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Article: [PHYSIOLOGY AND PHARMACOLOGICAL PROPERTIES OF NANOMATERIALS].

Chekman, I S

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)

2016 Volume 61, Issue 6, Page(s) 129–138

Abstract: Literature data and results of our department studies on theoretical and practical basics of nanoscience were summarized in the article. Much attention is paid to research in the field of physical, chemical, biological, medical, physiological, ... ...

Abstract	Literature data and results of our department studies on theoretical and practical basics of nanoscience were summarized in the article. Much attention is paid to research in the field of physical, chemical, biological, medical, physiological, pharmacological, and toxicological properties of nanomaterials with the aim of their wider implementation into practice lately. The discovery of new quantum/wave properties of nanoparticles is of particular importance. The author of the article advances an idea: wave properties of nanomaterials play greater role with a decrease in particle size. The preponderance of wave properties compared with corpuscular ones in nanostructures determines a great change in their physical. chemical properties and an increase in physical, mechanical biological, physiological, pharmacological, and toxicologica activity. The idea advanced in the article hasn't been verified by theoretical or experimental studies for now. Joined efforts of scientists of different scientific fields are needed. A confirmation of hypothesis by specific findings will be of great importance for physiology, medicine, pharmacology and promote an implementation of new efficacious preparations into clinical practice. New fundamental discoveries could be made only by multidisciplinary approach.
MeSH term(s)	Animals ; Bacteria/drug effects ; Bacteria/growth & development ; Cell Membrane/chemistry ; Cell Membrane/drug effects ; Cell Survival/drug effects ; Eukaryotic Cells/cytology ; Eukaryotic Cells/drug effects ; Humans ; Interdisciplinary Communication ; Microbial Viability/drug effects ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Particle Size ; Quantum Theory ; Structure-Activity Relationship
Language	Ukrainian
Publishing date	2016-03-29
Publishing country	Ukraine
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	420438-4
ISSN	2522-9028 ; 0015-3311 ; 0201-8489
ISSN	2522-9028 ; 0015-3311 ; 0201-8489
DOI	10.15407/fz61.06.129
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Wave properties of nanoparticles: the view of a problem.

Chekman, I S

Likars'ka sprava

2013 , Issue 7, Page(s) 3–8

Abstract: The results of studies on nanopharmacology have made conditions to develop a hypothesis: from the standpoint of quantum mechanics an increase in pharmacological properties of nano- particle based medications is driven by the preponderance of wave ... ...

Abstract	The results of studies on nanopharmacology have made conditions to develop a hypothesis: from the standpoint of quantum mechanics an increase in pharmacological properties of nano- particle based medications is driven by the preponderance of wave properties over corpuscular ones. According to results obtained the changes of spin states in molecules is one of the es- sential properties of living matter, which is characterized by self-organization. Self-organiza- tion is also common in nanostructur-es. Therefore, the quantum wave properties of nanopar- ticles with their high ability to change spin states determine pronounced pharmacological effect of nanoparticle based medications. At this stage of research the scientific facts received do not rise to the possibility to experimentally or mathematically justify the assumptions made, so pleasetake them for granted. I am convinced that this article will be the 'nanomotor' that will attract world's scientists to continue research in order to prove current hypothesis - the wave properties of nanoparticles determine their high activity - experimentally.
MeSH term(s)	Electrons ; Magnetics ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Optical Phenomena ; Particle Size ; Quantum Theory ; Surface Properties ; Thermodynamics
Language	English
Publishing date	2013-10
Publishing country	Ukraine
Document type	Journal Article ; Review
ZDB-ID	40876-1
ISSN	1019-5297 ; 0049-6804
ISSN	1019-5297 ; 0049-6804
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Article: [Capillaries of living systems: natural nanomechanisms of the functioning].

Chekman, I S

Likars'ka sprava

2013 , Issue 3, Page(s) 3–10

Abstract: This article summarizes the literature and research data that concerns role of capillaries in the functioning of natural nanomechanisms in living systems. Physiologically active substances the body--essential and non-essential amino-acids, ... ...

