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Article ; Online: Post-synthetic modification of graphene quantum dots bestows enhanced biosensing and antibiofilm ability: efficiency facet.

Agrawal, Neha / Bhagel, Dolly / Mishra, Priyanka / Prasad, Dipti / Kohli, Ekta

RSC advances

2022 Volume 12, Issue 20, Page(s) 12310–12320

Abstract: Graphene quantum dots (GQDs) are a luminescent class of carbon nanomaterials with a graphene-like core structure, possessing quantum confinement and edge effects. They have gained importance in the biological world due to their inherent biocompatibility, ...

Abstract	Graphene quantum dots (GQDs) are a luminescent class of carbon nanomaterials with a graphene-like core structure, possessing quantum confinement and edge effects. They have gained importance in the biological world due to their inherent biocompatibility, good water dispersibility, excellent fluorescence and photostability. The improved properties of GQDs require the logical enactment of functional groups, which can be easily attained through post-synthetic non-covalent routes of modification. In this regard, the present work has for the first time employed a simple one-pot post-modification method utilizing the salt of amino caproic acid, an FDA approved reagent. The adsorption of the modifier on GQDs with varying weight ratios is characterized through DLS, zeta potential, Raman, absorption and fluorescence spectroscopy. A decrease of 20% in the fluorescence intensity with an increase in the modifier ratio from 1 to 1000 and an increased DLS size as well as zeta potential demonstrate the efficient modification as well as higher stability of the modified GQDs. The modified GQDs with a high weight ratio (1 : 100) of the modifier showed superior ability to sense dopamine, a neurotransmitter, as well as competent biofilm degradation ability. The modified GQDs could sense more efficiently than pristine GQDs, with a sensitivity as low as 0.06 μM (limit of detection) and 90% selectivity in the presence of other neurotransmitters. The linear relationship showed a decrease in the fluorescence intensity with increasing dopamine concentration from 0.0625 μM to 50 μM. Furthermore, the efficiency of the modified GQDs was also assessed in terms of their antibiofilm effect against
Language	English
Publishing date	2022-04-22
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra00494a
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Article ; Online: Cardiovascular involvement in alpha-n-acetyl neuraminidase deficiency syndromes (sialidosis type I and II).

Prasanna, Priyanka / Sriram, Chenni S / Rodriguez, Sarah H / Kohli, Utkarsh

Cardiology in the young

2021 Volume 31, Issue 5, Page(s) 862–864

Abstract: Sialidosis, a rare autosomal recessive disorder, is caused by a deficiency of NEU1 encoded enzyme alpha-N-acetyl neuraminidase. We report a premature male with neonatal-onset type II sialidosis which was associated with left ventricular dysfunction. The ... ...

Abstract	Sialidosis, a rare autosomal recessive disorder, is caused by a deficiency of NEU1 encoded enzyme alpha-N-acetyl neuraminidase. We report a premature male with neonatal-onset type II sialidosis which was associated with left ventricular dysfunction. The clinical presentation and subsequent progression which culminated in his untimely death at 16 months of age are succinctly described. Early-onset cardiovascular involvement as noted in this patient is not well characterised. The case report is supplemented by a comprehensive review of the determinants, characteristics, and the clinical course of cardiovascular involvement in this rare condition.
MeSH term(s)	Humans ; Infant, Newborn ; Male ; Mucolipidoses/complications ; Mucolipidoses/diagnosis ; Mucolipidoses/genetics ; Neuraminidase/genetics ; Syndrome
Chemical Substances	Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1078466-4
ISSN	1467-1107 ; 1047-9511
ISSN (online)	1467-1107
ISSN	1047-9511
DOI	10.1017/S1047951120004953
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Article: Cardiovascular Phenotypic Spectrum of 1p36 Deletion Syndrome.

Kaur, Tripat / Sriram, Chenni S / Prasanna, Priyanka / Kohli, Utkarsh

Journal of pediatric genetics

2021 Volume 12, Issue 4, Page(s) 329–334

Abstract: Chromosome 1p36 deletion syndrome is a common genetic anomaly (prevalence: 1 in 5,000-1 in 10,000). Despite reports of cardiovascular involvement, the cardiovascular phenotypic spectrum of patients with 1p36 deletion syndrome is not well characterized. ... ...

