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Article: Tracking Psychodynamic Foci: Trajectories Through the Therapeutic Process.

Dagnino, Paula / Calderón, Ana

2022 Volume 13, Page(s) 786240

Abstract: Brief psychodynamic psychotherapy has gained importance in current clinical practice. To achieve brevity, a focus must be established and worked through. Different conceptualizations have emphasized the relational patterns and/or conflict foci as central ...

Abstract	Brief psychodynamic psychotherapy has gained importance in current clinical practice. To achieve brevity, a focus must be established and worked through. Different conceptualizations have emphasized the relational patterns and/or conflict foci as central but adopting a mono-schematic approach. However, patients come to treatment with more than one issue that must be addressed. Thus, another focus must be included because of its relevance, i.e., personality functioning. The aims of this study were to identify the presence and depth level of three foci (relational pattern, conflict, and personality functioning) in episodes of change throughout the process, and to evaluate the relationship of each focus with the complexity of patients' change. Initial OPD foci and the presence and depth of each were evaluated in 13 successful brief psychodynamic therapies. Change episodes of those therapies were analyzed as well. Results showed differences between foci in the initial phase with a higher presence of conflict focus. Throughout the process, only the presence and level of personality functioning improved. Also, complexity of patients' change was related to conflict focus, specifically on the emergence of competence feelings. The results provide evidence and enrich process research of brief psychodynamic therapies.
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.786240
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Article: Kinins and Their Receptors in Infectious Diseases.

Dagnino, Ana Paula A / Campos, Maria M / Silva, Rodrigo B M

Pharmaceuticals (Basel, Switzerland)

2020 Volume 13, Issue 9

Abstract: Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. ...

Abstract	Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence about the participation of kinins in infections caused by diverse agents, including viral, bacterial, fungal, protozoan, and helminth-related ills. It is tempting to propose that modulation of kinin actions and production might be an adjuvant strategy for management of infection-related complications.
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph13090215
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Article ; Online: Kinins and Their Receptors in Infectious Diseases

Ana Paula A. Dagnino / Maria M. Campos / Rodrigo B. M. Silva

Pharmaceuticals, Vol 13, Iss 215, p

2020 Volume 215

Abstract	Kinins and their receptors have been implicated in a series of pathological alterations, representing attractive pharmacological targets for several diseases. The present review article aims to discuss the role of the kinin system in infectious diseases. Literature data provides compelling evidence about the participation of kinins in infections caused by diverse agents, including viral, bacterial, fungal, protozoan, and helminth-related ills. It is tempting to propose that modulation of kinin actions and production might be an adjuvant strategy for management of infection-related complications.
Keywords	bradykinin ; B 1 receptors ; B 2 receptors ; infection ; therapeutics ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2020-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Health-Related Quality of Life and Long-Term Outcomes after Mildly Symptomatic COVID-19: The Post-COVID Brazil Study 2 Protocol.

Rover, Marciane Maria / Trott, Geraldine / Scolari, Fernando Luís / Silva, Mariana Motta Dias da / Souza, Denise de / Santos, Rosa da Rosa Minho Dos / Dagnino, Ana Paula Aquistapase / Mesquita Neto, Juliana de / Estivalete, Gabriel Pozza / Kozesinski-Nakatani, Amanda Christina / Marcolino, Milena Soriano / Barreto, Bruna Brandão / Schvartzman, Paulo Roberto / Antonio, Ana Carolina Peçanha / Robinson, Caroline Cabral / Falavigna, Maicon / Biolo, Andreia / Polanczyk, Carisi Anne / Rosa, Regis Goulart

Arquivos brasileiros de cardiologia

2023 Volume 120, Issue 9, Page(s) e20220835

Abstract: Background: The long-term effects of mild COVID-19 on physical, cognitive, and mental health are not yet well understood.: Objective: The purpose of this paper is to describe the protocol for the ongoing "Post-COVID Brazil" study 2, which aims to ... ...