Abstract	This article summarizes the literature and research data that concerns role of capillaries in the functioning of natural nanomechanisms in living systems. Physiologically active substances the body--essential and non-essential amino-acids, neurotransmitters (epinephrine, norepinephrine, acetylcholine), vitamins (retinol, ergocalciferol, etc.), albumin, ATP, DNA, RNA, fibrinogen and others--are at the nanoscale size. Natural nanostructures are ion channels of biological membranes, colloidal solutions of the body (blood, interstitial fluid). Only in recent years, scientists have begun to more actively explore the role of capillaries in the functioning of organs and body with position of natural nanomechanisms. To the nanomechanisms in functioning capillaries in the body of living systems maybe contribute: wall capillaries, vascular endothelium, as nanostructures, capillary forces, biological nanomotors, ion channels, surface tension and surface energy of nanoparticles, and such processes and phenomena as nanohydrophobic shift or "lotus-effect" double electric layer, entropy that occur in the structures of the body. The significance of water flow processes in capillaries studied enough. Establishing nanomechanisms in functioning capillaries in living systems requires an interdisciplinary approach involving different specialists in physics, chemistry, biology, physiology, pharmacology and toxicology.
MeSH term(s)	Animals ; Biological Transport ; Capillaries/metabolism ; Capillaries/physiology ; Capillaries/ultrastructure ; Capillary Permeability/physiology ; Cell Membrane/physiology ; Cell Membrane/ultrastructure ; Ion Channels/chemistry ; Nanomedicine ; Nanostructures/chemistry
Chemical Substances	Ion Channels
Language	Ukrainian
Publishing date	2013-04
Publishing country	Ukraine
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	40876-1
ISSN	1019-5297 ; 0049-6804
ISSN	1019-5297 ; 0049-6804
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Article: [Natural nanotechnologies in living cell: view on the problem].

Chekman, I S

Likars'ka sprava

2012 , Issue 8, Page(s) 3–13

Abstract: Literature and research data concerning natural nanotechnology in living systems is summarized in this article. Over millions of years, nature has evolved complex processes controlling the functioning of living organisms. Using the principles of nature ... ...

Abstract	Literature and research data concerning natural nanotechnology in living systems is summarized in this article. Over millions of years, nature has evolved complex processes controlling the functioning of living organisms. Using the principles of nature to create new tools and technologies is the current direction in the development of "smart" materials and systems. Physiologically active substances (amino acids, neurotransmitters, vitamins, albumin, ATP, fructose, DNA, RNA, fibrinogen, glutathione and others) are nano in size. Biological membranes, ion channels, nanopores, colloidal solutions of the body (blood, interstitial fluid) are nanostructures. The basic principle of nature reads: small tools make great work. In biological materials natural principle of high efficiency and minimum energy consumption is carried out due to the existence of natural nanotechnology that needs more study. In efficient energy-consuming processes during the evolution gradually disappeared and were replaced by more effective. The study and experimental proof of natural nanotechnology will bring a better understanding of the laws of physiological functioning of organs and those of metabolic processes that maintain life. The ability to reproduce biological form with nanoscale precision will find application in tissue engineering, drug delivery, modeling and development of sensory and immune systems, visualization and diagnostic tools. Natural nanotechnology is highly effective, low energy-consuming, causes a rapid flow of vital processes in the body, the ability to quickly response to external positive and negative factors. Not all data presented in this paper is experimentally confirmed, it may be controversial and require further extensive research by specialists of different areas to determine the role of nanotechnology and nanomechanisms in physiological, biochemical, immunological, genetic and other processes in living systems.
MeSH term(s)	Animals ; Biological Transport ; Biomimetic Materials/chemistry ; Biosensing Techniques ; Cell Physiological Phenomena ; Cells/metabolism ; Drug Delivery Systems/methods ; Humans ; Nanostructures/chemistry ; Nanotechnology/instrumentation ; Nanotechnology/methods ; Thermodynamics ; Tissue Engineering/methods
Language	Ukrainian
Publishing date	2012-12
Publishing country	Ukraine
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	40876-1
ISSN	1019-5297 ; 0049-6804
ISSN	1019-5297 ; 0049-6804
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Article: Ul'trastruktura limfotsitov krovi donorov, inkubirovannoĭ s iadom blednoĭ poganki.

Chekman, I S / Kuz'menko, S A

Biulleten' eksperimental'noi biologii i meditsiny

1992 Volume 114, Issue 9, Page(s) 291–293

Abstract: Heparinized donor blood was investigated incubated with Amanita Phalloides poison in the dose of 0.05 and 0.5 LD100 during 1 and 3 hours. Lymphocyte structure changes showed cytoplasma and organoid membrane destabilization, cytoplasma degranulation, ... ...

