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Article ; Online: Protective effects of m-(tert-butyl) trifluoroacetophenone, a transition state analogue of acetylcholine, against paraoxon toxicity and memory impairments.

Zueva, Irina / Lenina, Oksana / Kayumova, Ramilya / Petrov, Konstantin / Masson, Patrick

2021 Volume 345, Page(s) 109558

Abstract: m-(Tert-butyl) trifluoroacetophenone (TFK), a slow-binding inhibitor of acetylcholinesterase (AChE ...

Abstract	m-(Tert-butyl) trifluoroacetophenone (TFK), a slow-binding inhibitor of acetylcholinesterase (AChE), a transition state analog of acetylcholine, was investigated as a potential neuroprotectant of central and peripheral AChE against organophosphate paraoxon (POX) toxicity. Acute toxicity and pharmacological effects of TFK were investigated on mice and rats. Intraperitoneal administered TFK has low acute toxicity in mice (LD
MeSH term(s)	Acetophenones/chemistry ; Acetophenones/pharmacology ; Acetophenones/therapeutic use ; Acetylcholine/analogs & derivatives ; Animals ; Cholinesterase Inhibitors/chemistry ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/therapeutic use ; Hippocampus/drug effects ; Hippocampus/physiopathology ; Memory Disorders/chemically induced ; Memory Disorders/drug therapy ; Memory Disorders/physiopathology ; Mice ; Paraoxon/toxicity
Chemical Substances	3-(tert-butyl)trifluoroacetophenone ; Acetophenones ; Cholinesterase Inhibitors ; Acetylcholine (N9YNS0M02X) ; Paraoxon (Q9CX8P80JW)
Language	English
Publishing date	2021-06-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2021.109558
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Article ; Online: β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding.

Masson, Stewart W C / Sorrenson, Brie / Shepherd, Peter R / Merry, Troy L

Molecular metabolism

2020 Volume 42, Page(s) 101091

Abstract: Objective: Skeletal muscle glucose disposal following a meal is mediated through insulin-stimulated movement of the GLUT4-containing vesicles to the cell surface. The highly conserved scaffold-protein β-catenin is an emerging regulator of vesicle ... ...

Abstract	Objective: Skeletal muscle glucose disposal following a meal is mediated through insulin-stimulated movement of the GLUT4-containing vesicles to the cell surface. The highly conserved scaffold-protein β-catenin is an emerging regulator of vesicle trafficking in other tissues. Here, we investigated the involvement of β-catenin in skeletal muscle insulin-stimulated glucose transport. Methods: Glucose homeostasis and transport was investigated in inducible muscle specific β-catenin knockout (BCAT-mKO) mice. The effect of β-catenin deletion and mutation of β-catenin serine 552 on signal transduction, glucose uptake and protein-protein interactions were determined in L6-G4-myc cells, and β-catenin insulin-responsive binding partners were identified via immunoprecipitation coupled to label-free proteomics. Results: Skeletal muscle specific deletion of β-catenin impaired whole-body insulin sensitivity and insulin-stimulated glucose uptake into muscle independent of canonical Wnt signalling. In response to insulin, β-catenin was phosphorylated at serine 552 in an Akt-dependent manner, and in L6-G4-myc cells, mutation of β-catenin Conclusions: Our data suggest that β-catenin is a novel mediator of glucose transport in skeletal muscle and may contribute to insulin-induced actin-cytoskeleton remodelling to support GLUT4 translocation.
MeSH term(s)	Actins/metabolism ; Actins/physiology ; Animals ; Biological Transport ; Cadherins/metabolism ; Cadherins/physiology ; Glucose/metabolism ; Glucose Transport Proteins, Facilitative/genetics ; Glucose Transport Proteins, Facilitative/metabolism ; Glucose Transporter Type 4/genetics ; Glucose Transporter Type 4/metabolism ; Insulin/metabolism ; Insulin Resistance/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle, Skeletal/metabolism ; Protein Binding ; Protein Transport ; Signal Transduction ; beta Catenin/genetics ; beta Catenin/metabolism
Chemical Substances	Actins ; Cadherins ; Glucose Transport Proteins, Facilitative ; Glucose Transporter Type 4 ; Insulin ; Slc2a4 protein, mouse ; beta Catenin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-10-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2708735-9
ISSN	2212-8778 ; 2212-8778
ISSN (online)	2212-8778
ISSN	2212-8778
DOI	10.1016/j.molmet.2020.101091
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Book ; Online: Anomalous flow below 2700 m in the EPICA Dome C ice core detected using δ18O of atmospheric oxygen measurements