Title translation	Qualidade de Vida Relacionada à Saúde e Desfechos em Longo Prazo após COVID-19 Sintomática Leve: Protocolo do Estudo Pós-COVID Brasil 2.
Abstract	Background: The long-term effects of mild COVID-19 on physical, cognitive, and mental health are not yet well understood. Objective: The purpose of this paper is to describe the protocol for the ongoing "Post-COVID Brazil" study 2, which aims to evaluate the factors associated with health-related quality of life and long-term cardiovascular and non-cardiovascular outcomes one year after a mild episode of symptomatic COVID-19. Methods: The "Post-COVID Brazil" study 2 is a prospective multicenter study that plans to enroll 1047 patients (NCT05197647). Centralized, structured telephone interviews are conducted at 1, 3, 6, 9, and 12 months after COVID-19 diagnosis. The primary outcome is the health-related quality-of-life utility score, assessed using the EuroQol-5D-3L (EQ-5D-3L) questionnaire at 12 months. Secondary endpoints include the EQ-5D-3L at 3, 6, and 9 months, as well as all-cause mortality, major cardiovascular events, hospitalization, return to work or education, persistent symptoms, new disabilities in instrumental activities of daily living, cognitive impairment, anxiety, depression, and post-traumatic stress symptoms at 3, 6, 9, and 12 months after SARS-CoV-2 infection. A p-value < 0.05 will be considered statistically significant for all analyses. Results: The primary endpoint will be presented as the overall frequency of the EQ-5D-3L domains 12 months after SARS-CoV-2 infection. Main analysis will explore the association of independent variables with the study outcomes. Conclusion: The "Post-COVID Brazil" study 2 aims to clarify the impact of long COVID on the quality of life and cardiovascular and non-cardiovascular outcomes of Brazilian patients who have had mild COVID-19.
MeSH term(s)	Humans ; Activities of Daily Living ; Brazil/epidemiology ; COVID-19 ; COVID-19 Testing ; Multicenter Studies as Topic ; Post-Acute COVID-19 Syndrome ; Prospective Studies ; Quality of Life/psychology ; SARS-CoV-2 ; Surveys and Questionnaires
Language	Portuguese
Publishing date	2023-10-18
Publishing country	Brazil
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	730261-7
ISSN	1678-4170 ; 0066-782X
ISSN (online)	1678-4170
ISSN	0066-782X
DOI	10.36660/abc.20220835
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Article ; Online: Association between acute disease severity and one-year quality of life among post-hospitalisation COVID-19 patients: Coalition VII prospective cohort study.

Rosa, Regis Goulart / Cavalcanti, Alexandre Biasi / Azevedo, Luciano César Pontes / Veiga, Viviane Cordeiro / de Souza, Denise / Dos Santos, Rosa da Rosa Minho / Schardosim, Raíne Fogliati de Carli / Rech, Gabriela Soares / Trott, Geraldine / Schneider, Daniel / Robinson, Caroline Cabral / Haubert, Tainá Aparecida / Pallaoro, Victoria Emanuele Lobo / Brognoli, Liége Gregoletto / de Souza, Ana Paula / Costa, Lauren Sezerá / Barroso, Bruna Machado / Pelliccioli, Melissa Pezzetti / Gonzaga, Janine /

Studier, Nicole Dos Santos / Dagnino, Ana Paula Aquistapase / Neto, Juliana de Mesquita / da Silva, Sabrina Souza / Gimenes, Bruna Dos Passos / Dos Santos, Vanessa Brzoskowski / Estivalete, Gabriel Pozza Muller / Pellegrino, Carolina de Moraes / Polanczyk, Carisi Anne / Kawano-Dourado, Letícia / Tomazini, Bruno Martins / Lisboa, Thiago Costa / Teixeira, Cassiano / Zampieri, Fernando Godinho / Zavascki, Alexandre Prehn / Gersh, Bernard J / Avezum, Álvaro / Machado, Flávia Ribeiro / Berwanger, Otavio / Lopes, Renato Delascio / Falavigna, Maicon

Intensive care medicine

2023 Volume 49, Issue 2, Page(s) 166–177

Abstract: Purpose: To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19).: Methods: We conducted a prospective cohort study nested in 5 ... ...

