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  1. Article ; Online: Validation and reliability for the updated REAP-S dietary screener, (Rapid Eating Assessment of Participants, Short Version, v.2).

    Shankar, Viswanathan / Thompson, Kathryn H / Wylie-Rosett, Judith / Segal-Isaacson, C J

    BMC nutrition

    2023  Volume 9, Issue 1, Page(s) 88

    Abstract: ... v.2 is an updated version that is aligned with the 2020-2025 US Dietary Guidelines and is easily ... validity of the REAP-S v.2 scale by having first-year medical students (n = 167) complete both the REAP-S v ... the associations between REAP-S v.2 scale item responses and selected nutrient estimates from the food record ...

    Abstract Background: The American Heart Association (AHA) chose the REAP-S dietary screener in 2020 as one of three US dietary screeners recommended for integrating dietary assessment into clinical care. The REAP-S v.2 is an updated version that is aligned with the 2020-2025 US Dietary Guidelines and is easily incorporated into electronic medical records and taught to medical students.
    Methods: The University of New England, Institutional Review Board, approved the study protocol. We evaluated the reliability and validity of the REAP-S v.2 scale by having first-year medical students (n = 167) complete both the REAP-S v.2 and a three-day food record and then analyzing their data with the following statistical techniques: Internal consistency was measured using Cronbach's alpha. Construct validity was assessed with exploratory factor analysis. Criterion validity was evaluated using analysis of variance (ANOVA) that explored the associations between REAP-S v.2 scale item responses and selected nutrient estimates from the food record analyses. The hierarchical cluster analysis classified healthy and unhealthy diet grouping under each subscale. Further using these groupings, cut points for "good" and "bad" diets for each of the three main REAP-S v.2 subscales (Food Sufficiency/Food Insufficiency; Healthy Eating Pattern and Low Nutrient Density Foods) were calculated using receiver operating characteristics (ROC) analysis. Students analyzed their three-day food intake records using an online USDA application called SuperTracker.
    Results: The Cronbach's alpha measuring internal consistency was acceptable for the overall scale at 0.71. The exploratory factor analysis extracted three factors that roughly paralleled the three main subscales, suggesting construct validity. Most selected food record-derived nutrient values were significantly associated with scale items confirming criterion validity. The score cut points suggest that dietary counseling might be needed at ≤ 8, ≤ 10, and ≤ 16 for the above subscales.
    Conclusion: The REAP-S v.2 is intended for clinicians to use as a brief dietary screener with their patients. Tested in a population of first-year medical students, the REAP-S v.2 brief dietary screener showed acceptable internal consistency, criterion, and construct validity. It is easily scored and incorporated into the electronic medical record.
    Language English
    Publishing date 2023-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809847-X
    ISSN 2055-0928 ; 2055-0928
    ISSN (online) 2055-0928
    ISSN 2055-0928
    DOI 10.1186/s40795-023-00747-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The arrival of Sputnik V.

    Balakrishnan, Vijay Shankar

    The Lancet. Infectious diseases

    2020  Volume 20, Issue 10, Page(s) 1128

    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Vaccines ; Clinical Trials, Phase III as Topic ; Coronavirus Infections/immunology ; Coronavirus Infections/prevention & control ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/prevention & control ; Quality Control ; Russia ; SARS-CoV-2 ; Viral Vaccines/immunology
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(20)30709-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: PEACE V-Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM): Acute Toxicity of a Randomized Phase 2 Trial.

    Ost, Piet / Siva, Shankar / Brabrand, Sigmund / Dirix, Piet / Liefhooghe, Nick / Otte, François-Xavier / Gomez-Iturriaga, Alfonso / Everaerts, Wouter / Shelan, Mohamed / Conde-Moreno, Antonio / López Campos, Fernando / Papachristofilou, Alexandros / Guckenberger, Matthias / Scorsetti, Marta / Zapatero, Almudena / Villafranca Iturre, Ana-Elena / Eito, Clara / Couñago, Felipe / Muto, Paolo /
    Van De Voorde, Lien / Mach, Nicolas / Bultijnck, Renée / Fonteyne, Valérie / Moon, Daniel / Thon, Kristian / Mercier, Carole / Achard, Vérane / Stellamans, Karin / Goetghebeur, Els / Reynders, Dries / Zilli, Thomas

    European urology oncology

    2023  

    Abstract: ... ENRT).: Design, setting, and participants: PEACE V-Salvage Treatment of OligoRecurrent nodal ...

