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  1. Article ; Online: Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23.

    Degirolamo, Chiara / Sabbà, Carlo / Moschetta, Antonio

    Nature reviews. Drug discovery

    2016  Volume 15, Issue 1, Page(s) 51–69

    Abstract: The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation ...

    Abstract The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Given these functions, the endocrine FGFs have therapeutic potential in a wide array of chronic human diseases, including obesity, type 2 diabetes, cancer, and kidney and cardiovascular disease. However, the safety and feasibility of chronic endocrine FGF administration has been challenged, and FGF analogues and mimetics are now being investigated. Here, we discuss current knowledge of the complex biology of the endocrine FGFs and assess how this may be harnessed therapeutically.
    MeSH term(s) Animals ; Chronic Disease/drug therapy ; Drugs, Investigational/pharmacology ; Drugs, Investigational/therapeutic use ; Fibroblast Growth Factors/agonists ; Fibroblast Growth Factors/physiology ; Fibroblast Growth Factors/therapeutic use ; Homeostasis/physiology ; Humans ; Models, Biological
    Chemical Substances Drugs, Investigational ; FGF19 protein, human ; fibroblast growth factor 21 ; fibroblast growth factor 23 ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062954-0
    ISSN 1474-1784 ; 1474-1776
    ISSN (online) 1474-1784
    ISSN 1474-1776
    DOI 10.1038/nrd.2015.9
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  2. Article ; Online: Reorganization of Istituti Fisioterapici Ospitalieri, an oncological and dermatological clinical and research center, to face the coronavirus health emergency: adopted measures and metrics of success to achieve and keep a COVID-19-free status.

    De Luca, Assunta / Ripa di Meana, Francesco / Vujovic, Branka / Morrone, Aldo / Degirolamo, Chiara / Ciliberto, Gennaro / Lavalle, Tiziana

    Journal of experimental & clinical cancer research : CR

    2020  Volume 39, Issue 1, Page(s) 177

    Abstract: Background: A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and ... ...

    Abstract Background: A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and therapy outcomes. In this challenging and overwhelming scenario, our Institute confirmed its mission to provide expert cancer care. Here, we provide a report of strategic decisions made and of articulated measures developed to limit virus spreading while striving to make our hospital closer to patients.
    Conclusions: We hope our experience may serve as a resource to inform clinical care models in case of future epidemiological outbreaks.
    MeSH term(s) Benchmarking ; Betacoronavirus/pathogenicity ; COVID-19 ; Chronic Disease/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Humans ; Medical Oncology/trends ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Risk Factors ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Letter
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-020-01675-y
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  3. Article ; Online: Intestinal nuclear receptors in HDL cholesterol metabolism.

    Degirolamo, Chiara / Sabbà, Carlo / Moschetta, Antonio

    Journal of lipid research

    2014  Volume 56, Issue 7, Page(s) 1262–1270

    Abstract: The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary ... ...

    Abstract The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary cholesterol fecal disposal. Thus, intestine-based therapeutic interventions may hold promise in the management of diseases driven by cholesterol overload. Lipid-sensing nuclear receptors (NRs) are highly expressed in the intestinal epithelium and regulate transcriptionally the handling of cholesterol by the enterocytes. Here, we discuss the NR regulation of cholesterol fluxes across the enterocytes with special emphasis on NR exploitation as a bona fide novel HDL-raising strategy.
    MeSH term(s) Animals ; Cholesterol, HDL/metabolism ; Enterocytes/metabolism ; Gene Expression Regulation ; Homeostasis ; Humans ; Intestinal Mucosa/metabolism ; Intestines/cytology ; Receptors, Cytoplasmic and Nuclear/chemistry ; Receptors, Cytoplasmic and Nuclear/metabolism
    Chemical Substances Cholesterol, HDL ; Receptors, Cytoplasmic and Nuclear
    Language English
    Publishing date 2014-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1194/jlr.R052704
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  4. Article ; Online: Dietary monounsaturated fatty acids appear not to provide cardioprotection.

    Degirolamo, Chiara / Rudel, Lawrence L

    Current atherosclerosis reports

    2010  Volume 12, Issue 6, Page(s) 391–396

    Abstract: Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty ... ...

