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  1. Article: Labrune syndrome: A unique leukoencephalopathy.

    Pahuja, Leena / Patras, Elisheba / Sureshbabu, Sachin / Parkhe, Nittin / Khanna, Laxmi

    Annals of Indian Academy of Neurology

    2015  Volume 20, Issue 1, Page(s) 59–61

    Language English
    Publishing date 2015-10-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/0972-2327.192386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Labrune syndrome

    Leena Pahuja / Elisheba Patras / Sachin Sureshbabu / Nittin Parkhe / Laxmi Khanna

    Annals of Indian Academy of Neurology, Vol 20, Iss 1, Pp 59-

    A unique leukoencephalopathy

    2017  Volume 61

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Convalescent plasma in the management of moderate COVID-19 in India: An open-label parallel-arm phase II multicentre randomized controlled trial (PLACID Trial)

    Agarwal, Anup / Mukherjee, Aparna / Kumar, Gunjan / Chatterjee, Pranab / Bhatnagar, Tarun / Malhotra, Pankaj / Latha, B / Bundas, Sunita / Kumar, Vivek / Dosi, Ravi / Khambholja, Janak Kumar / de Souza, Rosemarie / Mesipogu, Raja Rao / Srivastava, Saurabh / Dube, Simmi / Chaudhary, Kiran / S, Subash / Mattuvar K, S. Anbuselvi / Rajendran, V /
    Sundararajaperumal, A / Balamanikandan, P / Maheswari, R S Uma / Jayanthi, R / Ragunanthanan, S / Bhandari, Sudhir / Singh, Ajeet / Pal, Ashok / Handa, Anjali / Rankawat, Govind / Kargirwar, Ketan / Regi, Joyce / Rathod, Darshana / Pathrose, Edwin / Bhutaka, Nirankar / Patel, Mayur H / Verma, Rahul J / Malukani, Kamal / Patel, Shivani / Thakur, Apurv / Joshi, Satish / Kulkarni, Rashmi / Suthar, Nilay N / Shah, Nehal M / Purohit, Hemang M / Shah, Cherry K / Patel, Monila N / Shah, Saket / Shah, Smit H / Memon, Tehsim / Beriwala, Vishal R / Jashnani, Kusum / Ezzy, Fatema / Agrawal, Simran / Bhadade, Rakesh / N, Atish M / Madke, Tushar / Kavishwar, Vikash / Waghmare, Ramesh / Valvi, Nitin / Chander, B Thrilok / Sekhar, A Vinaya / Maurya, Akhilesh Kumar / Hemanth, K / Nagamani, K / Sudha, K / Chandra, T Ravi / Rao, K Tushara / Vyshnavi, J / Upadhyay, Rashmi / Bahadur, Shalini / Pathak, Rambha / Seth, Shikha / Gupta, Rakesh / Saxena, Rita / Dwivedi, Preksha / Malik, Reeni / Chourasia, Deepti / Lalwani, Jaya / Sharma, UM / Marko, JL / Suri, Amit / Kumar, Vijay / Kaushik, Rajnish / Kodan, Parul / Acharya, Bhabani Prasad / Gaur, Kuldeep Kumar / Gupta, Anubhav / Sachdeva, Prerna / Dogra, Shruti / Jindal, Aikaj / John, M Joseph / Dhanju, Avtar Singh / Khetrepal, Ranjana / Sharma, Neeraj / Kukar, Neetu / Kavita, Divya / Kumar, Rajesh / Mahajan, Rajesh / Singh, Gurpreet / Kaur, Jaspreet / Singh, Raminder Pal / Bassi, Rajni / Parikh, Swapneil / Shrivastav, Om / Shastri, Jayanthi / Desai, Maherra / Udupa, Shreevatsa / Bafna, Varun A / Barge, Vijay / Madane, Rajendra / Yadav, Sheetal / Mishra, Sanjeev / Bajpayee, Archana / Garg, M K / Bohra, G K / Nag, Vijaylakshmi / Anne, Puneeth Babu / Nadeem, Mohd / Singh, Pallavi / Niwas, Ram / Khaire, Niranjan Shiwaji / Sharma, Rattiram / Singh, Mini p / Sachdeva, Naresh / Sachdev, Suchet / Hans, Rekha / Suri, Vikas / Yaddanapudi, L N / Lakshmi, PVM / Singh, Neha / Bhushan, Divendu / Kumar, Neeraj / Tambe, Muralidhar / Salvi, Sonali / Kadgi, Nalini / Sangle, Shashikala / Nakate, Leena / Joshi, Samir / Karyakarte, Rajesh / Goyanka, Suraj / Sharma, Nimisha / Verma, Nikhil / Das, Asim / Bahl, Monika / Wadhwa, Nitya / Bhat, Shreepad / Deshmukh, Shweta / Wagh, Vrushali / Kulkarni, Atul / Yardi, Tanvi / Kalgud, Ram S / Reddy, Purushottam / Yevoor, Kavitha / Gajula, Prashanth / Maleyur, Vivek / S, Medini / HN, Mohith / Gurtoo, Anil / Sud, Ritika / Pahuja, Sangeeta / Prakash, Anupam / Gogoi, Parijat / Shukla, Shailja / Reddy, D Himanshu / Chandra, Tulika / Pandey, Saurabh / Maurya, Pradeep / Wahid, Ali / Upadhyay, Kamlesh / Bhatnagar, Nidhi / Shah, Nilima / Shah, Mamta / Patel, Tarak / Jaiswal, Ram Mohan / Jain, Ashish / Sharma, Shweta / Rijhwani, Puneet / Gupta, Naveen / Patel, Tinkal C / Solu, Mahesh G / Patel, Jitendra / Shah, Yash R / Jarag, Mayur / Godbole, Varsha / Shah, Meenakshi / Raj, Rikin / Nagori, Irfan / Jha, Pramod R / Shah, Arti D / Yeeli, Gowtham / Jain, Archit / Gill, Rooppreet Kaur / Babu, KV Sreedhar / Babu, B Suresh / Mohan, Alladi / Vengamma, B / Sekhar, K Chandra / Damam, Srinivasulu / Narsimhulu, K / Aparna, C / Baleswari, G / K, Ravindranath Reddy / Chandrasekhar, P / Panjwani, Sunil Jodharam / Akholkar, Pankaj J / Joshi, Kairavi Parthesh / Shah, Pragnesh H / Barvaliya, Manish / Baldi, Milind / Yadav, Ashok / Gupta, Manoj / Rawat, Nitin / Chawda, Dilip / Natarajan, M / Sintha, M / Kumar, David Pradeep / Rabbani, Fathhur / Khadke, Vrushali Khirid / Patki, Dattatray / Marathe, Sonali / D Souza, Clyde / Tadha, Vipul / Arora, Satyam / Gupta, Devendra Kumar / Dua, Seema / Chauhan, Nitu / Chahar, Ajeet Singh / Mammen, Joy John / Kumar, Snehil / Daniel, Dolly / Singh, Ravindraa / Dhat, Venkatesh / Agarwal, Yogesh / Arora, Sohini / Pathak, Ashish / Purohit, Manju / Sharma, Ashish / Sharma, Jayashree / Madkaikar, Manisha / Joshi, Kavita / Yadav, Reetika Malik / Bhagwat, Swarupa / Karnik, Niteen D / Gokhale, Yojana A / Naik, Leena / Margam, Sangita / Das, Santasabuj / Turuk, Alka / Kumar, V Saravana / Kanagasabai, K / Sabarinathan, R / Deshpande, Gururaj / Sharma, Sharda / Gunjikar, Rashmi / Shete, Anita / Phagiwala, Darpan / Patil, Chetan / Shingade, Snehal / Jarande, Kajal / Kaushal, Himanshu / Yadav, Pragya / Sapkal, Gajanan / Abraham, Priya