    Abstract Background: Treatment recommendations for patients with limited nodal recurrences are lacking, and different locoregional treatment approaches are currently being used.
    Objective: The aim of this trial is to compare metastasis-directed therapy (MDT) with or without elective nodal pelvic radiotherapy (ENRT).
    Design, setting, and participants: PEACE V-Salvage Treatment of OligoRecurrent nodal prostate cancer Metastases (STORM) is an international, phase 2, open-label, randomized, superiority trial (ClinicalTrials.gov identifier: NCT03569241). Patients diagnosed with positron emission tomography-detected pelvic nodal oligorecurrence (five or fewer nodes) following radical local treatment for prostate cancer were randomized in a 1:1 ratio between arm A (MDT and 6 mo of androgen deprivation therapy [ADT]) and arm B (ENRT [25 × 1.8 Gy] with MDT and 6 mo of ADT).
    Outcome measurements and statistical analysis: We report the secondary endpoint acute toxicity, defined as worst grade ≥2 Common Terminology Criteria for Adverse Events v4.0 gastrointestinal (GI) or genitourinary (GU) toxicity within 3 mo of treatment. The chi-square test was used to compare toxicity between treatment arms. We also compare the quality of life (QoL) using the European Organisation for Research and Treatment of Cancer QLQ C30 and PR25 questionnaires.
    Results and limitations: Between June 2018 and April 2021, 196 patients were assigned randomly to MDT or ENRT. Ninety-seven of 99 patients allocated to MDT and 93 of 97 allocated to ENRT received per-protocol treatment. Worst acute GI toxicity proportions were as follows: grade ≥2 events in three (3%) in the MDT group versus four (4%) in the ENRT group (p = 0.11). Worst acute GU toxicity proportions were as follows: grade ≥2 events in eight (8%) in the MDT group versus 12 (13%) in the ENRT group (p = 0.95). We observed no significant difference between the study groups in the proportion of patients with a clinically significant QoL reduction from baseline for any subdomain score area.
    Conclusions: No clinically meaningful differences were observed in worst grade ≥2 acute GI or GU toxicity or in QoL subdomains between MDT and ENRT.
    Patient summary: We found no evidence of differential acute bowel or urinary side effects using metastasis-directed therapy and elective nodal radiotherapy for the treatment of patients with a pelvic lymph node recurrence.
    Language English
    Publishing date 2023-10-09
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epigenetically defined therapeutic targeting in H3.3G34R/V high-grade gliomas.

    Sweha, Stefan R / Chung, Chan / Natarajan, Siva Kumar / Panwalkar, Pooja / Pun, Matthew / Ghali, Amer / Bayliss, Jill / Pratt, Drew / Shankar, Anand / Ravikumar, Visweswaran / Rao, Arvind / Cieslik, Marcin / Wilder-Romans, Kari / Scott, Andrew J / Wahl, Daniel R / Jessa, Selin / Kleinman, Claudia L / Jabado, Nada / Mackay, Alan /
    Jones, Chris / Martinez, Daniel / Santi, Mariarita / Judkins, Alexander R / Yadav, Viveka Nand / Qin, Tingting / Phoenix, Timothy N / Koschmann, Carl J / Baker, Suzanne J / Chinnaiyan, Arul M / Venneti, Sriram

    Science translational medicine

    2021  Volume 13, Issue 615, Page(s) eabf7860

    Abstract: ... 3G34R/V) carry a dismal prognosis, and current treatments, including radiotherapy and chemotherapy, are ... not curative. Because H3.3G34R/V mutations reprogram epigenetic modifications, we undertook ... therapeutic dependencies in H3.3G34R/V gliomas. Our analyses revealed a convergence of epigenetic alterations ...

