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  1. Article ; Online: Dreams and Psychedelics: Neurophenomenological Comparison and Therapeutic Implications.

    Kraehenmann, Rainer

    Current neuropharmacology

    2017  Volume 15, Issue 7, Page(s) 1032–1042

    Abstract: Background: A resurgence of neurobiological and clinical research is currently underway into the therapeutic potential of serotonergic or 'classical' psychedelics, such as the prototypical psychedelic drug lysergic acid diethylamide (LSD), psilocybin (4- ...

    Abstract Background: A resurgence of neurobiological and clinical research is currently underway into the therapeutic potential of serotonergic or 'classical' psychedelics, such as the prototypical psychedelic drug lysergic acid diethylamide (LSD), psilocybin (4-phosphoryloxy-N,Ndimethyltryptamine), and ayahuasca - a betacarboline- and dimethyltryptamine (DMT)-containing Amazonian beverage. The aim of this review is to introduce readers to the similarities and dissimilarities between psychedelic states and night dreams, and to draw conclusions related to therapeutic applications of psychedelics in psychiatry.
    Methods: Research literature related to psychedelics and dreaming is reviewed, and these two states of consciousness are systematically compared. Relevant conclusions with regard to psychedelicassisted therapy will be provided.
    Results: Common features between psychedelic states and night dreams include perception, mental imagery, emotion activation, fear memory extinction, and sense of self and body. Differences between these two states are related to differential perceptual input from the environment, clarity of consciousness and meta-cognitive abilities. Therefore, psychedelic states are closest to lucid dreaming which is characterized by a mixed state of dreaming and waking consciousness.
    Conclusion: The broad overlap between dreaming and psychedelic states supports the notion that psychedelics acutely induce dreamlike subjective experiences which may have long-term beneficial effects on psychosocial functioning and well-being. Future clinical studies should examine how therapeutic outcome is related to the acute dreamlike effects of psychedelics.
    Language English
    Publishing date 2017
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1573413713666170619092629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue.

    Filippi, Marco / Krähenmann, Rainer / Fissler, Patrick

    Frontiers in psychology

    2022  Volume 13, Page(s) 920556

    Abstract: Energy-related sensations include sensation of energy and fatigue as well as subjective energizability and fatigability. First, we introduce interdisciplinary useful definitions of all constructs and review findings regarding the question of whether ... ...

    Abstract Energy-related sensations include sensation of energy and fatigue as well as subjective energizability and fatigability. First, we introduce interdisciplinary useful definitions of all constructs and review findings regarding the question of whether sensations of fatigue and energy are two separate constructs or two ends of a single dimension. Second, we describe different components of the bodily energy metabolism system (e.g., mitochondria; autonomic nervous system). Third, we review the link between sensation of fatigue and different components of energy metabolism. Finally, we present an overview of different treatments shown to affect both energy-related sensations and metabolism before outlining future research perspectives.
    Language English
    Publishing date 2022-06-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.920556
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Neuropsychodynamic Approach to Depression: Integrating Resting State Dysfunctions of the Brain and Disturbed Self-Related Processes.

    Boeker, Heinz / Kraehenmann, Rainer

    Frontiers in human neuroscience

    2018  Volume 12, Page(s) 247

    Abstract: A mechanism-based approach was developed focusing on the psychodynamic, psychological and neuronal mechanisms in healthy and depressed persons. In this integrative concept of depression, the self is a core dimension in depression. It is attributed to ... ...

    Abstract A mechanism-based approach was developed focusing on the psychodynamic, psychological and neuronal mechanisms in healthy and depressed persons. In this integrative concept of depression, the self is a core dimension in depression. It is attributed to negative emotions (e.g., failure, guilt). The
    Language English
    Publishing date 2018-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2018.00247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The link between energy-related sensations and metabolism

    Filippi, Marco / Krähenmann, Rainer / Fissler, Patrick

    Frontiers in Psychology

    Implications for treating fatigue

    2022  

    Abstract: Energy-related sensations include sensation of energy and fatigue as well as subjective energizability and fatigability. First, we introduce interdisciplinary useful definitions of all constructs and review findings regarding the question of whether ... ...

