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  1. Article ; Online: Erratum: CHATMONGKON SUWANNAPOOM, ZHI-YONG YUAN, JIN-MIN CHEN, MIAN HOU, HAI-PENG ZHAO, LI-JUN WANG, TRUONG SON NGUYEN, TRUONG Q. NGUYEN, ROBERT W. MURPHY, JAQUELINE SULLIVAN, DAVID S. MCLEOD & JING CHE (2016) Taxonomic revision of the Chinese Limnonectes (Anura, Dicroglossidae) with the description of a new species from China and Myanmar. Zootaxa, 4093: 181-200.

    Suwannapoom, Chatmongkon / Yuan, Zhi-Yong / Chen, Jin-Min / Hou, Mian / Zhao, Hai-Peng / Wang, Li-Jun / Nguyen, Truong Son / Nguyen, Truong Q / Murphy, Robert W / Sullivan, Jaqueline / Mcleod, David S / Che, Jing

    Zootaxa

    2016  Volume 4137, Issue 4, Page(s) 599–600

    Language English
    Publishing date 2016--13
    Publishing country New Zealand
    Document type Journal Article ; Published Erratum
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4137.4.13
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A standard 96-well based high throughput microfluidic perfusion biofilm reactor for in situ optical analysis.

    McLeod, David / Wei, Lai / Li, Zhenyu

    Biomedical microdevices

    2023  Volume 25, Issue 3, Page(s) 26

    Abstract: Biofilm infections represent a major public health threat due to their high tolerance to antimicrobials and the lack of specific anti-biofilm drugs. To develop such drugs, it is crucial to have high-throughput biofilm growth systems that can emulate in ... ...

    Abstract Biofilm infections represent a major public health threat due to their high tolerance to antimicrobials and the lack of specific anti-biofilm drugs. To develop such drugs, it is crucial to have high-throughput biofilm growth systems that can emulate in vivo conditions without the cost and complexity of animal models. However, no current biofilm reactor can provide in vivo-like conditions in a high throughput standard microtiter format. This paper demonstrates a novel high-throughput (HT) microfluidic perfusion biofilm reactor (HT-μPBR) compatible with a standard 96-well microtiter plate for in situ optical analysis. A snap-on liquid-tight cover for standard microtiter plates was designed and fabricated with fluidic channels to provide closed-loop recirculating perfusion. Our system takes steps toward providing in vivo-like conditions with controlled shear stress and nutrient delivery. We describe the system fabrication and usage in optical analysis of biomass and viability of Escherichia coli (E. coli) biofilms. The HT-μPBR was set to perfuse at 1 mL/min corresponding to an average shear rate of approximately [Formula: see text] on the bottom surface of a single well. Biofilms were detected on well plate bottoms and measured using a fluorescence microscope and plate reader to determine biomass and viability. Samples cultured in the HT-μPBR showed increased biomass while maintaining viability after 24 h. The HT-μPBR can further be combined with HT antibiotic susceptibility testing and additional optical techniques such as time-lapse imaging to improve understanding of the drug reaction mechanism as well as the optimization of drug combinations and delivery profiles.
    MeSH term(s) Animals ; Microfluidics ; Escherichia coli ; Biofilms ; Perfusion
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2004019-2
    ISSN 1572-8781 ; 1387-2176
    ISSN (online) 1572-8781
    ISSN 1387-2176
    DOI 10.1007/s10544-023-00668-w
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  3. Article ; Online: Nonperfused Inner Retina May Be Anoxic, Hypoxic, or Normoxic.

    McLeod, David

    JAMA ophthalmology

    2019  Volume 137, Issue 11, Page(s) 1333

    Language English
    Publishing date 2019-09-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.3588
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    Ul I Zs.26: Show issues Location:
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  4. Book ; Online: How Civil Institutions Build Resilience

    Langeland, Krista S / Manheim, David / McLeod, Gary / Nacouzi, George

    Organizational Practices Derived from Academic Literature and Case Studies

    2016  

    Keywords Air forces & warfare ; Political control & freedoms ; Population & demography ; Social impact of disasters ; Population Studies ; Political Science ; History ; Sociology
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030612905
    ISBN 9780833092014 ; 0833092014
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Article ; Online: Identification of three unexpected new psychoactive substances at an Australian drug checking service.

    Algar, Jess L / Lawes, Douglas J / Carroll, Adam J / Caldicott, David / McLeod, Malcolm D

    Drug testing and analysis

    2024  

    Abstract: Drug checking is a harm reduction measure that provides people with the opportunity to confirm the identity and purity of substances before consumption. The CanTEST Health and Drug Checking Service is Australia's first fixed-site drug checking service, ... ...

