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  1. Article ; Online: Corrigendum to "Cost-effectiveness of introducing a domestic pneumococcal conjugate vaccine (PCV7-TT) into the Cuban national immunization programme" [Int. J. Infect. Dis. 97 (2020) 182-189].

    Fariñas, Anai García / Linares-Pérez, Nivaldo / Clark, Andrew / Toledo-Romaní, María Eugenia / Omeiri, Nathalie El / Araújo, Martha C Marrero / Luis, Isabel Pilar Gonzálvez / Peraza, Gilda Toraño / Jiménez, Alicia Reyes / Ambrón, Lena López

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 103, Page(s) 643

    Language English
    Publishing date 2020-11-26
    Publishing country Canada
    Document type Published Erratum
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.08.072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Antiproliferative and Pro-Oxidant Effect of Polyphenols in Aqueous Leaf Extract of Passiflora alata Curtis on Activated T Lymphocytes from Non-Obese Diabetic (NOD SHILT/J) Mice

    Colomeu, Talita Cristina / de Figueiredo, Daniella / de Matos da Silva, Priscila / Fernandes, Luís Gustavo Romani / Zollner, Ricardo de Lima

    Antioxidants. 2022 July 30, v. 11, no. 8

    2022  

    Abstract: The antioxidant, anti-inflammatory and antiproliferative properties of Passiflora alata Curtis are due to the presence of polyphenols in its composition. Our previous work showed that non-obese diabetic (NOD) mice undergoing treatment with aqueous leaf ... ...

    Abstract The antioxidant, anti-inflammatory and antiproliferative properties of Passiflora alata Curtis are due to the presence of polyphenols in its composition. Our previous work showed that non-obese diabetic (NOD) mice undergoing treatment with aqueous leaf extract of P. alata present reduced insulitis in the pancreas, possibly due to its anti-inflammatory properties. However, depending on the concentration and their ability to interact with other molecules, these phenolic compounds may promote oxidation reactions in some cellular components, such as proteins and lipids, thus presenting a pro-oxidant effect. The present work aimed to evaluate the in vitro effects of aqueous leaf extract of P. alata and its polyphenols (vitexin, isoorientin, rutin and catechin) on lymphocyte proliferation and viability, the cell cycle and oxidative stress. Our results showed that T lymphocytes stimulated with concanavalin A mitogen (ConA) and in the presence of IC₅₀ concentrations of P. alata extract and polyphenols undergo cell injury via inhibition of proliferation, with these effects being more pronounced concerning CD4+ T cells (P. alata, 3.54 ± 0.34%; isoorientin, 57.07 ± 6.4%; vitexin, 16.95 ± 1.11%; catechin, 37.9 ± 4.2% and rutin, 40.14 ± 4.5%), compared to the non-treated group (77.17 ± 6.29) (p < 0.0001 for all comparisons). This process includes late apoptosis/necrosis induction (P. alata, 77.5 ± 0.7%; vitexin, 83 ± 3.3%; isoorientin, 83.8 ± 1.4%; catechin, 83 ± 1.9% and rutin, 74.9 ± 3.2, while the control presented 53.6% ± 3.1 (p < 0.0001 for all comparisons)) and mitochondrial depolarization leading to cell-death induction. Furthermore, an in vitro model of a mixed culture of NOD mice T cells with a mouse pancreatic beta-cell line (MIN6) showed increased intracellular nitric oxide and lipid peroxidation in NOD T cells submitted to P. alata extract (46.41 ± 3.08) compared to the untreated control group (33.57 ± 1.99, p = 0.01315). These results suggest that aqueous leaf extract of P. alata and the polyphenols in these leaves represent a target for translational research showing the plant’s benefits for developing new drugs with immunomodulatory properties against inflammatory diseases such as diabetes mellitus.
    Keywords Passiflora alata ; antioxidants ; apoptosis ; catechin ; cell cycle ; concanavalin A ; diabetes mellitus ; leaf extracts ; lipid peroxidation ; lymphocyte proliferation ; mice ; mitochondria ; mitogens ; mixed culture ; models ; necrosis ; nitric oxide ; oxidation ; oxidative stress ; pancreas ; polyphenols ; rutin ; viability
    Language English
    Dates of publication 2022-0730
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11081503
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: La Dermatología española en la era de la COVID-19.

