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Article ; Online: Spatiotemporal variations of tropospheric ozone in Spain (2008-2019).

Massagué, Jordi / Escudero, Miguel / Alastuey, Andrés / Mantilla, Enrique / Monfort, Eliseo / Gangoiti, Gotzon / García-Pando, Carlos Pérez / Querol, Xavier

Environment international

2023 Volume 176, Page(s) 107961

Abstract: This study aims to support the development of Spain's Ozone Mitigation Plan by evaluating the present-day spatial variation (2015-2019) and trends (2008-2019) for seven ground-level ozone ( ... ...

Abstract	This study aims to support the development of Spain's Ozone Mitigation Plan by evaluating the present-day spatial variation (2015-2019) and trends (2008-2019) for seven ground-level ozone (O
MeSH term(s)	Humans ; Ozone/analysis ; Spain ; Air Pollutants/analysis ; Ecosystem ; Air Pollution/analysis ; Environmental Monitoring/methods
Chemical Substances	Ozone (66H7ZZK23N) ; Air Pollutants
Language	English
Publishing date	2023-05-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2023.107961
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Article ; Online: Publisher Correction: Feasibility and sensitivity study of radiomic features in photoacoustic imaging of patient-derived xenografts.

Escudero Sanchez, Lorena / Brown, Emma / Rundo, Leonardo / Ursprung, Stephan / Sala, Evis / Bohndiek, Sarah E / Partarrieu, Ignacio Xavier

Scientific reports

2022 Volume 12, Issue 1, Page(s) 20657

Language	English
Publishing date	2022-11-30
Publishing country	England
Document type	Published Erratum
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-24697-2
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Article ; Online: Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis.

Fuenzalida, Marlene / Gómez, María Isabel / Ferrada, Evandro / Díaz, Cristóbal / Escudero, Viviana / González-Guerrero, Manuel / Jordana, Xavier / Roschzttardtz, Hannetz

Plant science : an international journal of experimental plant biology

2023 Volume 339, Page(s) 111931

Abstract: Iron is an essential micronutrient for life. During the development of the seed, iron accumulates during embryo maturation. In Arabidopsis thaliana, iron mainly accumulates in the vacuoles of only one cell type, the cell layer that surrounds ... ...

Abstract	Iron is an essential micronutrient for life. During the development of the seed, iron accumulates during embryo maturation. In Arabidopsis thaliana, iron mainly accumulates in the vacuoles of only one cell type, the cell layer that surrounds provasculature in hypocotyl and cotyledons. Iron accumulation pattern in Arabidopsis is an exception in plant phylogeny, most part of the dicot embryos accumulate iron in several cell layers including cortex and, in some cases, even in protodermis. It remains unknown how does iron reach the internal cell layers of the embryo, and in particular, the molecular mechanisms responsible of this process. Here, we use transgenic approaches to modify the iron accumulation pattern in an Arabidopsis model. Using the SDH2-3 embryo-specific promoter, we were able to express VIT1 ectopically in both a wild type background and a mutant vit1 background lacking expression of this vacuolar iron transporter. These manipulations modify the iron distribution pattern in Arabidopsis from one cell layer to several cell layers, including protodermis, cortex cells, and the endodermis. Interestingly, total seed iron content was not modified compared with the wild type, suggesting that iron distribution in embryos is not involved in the control of the total iron amount accumulated in seeds. This experimental model can be used to study the processes involved in iron distribution patterning during embryo maturation and its evolution in dicot plants.
MeSH term(s)	Arabidopsis/metabolism ; Iron/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Promoter Regions, Genetic/genetics ; Seeds/metabolism ; Gene Expression Regulation, Plant
Chemical Substances	Iron (E1UOL152H7) ; Arabidopsis Proteins
Language	English
Publishing date	2023-11-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	742010-9
ISSN	1873-2259 ; 0168-9452
ISSN (online)	1873-2259
ISSN	0168-9452
DOI	10.1016/j.plantsci.2023.111931
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Article ; Online: Spatiotemporal variations of tropospheric ozone in Spain (2008–2019)

Jordi Massagué / Miguel Escudero / Andrés Alastuey / Enrique Mantilla / Eliseo Monfort / Gotzon Gangoiti / Carlos Pérez García-Pando / Xavier Querol

Environment International, Vol 176, Iss , Pp 107961- (2023)

2023

Abstract: This study aims to support the development of Spain’s Ozone Mitigation Plan by evaluating the present-day spatial variation (2015–2019) and trends (2008–2019) for seven ground-level ozone (O3) metrics relevant for human/ecosystems exposure and regulatory ...