    Abstract Drug checking is a harm reduction measure that provides people with the opportunity to confirm the identity and purity of substances before consumption. The CanTEST Health and Drug Checking Service is Australia's first fixed-site drug checking service, where clients can learn about the contents of the samples they provide while receiving tailored harm reduction and health advice. Three samples were recently presented to the service with the expectation of 4-fluoromethylphenidate (4F-MPH) 1, methoxetamine (MXE) 2 and 3-methylmethcathinone (3-MMC) 3. The identity of all three samples did not meet these expectations and remained unknown on-site, as no high confidence identifications were obtained. However, further analysis by nuclear magnetic resonance spectroscopy, high resolution gas chromatography-electron ionisation-mass spectrometry and liquid chromatography-electrospray ionisation-mass spectrometry at the nearby Australian National University allowed for the structure elucidation of the three samples as 4-fluoro-α-pyrrolidinoisohexanophenone (4F-α-PiHP) 4, 1-(4-fluorobenzyl)-4-methylpiperazine (4F-MBZP) 5 and N-propyl-1,2-diphenylethylamine (propylphenidine) 6, respectively. Given all three samples were not of the expected identity and have not yet been described as new psychoactive substances in the literature, this study presents a full characterisation of each compound. As exemplified by this rapid identification of three unexpected new psychoactive substances, drug checking can be used as an effective method to monitor the unregulated drug market.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2462336-2
    ISSN 1942-7611 ; 1942-7603
    ISSN (online) 1942-7611
    ISSN 1942-7603
    DOI 10.1002/dta.3637
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    Zs.A 6792: Show issues Location:
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  6. Book ; Conference proceedings: Hormonal therapy for prostate cancer

    McLeod, David G.

    controversies and advances ; ... based on a symposium held May 24, 2002, in Orlando, Florida, USA

    (Urology ; 61,2A = Suppl.)

    2003  

    Author's details guest ed.: David G. McLeod
    Series title Urology ; 61,2A = Suppl.
    Collection
    Language English
    Size 38 S. : graph. Darst.
    Publisher Elsevier Science
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013599690
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 1142 -61,2A- not available for loan Zeitschriften-Lesesaal

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  7. Article ; Online: Global Health in the ANZ Journal of Surgery.

    McLeod, Elizabeth / Watters, David

    ANZ journal of surgery

    2020  Volume 90, Issue 10, Page(s) 1833–1834

    MeSH term(s) Australia ; General Surgery ; Global Health ; Humans ; New Zealand ; Periodicals as Topic ; Publishing
    Language English
    Publishing date 2020-07-31
    Publishing country Australia
    Document type Editorial
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.16305
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    Zs.A 180: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Misery Perfusion, Diffusive Oxygen Shunting and Interarterial Watershed Infarction Underlie Oxygenation-Based Hypoperfusion Maculopathy.

    McLeod, David

    American journal of ophthalmology

    2019  Volume 205, Page(s) 153–164

    Abstract: Purpose: To describe and explain the entire range of acute ischemic macular damage that follows panretinal hypoperfusion from central retinal artery or vein occlusion.: Design: Perspective article.: Methods: To correlate the fundoscopic, ... ...

    Abstract Purpose: To describe and explain the entire range of acute ischemic macular damage that follows panretinal hypoperfusion from central retinal artery or vein occlusion.
    Design: Perspective article.
    Methods: To correlate the fundoscopic, fluorescein angiographic, oximetric, and optical coherence tomographic (OCT) features developing within the posterior inner retina following incremental reductions in arteriovenous perfusion pressure across the retinal circulation.
    Results: The spectrum of acute oxygenation-based hypoperfusion maculopathy (OHM) is consistent with that predictable from a modified Krogh cylinder model of tissue oxygenation. Diffusive oxygen shunting plays a significant role in the "artery-dominated" generation of ischemic signs during misery perfusion. Three major grades of OHM severity can be discerned according to the predominant oxygenation status of ganglion cells within the superficial inner retina, whether this is normoxic (OHM1), hypoxic (OHM2), or anoxic (OHM3). Densely opaque axoplasmic sentinels are arranged along normoxic/hypoxic interfaces in OHM2. In OHM1 and OHM2, relative hypermetabolism and interarterial watershed infarction of fundal interneurons (WIFI) underpin subtle middle-retinal opacification with periarterial sparing. The fundal signs are optimally displayed en face using autofluorescence imaging whereas cross-sectional OCT reveals Paques' plaque formation.
    Conclusions: An exquisite and supremely accessible exhibition of classical oxygen physiopathology unfolds in eyes with panretinal hypoperfusion courtesy of the transparent ocular media and the pattern of macular neuroretinal opacification that evolves as upstream tissues extract oxygen to the detriment of tissues downstream. Recent attempts to overrule the simple conceptual framework embodied in WIFI have no plausible anatomical nor physiological basis. Overreliance on OCT can result in misdiagnosis.
    MeSH term(s) Fluorescein Angiography/methods ; Fundus Oculi ; Humans ; Ischemia/complications ; Ischemia/diagnosis ; Ischemia/metabolism ; Macula Lutea/pathology ; Macular Degeneration/diagnosis ; Macular Degeneration/etiology ; Macular Degeneration/metabolism ; Oximetry ; Oxygen/metabolism ; Retinal Artery/pathology ; Retinal Vein Occlusion/complications ; Retinal Vein Occlusion/diagnosis ; Retinal Vein Occlusion/metabolism ; Tomography, Optical Coherence/methods ; Visual Acuity
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2019-03-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2019.03.015
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    Ul I Zs.39: Show issues Location:
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  9. Article ; Online: A handheld plug-and-play microfluidic liquid handling automation platform for immunoassays.