    medRxiv

    Abstract: Objectives: Convalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management of viral diseases. We investigated its effectiveness for the treatment of COVID-19. ... ...

    Abstract Objectives: Convalescent plasma (CP) as a passive source of neutralizing antibodies and immunomodulators is a century-old therapeutic option used for the management of viral diseases. We investigated its effectiveness for the treatment of COVID-19. Design: Open-label, parallel-arm, phase II, multicentre, randomized controlled trial. Setting: Thirty-nine public and private hospitals across India. Participants: Hospitalized, moderately ill confirmed COVID-19 patients (PaO2/FiO2: 200-300 or respiratory rate > 24/min and SpO2 ≤ 93% on room air). Intervention: Participants were randomized to either control (best standard of care (BSC)) or intervention (CP + BSC) arm. Two doses of 200 mL CP was transfused 24 hours apart in the intervention arm. Main Outcome Measure: Composite of progression to severe disease (PaO2/FiO2<100) or all-cause mortality at 28 days post-enrolment. Results: Between 22 nd April to 14 th July 2020, 464 participants were enrolled; 235 and 229 in intervention and control arm, respectively. Composite primary outcome was achieved in 44 (18.7%) participants in the intervention arm and 41 (17.9%) in the control arm [aOR: 1.09; 95% CI: 0.67, 1.77]. Mortality was documented in 34 (13.6%) and 31 (14.6%) participants in intervention and control arm, respectively [aOR) 1.06 95% CI: -0.61 to 1.83]. Interpretation: CP was not associated with reduction in mortality or progression to severe COVID-19. This trial has high generalizability and approximates real-life setting of CP therapy in settings with limited laboratory capacity. A priori measurement of neutralizing antibody titres in donors and participants may further clarify the role of CP in management of COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-09-08
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.09.03.20187252
    Database COVID19

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