    Title translation Die Verbindung zwischen energiebezogenen Empfindungen und Stoffwechsel: Implikationen für die Behandlung von Fatigue
    Abstract Energy-related sensations include sensation of energy and fatigue as well as subjective energizability and fatigability. First, we introduce interdisciplinary useful definitions of all constructs and review findings regarding the question of whether sensations of fatigue and energy are two separate constructs or two ends of a single dimension. Second, we describe different components of the bodily energy metabolism system (e.g., mitochondria; autonomic nervous system). Third, we review the link between sensation of fatigue and different components of energy metabolism. Finally, we present an overview of different treatments shown to affect both energy-related sensations and metabolism before outlining future research perspectives.
    Keywords Autonomic Nervous System ; Energieeinsatz ; Energy Expenditure ; Entzündung ; Fatigue ; Inflammation ; Metabolism ; Mitochondria ; Mitochondrien ; Müdigkeit ; Stoffwechsel ; Vegetatives Nervensystem
    Language English
    Document type Article
    DOI 10.3389/fpsyg.2022.920556
    Database PSYNDEX

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  5. Article: CME: Krank durch chronischen Stress. Langzeitfolgen und Behandlung

    Krähenmann, Rainer / Seifritz, Erich

    Der Neurologe & Psychiater

    2019  Volume 20, Issue 4, Page(s) 38

    Language German
    Document type Article
    ZDB-ID 2036795-8
    ISSN 1616-2455
    Database Current Contents Medicine

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  6. Article ; Online: Effects of serotonergic psychedelics on mitochondria: Transdiagnostic implications for mitochondria-related pathologies.

    Fissler, Patrick / Vandersmissen, Anja / Filippi, Marco / Mavioglu, Rezan Nehir / Scholkmann, Felix / Karabatsiakis, Alexander / Krähenmann, Rainer

    Journal of psychopharmacology (Oxford, England)

    2023  Volume 37, Issue 7, Page(s) 679–686

    Abstract: The use of serotonergic psychedelics has gained increasing attention in research, clinical practice and society. Growing evidence suggests fast-acting, transdiagnostic health benefits of these 5-hydroxytryptamine 2A receptor agonists. Here, we provide a ... ...

    Abstract The use of serotonergic psychedelics has gained increasing attention in research, clinical practice and society. Growing evidence suggests fast-acting, transdiagnostic health benefits of these 5-hydroxytryptamine 2A receptor agonists. Here, we provide a brief overview of their benefits for psychological, cardiovascular, metabolic, neurodegenerative, and immunological pathologies. We then review their effect on mitochondria including mitochondrial biogenesis, functioning and transport. Mitochondrial dysregulation is a transdiagnostic mechanism that contributes to the aforementioned pathologies. Hence, we postulate that psychedelic-induced effects on mitochondria partially underlie their transdiagnostic benefits. Based on this assumption, we propose new treatment indications for psychedelics and that the health benefits induced by psychedelics depend on patient-specific mitochondrial dysregulation.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Mitochondria
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639313-5
    ISSN 1461-7285 ; 0269-8811
    ISSN (online) 1461-7285
    ISSN 0269-8811
    DOI 10.1177/02698811231164707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Experimental Psychosis Research and Schizophrenia-Similarities and Dissimilarities in Psychopathology.

    Hermle, Leo / Kraehenmann, Rainer

    Current topics in behavioral neurosciences

    2017  Volume 36, Page(s) 313–332

    Abstract: The aim of experimental psychopathology is to delineate overlapping functional disorders of psychoneurobiologically-defined systems where a set of common symptoms may correspond to a variety of nosological entities. According to the vulnerability model ... ...

