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  1. Book ; Online ; E-Book: Antifungal compounds discovery

    Soković, Marina / Liaras, Konstantinos

    natural and synthetic approaches

    2021  

    Author's details Marina Soković, Konstantinos Liaras
    Keywords Mycoses/Treatment ; Drug development ; Antifungal agents/Therapeutic use.
    Subject code 616.96
    Language English
    Size 1 online resource (xi, 284 pages) :, illustrations
    Publisher Elsevier
    Publishing place Amsterdam, Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 0-12-815825-5 ; 0-12-815824-7 ; 978-0-12-815825-8 ; 978-0-12-815824-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review.

    Stojković, Dejan / Petrović, Jovana / Carević, Tamara / Soković, Marina / Liaras, Konstantinos

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: This narrative review paper provides an up-to-date overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in resistant strains. The review focused on research conducted in the last five ... ...

    Abstract This narrative review paper provides an up-to-date overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in resistant strains. The review focused on research conducted in the last five years and investigated a range of compounds including azoles, indoles, thiophenes, glycopeptides, pleuromutilin derivatives, lactone derivatives, and chalcones. The emergence and spread of antibiotic-resistant bacterial strains is a growing public health concern, and new approaches are urgently needed to combat this threat. One promising approach is to target virulence factors, which are essential for bacterial survival and pathogenesis, but not for bacterial growth. By targeting virulence factors, it may be possible to reduce the severity of bacterial infections without promoting the development of resistance. We discuss the mechanisms of action of the various compounds investigated and their potential as antibacterials. The review highlights the potential of targeting virulence factors as a promising strategy to combat antibiotic resistance and suggests that further research is needed to identify new compounds and optimize their efficacy. The findings of this review suggest that novel synthetic and semisynthetic compounds that target virulence factors have great potential as antibacterials in the fight against antibiotic resistance.
    Language English
    Publishing date 2023-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12060963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An osteoma volume of the buttock.

    LIARAS, H

    Afrique francaise chirurgicale

    2007  , Issue 3-4, Page(s) 83

    Title translation Un volume ostéome de la fesse.
    MeSH term(s) Buttocks ; Humans ; Neoplasms ; Osteoma
    Language French
    Publishing date 2007-12-15
    Publishing country Algeria
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Thiazoles and Thiazolidinones as COX/LOX Inhibitors.

    Liaras, Konstantinos / Fesatidou, Maria / Geronikaki, Athina

    Molecules (Basel, Switzerland)

    2018  Volume 23, Issue 3

    Abstract: Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of ... ...

    Abstract Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflammatory drugs (NSAIDs), which act as selective or non-selective COX inhibitors. Almost all of them present a number of unwanted, often serious, side effects as a consequence of interference with the arachidonic acid cascade. In search for new drugs to avoid side effects, while maintaining high potency over inflammation, scientists turned their interest to the synthesis of dual COX/LOX inhibitors, which could provide numerous therapeutic advantages in terms of anti-inflammatory activity, improved gastric protection and safer cardiovascular profile compared to conventional NSAIDs. Τhiazole and thiazolidinone moieties can be found in numerous biologically active compounds of natural origin, as well as synthetic molecules that possess a wide range of pharmacological activities. This review focuses on the biological activity of several thiazole and thiazolidinone derivatives as COX-1/COX-2 and LOX inhibitors.
    MeSH term(s) Animals ; Cyclooxygenase 2 Inhibitors/chemistry ; Cyclooxygenase 2 Inhibitors/pharmacology ; Humans ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Structure-Activity Relationship ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Thiazolidines/chemistry ; Thiazolidines/pharmacology
    Chemical Substances Cyclooxygenase 2 Inhibitors ; Lipoxygenase Inhibitors ; Thiazoles ; Thiazolidines
    Language English
    Publishing date 2018-03-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23030685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Book ; Online: Turkey's Party System and the Paucity of Minority Policy Reform

    Liaras, Evangelos

    (EUI working papers / RSCAS ; 2009,56 ; Mediterranean Programme)

    2009  

    Institution Robert Schuman Centre for Advanced Studies
    Author's details Evangelos Liaras
    Series title EUI working papers / RSCAS ; 2009,56
    Mediterranean Programme
    Language English
    Size Online-Ressource (17 S., 259 KB)
    Publishing place Badia Fiesolana, San Domenico (Fl)
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  6. Article: Poumon et plèvre.