    Abstract High-grade gliomas with arginine or valine substitutions of the histone H3.3 glycine-34 residue (H3.3G34R/V) carry a dismal prognosis, and current treatments, including radiotherapy and chemotherapy, are not curative. Because H3.3G34R/V mutations reprogram epigenetic modifications, we undertook a comprehensive epigenetic approach using ChIP sequencing and ChromHMM computational analysis to define therapeutic dependencies in H3.3G34R/V gliomas. Our analyses revealed a convergence of epigenetic alterations, including (i) activating epigenetic modifications on histone H3 lysine (K) residues such as H3K36 trimethylation (H3K36me3), H3K27 acetylation (H3K27ac), and H3K4 trimethylation (H3K4me3); (ii) DNA promoter hypomethylation; and (iii) redistribution of repressive histone H3K27 trimethylation (H3K27me3) to intergenic regions at the
    MeSH term(s) Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/therapy ; Epigenesis, Genetic ; Glioma/genetics ; Glycine ; Histones/metabolism ; Humans ; Mice
    Chemical Substances Histones ; Glycine (TE7660XO1C)
    Language English
    Publishing date 2021-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abf7860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Oligorecurrent nodal prostate cancer: Radiotherapy quality assurance of the randomized PEACE V-STORM phase II trial.

    Achard, Vérane / Jaccard, Maud / Vanhoutte, Frederik / Siva, Shankar / Heikkilä, Reino / Dirix, Piet / Liefhooghe, Nick / Otte, François-Xavier / Gomez-Iturriaga, Alfonso / Berghen, Charlien / Shelan, Mohamed / Conde-Moreno, Antonio / López Campos, Fernando / Papachristofilou, Alexandros / Guckenberger, Matthias / Meersschout, Sabine / Putora, Paul Martin / Zwahlen, Daniel / Couñago, Felipe /
    Scorsetti, Marta / Eito, Clara / Barrado, Marta / Zapatero, Almudena / Muto, Paolo / Van De Voorde, Lien / Lamanna, Giorgio / Koutsouvelis, Nikolaos / Dipasquale, Giovanna / Ost, Piet / Zilli, Thomas

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2022  Volume 172, Page(s) 1–9

    Abstract: ... of the PEACE V-STORM randomized phase II trial for pelvic nodal oligorecurrent prostate cancer (PCa ...

    Abstract Purpose: Aim of this study is to report the results of the radiotherapy quality assurance program of the PEACE V-STORM randomized phase II trial for pelvic nodal oligorecurrent prostate cancer (PCa).
    Material and methods: A benchmark case (BC) consisting of a postoperative case with 2 nodal recurrences was used for both stereotactic body radiotherapy (SBRT, 30 Gy/3 fx) and whole pelvic radiotherapy (WPRT, 45 Gy/25 fx + SIB boost to 65 Gy).
    Results: BC of 24 centers were analyzed. The overall grading for delineation variation of the 1st BC was rated as 'UV' (Unacceptable Variation) or 'AV' (Acceptable Variation) for 1 and 7 centers for SBRT (33%), and 3 and 8 centers for WPRT (46%), respectively. An inadequate upper limit of the WPRT CTV (n = 2), a missing delineation of the prostate bed (n = 1), and a missing nodal target volume (n = 1 for SBRT and WPRT) constituted the observed 'UV'. With the 2nd BC (n = 11), the overall delineation review showed 2 and 8 'AV' for SBRT and WPRT, respectively, with no 'UV'. For the plan review of the 2nd BC, all treatment plans were per protocol for WPRT. SBRT plans showed variability in dose normalization (Median D
    Conclusions: Up to 46% of protocol deviations were observed in delineation of WPRT for nodal oligorecurrent PCa, while dosimetric results of SBRT showed the greatest disparities between centers. Repeated BC resulted in an improved adherence to the protocol, translating in an overall acceptable contouring and planning compliance rate among participating centers.
    MeSH term(s) Humans ; Lymph Nodes ; Male ; Prostatic Neoplasms/radiotherapy ; Radiosurgery/methods ; Radiotherapy Dosage ; Radiotherapy, Intensity-Modulated/methods
    Language English
    Publishing date 2022-04-26
    Publishing country Ireland
    Document type Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2022.04.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: V. Physician Burnout during COVID-19 Pandemic & Mental Health Support.

    Kandasamy, Ramesh Shankar

    Journal of stem cells & regenerative medicine

    2021  Volume 17, Issue 2, Page(s) 68

    Language English
    Publishing date 2021-12-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2587301-5
    ISSN 0973-7154
    ISSN 0973-7154
    DOI 10.46582/jsrm.1702011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Multicenter, Randomized, Phase 2 PEACE V-STORM Trial: Defining the Best Salvage Treatment for Oligorecurrent Nodal Prostate Cancer Metastases.