    Abstract The aim of experimental psychopathology is to delineate overlapping functional disorders of psychoneurobiologically-defined systems where a set of common symptoms may correspond to a variety of nosological entities. According to the vulnerability model of psychosis, experimental research needs to go beyond categories such as "schizophrenia". Prospective studies of the effects of psychoactive substances in normal control subjects offer several methodological advantages over routine clinical reviews of schizophrenic patients, especially in terms of standardization. Carefully designed studies utilizing a model psychosis paradigm are a step toward symptom-oriented research. Combining psychological and neurobiological techniques, the experimental psychopathological approach can provide us with a valuable tool for psychiatric research.
    MeSH term(s) Hallucinogens/pharmacology ; Humans ; Psychoses, Substance-Induced/psychology ; Schizophrenia ; Schizophrenic Psychology
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2017-05-03
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2016_460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neuropsychodynamic approach to depression

    Boeker, Heinz / Kraehenmann, Rainer

    Frontiers in Human Neuroscience

    Integrating resting state dysfunctions of the brain and disturbed self-related processes

    2018  

    Abstract: A mechanism-based approach was developed focusing on the psychodynamic, psychological and neuronal mechanisms in healthy and depressed persons. In this integrative concept of depression, the self is a core dimension in depression. It is attributed to ... ...

    Title translation Neuropsychodynamischer Zugang zur Depression: Integration von Ruhezustandstörungen des Gehirns und gestörten selbstbezogenen Prozessen (DeepL)
    Abstract A mechanism-based approach was developed focusing on the psychodynamic, psychological and neuronal mechanisms in healthy and depressed persons. In this integrative concept of depression, the self is a core dimension in depression. It is attributed to negative emotions (e.g., failure, guilt). The increased inward focus in depression is connected with a decreased environmental focus. The development of neuropsychodynamic hypotheses of the altered self-reference is based on the investigation of the emotional-cognitive interaction in depressed patients. It may be hypothesized that the increased negative self-attributions-as typical characteristics of an increased self-focus in depression-may result from altered neuronal activity in subcortical-cortical midline structures in the brain, especially from hyperactivity in the cortical-subcortical midline regions and hypoactivity in the lateral regions. The increased resting state activity in depression is especially associated with an increased resting state activity in the default mode network (DMN) and a dysbalance between DMN and executive network (EN) activity. Possible therapeutic consequences of the neuropsychodynamic approach to depression involve the necessary emotional attunement in psychotherapy of depressed patients and the adequate timing of therapeutic interventions. The hypotheses which have been developed in the context of the neuropsychodynamic model of depression may be used for more specific psychotherapeutic interventions, aiming at specific mechanisms of compensation and defence, which are related to the increased resting state activity and the disturbed resting state-stimulus-interaction.
    Keywords Biological Neural Networks ; Biologische Neuronale Netze ; Brain ; Default Mode Network ; Gehirn ; Major Depression ; Neuropsychiatrie ; Neuropsychiatry ; Psychodynamics ; Psychodynamik ; Psychotherapie ; Psychotherapy ; Ruhezustandsnetzwerk
    Language English
    Document type Article
    DOI 10.3389/fnhum.2018.00247
    Database PSYNDEX

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  9. Article: Effects of serotonergic psychedelics on mitochondria

    Fissler, Patrick / Vandersmissen, Anja / Filippi, Marco / Mavioglu, Rezan Nehir / Scholkmann, Felix / Karabatsiakis, Alexander / Krähenmann, Rainer

    Journal of Psychopharmacology

    Transdiagnostic implications for mitochondria-related pathologies

    2023  Volume 37, Issue 7, Page(s) 679–686

    Abstract: The use of serotonergic psychedelics has gained increasing attention in research, clinical practice and society. Growing evidence suggests fast-acting, transdiagnostic health benefits of these 5-hydroxytryptamine 2A receptor agonists. Here, we provide a ... ...

