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Article ; Online: La infección por coronavirus SARS-CoV-2 y su relación con el estado nutricional.

Remón Ruiz, Pablo Jesus / García Luna, Pedro Pablo

2020 Volume 34, Issue 3, Page(s) 411–413

Title translation	SARS-CoV-2 infection and its relation with the nutritional status.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Diarrhea/prevention & control ; Dietary Proteins/therapeutic use ; Dyslipidemias/epidemiology ; Energy Intake ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-3/adverse effects ; Fatty Acids, Omega-6/administration & dosage ; Humans ; Life Style ; Malnutrition/epidemiology ; Malnutrition/etiology ; Malnutrition/prevention & control ; Malnutrition/therapy ; Nutritional Status ; Obesity/epidemiology ; Overnutrition/epidemiology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Risk ; SARS-CoV-2 ; Social Determinants of Health
Chemical Substances	Dietary Proteins ; Fatty Acids, Omega-3 ; Fatty Acids, Omega-6
Keywords	covid19
Language	Spanish
Publishing date	2020-06-02
Publishing country	Spain
Document type	Editorial
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.20960/nh.03184
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update.

Jiménez-Sánchez, Andrés / Martínez-Ortega, Antonio Jesús / Remón-Ruiz, Pablo Jesús / Piñar-Gutiérrez, Ana / Pereira-Cunill, José Luis / García-Luna, Pedro Pablo

Nutrients

2022 Volume 14, Issue 7

Abstract: Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate the various characteristics and clinical applications of EVOO and its components-such as oleic acid, hydroxytyrosol, ... ...

Abstract	Extra virgin olive oil (EVOO) is a cornerstone of the Mediterranean diet (MedD). In this narrative review, we synthesize and illustrate the various characteristics and clinical applications of EVOO and its components-such as oleic acid, hydroxytyrosol, and oleuropein-in the field of clinical nutrition and dietetics. The evidence is split into diet therapy, oleic acid-based enteral nutrition formulations and oral supplementation formulations, oleic acid-based parenteral nutrition, and nutraceutical supplementation of minor components of EVOO. EVOO has diverse beneficial health properties, and current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition. Nevertheless, more intervention studies in humans are needed to chisel specific recommendations for its therapeutic use through different formulations in other specific diseases and clinical populations.
MeSH term(s)	Antioxidants/therapeutic use ; Diet, Mediterranean ; Dietary Supplements ; Humans ; Oleic Acid ; Olive Oil/therapeutic use
Chemical Substances	Antioxidants ; Olive Oil ; Oleic Acid (2UMI9U37CP)
Language	English
Publishing date	2022-03-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14071440
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: La infección por coronavirus SARS-CoV-2 y su relación con el estado nutricional./ [SARS-CoV-2 infection and its relation with the nutritional status]

Remón Ruiz, Pablo Jesus / García Luna, Pedro Pablo

Nutr Hosp

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #401410
Database	COVID19

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Article ; Online: Perioperative Nutritional Support: A Review of Current Literature.

Martínez-Ortega, Antonio Jesús / Piñar-Gutiérrez, Ana / Serrano-Aguayo, Pilar / González-Navarro, Irene / Remón-Ruíz, Pablo Jesús / Pereira-Cunill, José Luís / García-Luna, Pedro Pablo

Nutrients

2022 Volume 14, Issue 8

Abstract: Since the beginning of the practice of surgery, the reduction of postoperative complications and early recovery have been two of the fundamental pillars that have driven the improvement of surgical techniques and perioperative management. Despite great ... ...

Abstract	Since the beginning of the practice of surgery, the reduction of postoperative complications and early recovery have been two of the fundamental pillars that have driven the improvement of surgical techniques and perioperative management. Despite great advances in these fields, the rationalization of antibiotic prophylaxis, and other important innovations, postoperative recovery (especially in elderly patients, oncological pathology or digestive or head and neck surgery) is tortuous. This can be explained by several reasons, among which, malnutrition has a major role. Perioperative nutritional support, included within the ERAS (Enhanced Recovery After Surgery) protocol, has proven to be a main element and a critical step to achieve better surgical results. Starting with the preoperative nutritional assessment and treatment in elective surgery, we can improve nutritional status using oral supplements and immunomodulatory formulas. If we add early nutritional support in the postoperative scenario, we are able to significantly reduce infectious complications, need for intensive care unit (ICU) and hospital stay, costs, and mortality. Throughout this review, we will review the latest developments and the available literature.
MeSH term(s)	Aged ; Humans ; Length of Stay ; Malnutrition/prevention & control ; Nutrition Assessment ; Nutritional Status ; Nutritional Support ; Perioperative Care ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14081601
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Article ; Online: Prevalence of non-alcoholic fatty liver disease (NAFLD) in a cohort of patients with type 2 diabetes: the PHIGNA-DM2 study.

