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Article ; Online: rTMS reduces delta and increases theta oscillations in Alzheimer's disease: A visual-evoked and event-related potentials study.

Velioglu, Halil Aziz / Dudukcu, Esra Zeynep / Hanoglu, Lutfu / Guntekin, Bahar / Akturk, Tuba / Yulug, Burak

2024 Volume 30, Issue 1, Page(s) e14564

Abstract: Background: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for Alzheimer's disease (AD) due to its ability to modulate neural networks and enhance cognitive function. This treatment offers the unique ... ...

Abstract	Background: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative therapy for Alzheimer's disease (AD) due to its ability to modulate neural networks and enhance cognitive function. This treatment offers the unique advantage of enabling real-time monitoring of immediate cognitive effects and dynamic brain changes through electroencephalography (EEG). Objective: This study focused on exploring the effects of left parietal rTMS stimulation on visual-evoked potentials (VEP) and visual event-related potentials (VERP) in AD patients. Methods: Sixteen AD patients were recruited for this longitudinal study. EEG data were collected within a Faraday cage both pre- and post-rTMS to evaluate its impact on potentials. Results: Significant alterations were found in both VEP and VERP oscillations. Specifically, delta power in VEP decreased, while theta power in VERP increased post-rTMS, indicating a modulation of brain activities. Discussion: These findings confirm the positive modulatory impact of rTMS on brain activities in AD, evidenced by improved cognitive scores. They align with previous studies highlighting the potential of rTMS in managing hyperexcitability and oscillatory disturbances in the AD cortex. Conclusion: Cognitive improvements post-rTMS endorse its potential as a promising neuromodulatory treatment for cognitive enhancement in AD, thereby providing critical insights into the neurophysiological anomalies in AD and possible therapeutic avenues.
MeSH term(s)	Humans ; Transcranial Magnetic Stimulation ; Alzheimer Disease/therapy ; Longitudinal Studies ; Evoked Potentials/physiology ; Electroencephalography
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2423461-8
ISSN	1755-5949 ; 1755-5930
ISSN (online)	1755-5949
ISSN	1755-5930
DOI	10.1111/cns.14564
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Zs.A 4537: Show issues

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Article: Measuring the Impact of a Blood Supply Shortage Using Data Science.

Bahar, Burak / Gehrie, Eric A / Mo, Yunchuan D / Jacquot, Cyril / Delaney, Meghan

The journal of applied laboratory medicine

2023 Volume 8, Issue 1, Page(s) 77–83

Abstract: Background: Transfusion medicine is the only section of the clinical laboratory that performs diagnostic testing and dispenses a drug (blood) on the basis of those results. However, not all of the testing that informs the clinical decision to prescribe ... ...

Abstract	Background: Transfusion medicine is the only section of the clinical laboratory that performs diagnostic testing and dispenses a drug (blood) on the basis of those results. However, not all of the testing that informs the clinical decision to prescribe a blood transfusion is performed in the blood bank. To form a holistic assessment of blood bank responsiveness to clinical needs, it is important to be able to merge blood bank data with datapoints from the hematology laboratory and the electronic medical record. Methods: We built an interactive visualization of the time from hemoglobin result availability to initiation of red blood cell (RBC) transfusion and monitored the result over a 2-year period that coincided with several severe blood shortages. The visualization runs entirely on free software and was designed to be feasibly deployed on a variety of hospital information technology platforms without the need for significant data science expertise. Results: Patient factors, such as hemoglobin concentration, blood type, and presence of minor blood group antibodies influenced the time to initiation of transfusion. Time to transfusion initiation did not appear to be significantly affected by periods of blood shortage. Conclusion: Overall, we demonstrate a proof of concept that complex, but clinically important, blood bank quality metrics can be generated with the support of a free, user-friendly system that aggregates data from multiple sources.
MeSH term(s)	Humans ; Data Science ; Hemoglobins/analysis ; Blood Banks ; Erythrocyte Transfusion/methods ; Cognition
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-01-06
Publishing country	England
Document type	Journal Article
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1093/jalm/jfac084
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Article ; Online: Using trends and outliers in managing delayed transfusions.

