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  1. Book ; Thesis: Ergebnisse der Zweitbestrahlung von zerebralen Metastasen von malignen Tumoren

    Krebs, Heike

    2003  

    Author's details vorgelegt von Heike Krebs
    Language German
    Size 66 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2003
    HBZ-ID HT014017999
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: The promise of metabolic imaging in diffuse midline glioma.

    Lovibond, Samantha / Gewirtz, Alexandra N / Pasquini, Luca / Krebs, Simone / Graham, Maya S

    Neoplasia (New York, N.Y.)

    2023  Volume 39, Page(s) 100896

    Abstract: Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG) ...

    Abstract Recent insights into histopathological and molecular subgroups of glioma have revolutionized the field of neuro-oncology by refining diagnostic categories. An emblematic example in pediatric neuro-oncology is the newly defined diffuse midline glioma (DMG), H3 K27-altered. DMG represents a rare tumor with a dismal prognosis. The diagnosis of DMG is largely based on clinical presentation and characteristic features on conventional magnetic resonance imaging (MRI), with biopsy limited by its delicate neuroanatomic location. Standard MRI remains limited in its ability to characterize tumor biology. Advanced MRI and positron emission tomography (PET) imaging offer additional value as they enable non-invasive evaluation of molecular and metabolic features of brain tumors. These techniques have been widely used for tumor detection, metabolic characterization and treatment response monitoring of brain tumors. However, their role in the realm of pediatric DMG is nascent. By summarizing DMG metabolic pathways in conjunction with their imaging surrogates, we aim to elucidate the untapped potential of such imaging techniques in this devastating disease.
    MeSH term(s) Humans ; Child ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Glioma/diagnostic imaging ; Glioma/pathology ; Magnetic Resonance Imaging ; Positron-Emission Tomography/methods ; Prognosis
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483840-0
    ISSN 1476-5586 ; 1522-8002
    ISSN (online) 1476-5586
    ISSN 1522-8002
    DOI 10.1016/j.neo.2023.100896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of a workplace physical activity intervention on cognitive determinants of physical activity: a randomized controlled trial.

    Krebs, Simone / Wurst, Ramona / Göhner, Wiebke / Fuchs, Reinhard

    Psychology & health

    2020  Volume 36, Issue 6, Page(s) 629–648

    Abstract: Objective: The present randomized controlled trial evaluated if a workplace physical activity (PA) program that comprises both a PA component and a psychological coaching component (PA + C) is more effective in changing cognitive determinants of PA than ...

    Abstract Objective: The present randomized controlled trial evaluated if a workplace physical activity (PA) program that comprises both a PA component and a psychological coaching component (PA + C) is more effective in changing cognitive determinants of PA than a PA program without coaching component.
    MeSH term(s) Cognition ; Exercise/psychology ; Humans ; Occupational Health ; Program Evaluation ; Workplace
    Language English
    Publishing date 2020-06-16
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 625255-2
    ISSN 1476-8321 ; 0887-0446
    ISSN (online) 1476-8321
    ISSN 0887-0446
    DOI 10.1080/08870446.2020.1780233
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Detecting CXCR4 Expression in Meningioma on

    Krebs, Simone / Schwartz, Jazmin / Grommes, Christian / Young, Robert J / Schöder, Heiko / Mayerhoefer, Marius E

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 64, Issue 4, Page(s) 667–668

    MeSH term(s) Humans ; Gallium Radioisotopes ; Meningioma/diagnostic imaging ; Positron-Emission Tomography ; Peptides, Cyclic/metabolism ; Receptors, CXCR4/metabolism ; Coordination Complexes/metabolism ; Meningeal Neoplasms ; Magnetic Resonance Imaging ; Positron Emission Tomography Computed Tomography
    Chemical Substances 68Ga-pentixafor ; Gallium Radioisotopes ; Peptides, Cyclic ; Receptors, CXCR4 ; Coordination Complexes ; CXCR4 protein, human
    Language English
    Publishing date 2022-11-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of sacrocolpopexy for the management of pelvic organ prolapse on voiding dysfunction and uroflowmetry parameters: a prospective cohort study.

    Aichner, Simone / Fähnle, Ivo / Frey, Janine / Krebs, Jörg / Christmann-Schmid, Corina

    Archives of gynecology and obstetrics

    2022  Volume 306, Issue 4, Page(s) 1373–1380

    Abstract: Purpose: Voiding difficulties in the context of pelvic organ prolapse are often neglected or underestimated. To date, there are heterogeneous data available on the outcome of a surgical correction of pelvic organ prolapse and the impact on concomitant ... ...

