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Article ; Online: IgG anti-spike antibody levels in healthcare workers with and without prior COVID-19 up to 3 months after BNT162b2 vaccination.

Van Elslande, Jan / Weemaes, Matthias / Godderis, Lode / Van Pottelbergh, Gijs / Bossuyt, Xavier / Vermeersch, Pieter

Diagnostic microbiology and infectious disease

2022 Volume 102, Issue 4, Page(s) 115638

Abstract: We report IgG anti-spike levels up to 3 months after vaccination with 2 doses of BNT162b2 mRNA vaccine in healthcare workers (HCW). The antibody response was significantly stronger in previously infected vaccinated HCW compared to uninfected HCW, and ... ...

Abstract	We report IgG anti-spike levels up to 3 months after vaccination with 2 doses of BNT162b2 mRNA vaccine in healthcare workers (HCW). The antibody response was significantly stronger in previously infected vaccinated HCW compared to uninfected HCW, and stronger after vaccination compared to (mostly) mild natural infection.
MeSH term(s)	Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Personnel ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin G ; Vaccines, Synthetic ; mRNA Vaccines ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-01-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115638
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Article ; Online: High anion gap metabolic acidosis caused by D-lactate: mind the time of blood collection.

Weemaes, Matthias / Hiele, Martin / Vermeersch, Pieter

Biochemia medica

2019 Volume 30, Issue 1, Page(s) 11001

Abstract: Introduction: D-lactic acidosis is an uncommon cause of high anion gap acidosis.: Materials and methods: A 35-year old woman was admitted to the emergency room with somnolence, drowsiness, dizziness, incoherent speech and drunk appearance. Her past ... ...

Abstract	Introduction: D-lactic acidosis is an uncommon cause of high anion gap acidosis. Materials and methods: A 35-year old woman was admitted to the emergency room with somnolence, drowsiness, dizziness, incoherent speech and drunk appearance. Her past medical history included a Roux-en-Y bypass. Point-of-care venous blood analysis revealed a high anion gap acidosis. Based on the clinical presentation, routine laboratory results and negative toxicology screening, D-lactate and 5-oxoprolinuria were considered as the most likely causes of the high anion gap acidosis. Urine organic acid analysis revealed increased lactate, but no 5-oxoproline. Plasma D-lactate was < 1.0 mmol/L and could not confirm D-lactic acidosis. What happened: Further investigation revealed that the blood sample for D-lactate was drawn 12 hours after admission, which might explain the false-negative result. Data regarding the half-life of D-lactate are, however, scarce. During a second admission, one month later, D-lactic acidosis could be confirmed with an anion gap of 40.7 mmol/L and a D-lactate of 21.0 mmol/L measured in a sample collected at the time of admission. Main lesson: The time of blood collection is of utmost importance to establish the diagnosis of D-lactic acidosis due to the fast clearance of D-lactate in the human body.
MeSH term(s)	Acidosis/diagnosis ; Acidosis, Lactic/diagnosis ; Adult ; False Positive Reactions ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Lactic Acid/blood ; Lactic Acid/urine ; Pre-Analytical Phase
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2019-12-15
Publishing country	Croatia
Document type	Case Reports
ZDB-ID	1208725-7
ISSN	1846-7482 ; 1330-0962
ISSN (online)	1846-7482
ISSN	1330-0962
DOI	10.11613/BM.2020.011001
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Article ; Online: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2.

Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

Clinical chemistry and laboratory medicine

2020 Volume 58, Issue 10, Page(s) e197–e199

MeSH term(s)	Adult ; Antibodies, Viral/blood ; Betacoronavirus/immunology ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/trends ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Female ; Humans ; Male ; Pandemics ; Plasma/chemistry ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Sensitivity and Specificity
Chemical Substances	Antibodies, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	Germany
Document type	Letter
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0817
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Article ; Online: Implementation of a care pathway based computerized order entry system streamlines test ordering and offers tools for benchmarking clinical practice

Matthias Weemaes / Jeroen Appermont / Joris Welkenhuysen / Ivo Salden / Peter Leemans / Nicole De Wel / Katja Vanoosterwijck / Jef Vanderoost / Herman Arnauts / Leen Antonio / Brigitte Decallonne / Dirk Vanderschueren / Chantal Mathieu / Marc Van Ranst / Florent Vanstapel / Ann Verdonck

Informatics in Medicine Unlocked, Vol 41, Iss , Pp 101308- (2023)

2023

Abstract: Background and aims: This is a narrative report on the development of specifications and of the stepwise implementation of a computerized physician order entry system (CPOE) in the University Hospitals Leuven, based on order sets integrated in care ... ...

