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Article: Who is the winner, pre-, post-, or mixed-dilution hemodiafiltration?

Park, Hayne Cho / Lee, Young-Ki

2021 Volume 40, Issue 3, Page(s) 332–334

Language	English
Publishing date	2021-09-07
Publishing country	Korea (South)
Document type	Editorial
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.21.172
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Practical Issues in the Management of Polycystic Kidney Disease: Blood Pressure and Water Balance.

Park, Hayne Cho / Oh, Yun Kyu

Electrolyte & blood pressure : E & BP

2022 Volume 20, Issue 1, Page(s) 10–16

Abstract: Autosomal dominant polycystic kidney disease is the most common hereditary renal disease affecting more than 13 million people worldwide. Renal function deteriorates as the cysts in both kidneys increase in number and size, which eventually results in ... ...

Abstract	Autosomal dominant polycystic kidney disease is the most common hereditary renal disease affecting more than 13 million people worldwide. Renal function deteriorates as the cysts in both kidneys increase in number and size, which eventually results in end-stage kidney failure. Until recently, conservative management for chronic kidney disease such as blood pressure control, low sodium diet, adequate water intake, and weight control were known for the only treatment of polycystic kidney disease. However, the introduction of disease-modifying drug has led to the new paradigm shift in the management of polycystic kidney disease. Tolvaptan, the vasopressin V2 receptor antagonist, has been introduced to the patients with large kidneys since it can inhibit cyclic adenosine monophosphate, attenuates cyst growth, and delays renal failure. This article reviews the two important practical issues in the management of polycystic kidney disease: blood pressure and water balance. Firstly, the article will review the pathogenesis of high blood pressure in polycystic kidney disease and will demonstrate the current up-to-date management plan for blood pressure control. Secondly, this article will explain the mechanism of Tolvaptan on the treatment of polycystic kidney disease and its possible adverse effect on water and sodium balance.
Language	English
Publishing date	2022-06-30
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	3017960-9
ISSN	2092-9935 ; 1738-5997
ISSN (online)	2092-9935
ISSN	1738-5997
DOI	10.5049/EBP.2022.20.1.10
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Remaining life expectancy of Korean hemodialysis patients: how much longer can they live?

Park, Hayne Cho / Kim, Do Hyoung / Cho, AJin / Kim, Bo Yeon / Lee, Miri / Kim, Gui Ok / Kim, Jinseog / Lee, Young-Ki

Kidney research and clinical practice

2024

Abstract: Background: Hemodialysis (HD) patients have a higher mortality rate compared to the general population. However, no study has investigated life expectancy in Korean HD patients so far. Therefore, this study aimed to calculate the remaining life ... ...

Abstract	Background: Hemodialysis (HD) patients have a higher mortality rate compared to the general population. However, no study has investigated life expectancy in Korean HD patients so far. Therefore, this study aimed to calculate the remaining life expectancy among Korean maintenance HD patients and compare it to those of the general population as well as HD patients from other countries. Methods: Baseline data were retrieved from HD quality assessment data from 2015. Among the patients over 30 years old who were alive at the beginning of 2016 (20,304 males and 14,264 females), a total of 22,078 (12,621 males and 9,457 females) were still alive at the end of 2021 while 12,490 (7,683 males and 4,807 females) were deceased during 6 years of follow-up. We used the life table method to calculate the expected remaining years of life in 2-year increments. Results: The remaining life expectancies for 60-year-old patients were 11.64 years for males and 14.64 years for females. The average remaining lifetimes of the HD population were only about half of the general population. Diabetic patients demonstrated shorter life expectancy compared to patients with hypertension or glomerulonephritis. The remaining life expectancy of Korean HD patients was similar to that of Japanese and was almost double that of HD patients in Western countries such as Europe and the United States. Conclusion: The HD population shows shorter life expectancy compared to the general population. Longitudinal analysis should be warranted to analyze the effect of advanced dialysis technology on improved survival rates among the HD population.
Language	English
Publishing date	2024-02-19
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.241
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Geriatric Nutritional Risk Index and First-Year Mortality in Incident Hemodialysis Patients.

Song, Gi Hyun / Choi, Han Byul / Park, Hayne Cho / Kim, Do Hyoung / Lee, Young-Ki / Cho, AJin

Nutrients

2024 Volume 16, Issue 5

Abstract: Objective: The Geriatric Nutritional Risk Index is a simple nutritional screening method, and this study aimed to investigate the association between the initial Geriatric Nutritional Risk Index and all-cause mortality in incident patients in the first ... ...