    Abstract Purpose: Voiding difficulties in the context of pelvic organ prolapse are often neglected or underestimated. To date, there are heterogeneous data available on the outcome of a surgical correction of pelvic organ prolapse and the impact on concomitant voiding dysfunction. The primary aim of this study was to evaluate whether laparoscopic sacrocolpopexy would resolve preoperative voiding dysfunction and the impact on objective uroflowmetry parameters.
    Methods: Data from 103 women undergoing sacrocolpopexy for prolapse stage ≥ II with concurrent objective and/or subjective voiding dysfunction were prospectively evaluated. All women underwent full urogynecological examination, and completed a validated questionnaire pre- and postoperatively. Objective uroflowmetry parameters and subjective outcome data regarding voiding functions were compared pre- and postoperatively.
    Results: All points of the POP-Q system improved significantly pre- to postoperatively (p < 0.001). Preoperatively, 42 of 103 women showed a postvoid residual ≥ 100 ml, whereas only six women had a relevant postvoid residual postoperatively. In total, the postoperative postvoid residual in all women decreased significantly (p < 0.001). Voiding time decreased significantly postoperatively (p < 0.001) with no significant change in the voided volume (p = 0.352). The maximum flow rate increased postoperatively, reaching no statistically significant change (p = 0.132). Subjective outcome measurements (weak or prolonged stream, incomplete bladder emptying, and straining to void) improved significantly (p < 0.001 for all the questions).
    Conclusion: Our prospective study demonstrates that sacrocolpopexy to correct pelvic organ prolapse can successfully resolve voiding dysfunction, as both objective and subjective parameters improved significantly after surgery.
    MeSH term(s) Female ; Humans ; Pelvic Organ Prolapse/complications ; Pelvic Organ Prolapse/surgery ; Prospective Studies ; Treatment Outcome ; Urinary Retention ; Urination Disorders ; Urologic Surgical Procedures
    Language English
    Publishing date 2022-01-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-021-06369-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Imaging of CAR T-Cells in Cancer Patients: Paving the Way to Treatment Monitoring and Outcome Prediction.

    Krebs, Simone / Ponomarev, Vladimir / Slovin, Susan / Schöder, Heiko

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2019  Volume 60, Issue 7, Page(s) 879–881

    MeSH term(s) Humans ; Immunotherapy, Adoptive ; Molecular Imaging ; Neoplasms/diagnosis ; Neoplasms/diagnostic imaging ; Neoplasms/immunology ; Neoplasms/therapy ; Prognosis ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology ; Treatment Outcome
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2019-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.119.227561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laboratory-Proven Asymptomatic SARS-CoV-2 (COVID-19) Infection on 18F-FDG PET/CT.

    Krebs, Simone / Petkovska, Iva / Ho, Alan L / Ulaner, Gary A

    Clinical nuclear medicine

    2020  Volume 45, Issue 8, Page(s) 654–655

    Abstract: An 87-year-old man with primary salivary duct carcinoma and hepatic metastases was referred for restaging. F-FDG PET/CT demonstrated new FDG-avid ground-glass opacities with intralobular septal thickening in both lungs with a peripheral dominant ... ...

    Abstract An 87-year-old man with primary salivary duct carcinoma and hepatic metastases was referred for restaging. F-FDG PET/CT demonstrated new FDG-avid ground-glass opacities with intralobular septal thickening in both lungs with a peripheral dominant distribution. This was interpreted as a pattern highly suggestive of COVID-19 pneumonia, and the referring physician was contacted. The patient was currently asymptomatic and without clinical evidence of active pneumonia. However, the patient tested positive for COVID-19 using real-time reverse transcription-polymerase chain reaction. This case demonstrates that even asymptomatic outpatients undergoing PET/CT should be evaluated for radiologic findings suggestive of COVID-19 during this pandemic.
    MeSH term(s) Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/diagnostic imaging ; Fluorodeoxyglucose F18 ; Humans ; Laboratories ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnostic imaging ; Positron Emission Tomography Computed Tomography ; SARS-CoV-2 ; Salivary Ducts ; Salivary Gland Neoplasms/complications
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000003141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Positron emission tomography and magnetic resonance imaging in primary central nervous system lymphoma-a narrative review.

    Krebs, Simone / Barasch, Julia G / Young, Robert J / Grommes, Christian / Schöder, Heiko

    Annals of lymphoma

    2021  Volume 5

    Abstract: This review addresses the challenges of primary central nervous system (CNS) lymphoma diagnosis, assessment of treatment response, and detection of recurrence. Primary CNS lymphoma is a rare form of extra-nodal non-Hodgkin lymphoma that can involve brain, ...

