield, Tom

    medRxiv

    Abstract: SARS-CoV-2 infection in children results in a wide range of clinical outcomes. Paediatric Multisystem Inflammatory syndrome temporally associated with COVID-19(PIMS-TS) occurs weeks after a SARS-CoV-2 infection, and results in severe illness. This ... ...

    Abstract SARS-CoV-2 infection in children results in a wide range of clinical outcomes. Paediatric Multisystem Inflammatory syndrome temporally associated with COVID-19(PIMS-TS) occurs weeks after a SARS-CoV-2 infection, and results in severe illness. This protocol describes a study to fully characterize the circulating proteome of children who have PIMS-TS, the proteome of healthy children who have previously been infected with SARS-CoV-2 and the proteome of febrile children with a confirmed invasive infection. Orthogonal proteomic techniques will be utilized to provide a deep proteomic characterization
    Keywords covid19
    Language English
    Publishing date 2022-12-28
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.12.27.22283890
    Database COVID19

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  5. Article ; Online: Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents.

    Ratcliffe, Helen / Tiley, Karen S / Longet, Stephanie / Tonry, Claire / Roarty, Cathal / Watson, Chris / Amirthalingam, Gayatri / Vichos, Iason / Morey, Ella / Douglas, Naomi L / Marinou, Spyridoula / Plested, Emma / Aley, Parvinder K / Galiza, Eva / Faust, Saul N / Hughes, Stephen / Murray, Clare / Roderick, Marion R / Shackley, Fiona /
    Oddie, Sam / Lee, Tim W R / Turner, David P J / Raman, Mala / Owens, Stephen / Turner, Paul J / Cockerill, Helen / Lopez Bernal, Jamie / Ijaz, Samreen / Poh, John / Shute, Justin / Linley, Ezra / Borrow, Ray / Hoschler, Katja / Brown, Kevin E / Carroll, Miles W / Klenerman, Paul / Dunachie, Susanna J / Ramsay, Mary / Voysey, Merryn / Waterfield, Thomas / Snape, Matthew D

    iScience

    2023  Volume 26, Issue 12, Page(s) 108500

    Abstract: SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal ... ...

    Abstract SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of antibody decline for nucleocapsid and spike protein in serum and oral fluid against SARS-CoV-2 within the pediatric population. No differences in seasonal coronaviruses antibody concentrations were found at baseline between cases and controls, suggesting no protective effect from pre-existing immunity against seasonal coronaviruses. Antibodies against seasonal betacoronaviruses were boosted in response to SARS-CoV-2 infection. In serum, anti-nucleocapsid antibodies fell below the threshold of positivity more quickly than anti-spike protein antibodies. These findings add to our understanding of protection against infection with SARS-CoV-2 within the pediatric population, which is important when considering pediatric SARS-CoV-2 immunization policies.
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serum HCoV-spike specific antibodies do not protect against subsequent SARS-CoV-2 infection in children and adolescents

    Helen Ratcliffe / Karen S. Tiley / Stephanie Longet / Claire Tonry / Cathal Roarty / Chris Watson / Gayatri Amirthalingam / Iason Vichos / Ella Morey / Naomi L. Douglas / Spyridoula Marinou / Emma Plested / Parvinder K. Aley / Eva Galiza / Saul N. Faust / Stephen Hughes / Clare Murray / Marion R. Roderick / Fiona Shackley /
    Sam Oddie / Tim W.R. Lee / David P.J. Turner / Mala Raman / Stephen Owens / Paul J. Turner / Helen Cockerill / Jamie Lopez Bernal / Samreen Ijaz / John Poh / Justin Shute / Ezra Linley / Ray Borrow / Katja Hoschler / Kevin E. Brown / Miles W. Carroll / Paul Klenerman / Susanna J. Dunachie / Mary Ramsay / Merryn Voysey / Thomas Waterfield / Matthew D. Snape

    iScience, Vol 26, Iss 12, Pp 108500- (2023)

    2023  

    Abstract: Summary: SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive ... ...

    Abstract Summary: SARS-CoV-2 infections in children are generally asymptomatic or mild and rarely progress to severe disease and hospitalization. Why this is so remains unclear. Here we explore the potential for protection due to pre-existing cross-reactive seasonal coronavirus antibodies and compare the rate of antibody decline for nucleocapsid and spike protein in serum and oral fluid against SARS-CoV-2 within the pediatric population. No differences in seasonal coronaviruses antibody concentrations were found at baseline between cases and controls, suggesting no protective effect from pre-existing immunity against seasonal coronaviruses. Antibodies against seasonal betacoronaviruses were boosted in response to SARS-CoV-2 infection. In serum, anti-nucleocapsid antibodies fell below the threshold of positivity more quickly than anti-spike protein antibodies. These findings add to our understanding of protection against infection with SARS-CoV-2 within the pediatric population, which is important when considering pediatric SARS-CoV-2 immunization policies.
    Keywords Health sciences ; Medicine ; Medical specialty ; Immunology ; Virology ; Science ; Q
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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