Martínez-Ortega, Antonio Jesús / Piñar Gutiérrez, Ana / Lara-Romero, Carmen / Remón Ruiz, Pablo Jesús / Ampuero-Herrojo, Javier / de Lara-Rodríguez, Irene / Romero-Gómez, Manuel / García Luna, Pedro P / Soto-Moreno, Alfonso

Nutricion hospitalaria

2022 Volume 39, Issue 5, Page(s) 1012–1018

Abstract: Introduction: Background: type 2 diabetes (T2D) is a risk factor for nonalcoholic fatty liver disease (NAFLD). Objective: to evaluate the prevalence of NAFLD in a cohort of patients with T2D. Methods: an observational, descriptive study performed ... ...

Title translation	Prevalencia de la hepatopatía grasa no alcohólica (HGNA) en una cohorte de pacientes con diabetes de tipo 2: el estudio PHIGNA-DM2.
Abstract	Introduction: Background: type 2 diabetes (T2D) is a risk factor for nonalcoholic fatty liver disease (NAFLD). Objective: to evaluate the prevalence of NAFLD in a cohort of patients with T2D. Methods: an observational, descriptive study performed between May 2018 and December 2019 at the Endocrinology and Nutrition Unit. The χ² test was performed for qualitative variables and a non-parametric test for the comparison of medians of quantitative variables. Steatosis degree was defined by the coefficient attenuated parameter (CAP): (S0: < 248 dB/m; S1: 248-268 dB/m; S2: 268-288 dB/m; S3: > 288 dB/m) or stiffness: F0-F1: < 8 kPa; F2: 8-10 kPa; F3: 10-15 kPa; F4: > 15 kPa, using transient elastography (TE) (FibroScan®). A univariate analysis was performed and subsequently a multivariate analysis with statistically significant variables used to study the predictive factors of intense steatosis and advanced fibrosis. Results: n = 104 patients with T2D; 84 (80.7 %) were obese. TE demonstrated advanced fibrosis in 20 % and intense steatosis (S3) in more than 50 %. Lower total bilirubin (OR: 0.028; 95 % CI: (0.002-0.337); p = 0.005) was found to be an independent factor for S3 steatosis in the multivariate analysis. BMI ((OR: 1.497; 95 % CI: (1.102-2.034); p = 0.01)) was a predictive factor for advanced fibrosis in a multivariate analysis. Conclusions: NAFLD-associated intense steatosis and NAFLD-associated fibrosis were commonly found in patients with T2DM and obesity. Diabetic patients should be screened for liver disease as one more target organ.
MeSH term(s)	Bilirubin ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Fibrosis ; Humans ; Liver/pathology ; Liver Cirrhosis/complications ; Liver Cirrhosis/epidemiology ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology ; Obesity/epidemiology ; Prevalence
Chemical Substances	Bilirubin (RFM9X3LJ49)
Language	English
Publishing date	2022-09-22
Publishing country	Spain
Document type	Journal Article ; Observational Study
ZDB-ID	1481223-x
ISSN	1699-5198 ; 0212-1611
ISSN (online)	1699-5198
ISSN	0212-1611
DOI	10.20960/nh.03969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Postoperative water and electrolyte disturbances after extended endoscopic endonasal transsphenoidal surgery.

Canelo Moreno, Juan Manuel / Dios Fuentes, Elena / Venegas Moreno, Eva / Remón Ruíz, Pablo Jesús / Muñoz Gómez, Cristina / Piñar Gutiérrez, Ana / Cárdenas Valdepeñas, Eugenio / Kaen, Ariel / Soto Moreno, Alfonso

Frontiers in endocrinology

2022 Volume 13, Page(s) 963707

Abstract: Introduction: Water and electrolyte disturbances are common after pituitary surgery and can generally be classified into transient hypotonic polyuria and transient or permanent diabetes insipidus (DI). The prevalence varies in the literature between 31- ... ...