Title translation	Ultrastructure of donor blood lymphocytes incubated with Amanita phalloides poison.
Abstract	Heparinized donor blood was investigated incubated with Amanita Phalloides poison in the dose of 0.05 and 0.5 LD100 during 1 and 3 hours. Lymphocyte structure changes showed cytoplasma and organoid membrane destabilization, cytoplasma degranulation, appearance of autolysis foci and lysed cells. This destruction became particularly marked with increasing poison dose and infusion time.
MeSH term(s)	Amanita ; Autolysis ; Cytoplasm/ultrastructure ; Humans ; In Vitro Techniques ; Lymphocytes/drug effects ; Lymphocytes/ultrastructure ; Mushroom Poisoning/blood ; Mycotoxins/toxicity ; Organoids/ultrastructure ; Time Factors
Chemical Substances	Mycotoxins
Language	Russian
Publishing date	1992-09
Publishing country	Russia (Federation)
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	127365-6
ISSN	0365-9615 ; 0006-4041
ISSN	0365-9615 ; 0006-4041
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Article: Vzaimodeĭstvie neglikozidnykh kardiotonicheskikh sredstv s drugimi lekarstvennymi preparatami.

Grinevich, A I / Chekman, I S / Roshchupkina, E V / Angelutsa, P A

Kardiologiia

1993 Volume 33, Issue 6, Page(s) 56–61

Title translation	The interaction of nonglycoside cardiotonic agents with other drug preparations.
MeSH term(s)	Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Cardiovascular Agents/pharmacology ; Cardiovascular Agents/therapeutic use ; Drug Interactions ; Drug Therapy, Combination ; Heart Failure/drug therapy ; Humans ; In Vitro Techniques ; Myocardial Contraction/drug effects ; Myocardial Infarction/drug therapy
Chemical Substances	Cardiotonic Agents ; Cardiovascular Agents
Language	Russian
Publishing date	1993
Publishing country	Russia (Federation)
Document type	Journal Article ; Review
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
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Article: Vliianie soedineniĭ s gipotenzivnoĭ aktivnost'iu na mikroviazkost' fosfolipidnykh membran.

Goriushko, A G / Shnurko, E V / Chekman, I S / Skurskiĭ, S I

Ukrainskii biokhimicheskii zhurnal (1978)

1992 Volume 64, Issue 5, Page(s) 110–113

Abstract: Vincapane, apressin, raunatin, reserpine and prazosin have been studied for their effect on the state of microviscosity of phospholipid bilayers from lecithin and cardiolipine. The method of fluorescent probing using pyrene and asymmetrical polymethine ... ...

Title translation	Effect of compounds having hypotensive activity on microviscosity of phospholipids membranes.
Abstract	Vincapane, apressin, raunatin, reserpine and prazosin have been studied for their effect on the state of microviscosity of phospholipid bilayers from lecithin and cardiolipine. The method of fluorescent probing using pyrene and asymmetrical polymethine dye 4501 u have been used for this study. Character of changes of phospholipid bilayers microviscosity as affected by these compounds depends on their concentration in the solution. Vincapan lowers microviscosity of membranes from lecithin in the interval of the concentrations given. Advantages of fluorescent probing by means of asymmetric polymethine dye in comparison with pyrene were shown.
MeSH term(s)	Antihypertensive Agents/pharmacology ; Cardiolipins ; Fluorescent Dyes ; Lipid Bilayers ; Membranes, Artificial ; Phosphatidylcholines ; Spectrometry, Fluorescence ; Viscosity
Chemical Substances	Antihypertensive Agents ; Cardiolipins ; Fluorescent Dyes ; Lipid Bilayers ; Membranes, Artificial ; Phosphatidylcholines
Language	Russian
Publishing date	1992-09
Publishing country	Ukraine
Document type	English Abstract ; Journal Article
ZDB-ID	160680-3
ISSN	0201-8470 ; 0041-610X ; 0372-3909
ISSN	0201-8470 ; 0041-610X ; 0372-3909
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Book: Istorii͡a likoznavstva

Chekman, I. S

2014

Author's details	I.S. Chekman
MeSH term(s)	Pharmacology/history
Language	Ukrainian
Size	254 pages ;, 21 cm
Document type	Book
ISBN	9789664060766 ; 9664060763
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: [Pharmacological and pharmaceutical foundation of nanodrugs].