    Wang, Sheng / Li, Baichen / McLeod, David / Li, Zhenyu

    HardwareX

    2023  Volume 14, Page(s) e00420

    Abstract: Lab-on-a-chip technologies and microfluidics have pushed miniaturized liquid handling to unprecedented precision, integration, and automation, which improved the reaction efficiency of immunoassays. However, most microfluidic immunoassay systems still ... ...

    Abstract Lab-on-a-chip technologies and microfluidics have pushed miniaturized liquid handling to unprecedented precision, integration, and automation, which improved the reaction efficiency of immunoassays. However, most microfluidic immunoassay systems still require bulky infrastructures, such as external pressure sources, pneumatic systems, and complex manual tubing and interface connections. Such requirements prevent plug-and-play operation at the point-of-care (POC) settings. Here we present a fully automated handheld general microfluidic liquid handling automation platform with a plug-and-play 'clamshell-style' cartridge socket, a miniature electro-pneumatic controller, and injection-moldable plastic cartridges. The system achieved multi-reagent switching, metering, and timing control on the valveless cartridge using electro-pneumatic pressure control. As a demonstration, a SARS-CoV-2 spike antibody sandwich fluorescent immunoassay (FIA) liquid handling was performed on an acrylic cartridge without human intervention after sample introduction. A fluorescence microscope was used to analyze the result. The assay showed a limit of detection at 31.1 ng/mL, comparable to some previously reported enzyme-linked immunosorbent assays (ELISA). In addition to automated liquid handling on the cartridge, the system can operate as a 6-port pressure source for external microfluidic chips. A rechargeable battery with a 12 V 3000 mAh capacity can power the system for 42 h. The footprint of the system is 16.5 × 10.5 × 7 cm, and the weight is 801 g, including the battery. The system can find many other POC and research applications requiring complex liquid manipulation, such as molecular diagnostics, cell analysis, and on-demand biomanufacturing.
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ISSN 2468-0672
    ISSN (online) 2468-0672
    DOI 10.1016/j.ohx.2023.e00420
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  10. Article ; Online: Effects of epistasis and recombination between vaccine-escape and virulence alleles on the dynamics of pathogen adaptation.

    McLeod, David V / Gandon, Sylvain

    Nature ecology & evolution

    2022  Volume 6, Issue 6, Page(s) 786–793

    Abstract: Pathogen adaptation to public health interventions such as vaccination may take tortuous routes and involve multiple mutations at different locations in the pathogen genome, acting on distinct phenotypic traits. Yet how these multi-locus adaptations ... ...

    Abstract Pathogen adaptation to public health interventions such as vaccination may take tortuous routes and involve multiple mutations at different locations in the pathogen genome, acting on distinct phenotypic traits. Yet how these multi-locus adaptations jointly evolve is poorly understood. Here we consider the joint evolution of two adaptations: pathogen escape from the vaccine-induced immune response and adjustments to pathogen virulence affecting transmission or clearance. We elucidate the role played by epistasis and recombination, with an emphasis on the different protective effects of vaccination. We show that vaccines blocking infection, reducing transmission and/or increasing clearance generate positive epistasis between the vaccine-escape and virulence alleles, favouring strains that carry both mutations, whereas vaccines reducing virulence mortality generate negative epistasis, favouring strains that carry either mutation but not both. High rates of recombination can affect these predictions. If epistasis is positive, frequent recombination can prevent the transient build-up of more virulent escape strains. If epistasis is negative, frequent recombination between loci can create an evolutionary bistability, favouring whichever adaptation is more accessible. Our work provides a timely alternative to the variant-centred perspective on pathogen adaptation and captures the effect of different types of vaccine on the interference between multiple adaptive mutations.
    MeSH term(s) Alleles ; Epistasis, Genetic ; Recombination, Genetic ; Vaccines ; Virulence/genetics
    Chemical Substances Vaccines
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-022-01709-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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