    LIARAS, H

    Afrique francaise chirurgicale

    2003  Volume 12, Issue 1, Page(s) 73–81

    Title translation Lung and pleura.
    MeSH term(s) Disease ; Humans ; Lung ; Lung Diseases ; Pleura ; Pleural Diseases ; Pulmonary Surgical Procedures ; Thorax/surgery ; Tuberculosis ; Tuberculosis, Pulmonary/surgery
    Language Undetermined
    Publishing date 2003-09-12
    Publishing country Algeria
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Thiazoles and Thiazolidinones as COX/LOX Inhibitors

    Konstantinos Liaras / Maria Fesatidou / Athina Geronikaki

    Molecules, Vol 23, Iss 3, p

    2018  Volume 685

    Abstract: Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of ... ...

    Abstract Inflammation is a natural process that is connected to various conditions and disorders such as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase isoenzymes (COX-1, COX-2) are responsible for the production of prostaglandins that play an important role in inflammation, traditional treatment approaches include administration of non-steroidal anti-inflammatory drugs (NSAIDs), which act as selective or non-selective COX inhibitors. Almost all of them present a number of unwanted, often serious, side effects as a consequence of interference with the arachidonic acid cascade. In search for new drugs to avoid side effects, while maintaining high potency over inflammation, scientists turned their interest to the synthesis of dual COX/LOX inhibitors, which could provide numerous therapeutic advantages in terms of anti-inflammatory activity, improved gastric protection and safer cardiovascular profile compared to conventional NSAIDs. Τhiazole and thiazolidinone moieties can be found in numerous biologically active compounds of natural origin, as well as synthetic molecules that possess a wide range of pharmacological activities. This review focuses on the biological activity of several thiazole and thiazolidinone derivatives as COX-1/COX-2 and LOX inhibitors.
    Keywords thiazole ; thiazolidinone ; COX ; LOX ; anti-inflammatory ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Thiazoles and thiazolidinones as antioxidants.

    Geronikaki, A A / Pitta, E P / Liaras, K S

    Current medicinal chemistry

    2013  Volume 20, Issue 36, Page(s) 4460–4480

    Abstract: Antioxidants are of great interest because of their involvement in important biological and industrial processes. According to Halliwell antioxidants are substances that at low concentration significantly delay or prevent oxidation. Chemically, oxidation ...

    Abstract Antioxidants are of great interest because of their involvement in important biological and industrial processes. According to Halliwell antioxidants are substances that at low concentration significantly delay or prevent oxidation. Chemically, oxidation is a process in which a loss of electrons occurs. Oxidants play a significant role in the pathogenesis of a number of disorders leading to oxidative stress. Oxidative stress may be defined as an imbalance between cellular production of reactive oxygen species and antioxidant defense mechanisms. ROS (e.g., superoxide radical, peroxynitryl, hydroxyl radical and hydrogen peroxide) are constantly produced as a result of metabolic reactions in living systems. Oxidative damage caused by ROS is responsible for many degenerative diseases such as cancer, atherosclerosis, diabetes, cirrhosis, Alzheimer's and inflammatory diseases. The aim of this review is to describe recent developments in the study of the antioxidant activity of thiazole and thiazolidinone derivatives, which are the core structure in a variety of pharmaceuticals with a broad spectrum of biological activity and their role in preventing the formation of ROS.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Humans ; Oxidative Stress/drug effects ; Thiazoles/chemistry ; Thiazoles/pharmacology ; Thiazolidines/chemistry ; Thiazolidines/pharmacology
    Chemical Substances Antioxidants ; Thiazoles ; Thiazolidines
    Language English
    Publishing date 2013-06-02
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/09298673113209990143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4432: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Severe neuro-vegetative imbalance after cyclopropane-pentothal anesthesia.

    LIARAS, H / BISQUERRA / THALAMAS

    Afrique francaise chirurgicale

    2007  , Issue 7-8, Page(s) 170

    Title translation Déséquilibre neuro-végétatif grave apre3s anesthésie au cyclopropane-pentothal.
    MeSH term(s) Anesthesia ; Anesthesiology ; Cyclopropanes ; Humans
    Chemical Substances Cyclopropanes ; cyclopropane (99TB643425)
    Language French
    Publishing date 2007-12-15
    Publishing country Algeria
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: About a case of deformation of the convex surface of the liver.

    LIARAS, H / HUGUENIN, A / VENEZIA

    Algerie medicale

    2007  Volume 51, Issue 10, Page(s) 552–554

    Title translation A propos d'un cas de déformation de la face convexe du foie.
    MeSH term(s) Digestive System ; Digestive System Abnormalities ; Humans ; Liver/abnormalities ; Liver Diseases
    Language French
    Publishing date 2007-12-15
    Publishing country Algeria
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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