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  1. Article ; Online: Autophagy maintains endosperm quality during seed storage to preserve germination ability in Arabidopsis.

    Shinozaki, Daiki / Takayama, Erina / Kawakami, Naoto / Yoshimoto, Kohki

    Proceedings of the National Academy of Sciences of the United States of America

    2024  Volume 121, Issue 14, Page(s) e2321612121

    Abstract: To preserve germination ability, plant seeds must be protected from environmental stresses during the storage period. Here, we demonstrate that autophagy, an intracellular degradation system, maintains seed germination ability ... ...

    Abstract To preserve germination ability, plant seeds must be protected from environmental stresses during the storage period. Here, we demonstrate that autophagy, an intracellular degradation system, maintains seed germination ability in
    MeSH term(s) Arabidopsis/genetics ; Endosperm/genetics ; Germination/physiology ; Seeds/genetics ; Arabidopsis Proteins/metabolism ; Autophagy ; Gene Expression Regulation, Plant
    Chemical Substances Arabidopsis Proteins
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2321612121
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    Zs.A 1148: Show issues Location:
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  2. Article ; Online: Intravital Imaging of T Cells Within the Spinal Cord.

    Kawakami, Naoto

    Methods in molecular biology (Clifton, N.J.)

    2018  Volume 1763, Page(s) 119–127

    Abstract: Intravital imaging is a powerful tool for analyzing cellular functions in living animals. In particular, after the two-photon microscopy technique was introduced, a number of studies have visualized important processes. Here, we describe the methods for ... ...

    Abstract Intravital imaging is a powerful tool for analyzing cellular functions in living animals. In particular, after the two-photon microscopy technique was introduced, a number of studies have visualized important processes. Here, we describe the methods for performing intravital imaging of the central nervous system. This method can be used for imaging not only lymphocytes but also blood vessels for ischemia studies, as well as glia cell activities.
    MeSH term(s) Animals ; Intravital Microscopy/methods ; Mice ; Microscopy, Fluorescence, Multiphoton/methods ; Rats ; Spinal Cord/cytology ; T-Lymphocytes/cytology
    Language English
    Publishing date 2018-02-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-7762-8_11
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  3. Book ; Online ; Thesis: Discovery and validation of essential modules of T cell migration into the central nervous system in a genome-wide CRISPR/Cas9 screening in experimental autoimmune encephalomyelitis

    Lämmle, Katrin Franziska [Verfasser] / Kawakami, Naoto [Akademischer Betreuer]

    2023  

    Author's details Katrin Franziska Lämmle ; Betreuer: Naoto Kawakami
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  4. Article ; Online: In vivo imaging in autoimmune diseases in the central nervous system.

    Kawakami, Naoto

    Allergology international : official journal of the Japanese Society of Allergology

    2016  Volume 65, Issue 3, Page(s) 235–242

    Abstract: Intravital imaging is becoming more popular and is being used to visualize cellular motility and functions. In contrast to in vitro analysis, which resembles in vivo analysis, intravital imaging can be used to observe and analyze cells directly in vivo. ... ...

    Abstract Intravital imaging is becoming more popular and is being used to visualize cellular motility and functions. In contrast to in vitro analysis, which resembles in vivo analysis, intravital imaging can be used to observe and analyze cells directly in vivo. In this review, I will summarize recent imaging studies of autoreactive T cell infiltration into the central nervous system (CNS) and provide technical background. During their in vivo journey, autoreactive T cells interact with many different cells. At first, autoreactive T cells interact with endothelial cells in the airways of the lung or with splenocytes, where they acquire a migratory phenotype to infiltrate into the CNS. After arriving at the CNS, they interact with endothelial cells of the leptomeningeal vessels or the choroid plexus before passing through the blood-brain barrier. CNS-infiltrating T cells become activated by recognizing endogenous autoantigens presented by local antigen-presenting cells (APCs). This activation was visualized in vivo by using protein-based sensors. One such sensor detects changes in intracellular calcium concentration as an early marker of T cell activation. Another sensor detects translocation of Nuclear factor of activated T-cells (NFAT) from cytosol to nucleus as a definitive sign of T cell activation. Importantly, intravital imaging is not just used to visualize cellular behavior. Together with precise analysis, intravital imaging deepens our knowledge of cellular functions in living organs and also provides a platform for developing therapeutic treatments.
    MeSH term(s) Animals ; Autoimmune Diseases of the Nervous System/diagnostic imaging ; Autoimmune Diseases of the Nervous System/etiology ; Autoimmune Diseases of the Nervous System/therapy ; Autoimmunity ; Central Nervous System/diagnostic imaging ; Central Nervous System/immunology ; Humans ; Immune System/cytology ; Immune System/immunology ; Immune System/pathology ; Intravital Microscopy/methods ; Lymphocyte Activation/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism
    Language English
    Publishing date 2016-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1336498-4
    ISSN 1440-1592 ; 1323-8930
    ISSN (online) 1440-1592
    ISSN 1323-8930
    DOI 10.1016/j.alit.2016.02.001
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    Zs.A 5248: Show issues Location:
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  5. Article: Modulation of wheat grain dormancy by introducing the recombinant abscisic acid-stimulated abscisic acid biosynthesis gene.

