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  1. Article ; Online: Current state of therapeutic apheresis and cellular therapy education for transfusion medicine fellows in the United States.

    Pham, Huy P / Tran, Minh-Ha

    Journal of clinical apheresis

    2020  Volume 36, Issue 1, Page(s) 87–93

    Abstract: Background: Numerous conditions are responsive to therapeutic apheresis (TA) and cellular therapy (CT) treatments. Both TA and CT are two broad and diverse knowledge fields within transfusion medicine (TM). We therefore sought to survey all the TM ... ...

    Abstract Background: Numerous conditions are responsive to therapeutic apheresis (TA) and cellular therapy (CT) treatments. Both TA and CT are two broad and diverse knowledge fields within transfusion medicine (TM). We therefore sought to survey all the TM fellowship program directors (PDs) in the United States to examine the current fellow state education in TA and CT.
    Methods: A 37-question survey was sent to all PDs to collect details of TA and CT training for TM fellows.
    Results: Responses from 29/51 (56.9%) surveyed programs were received. Most PDs considered TA and CT training for their fellows more than adequate. Two PDs from programs that did not directly oversee TA and CT services at their training sites stated that their program's training in these two areas were only "slightly adequate" or "moderately inadequate." Detailed analysis of training in TA, cell collection, and CT suggests that trainees from programs with direct oversight of these services had longer training and more learning experiences compared to those in which outside rotations were required.
    Conclusions: Transfusion medicine fellowship training in TA and CT varies. Most respondents, and particularly those from programs directly overseeing TA services, reported their fellows were adequately prepared in TA. Cellular therapy collections and laboratory operations, however, are less consistent areas of training despite the rapid expansion of these fields. Our survey suggests that a greater emphasis in CT training is needed.
    MeSH term(s) Blood Component Removal/methods ; Cell- and Tissue-Based Therapy ; Fellowships and Scholarships ; Hematopoietic Stem Cells/cytology ; Humans ; Transfusion Medicine/education
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Emergency Release Transfusion Practices Provide an Enduring Reminder of Festina Lente-to Make Haste Slowly.

    Pomper, Gregory J / Pham, Huy P / Maracaja, Danielle L V / Fadeyi, Emmanuel A

    American journal of clinical pathology

    2022  Volume 158, Issue 4, Page(s) 445–446

    MeSH term(s) Blood Transfusion ; Erythrocyte Count ; Erythrocytes ; Humans
    Language English
    Publishing date 2022-09-06
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqac085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapeutic Plasma Exchange in Guillain-Barre Syndrome and chronic inflammatory demyelinating polyradiculoneuropathy.

    Pham, Huy P / Schwartz, Joseph

    Presse medicale (Paris, France : 1983)

    2019  Volume 48, Issue 11 Pt 2, Page(s) 338–346

    Abstract: Therapeutic plasma exchange (TPE) has been used as a treatment modality in many autoimmune disorders, including neurological conditions, such as Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The ... ...

    Abstract Therapeutic plasma exchange (TPE) has been used as a treatment modality in many autoimmune disorders, including neurological conditions, such as Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The American Society for Apheresis (ASFA) publishes its guidelines on the use of therapeutic apheresis every 3 years based on published evidence to assist physicians with both the medical and technical aspects of apheresis consults. The ASFA Guidelines included the use of TPE in both GBS and CIDP as an acceptable first-line therapy, either alone and/or in conjunction with other therapeutic modalities. In this article, we briefly reviewed GBS and CIDP, discussed the role of apheresis in these conditions as well as various technical aspects of the TPE procedure, such as apheresis calculation, number of volume exchange, replacement fluid, and management of potential complications.
    MeSH term(s) Guillain-Barre Syndrome/therapy ; Humans ; Plasma Exchange/methods ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/therapy ; Practice Guidelines as Topic
    Language English
    Publishing date 2019-10-31
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2019.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Granulocyte Transfusion: Clinical Updates and a Practical Approach to Transfusion.

    Cohen, Tobias / Simmons, Sierra C / Pham, Huy P / Staley, Elizabeth M

    Clinics in laboratory medicine

    2021  Volume 41, Issue 4, Page(s) 647–657

    Abstract: Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune ... ...

    Abstract Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune function to prevent and/or treat infections in patients with severe neutropenia or neutrophil dysfunction. However, evidence has been largely theoretical, experimental, and/or inconclusive. Clinical efficacy has yet to be confirmed by large-scale randomized controlled clinical trials. Performing such trials has been hampered by low granulocyte collection yield and poor patient accrual. We provide a practical summary of the current literature surrounding the practice of granulocyte transfusion.
    MeSH term(s) Granulocytes ; Humans ; Leukocyte Transfusion ; Neutropenia
    Language English
    Publishing date 2021-09-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2021.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adding neonatal hyperbilirubinemia/bilirubin encephalopathy to the American Society for Apheresis Guidelines on Therapeutic Apheresis.

    Pham, Huy P / Schwartz, Joseph

    Journal of clinical apheresis

    2017  Volume 33, Issue 3, Page(s) 449

    MeSH term(s) Blood Component Removal/methods ; Humans ; Hyperbilirubinemia, Neonatal/therapy ; Infant, Newborn ; Kernicterus/therapy ; Practice Guidelines as Topic
    Language English
    Publishing date 2017-11-27
    Publishing country United States
    Document type Letter
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21608
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cost analysis of the impact of caplacizumab in the treatment of acquired thrombotic thrombocytopenic purpura from a US hospital perspective.