Abstract	This study aims to support the development of Spain’s Ozone Mitigation Plan by evaluating the present-day spatial variation (2015–2019) and trends (2008–2019) for seven ground-level ozone (O3) metrics relevant for human/ecosystems exposure and regulatory purposes.Results indicate that the spatial variation of O3 depends on the part of the O3 distribution being analyzed. Metrics associated with moderate O3 concentrations depict an increasing O3 gradient between the northern and Mediterranean coasts due to climatic factors, while for metrics considering the upper end of the O3 distribution, this climatic gradient tends to attenuate in favor of hotspot regions pointing to relevant local/regional O3 formation. A classification of atmospheric regions in Spain is proposed based on their O3 pollution patterns, to identify priority areas (or O3 hotspots) where local/regional precursor abatement might significantly reduce O3 during pollution episodes.The trends assessment reveals a narrowing of the O3 distribution at the national level, with metrics influenced by lower concentrations tending to increase over time, and those reflecting the higher end of the O3 distribution tending to decrease. While most stations show no statistically significant variations, contrasting O3 trends are evident among the O3 hotspots. The Madrid area exhibits the majority of upward trends across all metrics, frequently with the highest increasing rates, implying increasing O3 associated with both chronic and episodic exposure. The Valencian Community area exhibits a mixed variation pattern, with moderate to high O3 metrics increasing and peak metrics decreasing, while O3 in areas downwind of Barcelona, the Guadalquivir Valley and Puertollano shows no variations. Sevilla is the only large Spanish city with generalized O3 decreasing trends.The different O3 trends among hotspots highlight the need for mitigation measures to be designed at a local/regional scale to be effective. This approach may offer valuable insights for other countries ...
Keywords	Tropospheric ozone concentration distribution ; Trends ; Mann-Kendall Theil-Sen test ; Air quality and pollution ; Human and vegetation exposure O3 metrics ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Publisher Correction

Lorena Escudero Sanchez / Emma Brown / Leonardo Rundo / Stephan Ursprung / Evis Sala / Sarah E. Bohndiek / Ignacio Xavier Partarrieu

Scientific Reports, Vol 12, Iss 1, Pp 1-

Feasibility and sensitivity study of radiomic features in photoacoustic imaging of patient-derived xenografts

2022 Volume 4

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Photoacoustic imaging radiomics in patient-derived xenografts: a study on feature sensitivity and model discrimination.

Escudero Sanchez, Lorena / Brown, Emma / Rundo, Leonardo / Ursprung, Stephan / Sala, Evis / Bohndiek, Sarah E / Partarrieu, Ignacio Xavier

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15142

Abstract: Photoacoustic imaging is an increasingly popular method of exploring the tumour microenvironment, which can provide insight into tumour oxygenation status and potentially treatment response assessment. Currently, the measurements most commonly performed ... ...

Abstract	Photoacoustic imaging is an increasingly popular method of exploring the tumour microenvironment, which can provide insight into tumour oxygenation status and potentially treatment response assessment. Currently, the measurements most commonly performed on such images are the mean and median of the pixel values of the tumour volumes of interest. We investigated expanding the set of measurements that can be extracted from these images by adding radiomic features. In particular, we found that Skewness was sensitive to differences between basal and luminal patient derived xenograft cancer models with an [Formula: see text] of 0.86, and that it was robust to variations in confounding factors such as reconstruction type and wavelength. We also built discriminant models with radiomic features that were correlated with the underlying tumour model and were independent from each other. We then ranked features by their importance in the model. Skewness was again found to be an important feature, as were 10th Percentile, Root Mean Squared, and several other texture-based features. In summary, this paper proposes a methodology to select radiomic features extracted from photoacoustic images that are robust to changes in acquisition and reconstruction parameters, and discusses features found to have discriminating power between the underlying tumour models in a pre-clinical dataset.
MeSH term(s)	Animals ; Diagnostic Imaging ; Disease Models, Animal ; Heterografts ; Humans ; Neoplasms/diagnostic imaging ; Photoacoustic Techniques ; Tumor Microenvironment
Language	English
Publishing date	2022-09-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-19084-w
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Article ; Online: Modeling the Photochrome-TiO