Abstract	Objective: The Geriatric Nutritional Risk Index is a simple nutritional screening method, and this study aimed to investigate the association between the initial Geriatric Nutritional Risk Index and all-cause mortality in incident patients in the first year after the initiation of hemodialysis. Materials and methods: This study is a retrospective cohort study and used the Korean Renal Data System database. Patients who were eligible for Geriatric Nutritional Risk Index assessment and underwent hemodialysis from January 2016 to December 2019 were included. The primary outcome was all-cause mortality, and outcome evaluation was performed in December 2020. A Cox proportional hazard model was used to analyze the association between the Geriatric Nutritional Risk Index and mortality. Results: A total of 10,545 patients were included, and the mean age was 63.9 ± 3.7 years. The patients were divided into four groups by the quartile of the Geriatric Nutritional Risk Index with a mean value of 96.2 ± 8.2. During the study period, 545 (5.2%) deaths occurred. The surviving patients had higher Geriatric Nutritional Risk Index values than ones who died in the first year of hemodialysis initiation (96.6 ± 7.5 vs. 88.2 ± 9.3, Conclusions: These findings suggest that a low Geriatric Nutritional Risk Index (<91.8) is associated with first-year all-cause and cardiovascular mortality in patients who start hemodialysis and may be a useful and reproducible tool for assessing prognoses in this population.
MeSH term(s)	Humans ; Aged ; Middle Aged ; Nutrition Assessment ; Nutritional Status ; Retrospective Studies ; Renal Dialysis ; Cardiovascular Diseases ; Geriatric Assessment/methods ; Risk Factors ; Risk Assessment
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050652
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Article ; Online: Mortality and Risk Factors in Very Elderly Patients Who Start Hemodialysis: Korean Renal Data System, 2016-2020.

Park, Ji Hyeon / Park, Hayne Cho / Kim, Do Hyoung / Lee, Young Ki / Cho, AJin

American journal of nephrology

2023 Volume 54, Issue 5-6, Page(s) 175–183

Abstract: Introduction: The number of elderly patients with end-stage renal disease (ESRD) is increasing worldwide. However, decision-making about elderly patients with ESRD remains complex because of the lack of studies, especially in very elderly patients (≥75 ... ...

Abstract	Introduction: The number of elderly patients with end-stage renal disease (ESRD) is increasing worldwide. However, decision-making about elderly patients with ESRD remains complex because of the lack of studies, especially in very elderly patients (≥75 years). We examined the characteristics of very elderly patients starting hemodialysis (HD) and the associated mortality and prognostic factors. Methods: Data were analyzed retrospectively using a nationwide cohort registry, the Korean Renal Data System. Patients who started HD between January 2016 and December 2020 were included and divided into three groups according to age at HD initiation (<65, 65-74, and ≥75 years). The primary outcome was all-cause mortality during the study period. Risk factors for mortality were analyzed using Cox proportional hazard models. Results: In total, 22,024 incident patients were included with 10,006, 5,668, and 6,350 in each group (<65, 65-74, and ≥75 years, respectively). Among the very elderly group, women had a higher cumulative survival rate than men. The survival rate was lower in patients with vascular access via a catheter than in those with an arteriovenous fistula or graft. Very elderly patients with more comorbid diseases had a significantly lower survival rate than those with fewer comorbidities. In the multivariate Cox models, old age, cancer presence, catheter use, low body mass index, low Kt/V, low albumin concentration, and capable status of partial self-care were associated with high risk of mortality. Conclusion: Preparation of an arteriovenous fistula or graft when starting HD should be considered in very elderly patients with fewer comorbid diseases.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Retrospective Studies ; Renal Dialysis ; Kidney Failure, Chronic ; Risk Factors ; Republic of Korea/epidemiology ; Arteriovenous Shunt, Surgical/adverse effects
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000530933
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Who is the winner, pre-, post-, or mixed-dilution hemodiafiltration?

Hayne Cho Park / Young-Ki Lee

Kidney Research and Clinical Practice, Vol 40, Iss 3, Pp 332-

2021 Volume 334

Keywords	Internal medicine ; RC31-1245 ; Specialties of internal medicine ; RC581-951
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	The Korean Society of Nephrology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis.