    Zilli, Thomas / Dirix, Piet / Heikkilä, Reino / Liefhooghe, Nick / Siva, Shankar / Gomez-Iturriaga, Alfonso / Everaerts, Wouter / Otte, François / Shelan, Mohamed / Mercier, Carole / Achard, Vérane / Thon, Kristian / Stellamans, Karin / Moon, Daniel / Conde-Moreno, Antonio / Papachristofilou, Alexandros / Scorsetti, Marta / Gückenberger, Matthias / Ameye, Filip /
    Zapatero, Almudena / Van De Voorde, Lien / López Campos, Fernando / Couñago, Felipe / Jaccard, Maud / Spiessens, An / Semac, Isabelle / Vanhoutte, Frederik / Goetghebeur, Els / Reynders, Dries / Ost, Piet

    European urology focus

    2020  Volume 7, Issue 2, Page(s) 241–244

    Abstract: ... PEACE V-STORM trial will explore the best treatment approach in this setting. Early results ...

    Abstract Optimal local treatment for nodal oligorecurrent prostate cancer is unknown. The randomized phase 2 PEACE V-STORM trial will explore the best treatment approach in this setting. Early results on the acute toxicity profile are projected to be published in quarter 3, 2021.
    MeSH term(s) Humans ; Male ; Prostatic Neoplasms/therapy ; Salvage Therapy
    Language English
    Publishing date 2020-12-29
    Publishing country Netherlands
    Document type Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 2405-4569
    ISSN (online) 2405-4569
    DOI 10.1016/j.euf.2020.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Porting of eChronos RTOS on RISC-V Architecture

    Singhal, Shubhendra Pal / Sridevi, M. / Narayanan, N Sathya / Raman, M J Shankar

    2019  

    Abstract: ... of the very few system software not been ported to RISC-V. RISC-V is an open-source Instruction Set ... tool chain have migrated to the RISC-V architecture. According to the latest trends, RISC-V is ... and PicoRV32 are some of the proven open-source RISC-V designs available. Now having a secure RTOS ...

    Abstract eChronos is a formally verified Real Time Operating System(RTOS) designed for embedded micro-controllers. eChronos was targeted for tightly constrained devices without memory management units. Currently, eChronos is available on proprietary designs like ARM, PowerPC and Intel architectures. eChronos is adopted in safety critical systems like aircraft control system and medical implant devices. eChronos is one of the very few system software not been ported to RISC-V. RISC-V is an open-source Instruction Set Architecture (ISA) that enables new era of processor development. Many standard Operating Systems, software tool chain have migrated to the RISC-V architecture. According to the latest trends, RISC-V is replacing many proprietary chips. As a secure RTOS, it is attractive to port on an open-source ISA. SHAKTI and PicoRV32 are some of the proven open-source RISC-V designs available. Now having a secure RTOS on an open-source hardware design, designed based on an open-source ISA makes it more interesting. In addition to this, the current architectures supported by eChronos are all proprietary designs, and porting eChronos to the RISC-V architecture increases the secure system development as a whole. This paper, presents an idea of porting eChronos on a chip which is open-source and effective, thus reducing the cost of embedded systems. Designing a open-source system that is completely open-source reduces the overall cost, increased the security and can be critically reviewed. This paper explores the design and architecture aspect involved in porting eChronos to RISC-V. The authors have successfully ported eChronos to RISC-V architecture and verified it on spike. The port of RISC-V to eChronos is made available open-source by authors. Along with that, the safe removal of architectural dependencies and subsequent changes in eChronos are also analyzed.

    Comment: 11 pages, 3 figures, Accepted for Publication for Springer LNCS Germany
    Keywords Computer Science - Operating Systems
    Subject code 720
    Publishing date 2019-08-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Effect of multiple micronutrient supplements v. iron and folic acid supplements on neonatal mortality: a reanalysis by iron dose

    Gomes, Filomena / Agustina, Rina / Black, Robert E / Christian, Parul / Dewey, Kathryn G / Kraemer, Klaus / Shankar, Anuraj H / Smith, Emily / Tumilowicz, Alison / Bourassa, Megan W

    Public health nutrition. 20222022 Aug. 25, Apr. 25, v. 25, no. 8

    2022  

    Abstract: ... to assess the effect of MMS v. IFA on neonatal mortality stratified by Fe dose in each supplement ... method and applied the random effects model to calculate the effect estimates of MMS v. IFA on neonatal ... mg of Fe v. IFA with 60 mg of Fe; MMS with 30 mg of Fe v. IFA with 30 mg of Fe; MMS with 30 mg of Fe ...