Dreyfus, G. B. / Parrenin, F. / Lemieux-Dudon, B. / Durand, G. / Masson-Delmotte, V. / Jouzel, J. / Barnola, J.-M. / Panno, L. / Spahni, R. / Tisserand, A. / Siegenthaler, U. / Leuenberger, M.

eISSN: 1814-9332

2018

Abstract: ... 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts ...

Abstract	While there are no indications of mixing back to 800 000 years in the EPICA Dome C ice core record, comparison with marine sediment records shows significant differences in the timing and duration of events prior to stage 11 (~430 ka, thousands of years before 1950). A relationship between the isotopic composition of atmospheric oxygen (δ 18 O of O 2 , noted δ 18 O atm ) and daily northern hemisphere summer insolation has been observed for the youngest four climate cycles. Here we use this relationship with new δ 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts the duration of events by up to a factor of 2. By tuning δ 18 O atm to orbital precession we derive a corrected thinning function and present a revised age scale for the interval corresponding to Marine Isotope Stages 11–20 in the EPICA Dome C ice core. Uncertainty in the phasing of δ 18 O atm with respect to insolation variations in the precession band limits the accuracy of this new agescale to ±6 kyr (thousand of years). The previously reported ~30 kyr duration of interglacial stage 11 is unchanged. In contrast, the duration of stage 15.1 is reduced by a factor of 2, from 31 to 16 kyr.
Subject code	333 ; 290
Language	English
Publishing date	2018-09-27
Publishing country	de
Document type	Book ; Online
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Article ; Online: β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding

Stewart W.C. Masson / Brie Sorrenson / Peter R. Shepherd / Troy L. Merry

Molecular Metabolism, Vol 42, Iss , Pp 101091- (2020)

2020

Abstract: ... and GLUT4 translocation. β-catenin was found to interact with M-cadherin in an insulin-dependent β ... cateninS552-phosphorylation dependent manner, and loss of M-cadherin in L6-G4-myc cells attenuated insulin ...

Abstract	Objective: Skeletal muscle glucose disposal following a meal is mediated through insulin-stimulated movement of the GLUT4-containing vesicles to the cell surface. The highly conserved scaffold-protein β-catenin is an emerging regulator of vesicle trafficking in other tissues. Here, we investigated the involvement of β-catenin in skeletal muscle insulin-stimulated glucose transport. Methods: Glucose homeostasis and transport was investigated in inducible muscle specific β-catenin knockout (BCAT-mKO) mice. The effect of β-catenin deletion and mutation of β-catenin serine 552 on signal transduction, glucose uptake and protein–protein interactions were determined in L6-G4-myc cells, and β-catenin insulin-responsive binding partners were identified via immunoprecipitation coupled to label-free proteomics. Results: Skeletal muscle specific deletion of β-catenin impaired whole-body insulin sensitivity and insulin-stimulated glucose uptake into muscle independent of canonical Wnt signalling. In response to insulin, β-catenin was phosphorylated at serine 552 in an Akt-dependent manner, and in L6-G4-myc cells, mutation of β-cateninS552 impaired insulin-induced actin-polymerisation, resulting in attenuated insulin-induced glucose transport and GLUT4 translocation. β-catenin was found to interact with M-cadherin in an insulin-dependent β-cateninS552-phosphorylation dependent manner, and loss of M-cadherin in L6-G4-myc cells attenuated insulin-induced actin-polymerisation and glucose transport. Conclusions: Our data suggest that β-catenin is a novel mediator of glucose transport in skeletal muscle and may contribute to insulin-induced actin-cytoskeleton remodelling to support GLUT4 translocation.
Keywords	Beta-catenin ; Actin-remodelling ; Glucose transport ; M-cadherin ; GLUT4 trafficking ; Internal medicine ; RC31-1245
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: What causes large submarine landslides on low gradient (<2°) continental slopes with slow (∼0.15 m/kyr) sediment accumulation?