    Abstract Dietary interventions have been consistently proposed as a part of a comprehensive strategy to lower the incidence and severity of coronary heart disease (CHD), in the process providing long-term cardioprotection. Replacement of dietary saturated fatty acids (SFA) with higher intakes of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) has been reported to be inversely associated with risk of CHD. The observed lower incidence of CHD among populations consuming a Mediterranean-type diet, mainly enriched in MUFA from olive oil, has long supported the belief that MUFA are an optimal substitution for SFA. However, both epidemiologic and interventional studies suggest that although substituting MUFA-rich foods for SFA-rich foods in the diet can potentially lower total plasma cholesterol concentrations, this substitution does not lower the extent of coronary artery atherosclerosis. In addition, although recent evidence suggests that the source of MUFA (animal fat vs vegetable oils) may differentially influence the correlation between MUFA intake and CHD mortality, animal studies suggest that neither source is cardioprotective.
    MeSH term(s) Animals ; Coronary Disease/prevention & control ; Fatty Acids, Monounsaturated/administration & dosage ; Humans
    Chemical Substances Fatty Acids, Monounsaturated
    Language English
    Publishing date 2010-08-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057369-8
    ISSN 1534-6242 ; 1523-3804
    ISSN (online) 1534-6242
    ISSN 1523-3804
    DOI 10.1007/s11883-010-0133-4
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  5. Article ; Online: Reorganization of Istituti Fisioterapici Ospitalieri, an oncological and dermatological clinical and research center, to face the coronavirus health emergency

    Assunta De Luca / Francesco Ripa di Meana / Branka Vujovic / Aldo Morrone / Chiara Degirolamo / Gennaro Ciliberto / Tiziana Lavalle

    Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-

    adopted measures and metrics of success to achieve and keep a COVID-19-free status

    2020  Volume 6

    Abstract: Abstract Background A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and ...

    Abstract Abstract Background A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and therapy outcomes. Main body of the abstract In this challenging and overwhelming scenario, our Institute confirmed its mission to provide expert cancer care. Here, we provide a report of strategic decisions made and of articulated measures developed to limit virus spreading while striving to make our hospital closer to patients. Conclusions We hope our experience may serve as a resource to inform clinical care models in case of future epidemiological outbreaks.
    Keywords Cancer care ; COVID-19 ; Telemedicine ; Triage ; Surveillance ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; covid19
    Subject code 360
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Reorganization of Istituti Fisioterapici Ospitalieri, an oncological and dermatological clinical and research center, to face the coronavirus health emergency

    De Luca, Assunta / Ripa di Meana, Francesco / Vujovic, Branka / Morrone, Aldo / Degirolamo, Chiara / Ciliberto, Gennaro / Lavalle, Tiziana

    Journal of Experimental & Clinical Cancer Research

    adopted measures and metrics of success to achieve and keep a COVID-19-free status

    2020  Volume 39, Issue 1

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-020-01675-y
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  7. Article: Reorganization of Istituti Fisioterapici Ospitalieri, an oncological and dermatological clinical and research center, to face the coronavirus health emergency: adopted measures and metrics of success to achieve and keep a COVID-19-free status

    De Luca, Assunta / Ripa di Meana, Francesco / Vujovic, Branka / Morrone, Aldo / Degirolamo, Chiara / Ciliberto, Gennaro / Lavalle, Tiziana

    J Exp Clin Cancer Res

    Abstract: BACKGROUND: A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and therapy ...

    Abstract BACKGROUND: A pronounced polarization of healthcare resources and workforce towards the prevention of the rapid spread of SARS-CoV-2 occurred at the expenses of the majority of chronic diseases and cancer, thus jeopardizing continuity of care and therapy outcomes. In this challenging and overwhelming scenario, our Institute confirmed its mission to provide expert cancer care. Here, we provide a report of strategic decisions made and of articulated measures developed to limit virus spreading while striving to make our hospital closer to patients. CONCLUSIONS: We hope our experience may serve as a resource to inform clinical care models in case of future epidemiological outbreaks.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #740372
    Database COVID19

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  8. Article ; Online: Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver.

    Cicione, Claudia / Degirolamo, Chiara / Moschetta, Antonio

    Hepatology (Baltimore, Md.)

    2012  Volume 56, Issue 6, Page(s) 2404–2411

    Abstract: Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the ... ...