Bahar, Burak / Gehrie, Eric A / Mo, Yunchuan D / Jacquot, Cyril / Delaney, Meghan

Transfusion medicine (Oxford, England)

2023 Volume 33, Issue 3, Page(s) 263–267

Abstract: Objectives: To investigate if time to initiate a blood transfusion after an informative laboratory test could feasibly be used by the transfusion medicine service as a metric to monitor for transfusion delays.: Background: Delayed transfusions may ... ...

Abstract	Objectives: To investigate if time to initiate a blood transfusion after an informative laboratory test could feasibly be used by the transfusion medicine service as a metric to monitor for transfusion delays. Background: Delayed transfusions may result in patient morbidity and mortality, but no standards for timely transfusion have been developed. Information technology tools could be implemented to identify gaps in provision of blood and to recognise areas of improvement. Materials and methods: Data obtained from a children's hospital's data science platform and time from the release of laboratory results to the initiation of transfusions were calculated and weekly medians were used for trend analyses. Outlier events were obtained using locally estimated scatterplot smoothing and generalised extreme studentized deviate test. Results: Overall, the number of outlier events on the timing of transfusions based on patients' haemoglobin level and platelet count were small (n = 1 and n = 0 for 139 weeks, respectively). Investigation of these events for adverse clinical outcomes was non-significant. Conclusions: Herein, we propose that the trends and outlier events could be further investigated and used to make decisions and implement protocols to improve patient care.
MeSH term(s)	Child ; Humans ; Blood Transfusion ; Platelet Count
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1067989-3
ISSN	1365-3148 ; 0958-7578
ISSN (online)	1365-3148
ISSN	0958-7578
DOI	10.1111/tme.12960
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Zs.A 3177: Show issues

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Article ; Online: Evaluation of Carbonmonoxide, Diffusion Capacity, Respiratory Muscle Strength Values, and Pulmonary Volume in Smoking Men over 40 Years Old.

Akgün, Kadir Burak / Özge, Cengiz / Taşdelen, Bahar

Turkish thoracic journal

2022 Volume 22, Issue 4, Page(s) 311–316

Abstract: Objective: To determine the effects of tobacco use on the lungs before respiratory symptoms or basic functional disorders occur.: Material and methods: Forty-six active smokers between June 2018 and June 2019 who did not have any respiratory ... ...

Abstract	Objective: To determine the effects of tobacco use on the lungs before respiratory symptoms or basic functional disorders occur. Material and methods: Forty-six active smokers between June 2018 and June 2019 who did not have any respiratory complaints, had no lung or chronic disease affecting the respiratory system, and consumed at least 20 packs/year were prospectively evaluated. In addition, a control group consisting of 50 non-smokers was formed. After confirming that spirometry and chest radiographs were normal, volunteers were taken to measure carboxymetry, plethysmography, respiratory muscle strength, and diffusion capacity, respectively. The changes in the lungs caused by smoking were analyzed with the data obtained from the measurements. Results: Carbon monoxide values measured by carboxymetry were higher in smokers than non-smokers. Plethysmography tests showed that TLC, TLC%, FRC, FRC%, and RV values were statistically higher in smokers. No significant difference was found between FVC%, FEV1%, PEF, PEF%, MEF75, MEF75%, MEF50, MEF50%, MEF25, MEF25%, sRaw (eff), sRaw (eff%), Raw (eff), Raw (eff%), Raw (tot), Raw (tot%), IC, IC%, ERV, ERV%, RV% values and FEV1/FVC, FEV3/FVC, IC/TLC, and RV/TLC ratios. MIP, MIP%, MEP, MEP% values which measured respiratory muscle strength were similar in smokers and non-smokers. DLCO%, DLCO/VA, DLCO/VA%, DLCOc%, DLCOc/VA, and DLCOc/VA% were found to be lower in the smoker subjects. DLCO and DLCOc values were similar in both groups. Conclusion: Smoking causes the accumulation of toxic gas in the lungs, contributes to the development of hyperinflation and disrupts gas exchange. In our study, there was no evidence that airway resistance developed or respiratory muscles were affected.
Language	English
Publishing date	2022-01-30
Publishing country	Turkey
Document type	Journal Article
ISSN	2149-2530
ISSN (online)	2149-2530
DOI	10.5152/TurkThoracJ.2021.19148
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Article: Variability in Serum Concentrations and Clinical Response in Artisanal Versus Pharmaceutical Cannabidiol Treatment of Pediatric Pharmacoresistant Epilepsy.

