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Article ; Online: The influence of cannabis use disorder on post-traumatic stress disorder symptoms, depression symptoms, and non-suicidal self-injury among college students.

Blessing, Alexis / Russell, Patricia D / DeBeer, Bryann B / Kimbrel, Nathan A / Meyer, Eric C / Morissette, Sandra B

Journal of American college health : J of ACH

2023 , Page(s) 1–5

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	604907-2
ISSN	1940-3208 ; 0744-8481
ISSN (online)	1940-3208
ISSN	0744-8481
DOI	10.1080/07448481.2022.2155471
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Article ; Online: Motility-Independent Vertical Transmission of Bacteria in Leaf Symbiosis.

Acar, Tessa / Moreau, Sandra / Coen, Olivier / De Meyer, Frédéric / Leroux, Olivier / Beaumel, Marine / Wilkin, Paul / Carlier, Aurélien

mBio

2022 Volume 13, Issue 5, Page(s) e0103322

Abstract: Hereditary symbioses have the potential to drive transgenerational effects, yet the mechanisms responsible for transmission of heritable plant symbionts are still poorly understood. The leaf symbiosis ... ...

Abstract	Hereditary symbioses have the potential to drive transgenerational effects, yet the mechanisms responsible for transmission of heritable plant symbionts are still poorly understood. The leaf symbiosis between
MeSH term(s)	Animals ; Symbiosis/physiology ; Alcaligenaceae ; Plant Leaves/microbiology ; Bacteria ; Plants
Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01033-22
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Article ; Online: The association between Dioscorea sansibarensis and Orrella dioscoreae as a model for hereditary leaf symbiosis.

Acar, Tessa / Moreau, Sandra / Jardinaud, Marie-Françoise / Houdinet, Gabriella / Maviane-Macia, Felicia / De Meyer, Frédéric / Hoste, Bart / Leroux, Olivier / Coen, Olivier / Le Ru, Aurélie / Peeters, Nemo / Carlier, Aurelien

PloS one

2024 Volume 19, Issue 4, Page(s) e0302377

Abstract: Hereditary, or vertically-transmitted, symbioses affect a large number of animal species and some plants. The precise mechanisms underlying transmission of functions of these associations are often difficult to describe, due to the difficulty in ... ...

Abstract	Hereditary, or vertically-transmitted, symbioses affect a large number of animal species and some plants. The precise mechanisms underlying transmission of functions of these associations are often difficult to describe, due to the difficulty in separating the symbiotic partners. This is especially the case for plant-bacteria hereditary symbioses, which lack experimentally tractable model systems. Here, we demonstrate the potential of the leaf symbiosis between the wild yam Dioscorea sansibarensis and the bacterium Orrella dioscoreae (O. dioscoreae) as a model system for hereditary symbiosis. O. dioscoreae is easy to grow and genetically manipulate, which is unusual for hereditary symbionts. These properties allowed us to design an effective antimicrobial treatment to rid plants of bacteria and generate whole aposymbiotic plants, which can later be re-inoculated with bacterial cultures. Aposymbiotic plants did not differ morphologically from symbiotic plants and the leaf forerunner tip containing the symbiotic glands formed normally even in the absence of bacteria, but microscopic differences between symbiotic and aposymbiotic glands highlight the influence of bacteria on the development of trichomes and secretion of mucilage. This is to our knowledge the first leaf symbiosis where both host and symbiont can be grown separately and where the symbiont can be genetically altered and reintroduced to the host.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0302377
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Article ; Online: Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study.

Vingerhoets, Johan / Van Dromme, Ilse / van Duijnhoven, Wilbert / Anderson, David / De Meyer, Sandra / Leopold, Lorant

Antiviral therapy

2023 Volume 28, Issue 3, Page(s) 13596535231174273

Abstract: Background: Pimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized double-blinded placebo-controlled phase 2b TOPAZ study demonstrated antiviral activity and safety of twice ...