Abstract	Chromosome 1p36 deletion syndrome is a common genetic anomaly (prevalence: 1 in 5,000-1 in 10,000). Despite reports of cardiovascular involvement, the cardiovascular phenotypic spectrum of patients with 1p36 deletion syndrome is not well characterized. In this article, we reported the clinical course of a full-term African American boy with chromosome 1p36 deletion syndrome and neonatal onset of severe cardiac disease with moderate-to-severe biventricular dysfunction and severe pulmonary hypertension. Early neonatal onset presentation of 1p36 deletion syndrome is rare and might be associated with a more guarded prognosis. This case based study is supplemented by a comprehensive review of cardiovascular involvement in this relatively common genetic syndrome.
Language	English
Publishing date	2021-07-29
Publishing country	Germany
Document type	Journal Article
ISSN	2146-4596
ISSN	2146-4596
DOI	10.1055/s-0041-1732473
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Article: Fibrotic interstitial lung disease occurring as sequelae of COVID-19 pneumonia despite concomitant steroids.

Udwadia, Zarir Farokh / Pokhariyal, Priyanka Kisan / Tripathi, Awatansh Kumar Rajkumar / Kohli, Anirudh

Lung India : official organ of Indian Chest Society

2021 Volume 38, Issue Supplement, Page(s) S61–S63

Abstract: A 75-year-old female with no history of lung disease developed severe pulmonary fibrosis within 1 month of acute severe COVID-19 pneumonia. She developed dry basal crackles, hypoxia needing home oxygen, and computed tomography changes which dramatically ... ...

Abstract	A 75-year-old female with no history of lung disease developed severe pulmonary fibrosis within 1 month of acute severe COVID-19 pneumonia. She developed dry basal crackles, hypoxia needing home oxygen, and computed tomography changes which dramatically evolved from acute ground-glass opacities to honeycombing and traction bronchiectasis. Interestingly, these changes occurred despite her being on steroids through most of her hospital stay. She is being commenced on pirfenidone and her responses are carefully monitored, but the role of antifibrotic drugs are unclear and will only be established from large clinical trials.
Language	English
Publishing date	2021-03-16
Publishing country	India
Document type	Case Reports
ZDB-ID	2410801-7
ISSN	0974-598X ; 0970-2113
ISSN (online)	0974-598X
ISSN	0970-2113
DOI	10.4103/lungindia.lungindia_533_20
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Article ; Online: Facial pain and trigeminal neuralgia secondary to metastasis: A case report.

Thomas, Davis C / Singer, Steven R / Kodaganallur Pitchumani, Priyanka / Katzmann, Giannina R / Kohli, Divya

Journal of the American Dental Association (1939)

2021 Volume 153, Issue 5, Page(s) 484–488

Abstract: Background and overview: Trigeminal neuralgia due to a metastatic lesion is a relatively rare occurrence. These cases pose a diagnostic challenge for the clinician due to a complex clinical presentation.: Case description: The authors describe the ... ...

Abstract	Background and overview: Trigeminal neuralgia due to a metastatic lesion is a relatively rare occurrence. These cases pose a diagnostic challenge for the clinician due to a complex clinical presentation. Case description: The authors describe the case of a 65-year-old woman with left-sided facial pain and occasional numbness. The patient also reported autonomic features associated with facial pain, facial muscular weakness, and hearing and visual impairment. The patient's history of breast cancer, for which she was receiving treatment for bone metastasis, warranted diagnostic imaging. Magnetic resonance imaging with and without contrast was performed and revealed a possible metastatic lesion. Conclusions and practical implications: Unusual clinical features must be identified, and prompt appropriate imaging is instrumental in making at an accurate diagnosis and management plan.
MeSH term(s)	Aged ; Facial Pain/etiology ; Female ; Humans ; Magnetic Resonance Imaging ; Trigeminal Neuralgia/complications ; Trigeminal Neuralgia/etiology
Language	English
Publishing date	2021-09-04
Publishing country	England
Document type	Case Reports
ZDB-ID	220622-5
ISSN	1943-4723 ; 0002-8177 ; 1048-6364
ISSN (online)	1943-4723
ISSN	0002-8177 ; 1048-6364
DOI	10.1016/j.adaj.2021.06.011
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Article: Post-synthetic modification of graphene quantum dots bestows enhanced biosensing and antibiofilm ability: efficiency facet