Escudero, Daniel / Duchemin, Ivan / Blase, Xavier / Jacquemin, Denis

The journal of physical chemistry letters

2017 Volume 8, Issue 5, Page(s) 936–940

Abstract: Hybrid organic-inorganic semiconductor systems have important applications in both molecular electronics and photoresponsive materials. The characterizations of the interface and of the electronic excited-states of these hybrid systems remain a challenge ...

Abstract	Hybrid organic-inorganic semiconductor systems have important applications in both molecular electronics and photoresponsive materials. The characterizations of the interface and of the electronic excited-states of these hybrid systems remain a challenge for state-of-the-art computational methods, as the systems of interest are large. In the present investigation, we present for the first time a many-body Green's function Bethe-Salpeter investigation of a series of photochromic molecules adsorbed onto TiO
Language	English
Publishing date	2017-03-02
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.7b00015
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Article ; Online: The SARS-CoV-2 (COVID-19) coronavirus pandemic: current situation and implications for Mexico.

Escudero, Xavier / Guarner, Jeannette / Galindo-Fraga, Arturo / Escudero-Salamanca, Mara / Alcocer-Gamba, Marco A / Del-Río, Carlos

Archivos de cardiologia de Mexico

2020 Volume 90, Issue Supl, Page(s) 7–14

Abstract: The Coronavirus pandemic (COVID-19) is one of the most devastating in this century. It originated in China in December 2019 caused by the SARS-Cov-2 virus, and in less than a month it had been classified as an "International Public Health Emergency". To ... ...

Title translation	La pandemia de Coronavirus SARS-CoV-2 (COVID-19): Situación actual e implicaciones para México.
Abstract	The Coronavirus pandemic (COVID-19) is one of the most devastating in this century. It originated in China in December 2019 caused by the SARS-Cov-2 virus, and in less than a month it had been classified as an "International Public Health Emergency". To date there are nearly 3 million people infected and more than 250,000 deaths caused by the disease worldwide. Initially it affects the respiratory tract with atypical pneumonia and in severe cases it produces systemic inflammation with cytokine storm that can cause rapid deterioration with circulatory and respiratory failure, coagulopathy and a lethality rate of approximately 7%. In Mexico, the first case was detected in February 2020, and to date there are 26,616 confirmed cases and 2,961 deaths throughout the country. The low number of diagnostic tests conducted in our country clearly underestimates the real incidence and impact of the disease. The most affected groups are those with risk factors such as age over 60, presence of hypertension, diabetes or cardiovascular disease. Of the confirmed cases, 15% are healthcare workers. There is no specific treatment or vaccine yet, so it is important to have hygiene, social isolation and personal protection measures. Health, social and economic consequences could have great impact in the near future.
MeSH term(s)	Age Factors ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Health Personnel/statistics & numerical data ; Humans ; Incidence ; Mexico/epidemiology ; Pandemics/prevention & control ; Personal Protective Equipment ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Risk Factors
Keywords	covid19
Language	English
Publishing date	2020-06-10
Publishing country	Mexico
Document type	Journal Article
ISSN	1665-1731
ISSN (online)	1665-1731
DOI	10.24875/ACM.M20000064
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Article ; Online: A Rational Approach to Organo-Photocatalysis: Novel Designs and Structure-Property Relationships.