Abstract	Background and aims: This is a narrative report on the development of specifications and of the stepwise implementation of a computerized physician order entry system (CPOE) in the University Hospitals Leuven, based on order sets integrated in care pathways. Integration of the CPOE into the electronic health record optimally supports those care pathways. Materials and methods: We investigated adherence to consensus-based use of laboratory tests. We analysed data post- versus pre-implementation test requests for departments selected to cover various patient populations, using the Mann-Whitney U test corrected for the False Discovery Rate. Results: We investigated the effect on the number of tests post- versus pre-implementation. In the emergency and inpatient wards, the CPOE implementation resulted in decreases in requests for uric acid, total protein, direct bilirubin, reticulocyte count, and increases in requests for albumin, glucose and calcium. In the outpatient clinics, where the medical specialties already used non-computerized consensus-based test requesting strategies, effects on the number of requested tests were marginal. In all settings, operational improvements could be inferred: the centrally managed CPOE system resulted in fast and well-controlled management of test strategies, digital traceability of the laboratory test requesting process, automatic archiving of requests, assurance of availability of obligatory information. Conclusions: Overall, test requesting strategies improved towards more consensus-based and operational benefits resulted in time gains and improved efficiency of time spend.
Keywords	Critical pathways ; Diagnostic tests ; Evidence-based practice ; Medical order entry systems ; Practice patterns ; physicians ; Utilization review ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	690
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2

Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

Clin Chem Lab Med

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #632974
Database	COVID19

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Article ; Online: Comparison of the diagnostic performance with whole blood and plasma of four rapid antibody tests for SARS-CoV-2

Decru, Bram / Van Elslande, Jan / Weemaes, Matthias / Houben, Els / Empsen, Ine / André, Emmanuel / Van Ranst, Marc / Lagrou, Katrien / Vermeersch, Pieter

Clinical Chemistry and Laboratory Medicine (CCLM)

2020 Volume 58, Issue 10, Page(s) e197–e199

Keywords	Clinical Biochemistry ; Biochemistry, medical ; General Medicine ; covid19
Publisher	Walter de Gruyter GmbH
Publishing country	de
Document type	Article ; Online
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2020-0817
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks.

Cuypers, Lize / Keyaerts, Els / Hong, Samuel Leandro / Gorissen, Sarah / Menezes, Soraya Maria / Starick, Marick / Van Elslande, Jan / Weemaes, Matthias / Wawina-Bokalanga, Tony / Marti-Carreras, Joan / Vanmechelen, Bert / Van Holm, Bram / Bloemen, Mandy / Dogne, Jean-Michel / Dufrasne, François / Durkin, Keith / Ruelle, Jean / De Mendonca, Ricardo / Wollants, Elke /

Vermeersch, Pieter / Boulouffe, Caroline / Djiena, Achille / Broucke, Caroline / Catry, Boudewijn / Lagrou, Katrien / Van Ranst, Marc / Neyts, Johan / Baele, Guy / Maes, Piet / André, Emmanuel / Dellicour, Simon / Van Weyenbergh, Johan

Nature aging

2023 Volume 3, Issue 6, Page(s) 722–733

Abstract: Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large ... ...

Abstract	Coronavirus Disease 2019 (COVID-19) vaccination has resulted in excellent protection against fatal disease, including in older adults. However, risk factors for post-vaccination fatal COVID-19 are largely unknown. We comprehensively studied three large nursing home outbreaks (20-35% fatal cases among residents) by combining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) aerosol monitoring, whole-genome phylogenetic analysis and immunovirological profiling of nasal mucosa by digital nCounter transcriptomics. Phylogenetic investigations indicated that each outbreak stemmed from a single introduction event, although with different variants (Delta, Gamma and Mu). SARS-CoV-2 was detected in aerosol samples up to 52 d after the initial infection. Combining demographic, immune and viral parameters, the best predictive models for mortality comprised IFNB1 or age, viral ORF7a and ACE2 receptor transcripts. Comparison with published pre-vaccine fatal COVID-19 transcriptomic and genomic signatures uncovered a unique IRF3 low/IRF7 high immune signature in post-vaccine fatal COVID-19 outbreaks. A multi-layered strategy, including environmental sampling, immunomonitoring and early antiviral therapy, should be considered to prevent post-vaccination COVID-19 mortality in nursing homes.
MeSH term(s)	Humans ; Aged ; Phylogeny ; COVID-19/epidemiology ; SARS-CoV-2/genetics ; Nursing Homes ; Vaccination ; Disease Outbreaks/prevention & control
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	2662-8465
ISSN (online)	2662-8465
DOI	10.1038/s43587-023-00421-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laboratory information system requirements to manage the COVID-19 pandemic: A report from the Belgian national reference testing center.

Journal of the American Medical Informatics Association : JAMIA

2020 Volume 27, Issue 8, Page(s) 1293–1299

Abstract: Objective: The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease 2019 ( ... ...