    Title translation Auswirkungen von serotonergen Psychedelika auf Mitochondrien: Transdiagnostische Implikationen für mitochondrienbezogene Pathologien (DeepL)
    Abstract The use of serotonergic psychedelics has gained increasing attention in research, clinical practice and society. Growing evidence suggests fast-acting, transdiagnostic health benefits of these 5-hydroxytryptamine 2A receptor agonists. Here, we provide a brief overview of their benefits for psychological, cardiovascular, metabolic, neurodegenerative, and immunological pathologies. We then review their effect on mitochondria including mitochondrial biogenesis, functioning and transport. Mitochondrial dysregulation is a transdiagnostic mechanism that contributes to the aforementioned pathologies. Hence, we postulate that psychedelic-induced effects on mitochondria partially underlie their transdiagnostic benefits. Based on this assumption, we propose new treatment indications for psychedelics and that the health benefits induced by psychedelics depend on patient-specific mitochondrial dysregulation.
    Keywords Cardiovascular Disorders ; Immunologic Disorders ; Immunologische Störungen ; Kardiovaskuläre Störungen ; Mental Disorders ; Metabolism Disorders ; Mitochondria ; Mitochondrien ; Neurodegenerative Diseases ; Neurodegenerative Erkrankungen ; Psychedelic Drugs ; Psychedelika ; Psychische Störungen ; Serotonin ; Stoffwechselstörungen ; Therapieergebnisse ; Transdiagnostic Treatment ; Transdiagnostische Behandlung ; Treatment Outcomes
    Language English
    Document type Article
    ZDB-ID 639313-5
    ISSN 0269-8811
    ISSN 0269-8811
    DOI 10.1177/02698811231164707
    Database PSYNDEX

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  10. Article ; Online: Characterization and prediction of acute and sustained response to psychedelic psilocybin in a mindfulness group retreat.

    Smigielski, Lukasz / Kometer, Michael / Scheidegger, Milan / Krähenmann, Rainer / Huber, Theo / Vollenweider, Franz X

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 14914

    Abstract: Meditation and psychedelics have played key roles in humankind's search for self-transcendence and personal change. However, neither their possible synergistic effects, nor related state and trait predictors have been experimentally studied. To elucidate ...

    Abstract Meditation and psychedelics have played key roles in humankind's search for self-transcendence and personal change. However, neither their possible synergistic effects, nor related state and trait predictors have been experimentally studied. To elucidate these issues, we administered double-blind the model psychedelic drug psilocybin (315 μg/kg PO) or placebo to meditators (n = 39) during a 5-day mindfulness group retreat. Psilocybin increased meditation depth and incidence of positively experienced self-dissolution along the perception-hallucination continuum, without concomitant anxiety. Openness, optimism, and emotional reappraisal were predictors of the acute response. Compared with placebo, psilocybin enhanced post-intervention mindfulness and produced larger positive changes in psychosocial functioning at a 4-month follow-up, which were corroborated by external ratings, and associated with magnitude of acute self-dissolution experience. Meditation seems to enhance psilocybin's positive effects while counteracting possible dysphoric responses. These findings highlight the interactions between non-pharmacological and pharmacological factors, and the role of emotion/attention regulation in shaping the experiential quality of psychedelic states, as well as the experience of selflessness as a modulator of behavior and attitudes. A better comprehension of mechanisms underlying most beneficial psychedelic experiences may guide therapeutic interventions across numerous mental conditions in the form of psychedelic-assisted applications.
    MeSH term(s) Attention/drug effects ; Buddhism ; Emotions/drug effects ; Female ; Hallucinogens/adverse effects ; Hallucinogens/pharmacology ; Humans ; Male ; Meditation/methods ; Meditation/psychology ; Middle Aged ; Mindfulness ; Psilocybin/adverse effects ; Psilocybin/pharmacology ; Social Behavior
    Chemical Substances Hallucinogens ; Psilocybin (2RV7212BP0)
    Language English
    Publishing date 2019-10-24
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-50612-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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