Vega-Peñaloza, Alberto / Mateos, Javier / Companyó, Xavier / Escudero-Casao, Margarita / Dell'Amico, Luca

Angewandte Chemie (International ed. in English)

2020 Volume 60, Issue 3, Page(s) 1082–1097

Abstract: Organic photocatalysts are emerging as viable and more sustainable tools than metal complexes. Recently, the field of organo-photocatalysis has experienced an explosion in terms of applications, redesign of well-established systems, and identification of ...

Abstract	Organic photocatalysts are emerging as viable and more sustainable tools than metal complexes. Recently, the field of organo-photocatalysis has experienced an explosion in terms of applications, redesign of well-established systems, and identification of novel scaffolds. A rational approach to the structural modification of the different photocatalysts is key to accessing unprecedented reactivity, while improving their catalytic performances. We herein discuss the concepts underpinning the scaffold modification of some of the most recently used photocatalysts and analyze how specific structural changes alter their physicochemical and redox properties.
Language	English
Publishing date	2020-10-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202006416
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Article ; Online: Functional analysis of PTEN variants of unknown significance from PHTS patients unveils complex patterns of PTEN biological activity in disease.

Torices, Leire / Mingo, Janire / Rodríguez-Escudero, Isabel / Fernández-Acero, Teresa / Luna, Sandra / Nunes-Xavier, Caroline E / López, José I / Mercadillo, Fátima / Currás, María / Urioste, Miguel / Molina, María / Cid, Víctor J / Pulido, Rafael

European journal of human genetics : EJHG

2022 Volume 31, Issue 5, Page(s) 568–577

Abstract: Heterozygous germline mutations in PTEN gene predispose to hamartomas and tumors in different tissues, as well as to neurodevelopmental disorders, and define at genetic level the PTEN Hamartoma Tumor Syndrome (PHTS). The major physiologic role of PTEN ... ...

Abstract	Heterozygous germline mutations in PTEN gene predispose to hamartomas and tumors in different tissues, as well as to neurodevelopmental disorders, and define at genetic level the PTEN Hamartoma Tumor Syndrome (PHTS). The major physiologic role of PTEN protein is the dephosphorylation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3), counteracting the pro-oncogenic function of phosphatidylinositol 3-kinase (PI3K), and PTEN mutations in PHTS patients frequently abrogate PTEN PIP3 catalytic activity. PTEN also displays non-canonical PIP3-independent functions, but their involvement in PHTS pathogeny is less understood. We have previously identified and described, at clinical and genetic level, novel PTEN variants of unknown functional significance in PHTS patients. Here, we have performed an extensive functional characterization of these PTEN variants (c.77 C > T, p.(Thr26Ile), T26I; c.284 C > G, p.(Pro95Arg), P95R; c.529 T > A, p.(Tyr177Asn), Y177N; c.781 C > G, p.(Gln261Glu), Q261E; c.829 A > G, p.(Thr277Ala), T277A; and c.929 A > G, p.(Asp310Gly), D310G), including cell expression levels and protein stability, PIP3-phosphatase activity, and subcellular localization. In addition, caspase-3 cleavage analysis in cells has been assessed using a C2-domain caspase-3 cleavage-specific anti-PTEN antibody. We have found complex patterns of functional activity on PTEN variants, ranging from loss of PIP3-phosphatase activity, diminished protein expression and stability, and altered nuclear/cytoplasmic localization, to intact functional properties, when compared with PTEN wild type. Furthermore, we have found that PTEN cleavage at the C2-domain by the pro-apoptotic protease caspase-3 is diminished in specific PTEN PHTS variants. Our findings illustrate the multifaceted molecular features of pathogenic PTEN protein variants, which could account for the complexity in the genotype/phenotype manifestations of PHTS patients.
MeSH term(s)	Humans ; Caspase 3/genetics ; Germ-Line Mutation ; Hamartoma Syndrome, Multiple/genetics ; Phosphatidylinositol 3-Kinases/genetics ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism
Chemical Substances	Caspase 3 (EC 3.4.22.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; PTEN Phosphohydrolase (EC 3.1.3.67) ; PTEN protein, human (EC 3.1.3.67)
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-022-01265-w
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