    Abstract Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. They present the intriguing characteristic to be transcribed and secreted in certain tissues and to act as hormones. The insulin-mimetic properties of FGF21 and the regulatory role of FGF15/19 in bile acid and glucose homeostasis endorse these hormones as druggable targets in metabolic disorders. Here, we present details on discoveries, identification, transcriptional regulation, and mechanism of actions of FGF15/19 and FGF21 with a critical perspective view on their putative role as metabolic integrators in the liver.
    MeSH term(s) Animals ; Bile Acids and Salts/metabolism ; Fibroblast Growth Factors/genetics ; Fibroblast Growth Factors/metabolism ; Glucose/metabolism ; Homeostasis ; Humans ; Lipid Metabolism ; Liver/metabolism ; Signal Transduction
    Chemical Substances Bile Acids and Salts ; FGF19 protein, human ; fibroblast growth factor 15, mouse ; fibroblast growth factor 21 ; Fibroblast Growth Factors (62031-54-3) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2012-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.25929
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    Zs.A 1660: Show issues Location:
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  9. Article ; Online: Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice.

    Degirolamo, Chiara / Rainaldi, Stefania / Bovenga, Fabiola / Murzilli, Stefania / Moschetta, Antonio

    Cell reports

    2014  Volume 7, Issue 1, Page(s) 12–18

    Abstract: Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation. Microbial imprinting on BA signature modifies pool size and hydrophobicity, thus contributing to BA ... ...

    Abstract Gut microbiota influences host health status by providing trophic, protective, and metabolic functions, including bile acid (BA) biotransformation. Microbial imprinting on BA signature modifies pool size and hydrophobicity, thus contributing to BA enterohepatic circulation. Microbiota-targeted therapies are now emerging as effective strategies for preventing and/or treating gut-related diseases. Here, we show that gut microbiota modulation induced by VSL#3 probiotics enhances BA deconjugation and fecal excretion in mice. These events are associated with changes in ileal BA absorption, repression of the enterohepatic farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF15) axis, and increased hepatic BA neosynthesis. Treatment with a FXR agonist normalized fecal BA levels in probiotic-administered mice, whereas probiotic-induced alterations in BA metabolism are abolished upon FXR and FGF15 deficiency. Our data provide clear in vivo evidence that VSL#3 probiotics promote ileal BA deconjugation with subsequent fecal BA excretion and induce hepatic BA neosynthesis via downregulation of the gut-liver FXR-FGF15 axis.
    MeSH term(s) Animals ; Bile Acids and Salts/biosynthesis ; Bile Acids and Salts/metabolism ; Down-Regulation ; Fibroblast Growth Factors/metabolism ; Intestines/drug effects ; Intestines/metabolism ; Intestines/microbiology ; Liver/drug effects ; Liver/metabolism ; Liver/microbiology ; Male ; Mice ; Mice, Inbred C57BL ; Microbiota/drug effects ; Probiotics/pharmacology ; Receptors, Cytoplasmic and Nuclear/metabolism ; Signal Transduction
    Chemical Substances Bile Acids and Salts ; Receptors, Cytoplasmic and Nuclear ; farnesoid X-activated receptor ; fibroblast growth factor 15, mouse ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2014-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2014.02.032
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  10. Article ; Online: Bile acids and colon cancer: Solving the puzzle with nuclear receptors.

    Degirolamo, Chiara / Modica, Salvatore / Palasciano, Giuseppe / Moschetta, Antonio

    Trends in molecular medicine

    2011  Volume 17, Issue 10, Page(s) 564–572

    Abstract: Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers ... ...

    Abstract Colorectal cancer is the third most common malignancy worldwide and is often linked to obesity, a sedentary lifestyle, carbohydrate- and fat-rich diets and elevated fecal excretion of secondary bile acids. Accumulation of toxic bile acids triggers oxidative damage, mitochondrial dysfunction and tumor progression. Nuclear receptors are transcription factors crucially involved in the regulation of bile acid metabolism and detoxification, and their activation may confer protection from bile acid tumor-promoting activity. In this review, we explore the tangled relationships among bile acids, nuclear receptors and the intestinal epithelium, with particular emphasis on the role of the farnesoid X receptor in colorectal cancer prevention and on novel nuclear receptor-based approaches to expand the portfolio of chemotherapeutic agents.
    MeSH term(s) Animals ; Bile Acids and Salts/genetics ; Bile Acids and Salts/metabolism ; Colon/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Intestinal Mucosa/metabolism ; Receptors, Cytoplasmic and Nuclear/genetics ; Receptors, Cytoplasmic and Nuclear/metabolism
    Chemical Substances Bile Acids and Salts ; Receptors, Cytoplasmic and Nuclear ; farnesoid X-activated receptor (0C5V0MRU6P)
    Language English
    Publishing date 2011-07-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2011.05.010
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