Abstract	Purpose: To assess the association between acute disease severity and 1-year quality of life in patients discharged after hospitalisation due to coronavirus disease 2019 (COVID-19). Methods: We conducted a prospective cohort study nested in 5 randomised clinical trials between March 2020 and March 2022 at 84 sites in Brazil. Adult post-hospitalisation COVID-19 patients were followed for 1 year. The primary outcome was the utility score of EuroQol five-dimension three-level (EQ-5D-3L). Secondary outcomes included all-cause mortality, major cardiovascular events, and new disabilities in instrumental activities of daily living. Adjusted generalised estimating equations were used to assess the association between outcomes and acute disease severity according to the highest level on a modified ordinal scale during hospital stay (2: no oxygen therapy; 3: oxygen by mask or nasal prongs; 4: high-flow nasal cannula oxygen therapy or non-invasive ventilation; 5: mechanical ventilation). Results: 1508 COVID-19 survivors were enrolled. Primary outcome data were available for 1156 participants. At 1 year, compared with severity score 2, severity score 5 was associated with lower EQ-5D-3L utility scores (0.7 vs 0.84; adjusted difference, - 0.1 [95% CI - 0.15 to - 0.06]); and worse results for all-cause mortality (7.9% vs 1.2%; adjusted difference, 7.1% [95% CI 2.5%-11.8%]), major cardiovascular events (5.6% vs 2.3%; adjusted difference, 2.6% [95% CI 0.6%-4.6%]), and new disabilities (40.4% vs 23.5%; adjusted difference, 15.5% [95% CI 8.5%-22.5]). Severity scores 3 and 4 did not differ consistently from score 2. Conclusions: COVID-19 patients who needed mechanical ventilation during hospitalisation have lower 1-year quality of life than COVID-19 patients who did not need mechanical ventilation during hospitalisation.
MeSH term(s)	Adult ; Humans ; COVID-19 ; SARS-CoV-2 ; Quality of Life ; Activities of Daily Living ; Prospective Studies ; Respiration, Artificial ; Hospitalization ; Patient Acuity ; Cardiovascular Diseases
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Comment
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-022-06953-1
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Article ; Online: Targeting FFA1 and FFA4 receptors in cancer-induced cachexia.

Freitas, Raquel D S / Muradás, Thaís C / Dagnino, Ana Paula A / Rost, Fernanda L / Costa, Kesiane M / Venturin, Gianina T / Greggio, Samuel / da Costa, Jaderson C / Campos, Maria M

American journal of physiology. Endocrinology and metabolism

2020 Volume 319, Issue 5, Page(s) E877–E892

Abstract: Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function in cancer cachexia remains unraveled. We assessed the role of FFA1 and FFA4 receptors in the mouse model of cachexia induced by ... ...