    Zheng, Lipeng / Abe, Fumitaka / Nonogaki, Mariko / Kanno, Yuri / Seo, Mitsunori / Nonogaki, Hiroyuki / Kawakami, Naoto

    Plant biotechnology (Tokyo, Japan)

    2023  Volume 40, Issue 1, Page(s) 31–41

    Abstract: Pre-harvest sprouting of cereals greatly reduces yield and quality of the grains. Abscisic acid (ABA) is an essential phytohormone for the induction and maintenance of seed dormancy. In this study, the ABA responsive promoter-driven ABA biosynthesis gene ...

    Abstract Pre-harvest sprouting of cereals greatly reduces yield and quality of the grains. Abscisic acid (ABA) is an essential phytohormone for the induction and maintenance of seed dormancy. In this study, the ABA responsive promoter-driven ABA biosynthesis gene system was introduced to common wheat (
    Language English
    Publishing date 2023-12-27
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2210142-1
    ISSN 1347-6114 ; 1342-4580
    ISSN (online) 1347-6114
    ISSN 1342-4580
    DOI 10.5511/plantbiotechnology.22.1219b
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  6. Article ; Online: Development of a Water Soluble Self-assembling Analogue of Vizantin.

    Nakano, Mayo / Sakamoto, Kyohei / Yamasaki, Naoto / Asano, Yui / Oda, Masataka / Takahashi, Hironobu / Kawakami, Takashige / Inoue, Masahisa / Yamamoto, Hirofumi

    Chemical & pharmaceutical bulletin

    2024  Volume 72, Issue 2, Page(s) 226–233

    Abstract: Vizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, has been developed as a safe immunostimulator on the basis of a structure-activity relationship study with trehalose 6,6'-dicorynomycolate. Our recent study indicated that vizantin acts as an ... ...

    Abstract Vizantin, 6,6'-bis-O-(3-nonyldodecanoyl)-α,α'-trehalose, has been developed as a safe immunostimulator on the basis of a structure-activity relationship study with trehalose 6,6'-dicorynomycolate. Our recent study indicated that vizantin acts as an effective Toll-like receptor-4 (TLR4) partial agonist to reduce the lethality of an immune shock caused by lipopolysaccharide (LPS). However, because vizantin has low solubility in water, the aqueous solution used in in vivo assay systems settles out in tens of minutes. Here, vizantin was chemically modified in an attempt to facilitate the preparation of an aqueous solution of the drug. This paper describes the concise synthesis of a water-soluble vizantin analogue in which all the hydroxyl groups of the sugar unit were replaced by sulfates. The vizantin derivative displayed micelle-forming ability in water and potent TLR-4 partial agonist activity.
    MeSH term(s) Glycolipids ; Lipopolysaccharides/pharmacology ; Trehalose/analogs & derivatives
    Chemical Substances 6,6'-bis-O-(3-nonyldodecanoyl)-alpha,alpha'-trehalose ; Glycolipids ; Lipopolysaccharides ; Trehalose (B8WCK70T7I)
    Language English
    Publishing date 2024-02-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c23-00716
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    Zs.A 770: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Book ; Online ; Thesis: Understanding the role of epithelial MyD88 signals in the early development of Experimental Autoimmune Encephalomyelitis (EAE)

    Solís González, Veronica E. [Verfasser] / Kawakami, Naoto [Akademischer Betreuer]

    2022  

    Author's details Veronica E. Solís González ; Betreuer: Naoto Kawakami
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  8. Article: Mining

    Ahmed, Monir Idres Yahya / Gorafi, Yasir Serag Alnor / Kamal, Nasrein Mohamed / Balla, Mohammed Yousif / Tahir, Izzat Sidahmed Ali / Zheng, Lipeng / Kawakami, Naoto / Tsujimoto, Hisashi

    Frontiers in plant science

    2023  Volume 14, Page(s) 1270925

    Abstract: Due to the low genetic diversity in the current wheat germplasm, gene mining from wild relatives is essential to develop new wheat cultivars that are more resilient to the changing climate. ...

    Abstract Due to the low genetic diversity in the current wheat germplasm, gene mining from wild relatives is essential to develop new wheat cultivars that are more resilient to the changing climate.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1270925
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  9. Article: [Intravital live imaging of effector autoreactive T cells].

    Kawakami, Naoto

    Nihon rinsho. Japanese journal of clinical medicine

    2013  Volume 71, Issue 5, Page(s) 766–769

    MeSH term(s) Animals ; Autoimmunity/immunology ; Cell Survival/immunology ; Disease Models, Animal ; Humans ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/physiopathology ; Neuroimaging/methods ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
    Language Japanese
    Publishing date 2013-05
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  10. Book ; Online ; Thesis: Microglia-regulated activation of CD4+ T cells in the development of experimental autoimmune encephalomyelitis

    Du, Cuilian [Verfasser] / Kawakami, Naoto [Akademischer Betreuer]

    2021  

    Author's details Cuilian Du ; Betreuer: Naoto Kawakami
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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