Agrawal, Neha / Bhagel, Dolly / Mishra, Priyanka / Prasad, Dipti / Kohli, Ekta

RSC advances. 2022 Apr. 22, v. 12, no. 20

2022

Abstract	Graphene quantum dots (GQDs) are a luminescent class of carbon nanomaterials with a graphene-like core structure, possessing quantum confinement and edge effects. They have gained importance in the biological world due to their inherent biocompatibility, good water dispersibility, excellent fluorescence and photostability. The improved properties of GQDs require the logical enactment of functional groups, which can be easily attained through post-synthetic non-covalent routes of modification. In this regard, the present work has for the first time employed a simple one-pot post-modification method utilizing the salt of amino caproic acid, an FDA approved reagent. The adsorption of the modifier on GQDs with varying weight ratios is characterized through DLS, zeta potential, Raman, absorption and fluorescence spectroscopy. A decrease of 20% in the fluorescence intensity with an increase in the modifier ratio from 1 to 1000 and an increased DLS size as well as zeta potential demonstrate the efficient modification as well as higher stability of the modified GQDs. The modified GQDs with a high weight ratio (1 : 100) of the modifier showed superior ability to sense dopamine, a neurotransmitter, as well as competent biofilm degradation ability. The modified GQDs could sense more efficiently than pristine GQDs, with a sensitivity as low as 0.06 μM (limit of detection) and 90% selectivity in the presence of other neurotransmitters. The linear relationship showed a decrease in the fluorescence intensity with increasing dopamine concentration from 0.0625 μM to 50 μM. Furthermore, the efficiency of the modified GQDs was also assessed in terms of their antibiofilm effect against Staphylococcus aureus. The unmodified GQDs showed only 10% disruption of the adhered bacterial colonies, while the modified GQDs (1 : 100) showed significantly more than 60% disruption of the biofilm, presenting the competency of the modified GQDs. The unique modifications of GQDs have thus proven to be an effective method for the proficient utilization of zero-dimensional carbon nanomaterials for biosensing, bioimaging, antibacterial and anti-biofilm applications.
Keywords	Staphylococcus aureus ; absorption ; adsorption ; biocompatibility ; biofilm ; bioimaging ; detection limit ; dispersibility ; dopamine ; fluorescence ; fluorescence emission spectroscopy ; graphene ; hexanoic acid ; neurotransmitters ; photostability ; zeta potential
Language	English
Dates of publication	2022-0422
Size	p. 12310-12320.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/d2ra00494a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adequate short- and long-term pain control with non-opiate analgesics after microdirect laryngoscopy.

Bisarya, Priyanka K / Jiang, Roy / Chao, Janet / Narwani, Vishal / Lerner, Michael / Kohli, Nikita

American journal of otolaryngology

2021 Volume 43, Issue 1, Page(s) 103267

Abstract: Objective: In otolaryngology, it is important to minimize the use of opioids for post-operative analgesia given the rise in opioid abuse and mortality due to overdose in the United States. We sought to quantitatively determine the efficacy of non-opiate ...

