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  1. Article ; Online: Pooled saliva samples as an approach to reduce the spread of infections with SARS-CoV-2.

    Möst, Johannes / Eigentler, Angelika / Orth-Höller, Dorothea

    Infection

    2021  Volume 49, Issue 4, Page(s) 797–798

    MeSH term(s) COVID-19 ; Humans ; RNA, Viral ; SARS-CoV-2 ; Saliva ; Specimen Handling
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-03-06
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01593-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 881: Show issues Location:
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  2. Article ; Online: Outcome 10 years after Shiga toxin-producing E. coli (STEC)-associated hemolytic uremic syndrome: importance of long-term follow-up.

    Rosales, Alejandra / Kuppelwieser, Sarah / Giner, Thomas / Hofer, Johannes / Riedl Khursigara, Magdalena / Orth-Höller, Dorothea / Borena, Wegene / Cortina, Gerard / Jungraithmayr, Therese / Würzner, Reinhard

    Pediatric nephrology (Berlin, Germany)

    2024  

    Abstract: Background: Hemolytic uremic syndrome (HUS) is an important cause of acute kidney injury in children. HUS is known as an acute disease followed by complete recovery, but patients may present with kidney abnormalities after long periods of time. This ... ...

    Abstract Background: Hemolytic uremic syndrome (HUS) is an important cause of acute kidney injury in children. HUS is known as an acute disease followed by complete recovery, but patients may present with kidney abnormalities after long periods of time. This study evaluates the long-term outcome of Shiga toxin-producing Escherichia coli-associated HUS (STEC-HUS) in pediatric patients, 10 years after the acute phase of disease to identify risk factors for long-term sequelae.
    Methods: Over a 6-year period, 619 patients under 18 years of age with HUS (490 STEC-positive, 79%) were registered in Austria and Germany. Long-term follow-up data of 138 STEC-HUS-patients were available after 10 years for analysis.
    Results: A total of 66% (n = 91, 95% CI 0.57-0.73) of patients fully recovered showing no sequelae after 10 years. An additional 34% (n = 47, 95% CI 0.27-0.43) presented either with decreased glomerular filtration rate (24%), proteinuria (23%), hypertension (17%), or neurological symptoms (3%). Thirty had sequelae 1 year after STEC-HUS, and the rest presented abnormalities unprecedented at the 2-year (n = 2), 3-year (n = 3), 5-year (n = 3), or 10-year (n = 9) follow-up. A total of 17 patients (36.2%) without kidney abnormalities at the 1-year follow-up presented with either proteinuria, hypertension, or decreased eGFR in subsequent follow-up visits. Patients needing extracorporeal treatments during the acute phase were at higher risk of presenting symptoms after 10 years (p < 0.05).
    Conclusions: Patients with STEC-HUS should undergo regular follow-up, for a minimum of 10 years following their index presentation, due to the risk of long-term sequelae of their disease. An initial critical illness, marked by need of kidney replacement therapy or plasma treatment may help predict poor long-term outcome.
    Language English
    Publishing date 2024-04-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-024-06355-z
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  3. Article ; Online: Antibody kinetics in primary- and secondary-care physicians with mild to moderate SARS-CoV-2 infection.

    Orth-Höller, Dorothea / Eigentler, Angelika / Weseslindtner, Lukas / Möst, Johannes

    Emerging microbes & infections

    2020  Volume 9, Issue 1, Page(s) 1692–1694

    Abstract: Three hundred and ninety-seven primary- and secondary-care physicians were tested for the presence of IgG (and IgA) antibodies against SARS-coronavirus-2 with a commercially available ELISA. In 19 of 20 individuals with PCR-proven infection and only mild ...

    Abstract Three hundred and ninety-seven primary- and secondary-care physicians were tested for the presence of IgG (and IgA) antibodies against SARS-coronavirus-2 with a commercially available ELISA. In 19 of 20 individuals with PCR-proven infection and only mild to moderate symptoms not requiring hospitalization positive IgG levels occurred within two to three weeks. Among the remaining 377 persons without clear-cut evidence of infection, unequivocally positive IgG antibodies were found in only one, showing a surprisingly low prevalence (0.3%, 95% CI: 0.01-1.5) in physicians with likely contacts with infected patients in a region highly affected by the pandemic (Tyrol, Austria).
    MeSH term(s) Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; Coronavirus Infections/immunology ; Female ; Humans ; Immunoglobulin A/blood ; Immunoglobulin G/blood ; Male ; Middle Aged ; Pandemics ; Physicians, Primary Care ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Secondary Care
    Chemical Substances Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G
    Keywords covid19
    Language English
    Publishing date 2020-07-11
    Publishing country United States
    Document type Letter
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2020.1793690
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  4. Article: Enzymatic Cleavage of Stx2a in the Gut and Identification of Pancreatic Elastase and Trypsin as Possible Main Cleavers.