Abstract	Free fatty acid (FFA) receptors FFA1 and FFA4 are omega-3 molecular targets in metabolic diseases; however, their function in cancer cachexia remains unraveled. We assessed the role of FFA1 and FFA4 receptors in the mouse model of cachexia induced by Lewis lung carcinoma (LLC) cell implantation. Naturally occurring ligands such as α-linolenic acid (ALA) and docosahexaenoic acid (DHA), the synthetic FFA1/FFA4 agonists GW9508 and TUG891, or the selective FFA1 GW1100 or FFA4 AH7614 antagonists were tested. FFA1 and FFA4 expression and other cachexia-related parameters were evaluated. GW9508 and TUG891 decreased tumor weight in LLC-bearing mice. Regarding cachexia-related end points, ALA, DHA, and the preferential FFA1 agonist GW9508 rescued body weight loss. Skeletal muscle mass was reestablished by ALA treatment, but this was not reflected in the fiber cross-sectional areas (CSA) measurement. Otherwise, TUG891, GW1100, or AH7614 reduced the muscle fiber CSA. Treatments with ALA, GW9508, GW1100, or AH7614 restored white adipose tissue (WAT) depletion. As for inflammatory outcomes, ALA improved anemia, whereas GW9508 reduced splenomegaly. Concerning behavioral impairments, ALA and GW9508 rescued locomotor activity, whereas ALA improved motor coordination. Additionally, DHA improved grip strength. Notably, GW9508 restored abnormal brain glucose metabolism in different brain regions. The GW9508 treatment increased leptin levels, without altering uncoupling protein-1 downregulation in visceral fat. LLC-cachectic mice displayed FFA1 upregulation in subcutaneous fat, but not in visceral fat or gastrocnemius muscle, whereas FFA4 was unaltered. Overall, the present study shed new light on FFA1 and FFA4 receptors' role in metabolic disorders, indicating FFA1 receptor agonism as a promising strategy in mitigating cancer cachexia.
MeSH term(s)	Animals ; Benzoates/pharmacology ; Biphenyl Compounds/pharmacology ; Body Weight/drug effects ; Cachexia/drug therapy ; Cachexia/etiology ; Cachexia/metabolism ; Carcinoma, Lewis Lung/complications ; Carcinoma, Lewis Lung/metabolism ; Disease Models, Animal ; Docosahexaenoic Acids/pharmacology ; Docosahexaenoic Acids/therapeutic use ; Methylamines/pharmacology ; Mice ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Neoplasm Transplantation ; Phenylpropionates/pharmacology ; Propionates/pharmacology ; Pyrimidines/pharmacology ; Receptors, G-Protein-Coupled/agonists ; Receptors, G-Protein-Coupled/metabolism ; Sulfonamides/pharmacology ; Xanthenes/pharmacology ; alpha-Linolenic Acid/pharmacology ; alpha-Linolenic Acid/therapeutic use
Chemical Substances	3-(4-((4-fluoro-4'-methyl-(1,1'-biphenyl)-2-yl)methoxy)phenyl)propanoic acid ; AH7614 ; Benzoates ; Biphenyl Compounds ; FFAR4 protein, mouse ; Ffar1 protein, mouse ; GW1100 ; GW9508 ; Methylamines ; Phenylpropionates ; Propionates ; Pyrimidines ; Receptors, G-Protein-Coupled ; Sulfonamides ; Xanthenes ; alpha-Linolenic Acid (0RBV727H71) ; Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2020-09-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603841-4
ISSN	1522-1555 ; 0193-1849
ISSN (online)	1522-1555
ISSN	0193-1849
DOI	10.1152/ajpendo.00509.2019
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Article: Leishmanicidal activity of lipophilic extracts of some Hypericum species

Dagnino, Ana Paula / Francisco Maikon CorrÃªa de Barros / Gari Vidal Ccana-Ccapatinta / Gilsane Lino von Poser / Josiane Somariva Prophiro / Pedro R.T. RomÃ£o

Phytomedicine. 2015 Jan. 15, v. 22

2015

Abstract: Leishmaniasis has emerged as the third most prevalent parasite-borne disease worldwide after malaria and filariasis, with about 350 million people at risk of infection. Antileishmanial drugs currently available have various limitations, mainly because of ...