    Pollissard, Laurence / Leinwand, Brian I / Fournier, Marie / Pham, Huy P

    Journal of medical economics

    2021  Volume 24, Issue 1, Page(s) 1178–1184

    Abstract: Aim: This study aimed to model the financial impact of caplacizumab with therapeutic plasma exchange (TPE) + immunosuppression for patients experiencing an acute acquired thrombotic thrombocytopenic purpura (aTTP) episode versus TPE + immunosuppression, ...

    Abstract Aim: This study aimed to model the financial impact of caplacizumab with therapeutic plasma exchange (TPE) + immunosuppression for patients experiencing an acute acquired thrombotic thrombocytopenic purpura (aTTP) episode versus TPE + immunosuppression, from a US hospital's perspective.
    Methods and materials: We developed an economic model to estimate the impact of caplacizumab on a US hospital's budget. Cost offsets from caplacizumab utilization targeted inpatient general ward days, intensive care unit (ICU) days, and TPE utilization. Costs and event probabilities were estimated from primary data analyses of the phase 3 HERCULES trial and peer-reviewed literature or other public sources. Plan reimbursement was obtained from 2019 Medicare Fee Schedules and adjusted to represent reimbursement from different US payers. Cost of ICU and general ward utilization were estimated from Medicare Provider Analysis and Review data analyses capturing hospital discharges.
    Results: The model results indicate that caplacizumab leads to hospitalization cost savings of over $8,000 ($23,148 versus $14,904) along with TPE cost savings of over $14,000 ($37,150 versus $23,033) per patient. When the cost of caplacizumab and plan reimbursement are incorporated into the results, the per-patient cost of TPE + immunosuppression is $23,120 versus $70,068 for caplacizumab with TPE + immunosuppression, an incremental cost of $46,948. The model was robust to several scenario analyses; however, when limited to Medicare fee-for-service (FFS), the incremental cost of caplacizumab per patient was reduced to $4,852 due to add-on payments.
    Conclusions: Caplacizumab with TPE + immunosuppression is associated with an increase in costs; however, the increase is nominal among payers who provide an add-on payment consistent with that of Medicare FFS.
    MeSH term(s) Aged ; Costs and Cost Analysis ; Fibrinolytic Agents/therapeutic use ; Hospitals ; Humans ; Medicare ; Purpura, Thrombotic Thrombocytopenic/drug therapy ; Single-Domain Antibodies ; United States
    Chemical Substances Fibrinolytic Agents ; Single-Domain Antibodies ; caplacizumab (2R27AB6766)
    Language English
    Publishing date 2021-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2021.1992413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: An observational analysis of disease burden in patients with cold agglutinin disease: Results from a large US electronic health record database.

    Pham, Huy P / Wilson, Amanda / Adeyemi, Ayoade / Miles, Gandarvaka / Kuang, Kammy / Carita, Paulo / Joly, Florence

    Journal of managed care & specialty pharmacy

    2022  Volume 28, Issue 12, Page(s) 1419–1428

    Abstract: BACKGROUND: ...

    Abstract BACKGROUND:
    MeSH term(s) Adult ; Humans ; Female ; Male ; Electronic Health Records ; Anemia, Hemolytic, Autoimmune/epidemiology ; Anemia, Hemolytic, Autoimmune/therapy ; Retrospective Studies ; Cost of Illness ; Hemolysis ; Bilirubin
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-11-24
    Publishing country United States
    Document type Observational Study ; Journal Article
    ISSN 2376-1032
    ISSN (online) 2376-1032
    DOI 10.18553/jmcp.2022.28.12.1419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Passenger Lymphocyte Syndrome and Autoimmune Hypothyroidism Following Hematopoietic Stem Cell Transplantation.

    Noubouossie, Denis F / Zaanona, Mohammed I A / Costa, Luciano J / Pham, Huy P / Marques, Marisa B / Di Stasi, Antonio

    Case reports in immunology

    2022  Volume 2022, Page(s) 1690489

    Abstract: We present the case of a 24-year-old male, who received a minor ABO-incompatible allogeneic hematopoietic stem cell transplant (HSCT, blood group ... ...

    Abstract We present the case of a 24-year-old male, who received a minor ABO-incompatible allogeneic hematopoietic stem cell transplant (HSCT, blood group O
    Language English
    Publishing date 2022-06-23
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2695564-7
    ISSN 2090-6617 ; 2090-6609
    ISSN (online) 2090-6617
    ISSN 2090-6609
    DOI 10.1155/2022/1690489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.

    Singer, Michele L / Shin, Mi-Kyung / Kim, Lenise J / Freire, Carla / Aung, O / Pho, Huy / East, Joshua A / Sgambati, Frank P / Latremoliere, Alban / Pham, Luu V / Polotsky, Vsevolod Y

    Frontiers in physiology

    2023  Volume 14, Page(s) 1320151

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1320151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Therapeutic plasma exchange in two patients with stiff-person syndrome.

    Pham, Huy P / Williams, Lance A

    Journal of clinical apheresis

    2016  Volume 31, Issue 5, Page(s) 493–494

    MeSH term(s) Adult ; Female ; Humans ; Middle Aged ; Plasma Exchange ; Stiff-Person Syndrome/therapy
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.21431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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