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  1. Article ; Online: [No title information]

    Sipka, Sándor

    Orvosi hetilap

    2024  Volume 165, Issue 9, Page(s) 358–359

    Title translation RAGÁLY – 2019. Orvos írók Dekameronja járvány idején (Szerk.: Brenyó József).
    MeSH term(s) Humans ; Epidemics ; Medical Writing
    Language Hungarian
    Publishing date 2024-03-03
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2024.9M
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  2. Article ; Online: Dr. Csaba Béla (1931–2022).

    Sipka, Sándor

    Orvosi hetilap

    2022  Volume 163, Issue 52, Page(s) 2093

    Title translation Dr. Béla Csaba (1931-2022).
    Language Hungarian
    Publishing date 2022-12-25
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2022.HO2740
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  3. Article ; Online: Radiation-Detoxified Form of Endotoxin Effectively Activates Th

    Bácsi, Attila / Ágics, Beatrix / Pázmándi, Kitti / Kocsis, Béla / Sándor, Viktor / Bertók, Lóránd / Bruckner, Geza / Sipka, Sándor

    International journal of molecular sciences

    2024  Volume 25, Issue 3

    Abstract: Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study aimed to ... ...

    Abstract Urbanization with reduced microbial exposure is associated with an increased burden of asthma and atopic symptoms. Conversely, environmental exposure to endotoxins in childhood can protect against the development of allergies. Our study aimed to investigate whether the renaturation of the indoor environment with aerosolized radiation-detoxified lipopolysaccharide (RD-LPS) has a preventative effect against the development of ragweed-induced Th
    MeSH term(s) Mice ; Humans ; Animals ; Endotoxins/pharmacology ; Lipopolysaccharides/pharmacology ; Ambrosia ; Th2 Cells ; Hypersensitivity ; Inflammation ; Mice, Inbred BALB C ; Ovalbumin/pharmacology ; Dendritic Cells
    Chemical Substances Endotoxins ; Lipopolysaccharides ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2024-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25031581
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  4. Article ; Online: Age-dependent possible role of contact-activated blood coagulation factor XII as a potential contributor to the “bradykinin storm” in COVID-19 patients

    Sipka, Sándor / Tóth, Attila / Sipka, Sándor

    Orvosi hetilap

    2020  Volume 161, Issue 50, Page(s) 2099–2103

    Title translation A felületaktivált XII-es véralvadási faktor életkortól függő lehetséges szerepe a "bradikininvihar" kialakításában COVID-19-betegekben.
    MeSH term(s) Age Factors ; Aged ; Angiotensin-Converting Enzyme Inhibitors ; Betacoronavirus ; Bradykinin ; COVID-19 ; Complement C1 Inhibitor Protein ; Endothelial Cells ; Factor XIIa ; Humans ; SARS-CoV-2
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Complement C1 Inhibitor Protein ; Factor XIIa (EC 3.4.21.38) ; Bradykinin (S8TIM42R2W)
    Language Hungarian
    Publishing date 2020-12-13
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2020.32075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Precíziós és perszonalizált medicina.

    Sipka, Sándor

    Orvosi hetilap

    2016  Volume 157, Issue 44, Page(s) 1739–1741

    Abstract: The author describes the concept of "personalized medicine" and the newly introduced "precision medicine". "Precision medicine" applies the terms of "phenotype", "endotype" and "biomarker" in order to characterize more precisely the various diseases. ... ...

    Title translation Precision and personalized medicine.
    Abstract The author describes the concept of "personalized medicine" and the newly introduced "precision medicine". "Precision medicine" applies the terms of "phenotype", "endotype" and "biomarker" in order to characterize more precisely the various diseases. Using "biomarkers" the homogeneous type of a disease (a "phenotype") can be divided into subgroups called "endotypes" requiring different forms of treatment and financing. The good results of "precision medicine" have become especially apparent in relation with allergic and autoimmune diseases. The application of this new way of thinking is going to be necessary in Hungary, too, in the near future for participants, controllers and financing boards of healthcare. Orv. Hetil., 2016, 157(44), 1739-1741.
    MeSH term(s) Delivery of Health Care ; Genome, Human ; Humans ; Precision Medicine ; Risk Assessment
    Language Hungarian
    Publishing date 2016-10
    Publishing country Hungary
    Document type Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2016.30564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Az allergia laboratóriumi diagnosztikájának rövid hazai története, a jelen lehetőségei és a jövő perspektívája.