Abstract	Leishmaniasis has emerged as the third most prevalent parasite-borne disease worldwide after malaria and filariasis, with about 350 million people at risk of infection. Antileishmanial drugs currently available have various limitations, mainly because of the parasite resistance and side effects. The search of new antileishmanial drugs is ventured throughout the world.The purpose of this study was to assess the leishmanicidal activity of lipophilic extracts of eight Hypericum species against promastigote forms of Leishmania (Leishmania) amazonensis.The dried and powered materials of aerial parts of H. andinum Gleason, H. brevistylum Choisy, H. caprifoliatum Cham. & Schltdl., H. carinatum Griseb., H. linoides A. St.-Hil., H. myrianthum Cham. & Schltdl., H. polyanthemum Klotzsch ex Reichardt and H. silenoides Juss. were extracted by static maceration with n-hexane. Extracts were evaporated to dryness under reduced pressure and stored at â20Â°C until biological evaluation and HPLC analysis. The metabolites investigated were dimeric phloroglucinol derivatives, benzophenones and benzopyrans. The yields were expressed as mean of three injections in mg of compound per g of extract (mg/g extract). The effect of Hypericum species on the viability of infective forms of L. (L.) amazonensis was determined using a hemocytometer. Amphotericin B was used as a standard drug. The 50% inhibitory concentration (IC50) values for each extract were determined by linear regression analysis. The cytotoxic effects of extracts were assessed on peritoneal macrophages of BALB/c mice by MTT assay. The concentration that causes 50% of macrophage cytotoxicity (CC50) was determined by linear regression analysis. The selectivity index (SI) of the extracts was determined considering the following equation: CC50 against mammalian cells/IC50 against L. amazonensis.We demonstrated that H. carinatum, H. linoides and H. polyanthemum were able to kill the parasites in a dose dependent manner. These extracts presented low cytotoxicity against murine macrophages. At 48h of incubation H. polyanthemum presented significant leishmanicidal activity with a 50% inhibitory concentration (IC50) of 36.1Âµg/ml. The leishmanicidal activity of H. myrianthum was significantly lower than that presented by H. polyanthemum, H. carinatum and H. linoides extracts. H. brevistylum and H. caprifoliatum showed significant leishmanicidal activity only at high concentrations (500 and 1000Âµg/ml), while H. andinum and H. silenoides were ineffective.The promising results demonstrate the importance of the species of the genus Hypericum as source of compounds potentially useful for the treatment of leishmaniasis.
Keywords	adverse effects ; aerial parts ; amphotericin B ; antileishmanials ; benzopyrans ; cytotoxicity ; dose response ; drugs ; equations ; filariasis ; hexane ; high performance liquid chromatography ; Hypericum ; inhibitory concentration 50 ; Leishmania ; leishmaniasis ; maceration ; macrophages ; malaria ; metabolites ; mice ; parasites ; regression analysis ; risk groups ; viability
Language	English
Dates of publication	2015-0115
Size	p. 71-76.
Publishing place	Elsevier GmbH
Document type	Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2014.10.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phloroglucinol derivatives from Hypericum species trigger mitochondrial dysfunction in Leishmania amazonensis.

Dagnino, Ana Paula Aquistapase / Mesquita, Camila Saporiti / Dorneles, Gilson Pires / Teixeira, Vivian de Oliveira Nunes / de Barros, Francisco Maikon Corrêa / Vidal Ccana-Ccapatinta, Gari / Fonseca, Simone Gonçalves / Monteiro, Marta Chagas / Júnior, Luiz Carlos Rodrigues / Peres, Alessandra / von Poser, Gilsane Lino / Romão, Pedro Roosevelt Torres

Parasitology

2018 Volume 145, Issue 9, Page(s) 1199–1209

Abstract: Bioactive molecules isolated from plants are promising sources for the development of new therapies against leishmaniasis. We investigated the leishmanicidal activity of cariphenone A (1), isouliginosin B (2) and uliginosin B (3) isolated from Hypericum ... ...