Urlaub, Morelia / Talling, Peter J / Zervos, Antonis / Masson , Douglas G

2015

Abstract: ... where sedimentation rates are low (<0.15 m/kyr), such as off northwest Africa. We use a fully coupled stress and fluid flow ...

Abstract	Submarine landslides can cause damaging tsunamis, the height of which scales up with the volume of the displaced mass. The largest underwater landslides are far bigger than any landslides on land, and these submarine megaslides tend to occur on open continental slopes with remarkably low gradients of less than 2°. For geohazard assessments it is essential to understand what preconditions and triggers slope failure on such low gradients. Previous work has suggested that generation of high excess pore pressure due to rapid sediment deposition plays a key role in such failures. However, submarine slope failure also occurs where sedimentation rates are low (<0.15 m/kyr), such as off northwest Africa. We use a fully coupled stress and fluid flow finite element model to test whether such low sedimentation rates can generate sufficient excess pore pressures to cause failure of a 2° slope. The sensitivity of overpressure generation and slope stability is assessed with respect to different sedimentation rates and patterns, sediment consolidation properties, and stratigraphic layer configurations. The simulations show that, in general, it is difficult to generate significant excess pore pressure if sediment accumulation is slow and the only pressure source. However, we identify a sediment compression behavior that can lead to submarine landslides in locations worldwide. Our results imply that compressibility is an important factor for the stability of low gradient continental slopes.
Subject code	550
Language	English
Publishing date	2015-10-19
Publisher	AGU (American Geophysical Union)
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Focusing on breadth of competence.

Masson, Maxime

Canadian family physician Medecin de famille canadien

2021 Volume 67, Issue 12, Page(s) 883

Language	English
Publishing date	2021-12-09
Publishing country	Canada
Document type	Letter ; Comment
ZDB-ID	603565-6
ISSN	1715-5258 ; 0008-350X
ISSN (online)	1715-5258
ISSN	0008-350X
DOI	10.46747/cfp.6712883
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Article: Water-Soluble Quaternary and Protonable Basic Chitotriazolans: Synthesis by Click Chemistry Conversion of Chitosan Azides and Investigation of Antibacterial Activity.

Rathinam, Sankar / Magdadaro, Romano / Hjálmarsdóttir, Martha Á / Másson, Már

Journal of functional biomaterials

2024 Volume 15, Issue 3

Abstract: The azide transfer reaction and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) can be used to convert the amino groups in chitosan to triazole 1,2,3-moieties. The resulting polymer has been named chitotriazolan. This synthesis was performed with ... ...

Abstract	The azide transfer reaction and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) can be used to convert the amino groups in chitosan to triazole 1,2,3-moieties. The resulting polymer has been named chitotriazolan. This synthesis was performed with six different quaternary ammonium alkynes and three amine alkynes to obtain a series of nine water-soluble chitotriazolan derivatives. The structure and complete conversion of the azide were confirmed by FT-IR and proton NMR spectroscopy. The derivatives were investigated for antibacterial activity against
Language	English
Publishing date	2024-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb15030063
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Article ; Online: Optimizing N,N,N-trimethyl chitosan synthesis: A design of experiments (DoE) approach.

Nagy, Vivien / Snorradóttir, Bergthóra S / Lauzon, Hélène Liette / Másson, Már

Carbohydrate polymers

2024 Volume 335, Page(s) 122065

Abstract: This study aimed to optimize the synthesis of trimethyl chitosan (TMC) with a high degree of N,N,N-trimethylation (DTM) through a one-step procedure, minimizing reagent use, reaction time, and avoiding O-methylation, using the Design of Experiments (DoE) ...