Abstract	Background: Pimodivir is a first-in-class polymerase basic protein 2 (PB2) subunit inhibitor of the influenza A polymerase complex. The randomized double-blinded placebo-controlled phase 2b TOPAZ study demonstrated antiviral activity and safety of twice daily pimodivir alone (300 mg, 600 mg) or in combination with oseltamivir (pimodivir 600 mg, oseltamivir 75 mg) in adult study participants with acute uncomplicated influenza A. The detailed genotypic and phenotypic characterization of viral variants observed in this study are reported. Methods: Population sequencing of PB2 and neuraminidase genes, and phenotypic susceptibility testing, were performed using baseline and last virus-positive post-baseline nasal swab samples. Results: Sequencing of baseline samples in 206 of 223 (92.4%) randomized study participants with confirmed influenza A infection identified no polymorphisms at any predefined PB2 positions of interest for pimodivir and no phenotypic reduced susceptibility to pimodivir was observed. Post-baseline sequencing data for 105/223 (47.1%) participants identified emergence of PB2 mutations at amino acid positions of interest in 10 (9.5%) participants (pimodivir 300 mg: Conclusions: Participants with acute uncomplicated influenza A treated with pimodivir in the TOPAZ study infrequently developed reduced susceptibility to pimodivir and combining pimodivir with oseltamivir further decreased the risk of reduced susceptibility development.
MeSH term(s)	Adult ; Humans ; Oseltamivir/therapeutic use ; Influenza, Human/drug therapy ; Genotype ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Influenza A virus/genetics
Chemical Substances	Oseltamivir (20O93L6F9H) ; pimodivir (DFC121MXC3) ; Antiviral Agents
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1339842-8
ISSN	2040-2058 ; 1359-6535
ISSN (online)	2040-2058
ISSN	1359-6535
DOI	10.1177/13596535231174273
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Zs.A 4877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Associations Among PTSD, Cognitive Functioning, and Health-Promoting Behavior in Post-9/11 Veterans.

Lawrence, Karen A / Garcia-Willingham, Natasha E / Slade, Emily / DeBeer, Bryann B / Meyer, Eric C / Morissette, Sandra B

Military medicine

2023

Abstract: Introduction: PTSD is associated with negative health behaviors that increase chronic disease risk, yet health behaviors and their determinants are not well investigated in this context. One understudied mechanism of health behaviors is cognitive ... ...

Abstract	Introduction: PTSD is associated with negative health behaviors that increase chronic disease risk, yet health behaviors and their determinants are not well investigated in this context. One understudied mechanism of health behaviors is cognitive functioning. Deficits in cognitive functioning may undermine engagement in health-promoting behavior, thereby increasing the negative impact of PTSD. We tested three hypotheses: (1) Greater PTSD symptom severity is associated with less health-promoting behavior; (2) greater PTSD symptom severity is associated with poorer cognitive functioning across verbal memory, processing speed, attention, and executive functioning domains; and (3) verbal memory and executive functioning exhibit indirect effects on the relationship between PTSD and health-promoting behavior. Materials and methods: We examined associations between PTSD symptom severity (Clinician-Administered PTSD Scale for DSM-IV), cognitive functioning, and health-promoting behavior (Health-Promoting Lifestyle Profile II) in 124 post-9/11 veterans (average age = 37.82; 85.5% male; 63.7% White; 18.5% Black; 26.6% Hispanic). Cognitive domains examined included verbal memory (California Verbal Learning Test), processing speed (Digit Symbol Coding), attention and working memory (Digit Span), and executive functions (Trail Making Test and Stroop Interference). Results: Regression analyses indicated that greater PTSD symptom severity was associated with less health-promoting behavior (B = -.0101, SE = 0.0016, P < .0001; R2 = 0.3052). Path analyses revealed that verbal learning and memory partially accounted for this relationship (R2 = 0.037- 0.043; P < .05). Conclusions: Therapeutic targeting of these relationships may have implications for the prevention of long-term disease impact in veterans; longitudinal research is needed to elucidate the potential impact on chronic disease.
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	391061-1
ISSN	1930-613X ; 0026-4075
ISSN (online)	1930-613X
ISSN	0026-4075
DOI	10.1093/milmed/usad035
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Article ; Online: Generation of a TMEM43 knockout human induced pluripotent stem cell line (HDZi003-A-1) using CRISPR/Cas9.

Ratnavadivel, Sandra / Dammeier, Joline / Gaertner, Anna / de Toledo, Marcelo A Szymanski / Zenke, Martin / Gummert, Jan / Bloch Rasmussen, Torsten / Klinke, Nora / Jürgens, Kai / Meyer, Heiko / Paululat, Achim / Milting, Hendrik

Stem cell research

2024 Volume 76, Page(s) 103354

Abstract: TMEM43 (LUMA) is a ubiquitously expressed protein with unknown function. The protein is phylogenetically highly conserved and also found in Drosophila melanogaster (Klinke et al., 2022). TMEM43-p.S358L is a rare, fully penetrant mutation that leads to ... ...