Abstract	Bioactive molecules isolated from plants are promising sources for the development of new therapies against leishmaniasis. We investigated the leishmanicidal activity of cariphenone A (1), isouliginosin B (2) and uliginosin B (3) isolated from Hypericum species. Promastigotes and amastigotes of Leishmania amazonensis were incubated with compounds 1-3 at concentrations 1-100 µm for 48 h. The anti-promastigote effect of compounds was also tested in combinations. The cytotoxicity against macrophages and human erythrocytes were determined using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method and hemolysis assay, respectively. The compounds 1-3 showed high leishmanicidal activity against promastigotes, IC50 values of 10.5, 17.5 and 11.3 µm, respectively. Synergistic interactions were found to the associations of compounds 1 and 2 [Σ fractional inhibitory concentration (FIC) = 0.41], and 2 and 3 (ΣFIC = 0.28) on promastigotes. All Hypericum compounds induced mitochondrial hyperpolarization and reactive oxygen species production in promastigotes. The compounds showed low cytotoxicity toward mammalian cells, high selectivity index and killed intracellular amastigotes probably mediated by oxidative stress. These results indicate that these compounds are promising candidates for the development of drugs against leishmaniasis.
MeSH term(s)	Antiprotozoal Agents/pharmacology ; Cells, Cultured ; Erythrocytes/drug effects ; Humans ; Hypericum/chemistry ; Inhibitory Concentration 50 ; Leishmania/drug effects ; Life Cycle Stages/drug effects ; Macrophages/drug effects ; Mitochondria/drug effects ; Mitochondria/pathology ; Oxidative Stress ; Phloroglucinol/analogs & derivatives ; Phloroglucinol/pharmacology ; Plant Extracts/pharmacology ; Reactive Oxygen Species/metabolism
Chemical Substances	Antiprotozoal Agents ; Plant Extracts ; Reactive Oxygen Species ; Phloroglucinol (DHD7FFG6YS) ; uliginosin B (OW8R9C8L96)
Language	English
Publishing date	2018-02-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182018000203
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Article ; Online: Neural Regenerative Potential of Stem Cells Derived from the Tooth Apical Papilla.

Dagnino, Ana Paula Aquistapase / Chagastelles, Pedro Cesar / Medeiros, Renata Priscila / Estrázulas, Marina / Kist, Luiza Wilges / Bogo, Maurício Reis / Weber, João Batista Blessmann / Campos, Maria Martha / Silva, Jefferson Braga

Stem cells and development

2020 Volume 29, Issue 23, Page(s) 1479–1496

Abstract: The regenerative effects of stem cells derived from dental tissues have been previously investigated. This study assessed the potential of human tooth stem cells from apical papilla (SCAP) on nerve regeneration. The SCAP collected from nine individuals ... ...

Abstract	The regenerative effects of stem cells derived from dental tissues have been previously investigated. This study assessed the potential of human tooth stem cells from apical papilla (SCAP) on nerve regeneration. The SCAP collected from nine individuals were characterized and polarized by exposure to interferon-γ (IFN-γ). IFN-γ increased kynurenine and interleukin-6 (IL-6) production by SCAP, without affecting the cell viability. IFN-γ-primed SCAP exhibited a decrease of brain-derived neurotrophic factor (BDNF) mRNA levels, followed by an upregulation of glial cell-derived neurotrophic factor mRNA. Ex vivo, the co-culture of SCAP with neurons isolated from the rat dorsal root ganglion induced neurite outgrowth, accompanied by increased BDNF secretion, irrespective of IFN-γ priming. In vivo, the local application of SCAP reduced the mechanical and thermal hypersensitivity in Wistar rats that had been submitted to sciatic chronic constriction injury. The SCAP also reduced the pain scores, according to the evaluation of the Grimace scale, partially restoring the myelin damage and BDNF immunopositivity secondary to nerve lesion. Altogether, our results provide novel evidence about the regenerative effects of human SCAP, indicating their potential to handle nerve injury-related complications.
MeSH term(s)	Adolescent ; Animals ; Cell Differentiation ; Cell Polarity/drug effects ; Chemokines/metabolism ; Chronic Disease ; Constriction, Pathologic ; Dental Papilla/cytology ; Disease Models, Animal ; Ganglia, Spinal/metabolism ; Humans ; Inflammation/pathology ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Interferon-gamma/pharmacology ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/cytology ; Nerve Regeneration/physiology ; Neurons/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Rats, Wistar ; Toll-Like Receptor 3/agonists ; Toll-Like Receptor 3/metabolism ; Toll-Like Receptor 4/agonists ; Toll-Like Receptor 4/metabolism ; Young Adult
Chemical Substances	Chemokines ; Intercellular Signaling Peptides and Proteins ; RNA, Messenger ; Toll-Like Receptor 3 ; Toll-Like Receptor 4 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2142214-X
ISSN	1557-8534 ; 1547-3287
ISSN (online)	1557-8534
ISSN	1547-3287
DOI	10.1089/scd.2020.0121
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Article ; Online: Nociceptin/orphanin FQ receptor modulates painful and fatigue symptoms in a mouse model of fibromyalgia.

