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  1. Book ; Online: ADAM

    Gabbard, Ryan / Beser, Deniz / Lichtefeld, Jacob / Cecil, Joe / Marcus, Mitch / Payne, Sarah / Yang, Charles / Freedman, Marjorie

    A Sandbox for Implementing Language Learning

    2021  

    Abstract: We present ADAM, a software system for designing and running child language learning experiments ... representations of the observed world. The modular nature of ADAM makes it easy to design and test different ... of the ADAM system in detail, and illustrate its components with examples. We provide our code. ...

    Abstract We present ADAM, a software system for designing and running child language learning experiments in Python. The system uses a virtual world to simulate a grounded language acquisition process in which the language learner utilizes cognitively plausible learning algorithms to form perceptual and linguistic representations of the observed world. The modular nature of ADAM makes it easy to design and test different language learning curricula as well as learning algorithms. In this report, we describe the architecture of the ADAM system in detail, and illustrate its components with examples. We provide our code.
    Keywords Computer Science - Computation and Language
    Publishing date 2021-05-05
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online ; Thesis: (123I)ADAM

    Makowski, Marcus Richard [Verfasser]

    Etablierung eines Mikro-SPECT-Systems für die Darstellung eines innovativen Radioliganden zur Untersuchung des serotonergen Systems sowie dessen erste präklinische Evaluierung am Menschen

    2012  

    Author's details Marcus Richard Makowski
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online ; Thesis: (123I)ADAM

    Makowski, Marcus Richard

    Etablierung eines Mikro-SPECT-Systems für die Darstellung eines innovativen Radioliganden zur Untersuchung des serotonergen Systems sowie dessen erste präklinische Evaluierung am Menschen

    2007  

    Title variant (Einhundertdreiundzwanzig I)ADAM
    Author's details vorgelegt von Marcus Richard Makowski
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--München, 2007
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Online ; Thesis: (123I)ADAM

    Makowski, Marcus Richard [Verfasser]

    Etablierung eines Mikro-SPECT-Systems für die Darstellung eines innovativen Radioliganden zur Untersuchung des serotonergen Systems sowie dessen erste präklinische Evaluierung am Menschen

    2007  

    Author's details vorgelegt von Marcus Richard Makowski
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes.

    Ebsen, Henriette / Lettau, Marcus / Kabelitz, Dieter / Janssen, Ottmar

    Molecular immunology

    2015  Volume 65, Issue 2, Page(s) 416–428

    Abstract: ... upon stimulation, we addressed where the death factor gets exposed to ADAM proteases. We report for the first time ... co-positioning of ADAM proteases in lipid raft-like platforms associated with an activation of raft ... The "A Disintegrin And Metalloproteinases" (ADAMs) form a subgroup of the metzincin endopeptidases ...

    Abstract The "A Disintegrin And Metalloproteinases" (ADAMs) form a subgroup of the metzincin endopeptidases. Proteolytically active members of this protein family act as sheddases and govern key processes in development and inflammation by regulating cell surface expression and release of cytokines, growth factors, adhesion molecules and their receptors. In T lymphocytes, ADAM10 sheds the death factor Fas Ligand (FasL) and thereby regulates T cell activation, death and effector function. Although FasL shedding by ADAM10 was confirmed in several studies, its regulation is still poorly defined. We recently reported that ADAM10 is highly abundant on T cells whereas its close relative ADAM17 is expressed at low levels and transiently appears at the cell surface upon stimulation. Since FasL is also stored intracellularly and brought to the plasma membrane upon stimulation, we addressed where the death factor gets exposed to ADAM proteases. We report for the first time that both ADAM10 and ADAM17 are associated with FasL-containing secretory lysosomes. Moreover, we demonstrate that TCR/CD3/CD28-stimulation induces a partial positioning of both proteases and FasL to lipid rafts and only the activation-induced raft-positioning results in FasL processing. TCR/CD3/CD28-induced FasL proteolysis is markedly affected by reducing both ADAM10 and ADAM17 protein levels, indicating that in human T cells also ADAM17 is implicated in FasL processing. Since FasL shedding is affected by cholesterol depletion and by inhibition of Src kinases or palmitoylation, we conclude that it requires mobilization and co-positioning of ADAM proteases in lipid raft-like platforms associated with an activation of raft-associated Src-family kinases.
    MeSH term(s) ADAM Proteins/immunology ; ADAM10 Protein ; ADAM17 Protein ; Amyloid Precursor Protein Secretases/immunology ; CD28 Antigens/immunology ; CD3 Complex/immunology ; Cell Line ; Enzyme Activation/immunology ; Fas Ligand Protein/immunology ; Female ; Gene Expression Regulation, Enzymologic/immunology ; Humans ; Lymphocyte Activation ; Lysosomes/immunology ; Male ; Membrane Microdomains/immunology ; Membrane Proteins/immunology ; Proteolysis ; Receptors, Antigen, T-Cell/immunology ; Secretory Vesicles/immunology ; T-Lymphocytes/immunology
    Chemical Substances CD28 Antigens ; CD3 Complex ; FASLG protein, human ; Fas Ligand Protein ; Membrane Proteins ; Receptors, Antigen, T-Cell ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM Proteins (EC 3.4.24.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81) ; ADAM17 Protein (EC 3.4.24.86) ; ADAM17 protein, human (EC 3.4.24.86)
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2015.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 166: Show issues Location:
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  6. Article: Subcellular localization and activation of ADAM proteases in the context of FasL shedding in T lymphocytes