    Kellnerová, Sára / Huber, Silke / Massri, Mariam / Fleischer, Verena / Losso, Klemens / Sarg, Bettina / Kremser, Leopold / Talasz, Heribert / He, Xiaohua / Varrone, Elisa / Brigotti, Maurizio / Ardissino, Gianluigi / Orth-Höller, Dorothea / Würzner, Reinhard

    Microorganisms

    2023  Volume 11, Issue 10

    Abstract: Shiga toxins (Stxs), especially the Stx2a subtype, are the major virulence factors involved in ... ...

    Abstract Shiga toxins (Stxs), especially the Stx2a subtype, are the major virulence factors involved in enterohemorrhagic
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11102487
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  5. Article ; Online: Complement C7 and clusterin form a complex in circulation.

    Massri, Mariam / Toonen, Erik J M / Sarg, Bettina / Kremser, Leopold / Grasse, Marco / Fleischer, Verena / Torres-Quesada, Omar / Hengst, Ludger / Skjoedt, Mikkel-Ole / Bayarri-Olmos, Rafael / Rosbjerg, Anne / Garred, Peter / Orth-Höller, Dorothea / Prohászka, Zoltán / Würzner, Reinhard

    Frontiers in immunology

    2024  Volume 15, Page(s) 1330095

    Abstract: Introduction: The complement system is part of innate immunity and is comprised of an intricate network of proteins that are vital for host defense and host homeostasis. A distinct mechanism by which complement defends against invading pathogens is ... ...

    Abstract Introduction: The complement system is part of innate immunity and is comprised of an intricate network of proteins that are vital for host defense and host homeostasis. A distinct mechanism by which complement defends against invading pathogens is through the membrane attack complex (MAC), a lytic structure that forms on target surfaces. The MAC is made up of several complement components, and one indispensable component of the MAC is C7. The role of C7 in MAC assembly is well documented, however, inherent characteristics of C7 are yet to be investigated.
    Methods: To shed light on the molecular characteristics of C7, we examined the properties of serum-purified C7 acquired using polyclonal and novel monoclonal antibodies. The properties of serum‑purified C7 were investigated through a series of proteolytic analyses, encompassing Western blot and mass spectrometry. The nature of C7 protein-protein interactions were further examined by a novel enzyme-linked immunosorbent assay (ELISA), as well as size‑exclusion chromatography.
    Results: Protein analyses showcased an association between C7 and clusterin, an inhibitory complement regulator. The distinct association between C7 and clusterin was also demonstrated in serum-purified clusterin. Further assessment revealed that a complex between C7 and clusterin (C7-CLU) was detected. The C7-CLU complex was also identified in healthy serum and plasma donors, highlighting the presence of the complex in circulation.
    Discussion: Clusterin is known to dissociate the MAC structure by binding to polymerized C9, nevertheless, here we show clusterin binding to the native form of a terminal complement protein in vivo. The presented data reveal that C7 exhibits characteristics beyond that of MAC assembly, instigating further investigation of the effector role that the C7-CLU complex plays in the complement cascade.
    MeSH term(s) Complement C7/metabolism ; Clusterin ; Complement System Proteins/metabolism ; Complement Membrane Attack Complex/metabolism ; Complement Activation
    Chemical Substances Complement C7 ; Clusterin ; Complement System Proteins (9007-36-7) ; Complement Membrane Attack Complex
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1330095
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  6. Article ; Online: Detection of Cleaved Stx2a in the Blood of STEC-Infected Patients.