Abstract	Objective: The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease 2019 (COVID-19) pandemic. Materials and methods: Our large (>12 000 000 tests/y) academic hospital laboratory is the Belgian National Reference Center for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We have performed a moving total of >25 000 SARS-CoV-2 polymerase chain reaction tests in parallel to standard routine testing since the start of the outbreak. A LIS implementation team dedicated to develop tools to remove the bottlenecks, primarily situated in the pre- and postanalytical phases, was established early in the crisis. Results: We outline the design, implementation, and requirements of LIS functionality related to managing increased test demand during the COVID-19 crisis, including tools for test ordering, standardized order sets integrated into a computerized provider order entry module, notifications on shipping requirements, automated triaging based on digital metadata forms, and the establishment of databases with contact details of other laboratories and primary care physicians to enable automated reporting. We also describe our approach to data mining and reporting of actionable daily summary statistics to governing bodies and other policymakers. Conclusions: Rapidly developed, agile extendable LIS functionality and its meaningful use alleviates the administrative burden on laboratory personnel and improves turnaround time of SARS-CoV-2 testing. It will be important to maintain an environment that is conducive for the rapid adoption of meaningful LIS tools after the COVID-19 crisis.
MeSH term(s)	Academic Medical Centers ; Belgium ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Change Management ; Clinical Laboratory Information Systems ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Evidence-Based Medicine ; Humans ; Laboratories, Hospital/organization & administration ; Meaningful Use ; Medical Order Entry Systems ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1093/jamia/ocaa081
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Article ; Online: Laboratory information system requirements to manage the COVID-19 pandemic

Journal of the American Medical Informatics Association

A report from the Belgian national reference testing center

2020 Volume 27, Issue 8, Page(s) 1293–1299

Abstract: Abstract Objective The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease ...

Abstract	Abstract Objective The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease 2019 (COVID-19) pandemic. Materials and Methods Our large (>12 000 000 tests/y) academic hospital laboratory is the Belgian National Reference Center for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We have performed a moving total of >25 000 SARS-CoV-2 polymerase chain reaction tests in parallel to standard routine testing since the start of the outbreak. A LIS implementation team dedicated to develop tools to remove the bottlenecks, primarily situated in the pre- and postanalytical phases, was established early in the crisis. Results We outline the design, implementation, and requirements of LIS functionality related to managing increased test demand during the COVID-19 crisis, including tools for test ordering, standardized order sets integrated into a computerized provider order entry module, notifications on shipping requirements, automated triaging based on digital metadata forms, and the establishment of databases with contact details of other laboratories and primary care physicians to enable automated reporting. We also describe our approach to data mining and reporting of actionable daily summary statistics to governing bodies and other policymakers. Conclusions Rapidly developed, agile extendable LIS functionality and its meaningful use alleviates the administrative burden on laboratory personnel and improves turnaround time of SARS-CoV-2 testing. It will be important to maintain an environment that is conducive for the rapid adoption of meaningful LIS tools after the COVID-19 crisis.
Keywords	covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	1205156-1
ISSN	1527-974X ; 1067-5027
ISSN (online)	1527-974X
ISSN	1067-5027
DOI	10.1093/jamia/ocaa081
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Laboratory information system requirements to manage the COVID-19 pandemic: A report from the Belgian national reference testing center

J Am Med Inform Assoc

Abstract: OBJECTIVE: The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease 2019 ( ... ...

Abstract	OBJECTIVE: The study sought to describe the development, implementation, and requirements of laboratory information system (LIS) functionality to manage test ordering, registration, sample flow, and result reporting during the coronavirus disease 2019 (COVID-19) pandemic. MATERIALS AND METHODS: Our large (>12 000 000 tests/y) academic hospital laboratory is the Belgian National Reference Center for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We have performed a moving total of >25 000 SARS-CoV-2 polymerase chain reaction tests in parallel to standard routine testing since the start of the outbreak. A LIS implementation team dedicated to develop tools to remove the bottlenecks, primarily situated in the pre- and postanalytical phases, was established early in the crisis. RESULTS: We outline the design, implementation, and requirements of LIS functionality related to managing increased test demand during the COVID-19 crisis, including tools for test ordering, standardized order sets integrated into a computerized provider order entry module, notifications on shipping requirements, automated triaging based on digital metadata forms, and the establishment of databases with contact details of other laboratories and primary care physicians to enable automated reporting. We also describe our approach to data mining and reporting of actionable daily summary statistics to governing bodies and other policymakers. CONCLUSIONS: Rapidly developed, agile extendable LIS functionality and its meaningful use alleviates the administrative burden on laboratory personnel and improves turnaround time of SARS-CoV-2 testing. It will be important to maintain an environment that is conducive for the rapid adoption of meaningful LIS tools after the COVID-19 crisis.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #141775
Database	COVID19

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