Abstract	This study aimed to optimize the synthesis of trimethyl chitosan (TMC) with a high degree of N,N,N-trimethylation (DTM) through a one-step procedure, minimizing reagent use, reaction time, and avoiding O-methylation, using the Design of Experiments (DoE) approach. Initially, sequential designs were done. Following the determination of the initial conditions a Fractional Factorial Design was used, investigating methyl iodide (MeI) and NaHCO
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2024.122065
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Article ; Online: Anomalous flow below 2700 m in the EPICA Dome C ice core detected using δ 18 O of atmospheric oxygen measurements

A. Tisserand / R. Spahni / L. Panno / J.-M. Barnola / J. Jouzel / V. Masson-Delmotte / G. Durand / B. Lemieux-Dudon / F. Parrenin / G. B. Dreyfus / U. Siegenthaler / M. Leuenberger

Climate of the Past Discussions, Vol 3, Iss 1, Pp 63-

2007 Volume 93

Abstract: ... 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts ...

Abstract	While there are no indications of mixing back to 800 000 years in the EPICA Dome C ice core record, comparison with marine sediment records shows significant differences in the timing and duration of events prior to stage 11 (~430 ka, thousand of years before 1950). A relationship between the isotopic composition of atmospheric oxygen (δ 18 O of O 2 , noted δ 18 O atm ) and daily northern hemisphere summer insolation has been observed for the youngest four climate cycles. Here we use this relationship with new δ 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts the duration of events by up to a factor of 2. By tuning δ 18 O atm to orbital precession we derive a corrected thinning function and present a revised age scale for the interval corresponding to Marine Isotope Stages 11–20 in the EPICA Dome C ice core. Uncertainty in the phasing of δ 18 O atm with respect to insolation variations in the precession band limits the accuracy of this new agescale to ±6 kyr (thousand of years). The previously reported ~30 kyr duration of interglacial stage 11 is unchanged. In contrast, the duration of stage 15.1 is reduced by a factor of 2, from 31 to 16 kyr.
Keywords	Environmental sciences ; GE1-350 ; Geography. Anthropology. Recreation ; G ; DOAJ:Environmental Sciences ; DOAJ:Earth and Environmental Sciences
Subject code	333 ; 290
Language	English
Publishing date	2007-01-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Anomalous flow below 2700 m in the EPICA Dome C ice core detected using δ 18 O of atmospheric oxygen measurements

M. Leuenberger / U. Siegenthaler / A. Tisserand / R. Spahni / L. Panno / J.-M. Barnola / J. Jouzel / V. Masson-Delmotte / G. Durand / B. Lemieux-Dudon / F. Parrenin / G. B. Dreyfus

Climate of the Past, Vol 3, Iss 2, Pp 341-

2007 Volume 353

Abstract: ... 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts ...

Abstract	While there are no indications of mixing back to 800 000 years in the EPICA Dome C ice core record, comparison with marine sediment records shows significant differences in the timing and duration of events prior to stage 11 (~430 ka, thousands of years before 1950). A relationship between the isotopic composition of atmospheric oxygen (δ 18 O of O 2 , noted δ 18 O atm ) and daily northern hemisphere summer insolation has been observed for the youngest four climate cycles. Here we use this relationship with new δ 18 O of O 2 measurements to show that anomalous flow in the bottom 500 m of the core distorts the duration of events by up to a factor of 2. By tuning δ 18 O atm to orbital precession we derive a corrected thinning function and present a revised age scale for the interval corresponding to Marine Isotope Stages 11–20 in the EPICA Dome C ice core. Uncertainty in the phasing of δ 18 O atm with respect to insolation variations in the precession band limits the accuracy of this new agescale to ±6 kyr (thousand of years). The previously reported ~30 kyr duration of interglacial stage 11 is unchanged. In contrast, the duration of stage 15.1 is reduced by a factor of 2, from 31 to 16 kyr.
Keywords	Environmental pollution ; TD172-193.5 ; Environmental protection ; TD169-171.8 ; Environmental sciences ; GE1-350
Subject code	333 ; 290
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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