Abstract	Objective: In otolaryngology, it is important to minimize the use of opioids for post-operative analgesia given the rise in opioid abuse and mortality due to overdose in the United States. We sought to quantitatively determine the efficacy of non-opiate analgesia in postoperative pain management after microdirect laryngoscopy (MDL). Methods: This is a single institution prospective study monitoring post-operative pain using a visual analog scale (VAS, 1-10). Patients with a history of vocal fold lesions, paralysis, and stenosis who underwent MDL were surveyed for one month following their procedure (daily for the first week and weekly thereafter). Student's t-test was used to determine whether short (1 week) and long term (1 month) pain was controlled by over-the-counter (OTC) medications. We defined adequate pain control as an average daily VAS score below 4 for the first 4 days and below 1 in the following 3 weeks and hypothesized that patients would report adequate pain control without the use of opioids. Results: Post-operative pain after MDL was generally mild. The average daily VAS score was 2.16 (95% CI [0.0-5.2], P = 0.0014) in the first 4 days post-procedure and 0.28 (95% CI [0.0-1.3], P = 0.0007) in the 3 weeks post-procedure confirming our hypothesis. On average, patients used 3.14 (CI: [0.0-12.8]) pills of acetaminophen and 0.57 (CI: [0.0-4.7]) pills of an NSAID per day in the first week. Only three patients required opioid analgesia, all of whom used opioids in the first 48 h. Conclusions: OTC analgesics provide sufficient pain control after microdirect laryngoscopy for most patients. Given the potential for substance abuse from opioid medications, this study demonstrates that adequate pain control requires, at most, 48 h of opioid medications. Further study is needed to determine factors that contribute to increased pain after laryngoscopy.
MeSH term(s)	Acetaminophen/therapeutic use ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Female ; Humans ; Laryngoscopy/adverse effects ; Laryngoscopy/methods ; Male ; Middle Aged ; Opioid-Related Disorders/prevention & control ; Pain Management/methods ; Pain Measurement ; Pain, Postoperative/diagnosis ; Pain, Postoperative/drug therapy ; Pain, Postoperative/etiology ; Prospective Studies ; Time Factors
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Acetaminophen (362O9ITL9D)
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2021.103267
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Article: Cardiovascular Phenotypic Spectrum of 1p36 Deletion Syndrome

Kaur, Tripat / Sriram, Chenni S. / Prasanna, Priyanka / Kohli, Utkarsh

Journal of Pediatric Genetics

2021 Volume 12, Issue 04, Page(s) 329–334

Abstract: Chromosome 1p36 deletion syndrome is a common genetic anomaly (prevalence: 1 in 5,000–1 in 10,000). Despite reports of cardiovascular involvement, the cardiovascular phenotypic spectrum of patients with 1p36 deletion syndrome is not well characterized. ... ...

Abstract	Chromosome 1p36 deletion syndrome is a common genetic anomaly (prevalence: 1 in 5,000–1 in 10,000). Despite reports of cardiovascular involvement, the cardiovascular phenotypic spectrum of patients with 1p36 deletion syndrome is not well characterized. In this article, we reported the clinical course of a full-term African American boy with chromosome 1p36 deletion syndrome and neonatal onset of severe cardiac disease with moderate-to-severe biventricular dysfunction and severe pulmonary hypertension. Early neonatal onset presentation of 1p36 deletion syndrome is rare and might be associated with a more guarded prognosis. This case based study is supplemented by a comprehensive review of cardiovascular involvement in this relatively common genetic syndrome.
Keywords	1p36 deletion ; congenital heart disease ; pulmonary hypertension ; noncompaction cardiomyopathy ; dilated cardiomyopathy
Language	English
Publishing date	2021-07-29
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2146-460X ; 2146-4596
ISSN (online)	2146-460X
ISSN	2146-4596
DOI	10.1055/s-0041-1732473
Database	Thieme publisher's database

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Article ; Online: Comparing and Analyzing Applications of Intelligent Techniques in Cyberattack Detection

Priyanka Dixit / Rashi Kohli / Angel Acevedo-Duque / Romel Ramon Gonzalez-Diaz / Rutvij H. Jhaveri

Security and Communication Networks, Vol

2021 Volume 2021

Abstract: Now a day’s advancement in technology increases the use of automation, mobility, smart devices, and application over the Internet that can create serious problems for protection and the privacy of digital data and raised the global security issues. ... ...