    Sipka, Sándor

    Orvosi hetilap

    2015  Volume 156, Issue 32, Page(s) 1275–1280

    Abstract: Up to know the indications for the optimal applications of laboratory diagnosis of allergic diseases have become widely known. Measurements of allergy specific IgE and various tests of cell mediated immunity are included in the practice. It can be stated ...

    Title translation Short history of laboratory diagnostics of allergy in Hungary, current possibilities and future perspectives.
    Abstract Up to know the indications for the optimal applications of laboratory diagnosis of allergic diseases have become widely known. Measurements of allergy specific IgE and various tests of cell mediated immunity are included in the practice. It can be stated that measurements of total serum IgE and allergen specific IgE (kU/l and RAST classes) can be maintained further in the Hungarian practice with the expected continuous participation of all laboratories in the external quality control program (QualiCont). However, it is also apparent that regional introduction of the urgent "molecular (component) based allergy diagnostics" has become necessary for efficient allergen specific immunotherapy in Hungary. In cases of the allergen specific cell mediated immunologic reactions, allergen induced cell proliferation and cytokine release measurements are recommended. However, it is also obvious that application of these measurements in clinical practice need correct financial support from health care authorities.
    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Hungary ; Hypersensitivity/diagnosis ; Hypersensitivity/history ; Hypersensitivity/immunology ; Hypersensitivity, Delayed/diagnosis ; Hypersensitivity, Delayed/immunology ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/immunology ; Immunoglobulin E/blood ; Immunologic Tests/history ; Immunologic Tests/standards ; Immunologic Tests/trends ; Laboratory Proficiency Testing
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language Hungarian
    Publishing date 2015-08-09
    Publishing country Hungary
    Document type English Abstract ; Historical Article ; Journal Article ; Review
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2015.30223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Standardized data on the incidence and mortality of female and male breast cancers in Hungary between 2000 and 2016.

    Béres, Edit / Nagy, János / Tóth, Judit / Árkosy, Péter / Sipka, Sándor

    Orvosi hetilap

    2022  Volume 163, Issue 5, Page(s) 181–186

    Title translation A női és a férfiemlőrák standardizált incidencia- és mortalitásadatai Magyarországon 2000 és 2016 között.
    MeSH term(s) Breast Neoplasms/epidemiology ; Female ; Humans ; Hungary/epidemiology ; Incidence ; Male ; Prevalence ; Registries
    Language Hungarian
    Publishing date 2022-01-30
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 123879-6
    ISSN 1788-6120 ; 0030-6002
    ISSN (online) 1788-6120
    ISSN 0030-6002
    DOI 10.1556/650.2022.32344
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  8. Article ; Online: Adenosine inhibits the release of arachidonic acid in activated human peripheral mononuclear cells. A proposed model for physiologic and pathologic regulation in systemic lupus erythematosus.

    Sipka, Sándor

    TheScientificWorldJournal

    2011  Volume 11, Page(s) 972–980

    Abstract: In the current work, the pathways are presented and reviewed showing how adenosine acts on the production and release of arachidonic acid (AA) in activated human monocytes by the involvement of various phospholipase A2 (PLA2) and protein kinase C (PKC) ... ...

    Abstract In the current work, the pathways are presented and reviewed showing how adenosine acts on the production and release of arachidonic acid (AA) in activated human monocytes by the involvement of various phospholipase A2 (PLA2) and protein kinase C (PKC) enzymes in physiological (normal) conditions and in a pathologic state in systemic lupus erythematosus (SLE). Two molecules of activated monocytes mainly determine the actual amounts of AA released: (1) interleukin-1 beta (IL-1 beta) increasing and (2) adenosine (Ado) suppressing this process. The AA production of monocytes mainly depends on two (IV and VI) types of PLA2 enzymes. PKC alpha phosphorylates the cytosolic, Ca2+-dependent and steroid-sensitive PLA2 (type IV), whereas PKC delta phosphorylates the Ca2+-independent PLA2 (type VI). By the suppression of IL-1 beta production in the activated human monocytes, adenosine can decrease the release of AA causing a diminished phosphorylation of both PKC isoenzymes. In SLE monocytes, the disease-specific decreased release of AA that we found earlier could be related to the decreased expression of PKC delta. These pathways are summarized in a proposed model.
    MeSH term(s) Adenosine/chemistry ; Adenosine/metabolism ; Adenosine/physiology ; Arachidonic Acid/biosynthesis ; Arachidonic Acid/metabolism ; Arachidonic Acid/physiology ; Humans ; Interleukin-1beta/metabolism ; Interleukin-1beta/physiology ; Lupus Erythematosus, Systemic/metabolism ; Models, Biological ; Monocytes, Activated Killer/metabolism ; Protein Kinase C/metabolism ; Protein Kinase C/physiology
    Chemical Substances Interleukin-1beta ; Arachidonic Acid (27YG812J1I) ; Protein Kinase C (EC 2.7.11.13) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2011-04-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2075968-X
    ISSN 1537-744X ; 1537-744X
    ISSN (online) 1537-744X
    ISSN 1537-744X
    DOI 10.1100/tsw.2011.88
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  9. Article ; Online: The role of protein kinase C isoenzymes in the pathogenesis of human autoimmune diseases.