    Ebsen, Henriette / Dieter Kabelitz / Marcus Lettau / Ottmar Janssen

    Molecular Immunology. 2015 June, v. 65

    2015  

    Abstract: ... brought to the plasma membrane upon stimulation, we addressed where the death factor gets exposed to ADAM ... we conclude that it requires mobilization and co-positioning of ADAM proteases in lipid raft-like platforms ... The “A Disintegrin And Metalloproteinases” (ADAMs) form a subgroup of the metzincin ...

    Abstract The “A Disintegrin And Metalloproteinases” (ADAMs) form a subgroup of the metzincin endopeptidases. Proteolytically active members of this protein family act as sheddases and govern key processes in development and inflammation by regulating cell surface expression and release of cytokines, growth factors, adhesion molecules and their receptors. In T lymphocytes, ADAM10 sheds the death factor Fas Ligand (FasL) and thereby regulates T cell activation, death and effector function. Although FasL shedding by ADAM10 was confirmed in several studies, its regulation is still poorly defined. We recently reported that ADAM10 is highly abundant on T cells whereas its close relative ADAM17 is expressed at low levels and transiently appears at the cell surface upon stimulation. Since FasL is also stored intracellularly and brought to the plasma membrane upon stimulation, we addressed where the death factor gets exposed to ADAM proteases. We report for the first time that both ADAM10 and ADAM17 are associated with FasL-containing secretory lysosomes. Moreover, we demonstrate that TCR/CD3/CD28-stimulation induces a partial positioning of both proteases and FasL to lipid rafts and only the activation-induced raft-positioning results in FasL processing. TCR/CD3/CD28-induced FasL proteolysis is markedly affected by reducing both ADAM10 and ADAM17 protein levels, indicating that in human T cells also ADAM17 is implicated in FasL processing. Since FasL shedding is affected by cholesterol depletion and by inhibition of Src kinases or palmitoylation, we conclude that it requires mobilization and co-positioning of ADAM proteases in lipid raft-like platforms associated with an activation of raft-associated Src-family kinases.
    Keywords cholesterol ; cytokines ; growth factors ; humans ; inflammation ; ligands ; lysosomes ; metalloproteinases ; palmitoylation ; phosphotransferases (kinases) ; plasma membrane ; proteolysis ; receptors ; T-lymphocytes
    Language English
    Dates of publication 2015-06
    Size p. 416-428.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2015.02.008
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Conference proceedings: Adams Oliver Syndom – seltenes Krankheitsbild mit großer klinischer Bedeutung

    Brickmann, Christian / Ackermann, Kilian / Brodkorb, Silke / Brosch, Sabine / Mommsen, Helge / Krüger, Marcus

    Zeitschrift für Geburtshilfe und Neonatologie

    2023  Volume 227, Issue 03

    Event/congress Abstracts zur 49. Jahrestagung der Gesellschaft für Neonatologie und Pädiatrische Intensivmedizin (GNPI), Hamburg, 2023-06-15
    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1226748-x
    ISSN 1439-1651 ; 0948-2393 ; 0300-967X ; 1615-5300
    ISSN (online) 1439-1651
    ISSN 0948-2393 ; 0300-967X ; 1615-5300
    DOI 10.1055/s-0043-1769434
    Database Thieme publisher's database

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  8. Book: Neue Gedanken zum ethischen und ökonomischen Konzept Adam Smiths

    Stewen, Marcus

    (Beiträge zur Wirtschaftsforschung ; Nr. 40)

    1994  

    Author's details von Marcus Stewen. [Johannes-Gutenberg-Universität Mainz, Fachbereich Rechts- und Wirtschaftswissenschaften]
    Series title Beiträge zur Wirtschaftsforschung ; Nr. 40
    Language German
    Size 47 S, 30 cm
    Publisher Univ., Fachbereich Rechts- und Wirtschaftswiss
    Publishing place Mainz
    Document type Book
    Note Literaturverz
    Database ECONomics Information System

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  9. Book: Neue Gedanken zum ethischen und ökonomischen Konzept Adam Smiths

    Stewen, Marcus

    (Beiträge zur Wirtschaftsforschung ; 43)

    1994  

    Institution Johannes Gutenberg-Universität Mainz / Fachbereich Rechts- und Wirtschaftswissenschaften
    Author's details von Marcus Stewen
    Series title Beiträge zur Wirtschaftsforschung ; 43
    Keywords Wirtschaftsethik ; Staatliche Einflussnahme ; Theorie ; 13*23 ; Smith
    Language German
    Size 47 S
    Document type Book
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  10. Article ; Online: How bibliometrics and school rankings reward unreliable science.

    Oransky, Ivan / Marcus, Adam / Abritis, Alison

    BMJ (Clinical research ed.)

    2023  Volume 382, Page(s) 1887

    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.p1887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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