    Abstract Antenatal multiple micronutrient supplements (MMS) are a cost-effective intervention to reduce adverse pregnancy and birth outcomes. However, the current WHO recommendation on the use of antenatal MMS is conditional, partly due to concerns about the effect on neonatal mortality in a subgroup of studies comparing MMS with iron and folic acid (IFA) supplements containing 60 mg of Fe. We aimed to assess the effect of MMS v. IFA on neonatal mortality stratified by Fe dose in each supplement. We updated the neonatal mortality analysis of the 2020 WHO guidelines using the generic inverse variance method and applied the random effects model to calculate the effect estimates of MMS v. IFA on neonatal mortality in subgroups of trials (n 13) providing the same or different amounts of Fe, that is, MMS with 60 mg of Fe v. IFA with 60 mg of Fe; MMS with 30 mg of Fe v. IFA with 30 mg of Fe; MMS with 30 mg of Fe v. IFA with 60 mg of Fe; and MMS with 20 mg of Fe v. IFA with 60 mg of Fe. There were no statistically significant differences in neonatal mortality between MMS and IFA within any of the subgroups of trials. Analysis of MMS with 30 mg v. IFA with 60 mg of Fe (7 trials, 14 114 participants), yielded a non-significant risk ratio of 1·12 (95 % CI 0·83 to 1·50). Neonatal mortality did not differ between MMS and IFA regardless of Fe dose in either supplement.
    Keywords cost effectiveness ; folic acid ; iron ; neonatal mortality ; nutrition ; pregnancy ; public health ; relative risk ; variance
    Language English
    Dates of publication 2022-0425
    Size p. 2317-2321.
    Publishing place Cambridge University Press
    Document type Article
    ZDB-ID 1436024-x
    ISSN 1475-2727 ; 1368-9800
    ISSN (online) 1475-2727
    ISSN 1368-9800
    DOI 10.1017/S1368980022001008
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Architectural Change of the Shell-Forming Block from Linear to V-Shaped Accelerates Micellar Disassembly, but Slows the Complete Enzymatic Degradation of the Amphiphiles.

    Segal, Merav / Ozery, Lihi / Slor, Gadi / Wagle, Shreyas Shankar / Ehm, Tamara / Beck, Roy / Amir, Roey J

    Biomacromolecules

    2020  Volume 21, Issue 10, Page(s) 4076–4086

    Abstract: ... we prepared two types of well-defined PEG-dendron amphiphiles bearing linear or V-shaped PEG chains ... disassembly of the two types of amphiphiles with high resolution. Interestingly, the micelles of the V-shaped ... for the V-shaped amphiphiles. Our results show that the V-shaped architecture can stabilize the unimer state ...

    Abstract Tuning the enzymatic degradation and disassembly rates of polymeric amphiphiles and their assemblies is crucial for designing enzyme-responsive nanocarriers for controlled drug delivery applications. The common methods to control the enzymatic degradation of amphiphilic polymers are to tune the molecular weights and ratios of the hydrophilic and hydrophobic blocks. In addition to these approaches, the architecture of the hydrophilic block can also serve as a tool to tune enzymatic degradation and disassembly. To gain a deeper understanding of the effect of the molecular architecture of the hydrophilic block, we prepared two types of well-defined PEG-dendron amphiphiles bearing linear or V-shaped PEG chains as the hydrophilic blocks. The high molecular precision of these amphiphiles, which emerges from the utilization of dendrons as the hydrophobic blocks, allowed us to study the self-assembly and enzymatic degradation and disassembly of the two types of amphiphiles with high resolution. Interestingly, the micelles of the V-shaped amphiphiles were significantly smaller and disassembled faster than those of the amphiphiles based on linear PEG. However, the complete enzymatic cleavage of the hydrophobic end groups was significantly slower for the V-shaped amphiphiles. Our results show that the V-shaped architecture can stabilize the unimer state and, hence, plays a double role in the enzymatic degradation and the induced disassembly and how it can be utilized to control the release of encapsulated or bound molecular cargo.
    MeSH term(s) Drug Delivery Systems ; Hydrophobic and Hydrophilic Interactions ; Micelles ; Polyethylene Glycols ; Polymers
    Chemical Substances Micelles ; Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.0c00882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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