    Sipka, Sándor / Bíró, Tamás / Czifra, Gabriella / Griger, Zoltán / Gergely, Pál / Brugós, Boglárka / Tarr, Tünde

    Clinical immunology (Orlando, Fla.)

    2022  Volume 241, Page(s) 109071

    Abstract: The physiological role of protein kinase C (PKC) enzymes in the immune system is presented briefly. From earlier publications of others data were collected how the defects of one/two isoenzymes of PKC system suggested their involvement in the ... ...

    Abstract The physiological role of protein kinase C (PKC) enzymes in the immune system is presented briefly. From earlier publications of others data were collected how the defects of one/two isoenzymes of PKC system suggested their involvement in the pathogenesis of human autoimmune diseases. Our observations on the defects of seven PKC isoenzymes in the peripheral blood mononuclear cells (PBMC) demonstrate that these molecular impairments are not prerequisits of the pathogenesis of systemic lupus erythematosus (SLE), mixed connective tissue disease and Sjögren's syndrome. However, these defects can modulate the disease activity and symptoms especially in SLE by several pathways. The role of PKC system in other forms of autoimmune diseases is also very small. It was of note that we detected decreased expression of PKC isoenzymes in PBMC of a European white family with an X-linked genetic background showing seasonal undulations in the lupus patient and also in her healthy mother.
    MeSH term(s) Autoimmune Diseases/etiology ; Female ; Humans ; Isoenzymes/genetics ; Leukocytes, Mononuclear/metabolism ; Lupus Erythematosus, Systemic/metabolism ; Protein Kinase C ; Sjogren's Syndrome/genetics
    Chemical Substances Isoenzymes ; Protein Kinase C (EC 2.7.11.13)
    Language English
    Publishing date 2022-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2022.109071
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  10. Article ; Online: The Hardness of Drinking Water Negatively while Socio-Economic Deprivation Positively Correlate with the Age-Adjusted Mortality Rates due to Cardiovascular Diseases in Hungarian Wine Regions.

    Nagy, János / Sipka, Sándor / SipkaJr, Sándor / Kocsis, Judit / Horváth, Zsolt

    International journal of environmental research and public health

    2019  Volume 16, Issue 18

    Abstract: We compared the age-adjusted death rates (AADR) for cardiovascular diseases (CVD) among 206,159 inhabitants analyzed between 2000 and 2010 in four wine territories of Hungary: Tokaj (white wines), Eger (mostly red wines), Balaton (mostly white wines), ... ...

    Abstract We compared the age-adjusted death rates (AADR) for cardiovascular diseases (CVD) among 206,159 inhabitants analyzed between 2000 and 2010 in four wine territories of Hungary: Tokaj (white wines), Eger (mostly red wines), Balaton (mostly white wines), Szekszárd-Villány (mostly red wines) and Hódmezővásárhely (HMV) (not a wine region). The mortality rates were also assessed from the aspects of total hardness of drinking water and index of socio-economic deprivation (ID). We found the highest cardiovascular mortality in the Tokaj region and HMV. On the other hand, lower numbers of CVD were observed in Szekszárd-Villány, Balaton and Eger. These findings on cardiovascular mortality correlated negatively and significantly with the values of total hardness of drinking waters, which were low in Tokaj and HMV. They were higher in Szekszárd-Villány, Balaton and Eger. Additionally, and surprisingly, the mortality of CVD correlated positively and significantly with the ID values despite of the small numeric differences. The hardness of drinking water and the level of socio-economic state seem to have a greater impact on the mortality rate of CVD than the consumption of "red" or "white" dominant types of wines at a region. This study shows data on a population larger than 200,000 persons.
    MeSH term(s) Cardiovascular Diseases/mortality ; Drinking Water/chemistry ; Hardness ; Humans ; Hungary/epidemiology ; Socioeconomic Factors ; Wine
    Chemical Substances Drinking Water
    Language English
    Publishing date 2019-09-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph16183437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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