Cohen, Nathan T / Bahar, Burak / Conry, Joan A / Schreiber, John M

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG

2022 Volume 27, Issue 6, Page(s) 558–563

Abstract: Objective: We hypothesized that serum cannabidiol (CBD) concentrations would be higher in patients taking pharmaceutical- versus artisanal-CBD oil, and higher serum CBD concentrations would correlate with increased side effects and decreased seizure ... ...

Abstract	Objective: We hypothesized that serum cannabidiol (CBD) concentrations would be higher in patients taking pharmaceutical- versus artisanal-CBD oil, and higher serum CBD concentrations would correlate with increased side effects and decreased seizure frequency. Methods: This was a retrospective chart review. We included patients with pharmacoresistant epilepsy, treated with artisanal-CBD or pharmaceutical-CBD (Epidiolex), and with quantitative serum CBD concentrations. We tracked epilepsy diagnosis, artisanal-CBD dosage, pharmaceutical-CBD dose, serum CBD concentration, clobazam concentration, N-desmethylclobazam concentration, seizure history (frequency of motor seizures), response to medication (percentage reduction in motor seizures), and side effects. Results: Forty-two patients met inclusion criteria. Mean serum CBD concentration was 51.1 ng/mL (artisanal group) and 124 ng/mL (pharmaceutical group) (p = 0.022). Patients receiving artisanal-CBD had no change in median overall seizures (IQR, -50% to 50%); the pharmaceutical-CBD group had median 50% reduction (IQR, -90% to no change) (p = 0.199). Conclusions: Pharmaceutical-CBD achieves higher serum CBD concentrations than artisanal-CBD in pediatric patients with refractory epilepsy. These higher CBD concentrations are associated with increased reported adverse effects, but no detectable difference in seizure frequency.
Language	English
Publishing date	2022-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028543-4
ISSN	1551-6776
ISSN	1551-6776
DOI	10.5863/1551-6776-27.6.558
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Article ; Online: Two cases of IgA nephropathy after splenectomy: spleen as a silent culprit in the pathogenesis of IgA nephropathy.

Dirim, Ahmet Burak / Agargun, Besim Fazil / Hurdogan, Ozge / Ozluk, Yasemin / Safak, Seda / Garayeva, Nurane / Esen, Bahar Artim / Besisik, Sevgi Kalayoglu / Yazici, Halil

Journal of nephrology

2023 Volume 36, Issue 8, Page(s) 2381–2385

Language	English
Publishing date	2023-09-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-023-01764-z
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Zs.A 3369: Show issues

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Article ; Online: Association of anosmia and neutralizing antibody production in adolescents with SARS-CoV-2.

Gitman, Lyuba / Newman, Daniel / Burak, Bahar / Reilly, Brian K / Mudd, Pamela

International journal of pediatric otorhinolaryngology

2022 Volume 164, Page(s) 111403

Abstract: Background: To monitor olfactory/gustatory dysfunction and its relationship to SARS-CoV-2 IgG antibody responses in an adolescent population.: Methods: Adolescents with changes in olfactory/gustatory functions were enrolled in a 15-month study. The ... ...