Abstract	Introduction: Water and electrolyte disturbances are common after pituitary surgery and can generally be classified into transient hypotonic polyuria and transient or permanent diabetes insipidus (DI). The prevalence varies in the literature between 31-51% for transient hypotonic polyuria, 5.1-25.2% for transient DI, and 1-8.8% for permanent DI. Objective: The aim of this study was to identify the prevalence of water and electrolyte disturbances with polyuria and the preoperative and postoperative predictive factors in patients undergoing surgery with an extended endoscopic endonasal approach. Material and methods: This retrospective observational descriptive study included 203 patients with a diagnosis of pituitary adenoma who underwent their first transsphenoidal surgery Results: The overall prevalence of water and electrolyte disorders was 30.5% (62), and the prevalence of postoperative polyuria was 23.6% (48). The median number of desmopressin doses administered to patients with postoperative polyuria was one dose (interquartile range [IQR] 1-2), and thus the median duration of treatment was 0 days. The median initiation of desmopressin was the second day after surgery (IQR 1-2). The overall prevalence of DI was 6.89%. Among the patients with transient DI, the duration was less than 3 months in three patients (1.47%), and between 3 and 6 months in two (0.98%). Nine patients had permanent DI (4.43%). (4.43%). Conclusions: The prevalence of electrolyte disturbances in our study was high, although similar to that found in the literature. Most of the cases were transient hypotonic polyuria that resolved within one day. The prevalence of transient DI in our cohort was lower than that described in the literature, while permanent DI was similar.
MeSH term(s)	Deamino Arginine Vasopressin ; Diabetes Insipidus/etiology ; Humans ; Pituitary Neoplasms/surgery ; Polyuria/etiology ; Postoperative Complications ; Retrospective Studies ; Water-Electrolyte Imbalance/etiology
Chemical Substances	Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2022-08-23
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.963707
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Article: Description of a Cohort of Type 1 Diabetes Patients: Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia.

Martínez-Ortega, Antonio J / Muñoz-Gómez, Cristina / Gros-Herguido, Noelia / Remón-Ruiz, Pablo Jesús / Acosta-Delgado, Domingo / Losada-Viñau, Fernando / Pumar-López, Alfonso / Mangas-Cruz, Miguel Ángel / González-Navarro, Irene / López-Gallardo, Gema / Bellido, Virginia / Soto-Moreno, Alfonso Manuel

Journal of clinical medicine

2022 Volume 11, Issue 4

Abstract: Background: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention ... ...

Abstract	Background: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention strategies. Methods: Cross-sectional, observational study, including T1D patients treated at our center, from 1 March 2017 to 31 March 2020. Inclusion criteria: T1D, age > 14 years and signed informed consent. Exclusion criteria: diabetes other than T1D, age < 14 years and/or refusal to participate. Results: Study population Conclusions: Our T1D population is similar to other T1D populations. We should minimize the risk of SH, and male patients should perhaps be treated more aggressively regarding cardiovascular risk factors.
Language	English
Publishing date	2022-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11041039
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Article ; Online: Description of a Cohort of Type 1 Diabetes Patients

Antonio J. Martínez-Ortega / Cristina Muñoz-Gómez / Noelia Gros-Herguido / Pablo Jesús Remón-Ruiz / Domingo Acosta-Delgado / Fernando Losada-Viñau / Alfonso Pumar-López / Miguel Ángel Mangas-Cruz / Irene González-Navarro / Gema López-Gallardo / Virginia Bellido / Alfonso Manuel Soto-Moreno

