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Article ; Online: Approaches to ventricular assist device exchange: Resternotomy versus limited incisions.

Osho, Asishana A / D'Alessandro, David A

JTCVS techniques

2022 Volume 12, Page(s) 94–99

Language	English
Publishing date	2022-01-17
Publishing country	United States
Document type	Editorial
ISSN	2666-2507
ISSN (online)	2666-2507
DOI	10.1016/j.xjtc.2021.10.062
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Article ; Online: Elimination of the "Increased Risk" Label Has Not Improved Donor Heart Utilization in the U.S.

Paneitz, Dane C / Wolfe, Stanley B / Proudian, Jasmine / Rabi, Seyed Alireza / Li, Selena / Michel, Eriberto / Kataria, Rachna / Ton, Van-Khue / D'Alessandro, David A / Osho, Asishana A

JACC. Heart failure

2023 Volume 11, Issue 5, Page(s) 610–611

MeSH term(s)	Humans ; Heart Transplantation ; Tissue Donors ; Heart Failure ; Risk Assessment ; Time Factors
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Letter
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2022.09.014
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Article ; Online: Interventional Therapies for Acute Pulmonary Embolism.

Osho, Asishana A / Dudzinski, David M

The Surgical clinics of North America

2022 Volume 102, Issue 3, Page(s) 429–447

Abstract: Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality in the United States. Unfortunately, significant gaps exist in outcome data around many interventional therapies, a fact that is reflected in the low strength of management ... ...

Abstract	Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality in the United States. Unfortunately, significant gaps exist in outcome data around many interventional therapies, a fact that is reflected in the low strength of management recommendations found in consensus major society guidelines. In addition to careful risk stratification, therapeutic anticoagulation generally should be an early part of PE management in all cases. For patients presenting with acute high-risk PE or intermediate-risk PE with higher risk features, consideration should be given to systemic thrombolysis after careful evaluation for potential bleeding complications. In patients with contraindications to systemic thrombolysis, failure of this therapy, or significant ongoing cardiopulmonary distress, consideration should be given to interventional therapies like catheter-directed lysis, catheter-directed embolectomy, surgical embolectomy, and mechanical circulatory support. Until more robust comparative outcome data are put forward, pulmonary embolism response teams (PERT) should be considered for multi-disciplinary patient evaluation and management.
MeSH term(s)	Acute Disease ; Embolectomy ; Humans ; Pulmonary Embolism/etiology ; Pulmonary Embolism/therapy ; Risk Factors ; Thrombolytic Therapy ; Treatment Outcome
Language	English
Publishing date	2022-04-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215713-5
ISSN	1558-3171 ; 0039-6109
ISSN (online)	1558-3171
ISSN	0039-6109
DOI	10.1016/j.suc.2022.02.004
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Article ; Online: Operative Management for Type A Acute Aortic Dissection: No Harm in Coming Back.

Divya, Aabha / Osho, Asishana Avo / Hosseini, Motahar

The Annals of thoracic surgery

2023 Volume 117, Issue 5, Page(s) 922

MeSH term(s)	Humans ; Aortic Dissection/surgery ; Aortic Aneurysm, Thoracic/surgery ; Aortic Aneurysm, Thoracic/diagnosis ; Acute Disease
Language	English
Publishing date	2023-12-23
Publishing country	Netherlands
Document type	Editorial ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2023.12.002
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Article ; Online: Commentary: Moving the Dial on DOAC use Early After Cardiac Surgery.

Osho, Asishana A / Vlahakes, Gus J

Seminars in thoracic and cardiovascular surgery

2021 Volume 34, Issue 3, Page(s) 960–961

MeSH term(s)	Anticoagulants ; Atrial Fibrillation/surgery ; Cardiac Surgical Procedures/adverse effects ; Humans ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-06-15
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1038278-1
ISSN	1532-9488 ; 1043-0679
ISSN (online)	1532-9488
ISSN	1043-0679
DOI	10.1053/j.semtcvs.2021.06.007
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Zs.A 2747: Show issues

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Article ; Online: Racial Disparities in Coronavirus Disease 2019 Mortality Are Present in Heart Transplant Recipients.

Wolfe, Stanley B / Calero, Tiffany / Osho, Asishana A / Michel, Eriberto / Sundt, Thoralf M / D'Alessandro, David A

The Annals of thoracic surgery

2022 Volume 115, Issue 4, Page(s) 1009–1015

Abstract: Background: Studies have demonstrated the devastating effects of coronavirus disease 2019 (COVID-19) on vulnerable populations. Although they receive close follow-up, heart transplant recipients represent a particularly vulnerable population, given long- ...