Abstract	Background: To monitor olfactory/gustatory dysfunction and its relationship to SARS-CoV-2 IgG antibody responses in an adolescent population. Methods: Adolescents with changes in olfactory/gustatory functions were enrolled in a 15-month study. The patients were evaluated with 1) SNOT-22, 2) pediatric smell wheel, and 3) SARS-CoV-2 antibody testing. The relationship between these scores and length of anosmia, and the amount of SARS-CoV-2 IgG antibodies were assessed. A brain MRI was performed in cases of persistent special sensory symptoms. Results: Eighteen patients were identified with smell and/or taste complaints. Most of the patients were female (67%) and median age was 15 years (range 11-17). Twelve patients had prior SARS-CoV-2 PCR testing, with only five patients with a positive result. The median SNOT-22 score was 16 (range 0-52) and the median smell wheel score was 6.5 (range 1-11). Patients with taste difficulty were more likely to have a score less than eight. 78% of the patients tested positive for antibodies and there was a strong negative correlation between smell wheel score and antibody level (Spearman, ρ = -0.798, p = 0.002). Five patients underwent MRI scan, and all resulted as normal olfactory bulb structures. 66% received nasal corticosteroids. 11 patients presented in follow up. Conclusions: Adolescents presenting to a pediatric ENT clinic during the SARS-CoV-2 pandemic were likely to have prolonged (>6 weeks) symptoms of SARS-CoV-2. The majority do not report positive PCR testing result but do report systemic symptoms including anosmia. This suggests that anosmia may be both a late and prolonged symptom of SARS-CoV-2.
Language	English
Publishing date	2022-11-25
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2022.111403
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Zs.A 1507: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 134: Show issues

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Article ; Online: Third-trimester fetal pancreas imaging in uncomplicated pregnancies and association with pregnancy outcomes.

Golbasi, Hakan / Bayraktar, Burak / Golbasi, Ceren / Omeroglu, Ibrahim / Atakul, Bahar Konuralp / Cakir, Zubeyde Emiralioglu / Toka, Ilknur Gumus / Ekin, Atalay

Journal of clinical ultrasound : JCU

2024

Abstract: Objective: To examine third-trimester sonographic imaging of the fetal pancreas in uncomplicated pregnancies and its association with pregnancy outcomes.: Methods: This was a prospective cohort study including 274 pregnant women. Uncomplicated ... ...

Abstract	Objective: To examine third-trimester sonographic imaging of the fetal pancreas in uncomplicated pregnancies and its association with pregnancy outcomes. Methods: This was a prospective cohort study including 274 pregnant women. Uncomplicated pregnancies in the third trimester (28-40 weeks) were included in the study. Maternal chronic disease, pregnancy-related disorders such as hypertension, diabetes, cholestasis, smoking, and fetal abnormalities were determined as exclusion criteria. Sonographic fetal pancreatic measurement and echogenicity were evaluated in all participants. For intra-observer reliability, each participant's fetal pancreatic circumference was measured two times. The echogenicity of the pancreas was compared with the liver and ribs and classified as grade 1, 2, and 3. The pregnancy outcomes of all participants were obtained from the hospital digital registration system. Results: The average fetal pancreatic circumference in the third trimester was 70.7 ± 0.6 mm (median, 70 [44-100.7]), with high intra-observer agreement (ICC 0.996 [0.995; 0.997]). A significant positive correlation was found between pancreatic circumference, body mass index (BMI), gestational age, and birth weight. Pancreatic measurements were significantly higher in composite adverse outcomes cases that included at least one of respiratory distress syndrome, hyperbilirubinemia, neonatal pneumonia, infection, and sepsis (p < 0.001). No relationship was found between pancreatic echogenicity and perinatal outcomes. Conclusion: Fetal pancreas size was positively correlated with gestational age, BMI, and birth weight, and increased fetal pancreas size was associated with composite adverse neonatal outcomes.
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	189393-2
ISSN	1097-0096 ; 0091-2751
ISSN (online)	1097-0096
ISSN	0091-2751
DOI	10.1002/jcu.23667
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Zs.A 1186: Show issues

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Article ; Online: Prevention of Transfusion-Associated Graft-Versus-Host Disease With Blood Product Irradiation: The Past, Present, and Future.