    Varrone, Elisa / Carnicelli, Domenica / He, Xiaohua / Grasse, Marco / Stampfer, Karin / Huber, Silke / Kellnerová, Sára / Tazzari, Pier Luigi / Ricci, Francesca / Paterini, Paola / Ardissino, Gianluigi / Morabito, Stefano / Orth-Höller, Dorothea / Würzner, Reinhard / Brigotti, Maurizio

    Toxins

    2023  Volume 15, Issue 12

    Abstract: Typical hemolytic uremic syndrome (HUS) is mainly caused by Shiga toxin- ... ...

    Abstract Typical hemolytic uremic syndrome (HUS) is mainly caused by Shiga toxin-producing
    MeSH term(s) Humans ; Shiga-Toxigenic Escherichia coli ; Shiga Toxin 2 ; Shiga Toxin ; Neutrophils ; Bacteria ; Escherichia coli Infections/microbiology
    Chemical Substances Shiga Toxin 2 ; Shiga Toxin (75757-64-1)
    Language English
    Publishing date 2023-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15120690
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  7. Article ; Online: Kinetics of SARS-CoV-2 specific antibodies (IgM, IgA, IgG) in non-hospitalized patients four months following infection.

    Orth-Höller, Dorothea / Eigentler, Angelika / Stiasny, Karin / Weseslindtner, Lukas / Möst, Johannes

    The Journal of infection

    2020  Volume 82, Issue 2, Page(s) 282–327

    MeSH term(s) COVID-19 ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M ; Kinetics ; SARS-CoV-2
    Chemical Substances Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
    Keywords covid19
    Language English
    Publishing date 2020-09-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.09.015
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  8. Article: Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients.

    Eichhorn, Tanja / Huber, Silke / Weiss, René / Ebeyer-Masotta, Marie / Lauková, Lucia / Emprechtinger, Robert / Bellmann-Weiler, Rosa / Lorenz, Ingo / Martini, Judith / Pirklbauer, Markus / Orth-Höller, Dorothea / Würzner, Reinhard / Weber, Viktoria

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 6

    Abstract: Immunothrombosis, an excessive inflammatory response with simultaneous overactivation of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is associated with cellular activation, vascular damage, and microvascular thrombosis, ...

    Abstract Immunothrombosis, an excessive inflammatory response with simultaneous overactivation of the coagulation system, is a central pathomechanism in sepsis and COVID-19. It is associated with cellular activation, vascular damage, and microvascular thrombosis, which can lead to multiple organ failure and death. Here, we characterized factors related to immunothrombosis in plasma samples from 78 sepsis patients. In the course of routine clinical testing, SARS-CoV-2 was detected in 14 of these patients. Viral infection was associated with a higher mortality. Both, COVID-19 negative and COVID-19 positive sepsis patients showed increased levels of effectors of immunothrombosis, including platelet factor 4, D-dimer, nucleosomes, citrullinated histone H3, high mobility group box-1 protein, as well as phosphatidylserine-expressing platelet-derived extracellular vesicles, compared to healthy controls (
    Language English
    Publishing date 2023-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13061069
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  9. Article ; Online: Comparison of rapid hybridization-based pathogen identification and resistance evaluation in sepsis using the Verigene® device paired with "good old culture".

    Berktold, Michael / Mutschlechner, Wolfgang / Orth-Höller, Dorothea

    Wiener klinische Wochenschrift

    2017  Volume 129, Issue 11-12, Page(s) 435–441

    Abstract: Rapid microbial diagnostics is important for septicemic patients. The current gold standard is blood culture with consecutive pathogen identification and antimicrobial susceptibility testing. However, these culture-based methods need at least 48 h.The ... ...

    Abstract Rapid microbial diagnostics is important for septicemic patients. The current gold standard is blood culture with consecutive pathogen identification and antimicrobial susceptibility testing. However, these culture-based methods need at least 48 h.The aim of this study was to compare Verigene
    Language English
    Publishing date 2017-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-016-1057-y
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  10. Article ; Online: Control of hospital-acquired infections in Austria.

    Kuppelwieser, Bettina / Berktold, Michael / Orth-Höller, Dorothea / Lass-Flörl, Cornelia

    Wiener klinische Wochenschrift

    2018  Volume 130, Issue 21-22, Page(s) 673–679

    MeSH term(s) Austria ; Cross Infection ; Humans ; Risk Factors
    Language English
    Publishing date 2018-08-02
    Publishing country Austria
    Document type Letter
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-018-1369-1
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