Kee, Youn Kyung / Park, Hayne Cho / Yoon, Su Jin / Yu, Sungbong / Ko, Eunsil / Cho, AJin / Kim, Do Hyoung / Kim, Jinseog / Lee, Young-Ki

Kidney research and clinical practice

2024 Volume 43, Issue 1, Page(s) 111–121

Abstract: Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the ... ...

Abstract	Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the effectiveness of regdanvimab on mortality in COVID-19-infected patients on hemodialysis (HD). Methods: We conducted an observational retrospective study in 230 COVID-19-infected patients on HD, of whom 77 (33.5%) were administered regdanvimab alone or in combination with dexamethasone or remdesivir during hospitalization (regdanvimab group) and 153 patients (66.5%) were not (no regdanvimab group). The primary outcome was in-hospital mortality. We compared mortality rates according to the use of regdanvimab and investigated the factors associated with mortality. Results: Fifty-nine deaths occurred during hospitalization, 49 in the no regdanvimab group (32.0%) and 10 in the regdanvimab group (13.0%), and the mortality rate was significantly higher in the no regdanvimab group than that in the regdanvimab group (p = 0.001). Multivariate Cox regression analysis showed that malignancy (p = 0.001), SPO2 of <95% at admission (p = 0.003), and administration of antibiotics and regdanvimab (p = 0.007 and p = 0.002, respectively) were significantly associated factors with mortality. Conclusion: Regdanvimab administration is beneficial in improving prognosis in hospitalized COVID-19 patients on HD. Considering the vulnerability to infection and high mortality of ESRD patients, regdanvimab may be considered as a therapeutic option in COVID-19 patients on HD.
Language	English
Publishing date	2024-01-23
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2656420-8
ISSN	2211-9132
ISSN	2211-9132
DOI	10.23876/j.krcp.23.137
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Geriatric Nutritional Risk Index Is an Optimal Evaluation Parameter for Predicting Mortality in Adult All Ages Hemodialysis Patients: A Korean Population-Based Study.

Kim, Do Hyoung / Lee, Young-Ki / Park, Hayne Cho / Kim, Bo Yeon / Lee, Miri / Kim, Gui Ok / Kim, Jinseog / Cho, Ajin

Nutrients

2023 Volume 15, Issue 17

Abstract: The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening tool used for predicting mortality in patients undergoing hemodialysis (HD). This study investigated the cutoff values for the GNRI for predicting mortality in HD patients using ... ...

Abstract	The Geriatric Nutritional Risk Index (GNRI) is a nutritional screening tool used for predicting mortality in patients undergoing hemodialysis (HD). This study investigated the cutoff values for the GNRI for predicting mortality in HD patients using Korean HD quality assessment data from 2015. To identify the optimal GNRI cutoff value, we used Harrell's C-index with multivariate Cox regression models. The highest value of C-index was identified as the cutoff value of GNRI for all-cause mortality in this population. In total, 34,933 patients were included; 90.8 of GNRI was the highest value of C-index, and it was used as a cutoff value to predict mortality; 3311 patients (9.5%) had GNRI values < 90.8, and there were 12,499 deaths during the study period. The mean follow-up period was 53.7 months. The crude mortality rates in patients with GNRI values < 90.8 and ≥ 90.8 were 160.4/1000 and 73.2/1000 person-years respectively. In the fully adjusted Cox model, patients with a GNRI < 90.8 had a 1.78 times higher risk of mortality than those with a GNRI ≥ 90.8. These findings suggest that the optimal GNRI cutoff value is 90.8 for predicting mortality in maintenance HD patients.
MeSH term(s)	Adult ; Humans ; Asian People ; Nutrition Assessment ; Nutritional Status ; Renal Dialysis ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-09-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15173831
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of electrolyte-rich dialysate during continuous renal replacement therapy on serum phosphate and potassium in ICU patients.

Cho, AJin / Lee, Young-Ki / Park, Hayne Cho

PloS one

2020 Volume 15, Issue 9, Page(s) e0238867

Abstract: Background: Hypophosphatemia and hypokalemia occur frequently during continuous renal replacement therapy (CRRT). We evaluated serum phosphate and potassium levels in patients administered three different types of dialysis solution.: Methods: The ... ...