    Abstract This review addresses the challenges of primary central nervous system (CNS) lymphoma diagnosis, assessment of treatment response, and detection of recurrence. Primary CNS lymphoma is a rare form of extra-nodal non-Hodgkin lymphoma that can involve brain, spinal cord, leptomeninges, and eyes. Primary CNS lymphoma lesions are most commonly confined to the white matter or deep cerebral structures such as basal ganglia and deep periventricular regions. Contrast-enhanced magnetic resonance imaging (MRI) is the standard diagnostic modality employed by neuro-oncologists. MRI often shows common morphological features such as a single or multiple uniformly well-enhancing lesions without necrosis but with moderate surrounding edema. Other brain tumors or inflammatory processes can show similar radiological patterns, making differential diagnosis difficult. [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET) has selected utility in cerebral lymphoma, especially in diagnosis. Primary CNS lymphoma can sometimes present with atypical findings on MRI and FDG PET, such as disseminated disease, non-enhancing or ring-like enhancing lesions. The complementary strengths of PET and MRI have led to the development of combined PET-MR systems, which in some cases may improve lesion characterization and detection. By highlighting active developments in this field, including advanced MRI sequences, novel radiotracers, and potential imaging biomarkers, we aim to spur interest in sophisticated imaging approaches.
    Language English
    Publishing date 2021-06-30
    Publishing country China
    Document type Journal Article
    DOI 10.21037/aol-20-52
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interim Analysis of a Prospective Validation of 2 Blood-Based Genomic Assessments (PPQ and NETest) to Determine the Clinical Efficacy of

    Bodei, Lisa / Raj, Nitya / Do, Richard K / Mauguen, Audrey / Krebs, Simone / Reidy-Lagunes, Diane / Schöder, Heiko

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 64, Issue 4, Page(s) 567–573

    Abstract: Reliable biomarkers for neuroendocrine tumor (NET) management during peptide receptor radionuclide therapy (PRRT) are lacking. We validated the role of 2 circulating biomarkers: the PRRT prediction quotient (PPQ) as a predictive marker for response and ... ...

    Abstract Reliable biomarkers for neuroendocrine tumor (NET) management during peptide receptor radionuclide therapy (PRRT) are lacking. We validated the role of 2 circulating biomarkers: the PRRT prediction quotient (PPQ) as a predictive marker for response and the NETest as a monitoring biomarker. Furthermore, we evaluated whether tissue-based genetic alterations are effective in predicting progression-free survival (PFS).
    MeSH term(s) Humans ; Female ; Aged ; Male ; Neuroendocrine Tumors/genetics ; Neuroendocrine Tumors/radiotherapy ; Neuroendocrine Tumors/drug therapy ; Treatment Outcome ; Somatostatin/therapeutic use ; Genomics ; Octreotide/therapeutic use ; Organometallic Compounds/therapeutic use
    Chemical Substances copper dotatate CU-64 ; Somatostatin (51110-01-1) ; Octreotide (RWM8CCW8GP) ; Organometallic Compounds
    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.264363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: TriDFusion (3DF) image viewer.

    Lafontaine, Daniel / Schmidtlein, C Ross / Kirov, Assen / Reddy, Ryan P / Krebs, Simone / Schöder, Heiko / Humm, John L

    EJNMMI physics

    2022  Volume 9, Issue 1, Page(s) 72

    Abstract: Background: An open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with several tools not available in ... ...

    Abstract Background: An open-source, extensible medical viewing platform is described, called the TriDFusion image viewer (3DF). The 3DF addresses many broad unmet needs in nuclear medicine research; it provides a viewer with several tools not available in commercial nuclear medicine workstations, yet invaluable for imaging in research studies.
    Results: The 3DF includes an image integration platform to register images from multiple imaging modalities together with delineated volumes of interest (VOIs), structures and dose distributions. It can process images from different vendors' systems and is therefore vendor neutral. The 3DF also provides a convenient tool for performing multi-modality image analysis and fusion. The functional components currently being distributed is open-source code that includes: (1) a high quality viewer that can display axial, coronal, and sagittal tomographic images, maximum intensity projection images, structure contours, and isointensity contour lines or dose colorwash, (2) multi-image fusion allowing multiple images to be fused with VOI and dose distributions, (3) a suite of segmentation tools to edit and/or create tumor and organ VOIs, (4) dosimetry tools for several radioisotopes, (5) clinical tools for correcting acquisition errors, including patient orientation, and (6) the ability to save the resultant image and VOI as DICOM files or to export the numerical results as comma separated values files. Because the code is written in MATLAB™, it is highly readable and is easier for the coder to make changes compared to languages such as C or C++. In what follows, we describe the content of the new TriDFusion (3DF) image viewer software platform using examples of a number of clinical research workflows. Such examples vary in complexity but illustrate the main attributes of the software.
    Conclusions: In summary, 3DF provides a powerful, convenient, easy-to-use suite of open-source imaging research tools for the nuclear medicine community that allows physicians, medical physicists, and academic researchers to display, manipulate, and analyze images.
    Language English
    Publishing date 2022-10-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-022-00501-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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