Abstract	Now a day’s advancement in technology increases the use of automation, mobility, smart devices, and application over the Internet that can create serious problems for protection and the privacy of digital data and raised the global security issues. Therefore, the necessity of intelligent systems or techniques can prevent and protect the data over the network. Cyberattack is the most prominent problem of cybersecurity and now a challenging area of research for scientists and researchers. These attacks may destroy data, system, and resources and sometimes may damage the whole network. Previously numerous traditional techniques were used for the detection and mitigation of cyberattack, but the techniques are not efficient for new attacks. Today’s machine learning and metaheuristic techniques are popularly applied in different areas to achieve efficient computation and fast processing of complex data of the network. This paper is discussing the improvements and enhancement of security models, frameworks for the detection of cyberattacks, and prevention by using different machine learning and optimization techniques in the domain of cybersecurity. This paper is focused on the literature of different metaheuristic algorithms for optimal feature selection and machine learning techniques for the classification of attacks, and some of the prominent algorithms such as GA, evolutionary, PSO, machine learning, and others are discussed in detail. This study provides descriptions and tutorials that can be referred from various literature citations, references, or latest research papers. The techniques discussed are efficiently applied with high performance for detection, mitigation, and identification of cyberattacks and provide a security mechanism over the network. Hence, this survey presents the description of various existing intelligent techniques, attack datasets, different observations, and comparative studies in detail.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	006
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Amelioration potential of β-pinene on Cr(VI)-induced toxicity on morphology, physiology and ultrastructure of maize.

Mahajan, Priyanka / Sharma, Padma / Singh, Harminder Pal / Rathee, Sonia / Sharma, Mansi / Batish, Daizy Rani / Kohli, Ravinder Kumar

Environmental science and pollution research international

2021 Volume 28, Issue 44, Page(s) 62431–62443

Abstract: Heavy metals' amassment in the soil environment is a threat to crop and agricultural sustainability and consequentially the global food security. For achieving enhancement of crop productivity in parallel to reducing chromium (Cr) load onto food chain ... ...

Abstract	Heavy metals' amassment in the soil environment is a threat to crop and agricultural sustainability and consequentially the global food security. For achieving enhancement of crop productivity in parallel to reducing chromium (Cr) load onto food chain demands continuous investigation and efforts to develop cost-effective strategies for maximizing crop yield and quality. In this context, we investigated the amelioration of Cr(VI) toxicity through β-pinene in experimental dome simulating natural field conditions. The protective role of β-pinene was determined on physiology, morphology and ultrastructure in Zea mays under Cr(VI) stress (250 and 500 μM). Results exhibited a marked reduction in the overall growth (shoot and root length and dry matter) of Z. mays plants subjected to Cr(VI) stress. Photosynthetic pigments (chlorophyll and carotenoids) were evidently reduced, and there was a loss of membrane integrity. Supplementation of β-pinene (100 μM), however, declined the toxicity induced by Cr(VI). Interestingly, Cr-tolerant abilities were improved in relation to plant growth, photosynthetic pigments and membrane integrity with the combined treatment of Cr(VI) and β-pinene. β-Pinene also reduced the root-mediated uptake of Cr(VI) and translocation to shoots. Moreover, significant ultrastructural damages recorded in roots and shoots under Cr(VI) stress were partially reverted upon addition of β-pinene. Our analyses revealed that β-pinene mitigates Cr(VI) toxicity in Z. mays, either by membrane stabilization or serving as a barrier to the uptake of Cr from soil. Thus, exogenous supply of β-pinene can be an effective alternative to mitigate Cr toxicity in soil. However, it is deemed essential to investigate further the responses throughout the life cycle of the plant on β-pinene supplementation under natural conditions.
MeSH term(s)	Antioxidants ; Bicyclic Monoterpenes ; Chromium/analysis ; Chromium/toxicity ; Plant Roots/chemistry ; Soil Pollutants/toxicity ; Zea mays
Chemical Substances	Antioxidants ; Bicyclic Monoterpenes ; Soil Pollutants ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; beta-pinene (4MS8VHZ1HJ)
Language	English
Publishing date	2021-07-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-15018-7
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