Bahar, Burak / Tormey, Christopher A

Archives of pathology & laboratory medicine

2018 Volume 142, Issue 5, Page(s) 662–667

Abstract: Transfusion-associated graft-versus-host disease (TA-GVHD) is a disease with a very high mortality rate. In this report, we discuss TA-GVHD from a historical perspective, highlight the pathogenesis of TA-GVHD, and emphasize the importance of blood ... ...

Abstract	Transfusion-associated graft-versus-host disease (TA-GVHD) is a disease with a very high mortality rate. In this report, we discuss TA-GVHD from a historical perspective, highlight the pathogenesis of TA-GVHD, and emphasize the importance of blood product irradiation, which is a very effective means to prevent this disease. We summarize the current recommendations in different patient populations from different countries and review recent developments, such as alternatives for the use of radioactive materials. We also speculate on future directions.
MeSH term(s)	Blood/radiation effects ; Humans ; Transfusion Reaction/prevention & control
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2016-0620-RS
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Ud II Zs.36: Show issues

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Article ; Online: Endovascular and surgical management of splenic artery aneurysms.

Yanar, Fatih / Canbay Torun, Bahar / Ilhan, Burak / Gok, Ali Fuat Kaan / Azamat, İbrahim Fethi / Sengun, Berke / Çakır, Mehmet Semih / Genc, Fatih Ata

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

2024 Volume 30, Issue 1, Page(s) 38–42

Abstract: Background: Although true splenic artery aneurysms (SAA) are rare, due to advancements in imaging techniques, they are seen more frequently. The aim of this study is to present our strategy of managing patients with SAA.: Methods: Retrospectively, 13 ...

Title translation	Splenik arter anevrizmalarında endovasküler ve cerrahi tedavi.
Abstract	Background: Although true splenic artery aneurysms (SAA) are rare, due to advancements in imaging techniques, they are seen more frequently. The aim of this study is to present our strategy of managing patients with SAA. Methods: Retrospectively, 13 patients who were treated in a tertiary university care center between 2012 and 2020 were included. Their demographic, clinical information, and post-operative complications were analyzed. Results: Seven male and six female patients were evaluated between the ages of 27 and 73. The mean age was 49.8±13.2. The diameter of the aneurysm was between 17 and 80 mm with a mean range of 31.5±16 mm. Seven patients were treated with endovascular interventions (EV). Two patients were referred to surgery with failed attempt of EV, but patients refused surgery and were followed up consequently. Patients who had larger aneurysms with an increased risk of rupture underwent aneurysmectomy and splenectomy. Conservative management was decided on two patients initially: A patient who was previously operated on for a sigmoid colon tumor, and had an aneurysm size of 15 mm and another patient with a surgical history of thoracic aortic dissection with an aneurysm size of 18 mm. One patient who underwent surgery had post-operative pancreatic fistula and was treated with percutaneous drainage. The treatment of the remaining 12 patients was completed without any further complications. Conclusion: Splenic artery aneurysm treatment should be individualized. Endovascular treatment can be considered for patients with stable aneurysms larger than 2 cm in the elective setting. Open surgical treatment should be considered in patients with ruptured SAA or hemodynamically unstable, complicated patients.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Middle Aged ; Aged ; Splenic Artery/diagnostic imaging ; Splenic Artery/surgery ; Retrospective Studies ; Endovascular Procedures/adverse effects ; Aneurysm/diagnostic imaging ; Aneurysm/surgery ; Aneurysm/etiology ; Embolization, Therapeutic/adverse effects ; Gastrointestinal Diseases ; Treatment Outcome
Language	English
Publishing date	2024-01-15
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2253739-9
ISSN	1307-7945 ; 1306-696X
ISSN (online)	1307-7945
ISSN	1306-696X
DOI	10.14744/tjtes.2023.23793
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