Dagnino, Ana Paula Aquistapase / da Silva, Rodrigo Braccini Madeira / Chagastelles, Pedro Cesar / Pereira, Talita Carneiro Brandão / Venturin, Gianina Teribele / Greggio, Samuel / Costa da Costa, Jaderson / Bogo, Maurício Reis / Campos, Maria Martha

Pain

2019 Volume 160, Issue 6, Page(s) 1383–1401

Abstract: Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite etiology. The treatment options for fibromyalgia are currently limited, probably because of its intricate pathophysiology. Thus, further basic and clinical ... ...

Abstract	Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite etiology. The treatment options for fibromyalgia are currently limited, probably because of its intricate pathophysiology. Thus, further basic and clinical research on this condition is currently needed. This study investigated the effects of nociceptin/orphanin FQ (N/OFQ) receptor (NOPr) ligands and the modulation of the NOP system in the preclinical mouse model of reserpine-induced fibromyalgia. The effects of administration of the natural agonist N/OFQ and the selective NOPr antagonists (UFP-101 and SB-612111) were evaluated in fibromyalgia-related symptoms in reserpine-treated mice. The expression of prepronociceptin/orphanin FQ and NOPr was assessed in central and peripheral sites at different time points after reserpine administration. Nociceptin/orphanin FQ displayed dual effects in the behavioral changes in the reserpine-elicited fibromyalgia model. The peptide NOPr antagonist UFP-101 produced analgesic and antifatigue effects, by preventing alterations in brain activity and skeletal muscle metabolism, secondary to fibromyalgia induction. The nonpeptide NOPr antagonist SB-612111 mirrored the favorable effects of UFP-101 in painful and fatigue alterations induced by reserpine. A time-related up- or downregulation of prepronociceptin/orphanin FQ and NOPr was observed in supraspinal, spinal, and peripheral sites of reserpine-treated mice. Our data shed new lights on the mechanisms underlying the fibromyalgia pathogenesis, supporting a role for N/OFQ-NOP receptor system in this syndrome.
MeSH term(s)	Analgesics/pharmacology ; Animals ; Disease Models, Animal ; Fatigue/drug therapy ; Female ; Fibromyalgia/drug therapy ; Male ; Mice ; Narcotic Antagonists/pharmacology ; Opioid Peptides/pharmacology ; Pain/drug therapy ; Protein Precursors/pharmacology ; Receptors, Opioid/drug effects ; Nociceptin Receptor ; Nociceptin
Chemical Substances	Analgesics ; Narcotic Antagonists ; Opioid Peptides ; Protein Precursors ; Receptors, Opioid ; prepronociceptin ; Nociceptin Receptor ; Oprl1 protein, mouse
Language	English
Publishing date	2019-02-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000001513
Database	MEDical Literature Analysis and Retrieval System OnLINE

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