Abstract	Background: Studies have demonstrated the devastating effects of coronavirus disease 2019 (COVID-19) on vulnerable populations. Although they receive close follow-up, heart transplant recipients represent a particularly vulnerable population, given long-term immunosuppression and comorbid conditions. We sought to investigate the association between race/ethnicity and the probability of death due to COVID-19 in adult heart transplant recipients in the United States. Methods: Adult isolated heart transplant recipients were identified using the Organ Procurement and Transplantation Network database. Recipients who were described as deceased or lost to follow-up before January 2020 were excluded. Recipients were stratified into 4 cohorts by race/ethnicity. The primary outcome of interest was death due to COVID-19. Results: A total of 22 157 adult recipients were identified. During the course of follow-up, 153 recipients had COVID-19 reported as the primary cause of death. COVID-19 mortality was significantly different between race/ethnicity cohorts (Black, n = 34 [0.79%]; Hispanic, n = 23 [1.33%]; White, n = 92 [0.60%]; other, n = 4 [0.44%]; P = .007). COVID-19 was listed as a contributing cause of mortality in 0.12% of Black, 0.23% of Hispanic, 0.04% of White, and 0.33% of other recipients (P = .002). No significant difference in non-COVID mortality or all-cause mortality was observed. After multivariable adjustment, Black (hazard ratio, 2.78 [1.40-5.52]; P = .003) and Hispanic (hazard ratio, 3.92 [1.88-8.16]; P < .001) recipients were at higher risk of death due to COVID-19 compared with White recipients. Conclusions: Compared with White recipients, Black and Hispanic recipients experienced higher rates of COVID-19 mortality after transplantation. These findings suggest that racial/ethnic disparities of COVID-19 mortality in the general population persist in adult heart transplant recipients.
MeSH term(s)	Adult ; Humans ; COVID-19/ethnology ; COVID-19/mortality ; Ethnicity ; Heart Transplantation ; Hispanic or Latino ; United States/epidemiology ; White ; Health Status Disparities ; Black or African American ; Transplant Recipients
Language	English
Publishing date	2022-07-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.06.029
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Article ; Online: The effect of warm ischemia and donor ejection fraction on 30-day mortality after donation after circulatory death heart transplantation: A national database analysis.

Paneitz, Dane C / Basha, Ameen M / Van Kampen, Antonia / Giao, Duc / Thomas, Jason / Rabi, S Alireza / Michel, Eriberto / D'Alessandro, David A / Osho, Asishana A

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2023 Volume 42, Issue 11, Page(s) 1493–1496

Abstract: Donation after circulatory death (DCD) donor hearts recovered using the direct procurement and perfusion method experience variable durations of warm ischemia at the time of procurement (WIP). We used the Organ Procurement and Transplantation Network ... ...

Abstract	Donation after circulatory death (DCD) donor hearts recovered using the direct procurement and perfusion method experience variable durations of warm ischemia at the time of procurement (WIP). We used the Organ Procurement and Transplantation Network database to assess the effect of WIP on 30-day mortality after DCD heart transplantation. The analysis evaluated outcomes in 237 recipients of DCD heart transplantation, demonstrating an optimal WIP cut point of <36 minutes. Multivariable logistic regression modeling identified donor left ventricular ejection fraction (LVEF) <60% as an independent predictor of 30-day mortality. The area under the receiver operating characteristic curve for predicting 30-day mortality based on WIP ≥36 minutes and donor LVEF <60% was 0.90. Based on these findings, we do not recommend proceeding with DCD heart transplantation for patients with WIP ≥36 minutes, particularly in donors with LVEF <60%.
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2023.07.013
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Zs.A 2056: Show issues

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Article ; Online: Acute rejection in donation after circulatory death (DCD) heart transplants.

Li, Selena S / Funamoto, Masaki / Osho, Asishana A / Rabi, Seyed A / Paneitz, Dane / Singh, Ruby / Michel, Eriberto / Lewis, Gregory D / D'Alessandro, David A

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2023 Volume 43, Issue 1, Page(s) 148–157

Abstract: Background: Donation after circulatory death (DCD) heart transplantation has promising early survival, but the effects on rejection remain unclear.: Methods: The United Network for Organ Sharing database was queried for adult heart transplants from ... ...