Journal of Clinical Medicine, Vol 11, Iss 1039, p

Analysis of Comorbidities, Prevalence of Complications and Risk of Hypoglycemia

2022 Volume 1039

Abstract	Background: Despite major medical advances, Type 1 Diabetes (T1D) patients still have greater morbimortality than the general population. Our aim was to describe our cohort of T1D patients and identify potential risk factors susceptible to prevention strategies. Methods: Cross-sectional, observational study, including T1D patients treated at our center, from 1 March 2017 to 31 March 2020. Inclusion criteria: T1D, age > 14 years and signed informed consent. Exclusion criteria: diabetes other than T1D, age < 14 years and/or refusal to participate. Results: Study population n = 2181 (49.8% females, median age at enrollment 41 years, median HbA1c 7.7%; 38.24% had at least one comorbidity). Roughly 7.45% had severe hypoglycemia (SH) within the prior year. Macro/microvascular complications were present in 42.09% (5.83% and 41.14%, respectively). The most frequent microvascular complication was diabetic retinopathy (38.02%), and coronary disease (3.21%) was the most frequent macrovascular complication. The risk of complications was higher in males than in females, mainly macrovascular. Patients with SH had a higher risk of complications (OR 1.42; 1.43 in males versus 1.42 in females). Conclusions: Our T1D population is similar to other T1D populations. We should minimize the risk of SH, and male patients should perhaps be treated more aggressively regarding cardiovascular risk factors.
Keywords	Type 1 Diabetes ; macrovascular complications ; microvascular complications ; severe hypoglycemia ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Surgical Outcomes and Comorbidities in Cushing Disease: 30 Years of Experience in a Referral Center.

Martínez Ortega, Antonio Jesús / Venegas-Moreno, Eva / Dios, Elena / Remón Ruíz, Pablo Jesús / Márquez Rivas, Francisco Javier / Valdepeñas, Eugenio Cárdenas / Kaen, Ariel Matías / Cano, David A / Soto-Moreno, Alfonso

World neurosurgery

2018 Volume 122, Page(s) e436–e442

Abstract: Objective: Cushing disease (CD) is a rare, poorly understood entity. Our aim was to add our clinical experience of >30 years in a multidisciplinary specialized unit to the global knowledge of CD.: Methods: This descriptive retrospective study ... ...

Abstract	Objective: Cushing disease (CD) is a rare, poorly understood entity. Our aim was to add our clinical experience of >30 years in a multidisciplinary specialized unit to the global knowledge of CD. Methods: This descriptive retrospective study included all patients admitted to the Endocrinology and Nutrition Department of the Virgen del Rocío University Hospital, Seville, Spain, from January 1980 to May 2016. All patients had a definitive diagnosis of CD. Results: Total sample included 119 patients; 100 (84%) were female. Median age at diagnosis was 37.97 years (interquartile range [IQR]: 25.89-45.07 years). Median follow-up was 88 months (IQR: 45.50-157.00 months). Most tumors were microadenomas (62/95) (5.1 mm [IQR: 4.0-7.0 mm]) without sinus invasion. Surgical procedures were conventional transsphenoidal surgery (CTSS) (101/108; cured 70 after first attempt) and expanded endoscopic transsphenoidal surgery (EETSS) (7/108; cured 5 after first attempt); 11 patients did not receive surgical treatment. Fourteen patients received radiotherapy after a first surgery and 5 patients after a second surgical removal attempt. In 13 patients (12.04%), CD relapse was demonstrated after initial CTSS (median disease-free period 65 months [IQR: 45-120 months]). Ten patients developed panhypopituitarism owing to the surgical procedure (CTSS); 8 patients developed panhypopituitarism after adjuvant radiotherapy. Conclusions: We observed slightly inferior cure rate after first surgery compared with moderately better relapse rates and time to relapse. Radiotherapy after surgery failure seemed to be more effective than CTSS; however, EETSS may be a valid alternative. Postoperative panhypopituitarism rate after first surgery was lower than expected; after radiotherapy, our results were comparable to other series.
MeSH term(s)	ACTH-Secreting Pituitary Adenoma/complications ; ACTH-Secreting Pituitary Adenoma/surgery ; Adenoma/complications ; Adenoma/surgery ; Adult ; Endoscopy/methods ; Female ; Humans ; Hypopituitarism/etiology ; Male ; Middle Aged ; Pituitary ACTH Hypersecretion/radiotherapy ; Pituitary ACTH Hypersecretion/surgery ; Postoperative Complications/etiology ; Radiotherapy, Adjuvant/adverse effects ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2018-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2018.10.067
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