    Romaní, J

    Actas dermo-sifiliograficas

    2020  Volume 111, Issue 9, Page(s) 709–710

    Title translation Spanish Dermatology in the COVID-19 Era.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/therapy ; Dermatology ; Humans ; SARS-CoV-2 ; Skin Diseases, Viral/diagnosis ; Spain/epidemiology
    Keywords covid19
    Language Spanish
    Publishing date 2020-05-15
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2020.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: M. L. Weitzman vs J. M. Buchanan

    Romani, Umberto / Tondini, Giovanni

    International journal of social economics Vol. 32, No. 1/2 , p. 5-16

    a comparison between share economy and constitutional economy

    2005  Volume 32, Issue 1, Page(s) 5–16

    Author's details Umberto Romani and Giovanni Tondini
    Keywords Erfolgsbeteiligung ; Verfassungsökonomik
    Language English
    Publisher Emerald
    Publishing place Bradford
    Document type Article
    ZDB-ID 188656-3
    Database ECONomics Information System

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  5. Article: La Dermatología española en la era de la COVID-19./ La Dermatología española en la era de la COVID-19./ Spanish Dermatology in the COVID-19 Era

    Romaní, J

    Actas dermo-sifiliogr. (Ed. impr.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32422217
    Database COVID19

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  6. Article ; Online: Spanish Dermatology in the COVID-19 Era

    Romaní, J.

    Actas Dermo-Sifiliográficas (English Edition) ; ISSN 1578-2190

    2020  

    Keywords Pathology and Forensic Medicine ; Histology ; Dermatology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.adengl.2020.05.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: La Dermatología española en la era de la COVID-19

    Romaní, J.

    Actas Dermo-Sifiliográficas ; ISSN 0001-7310

    2020  

    Keywords Pathology and Forensic Medicine ; Histology ; Dermatology ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.ad.2020.05.002
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Antimicrobial Photodynamic Therapy: An Unexplored New Field.

    Romaní, J

    Actas dermo-sifiliograficas

    2017  Volume 108, Issue 6, Page(s) 500

    Title translation Terapia fotodinámica antimicrobiana: un mundo por explorar.
    Language Spanish
    Publishing date 2017-07
    Publishing country Spain
    Document type Letter
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2017.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Causes and Cures of Skin Diseases in the Work of Hildegard of Bingen.

    Romaní, J / Romaní, M

    Actas dermo-sifiliograficas

    2016  Volume 108, Issue 6, Page(s) 538–543

    Title translation Causas y curas de las dermatosis en la obra de Hildegarda de Bingen.
    MeSH term(s) Germany ; History, Medieval ; Skin Diseases/etiology ; Skin Diseases/history ; Skin Diseases/therapy
    Language Spanish
    Publishing date 2016-10-24
    Publishing country Spain
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2016.09.002
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  10. Article ; Online: Gluteal Hidradenitis Suppurativa: Analysis of 83 Patients.

    Riera-Martí, N / Vilarrasa, E / López-Llunell, C / Gamissans, M / Sin, M / Romaní, J

    Actas dermo-sifiliograficas

    2023  Volume 115, Issue 2, Page(s) 137–142

    Abstract: Background: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement.: Objective: To improve the classification of the gluteal phenotype (LC3) ... ...

    Abstract Background: In 2013, Canoui-Poitrine et al. identified three hidradenitis suppurativa (HS) phenotypes by a latent class (LC) analysis, based on anatomical sites of involvement.
    Objective: To improve the classification of the gluteal phenotype (LC3) patients given their diverse lesion types and differences in clinical profile.
    Material and methods: We designed a bicentric study gathering all LC3 patients (n=83) from two hospitals. We conducted a two-step cluster analysis among them and also compared their characteristics with the rest of the HS patients (n=661).
    Results: Compared with global HS series, LC3 patients were more frequently non-obese men, with smoking habit, an associated arthropathy, and a more frequent history of pilonidal sinus. The analysis of LC3 patients yielded two clusters: cluster 1 (38.3%) included elderly female patients, with later diagnosis of the disease and more sinus tracts; cluster 2 (61.7%) encompassed more men with earlier disease onset and more nodules and folliculitis lesions.
    Limitations: The study's limitations include its retrospective nature, bicentric design, and small sample size.
    Conclusion: The heterogeneous clinical presentation of HS makes it essential to have a good classification of the patients. Gluteal phenotype could actually be classified into two "subphenotypes" with a different clinical profiles and management.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/epidemiology ; Hidradenitis Suppurativa/genetics ; Retrospective Studies ; Hospitals ; Severity of Illness Index
    Language Spanish
    Publishing date 2023-10-04
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 390255-9
    ISSN 1578-2190 ; 0001-7310 ; 1138-8196
    ISSN (online) 1578-2190
    ISSN 0001-7310 ; 1138-8196
    DOI 10.1016/j.ad.2023.09.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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