Abstract	Background: Donation after circulatory death (DCD) heart transplantation has promising early survival, but the effects on rejection remain unclear. Methods: The United Network for Organ Sharing database was queried for adult heart transplants from December 1, 2019, to December 31, 2021. Multiorgan transplants and loss to follow-up were excluded. The primary outcome was acute rejection, comparing DCD and donation after brain death (DBD) transplants. Results: A total of 292 DCD and 5,582 DBD transplants met study criteria. Most DCD transplants were transplanted at status 3-4 (61.0%) compared to 58.6% of DBD recipients at status 1-2. DCD recipients were less likely to be hospitalized at transplant (26.7% vs 58.3%, p < 0.001) and to require intra-aortic balloon pumping (IABP; 9.6% vs 28.9%, p < 0.001), extracorporeal membrane oxygenation (ECMO; 0.3% vs 5.9%, p < 0.001) or temporary left ventricular assist device (LVAD; 1.0% vs 2.7%, p < 0.001). DCD recipients were more likely to have acute rejection prior to discharge (23.3% vs 18.4%, p = 0.044) and to be hospitalized for rejection (23.4% vs 11.4%, p = 0.003) at a median follow-up of 15 months; the latter remained significant after propensity matching. On multivariable logistic regression, DCD donation was an independent predictor of acute rejection (odds ratio [OR] 1.47, 95% confidence interval [CI] 1.00-2.15, p = 0.048) and hospitalization for rejection (OR 2.03, 95% CI 1.06-3.70, p = 0.026). On center-specific subgroup analysis, DCD recipients continued to have higher rates of hospitalization for rejection (23.4% vs 13.8%, p = 0.043). Conclusions: DCD recipients are more likely to experience acute rejection. Early survival is similar between DCD and DBD recipients, but long-term implications of increased early rejection in DCD recipients require further investigation.
MeSH term(s)	Adult ; Humans ; Tissue and Organ Procurement ; Tissue Donors ; Graft Survival ; Brain Death ; Heart Transplantation ; Retrospective Studies ; Death
Language	English
Publishing date	2023-09-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2023.09.004
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Article ; Online: Directed Hypercapnia for Weaning From ECMO to Mechanical Ventilation-Progress or Just a Process?

Megna, Dominick / Osho, Asishana / Catarino, Pedro

The Annals of thoracic surgery

2022 Volume 114, Issue 5, Page(s) e311

MeSH term(s)	Humans ; Respiration, Artificial ; Hypercapnia/therapy ; Extracorporeal Membrane Oxygenation ; Ventilator Weaning ; Time Factors
Language	English
Publishing date	2022-06-01
Publishing country	Netherlands
Document type	Journal Article ; Comment
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2022.05.029
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Article ; Online: Outcomes of Lung Transplantation From Hepatitis C Viremic Donors.

Li, Selena S / Osho, Asishana / Moonsamy, Philicia / Wolfe, Stanley / Villavicencio, Mauricio A / Langer, Nathaniel / Sundt, Thoralf M / Funamoto, Masaki

The Annals of thoracic surgery

2021 Volume 113, Issue 5, Page(s) 1598–1607

Abstract: Background: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) has encouraged lung transplantation with HCV positive donors. Early trials have been promising; however, nationwide data have not been previously examined.: Methods: The ... ...

Abstract	Background: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) has encouraged lung transplantation with HCV positive donors. Early trials have been promising; however, nationwide data have not been previously examined. Methods: The United Network for Organ Sharing registry was queried for adult patients receiving lung transplants from 2016 to 2019. We excluded multiorgan transplants, incomplete data, and loss to follow-up. Nucleic acid testing (NAT) determined HCV status. Propensity matching was performed for comparison of outcomes. Results: Hepatitis C virus NAT-positive lungs were transplanted in 189 patients, compared with 9511 recipients of NAT-negative lungs. The HCV NAT-positive donors were younger (mean 33 vs 35 years, P = .017) with higher rates of Pao Conclusions: Short-term outcomes of lung transplantation from HCV viremic donors are promising, with no difference in early complications or survival. The effects of seroconversion and long-term outcomes including chronic rejection and infection need to be further explored.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C, Chronic ; Humans ; Lung Transplantation ; Tissue Donors ; Viremia/drug therapy
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-05-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2021.05.010
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