Abstract	Background: Hypophosphatemia and hypokalemia occur frequently during continuous renal replacement therapy (CRRT). We evaluated serum phosphate and potassium levels in patients administered three different types of dialysis solution. Methods: The study population consisted of 324 intensive care unit patients who underwent CRRT between January 2015 and December 2018. Patients were divided into three groups: group 1 (n = 105) received Hemosol B0 (no potassium or phosphate); group 2 (n = 78) received Hemosol B0 and potassium-containing solution (MultiBic); and group 3 (n = 141) received phosphate- and potassium-containing solution (Phoxilium), Hemosol B2, Prismasol 2, and Prismasol 4. A different protocol was followed in each group. Results: The incidence rate of hypophosphatemia was 55% lower in group 3 compared to group 1 (incidence rate ratio (IRR) 0.45, 95% confidence interval (CI): 0.33 to 0.61) and 61% lower compared to group 2 (IRR 0.39, 95% CI: 0.29 to 0.53). Group 3 also had a 50% lower incidence rate of hypokalemia compared to group 1 (IRR 0.50, 95% CI: 0.29 to 0.88). The negative slope in phosphate level in group 3 was greater than that in group 1 (ß = 0.19, 95% CI: 0.02 to 0.37, p = 0.032), while the negative slope in the potassium level was greater in group 2 than in group 1(ß = 0.10, 95% CI: 0.03 to 0.17, p = 0.008). Additional intravenous calcium was not used in any case, and most cases of acid-base disturbances were well controlled. Conclusions: The use of phosphate- and potassium-containing with a proper CRRT protocol prevented decreases in serum phosphate and potassium levels, thus also preventing hypophosphatemia and hypokalemia, and additional replacement during CRRT.
MeSH term(s)	Acute Kidney Injury/blood ; Acute Kidney Injury/pathology ; Acute Kidney Injury/therapy ; Aged ; Continuous Renal Replacement Therapy/methods ; Dialysis Solutions/chemistry ; Electrolytes/chemistry ; Female ; Humans ; Hypokalemia/prevention & control ; Hypophosphatemia/prevention & control ; Intensive Care Units ; Male ; Phosphates/administration & dosage ; Phosphates/blood ; Potassium/administration & dosage ; Potassium/blood ; Retrospective Studies
Chemical Substances	Dialysis Solutions ; Electrolytes ; Phosphates ; Potassium (RWP5GA015D)
Language	English
Publishing date	2020-09-11
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0238867
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regular laboratory testing and patient survival among patients undergoing maintenance hemodialysis: a Korean nationwide cohort study.

Kim, Do Hyoung / Cho, AJin / Park, Hayne Cho / Kim, Bo Yeon / Lee, Miri / Kim, Gui Ok / Kim, Jinseog / Lee, Young-Ki

Scientific reports

2023 Volume 13, Issue 1, Page(s) 18360

Abstract: Routine laboratory tests are regularly performed in patients undergoing maintenance hemodialysis (HD) to detect anemia, chronic kidney disease-mineral bone disorders, and cardiovascular disease. More frequent laboratory tests may be associated with ... ...

Abstract	Routine laboratory tests are regularly performed in patients undergoing maintenance hemodialysis (HD) to detect anemia, chronic kidney disease-mineral bone disorders, and cardiovascular disease. More frequent laboratory tests may be associated with better outcomes. However, there is little evidence supporting a specific monitoring interval. This study evaluated the impact of regular laboratory testing on mortality in Korean patients undergoing maintenance HD. We used HD quality assessments, and National Health Insurance Service claims data from October to December 2015. In HD quality assessment, 22 tests are recommended every 1-6 months. A total of 34,950 patients were divided into two groups based on the regularity of laboratory testing. A Cox proportional hazards model was used to assess the effects of regular laboratory tests on patient mortality during a mean follow-up duration of 53.7 months. The proportion of patients with and without regular laboratory testing was 85.6% (n = 29,914) and 14.4% (n = 5036), respectively. Patients who underwent regular laboratory testing had a longer dialysis duration, lower serum phosphorus levels and diastolic blood pressure, and higher hemoglobin and single-pool Kt/V levels than those who did not. After adjusting for demographic and clinical parameters, regular laboratory testing independently reduced mortality risk (hazard ratio, 0.90; 95% confidence interval 0.85-0.95; P < 0.001). Regular laboratory testing was associated with a decreased mortality risk among patients undergoing HD. Management of end-stage kidney disease-related complications based on laboratory tests can improve survival.
MeSH term(s)	Humans ; Renal Dialysis/adverse effects ; Cohort Studies ; Kidney Failure, Chronic/complications ; Cardiovascular Diseases/etiology ; Proportional Hazards Models ; Republic of Korea/epidemiology
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45502-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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