Chekman, I S

Likars'ka sprava

2010 , Issue 1-2, Page(s) 3–10

Abstract: Literary data and results of own investigations about pharmacological and pharmaceutical grounds of nanodrugs are analyzed in the article. Main requirements to nanodrugs are summarized. (1) To have much more expressed effect in comparison with drugs used ...

Abstract	Literary data and results of own investigations about pharmacological and pharmaceutical grounds of nanodrugs are analyzed in the article. Main requirements to nanodrugs are summarized. (1) To have much more expressed effect in comparison with drugs used in a medicinal practice. (2) New nanodrug mustn't have adverse reactions. (3) Nanodrugs must decrease adverse effects of other drugs. (4) Nanodrugs mustn't negatively influence on clinic-pharmacological properties of drugs used in medicinal practice forthe treatment of different disorders. (5) One of the requirements to nanodrugs is positive pharmacoeconomic parameters. (6) Medicinal form of nanodrug must be usable for different ways of drug administration. (7) Technology of drug production should be inexpensive, without negative influence on ecology. Comprehensive experimental researches of nanoparticle pharmacodynamics and pharmacokinetics in the human body and its influence on environment should be done. A new technology of obtaining nanoparticles of iron oxide, silver, copper and their composites has been developed in the laboratory of electron-beam nanotechnology of nonorganic materials for medicine. It was shown, that nanoparticles of iron and silver oxide have more significant antimicrobial activity than oxides of these metals in normal size.
MeSH term(s)	Drug-Related Side Effects and Adverse Reactions ; Nanostructures ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/standards
Chemical Substances	Pharmaceutical Preparations
Language	Ukrainian
Publishing date	2010-01
Publishing country	Ukraine
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	40876-1
ISSN	1019-5297 ; 0049-6804
ISSN	1019-5297 ; 0049-6804
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Article: [Physiological processes in organism: nanomechanism].

Chekman, I S

Likars'ka sprava

2010 , Issue 7-8, Page(s) 3–10

Abstract: Physiologically active substances by nanosizes are divided into 4 groups. The first group includes substances up to 100 nm: leukocytes, erythrocytes, cell components (nucleus, mitochondria), cancer cells, bacteria and bacteriophages. The second group ... ...

Abstract	Physiologically active substances by nanosizes are divided into 4 groups. The first group includes substances up to 100 nm: leukocytes, erythrocytes, cell components (nucleus, mitochondria), cancer cells, bacteria and bacteriophages. The second group consists of nanoparticles with size from 10 to 100 nm. These are antibody, ribosomes, glycogen granules, liposomes, and others. The third group of substances has sizes from 10 to 1 nm. This group includes: albumin, hemoglobin, membrane cells, fibrixogen, receptors (serotonin, beta-adrenergic receptor and others), insulin, fat soluble vitamins (ergocalciferol, retinol), folic acid, drugs (digoxin, quetcitin), chlorophyll plants, fullerenes. The fourth group consists of matter smaller than 1 nm, in particular: ATP, fructose, mediators (acetyl-choline, adrenaline, noradrenaline), phenylephrine, amino acids, water molecules, CO2, NO, oxygen atoms, hydrogen. The existence in the body of physiological processes based on natural nanotechnology may be proved by the following facts. 1. Physiologically active substances have nanosizes. 2. Cell membranes, the capillary wall have also nanosizes, promoting effective physiological processes involving biologically active substances with nanosizes. 3. Due to the small size of nanoparticles can penetrate through cell membranes and be distributed in the body. 4. From the position of modern nanoscience functioning organs, cells, subcellular structures, calcium channels, sodium-potassium pump is under the laws of natural nanomechanisms. 5. Summarising the literature data and own research, we can argue that the body's physiological processes based on natural nanomechanisms require more detailed, in-depth research. Nanophysiology studies peculiarities of the physiological processes in the body from the position of nanoscience and the impact of nanoparticles on the function of cells and organs. The author accepts the fact that not all ideas reported in this article have experimental confirmations, discussion is necessary for further comprehensive research, specialists of different directions to discover the role of nanomechanismes in physiological processes in the body.
MeSH term(s)	Animals ; Humans ; Nanomedicine ; Nanostructures/chemistry ; Nanostructures/ultrastructure ; Physiology/methods
Language	Ukrainian
Publishing date	2010-10
Publishing country	Ukraine
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	40876-1
ISSN	1019-5297 ; 0049-6804
ISSN	1019-5297 ; 0049-6804
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