Abstract	TMEM43 (LUMA) is a ubiquitously expressed protein with unknown function. The protein is phylogenetically highly conserved and also found in Drosophila melanogaster (Klinke et al., 2022). TMEM43-p.S358L is a rare, fully penetrant mutation that leads to arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). To understand the function of the ARVC5-associated mutation it is first important to understand the function of the TMEM43 protein. Therefore, a TMEM43 knockout induced pluripotent stem cell (iPSC) line was generated using the CRISPR/Cas9 genome editing system. The resulting cell line had a deficiency of TMEM43 and showed normal morphology and a stable karyotype. The colonies were positive for pluripotency markers and could be differentiated into the three germ layers.
MeSH term(s)	Animals ; Humans ; Induced Pluripotent Stem Cells/metabolism ; CRISPR-Cas Systems/genetics ; Drosophila melanogaster/metabolism ; Arrhythmogenic Right Ventricular Dysplasia/genetics ; Mutation ; Membrane Proteins/genetics ; Membrane Proteins/metabolism
Chemical Substances	TMEM43 protein, human ; Membrane Proteins
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2024.103354
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Article ; Online: Design and validation of equations for weight estimation in adolescents.

Coracini, Daniel Meyer / Detregiachi, Cláudia Rucco Penteado / Barbalho, Sandra Maria / Teixeira, Daniel De Bortoli

PloS one

2023 Volume 18, Issue 2, Page(s) e0273824

Abstract: Introduction: Measuring weight is difficult to be carried out in bedridden people, with physical deformity or in emergency units. Under these circumstances, one option is to estimate the weight.: Objectives: The aim of this study is to propose and ... ...

Abstract	Introduction: Measuring weight is difficult to be carried out in bedridden people, with physical deformity or in emergency units. Under these circumstances, one option is to estimate the weight. Objectives: The aim of this study is to propose and validate equations for estimating the weight of Brazilian adolescents based on anthropometric variables related to body weight. Methods: The study was developed based on a database created from data collection of a primary project, which had information from 662 Brazilian adolescents (10 to 19 years old). Based on the variables sex, age (days), weight (kg), height (m) and neck circumference (NC) (cm), equations for estimating weight of adolescents were proposed. The formulas were proposed after performing multiple linear regression models and subsequently tested and validated using appropriate statistical tests, considering 99% confidence. Results: Two formulas were generated, the "Rucco Formulas-Adolescents", one for girls: -131.63091 + (0.00209 × A) + (37.57813 × H) + (3.71482 x NC) and another for boys: - 15.2854 + (-0.00414 × A)+ (14.30315 × H2)+ (0.04888 x NC2). Statistical test (R2) indicated that the proposed formulas are suitable for estimating weight. Low values of REQM and high values of CCI (> 0.8) also reinforce the quality of the proposed formulas. Conclusions: The current weight of adolescents can be estimated with adequate accuracy and precision using sex-specific "Rucco Formulas-Adolescents", generated from regression models using only three predictor variables.
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; Child ; Young Adult ; Adult ; Body Composition ; Anthropometry ; Brazil ; Body Weight
Language	English
Publishing date	2023-02-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0273824
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Article ; Online: A brief report on the temporal relations between social functioning and behavioral health among veterans.

Perrotte, Jessica K / Weston, Rebecca / Meyer, Eric C / DeBeer, Bryann B / Kimbrel, Nathan A / Gulliver, Suzy B / Morissette, Sandra B

Social psychiatry and psychiatric epidemiology

2022 Volume 58, Issue 1, Page(s) 177–181

Abstract: Using a four-wave longitudinal design, three competing hypotheses (i.e., social selection, social causation, and reciprocal causation) were tested pertaining to the relation between social functioning and several indices of behavioral health [i.e., post- ... ...

Abstract	Using a four-wave longitudinal design, three competing hypotheses (i.e., social selection, social causation, and reciprocal causation) were tested pertaining to the relation between social functioning and several indices of behavioral health [i.e., post-traumatic stress symptoms (PTSS), distress, and alcohol-related problems] among military veterans exposed to trauma. Across two latent growth curve analyses, data largely supported longitudinal links between improved social functioning and positive behavioral health, often indicating that the improvements in social functioning frequently precede improvements in behavioral health. Overall, findings underscore the merit of directly targeting social functioning as part of mental health treatment among trauma-exposed individuals.
MeSH term(s)	Humans ; Veterans/psychology ; Social Interaction ; Stress Disorders, Post-Traumatic/psychology ; Social Adjustment ; Psychotherapy
Language	English
Publishing date	2022-09-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-022-02364-1
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Article ; Online: Cell Guiding Multicomponent Nanoyarn Tendon Scaffolds with Tunable Morphology and Flexibility.

Schynkel, Lucas / Meeremans, Marguerite / Meyer, Anna A / Schoolaert, Ella / Geltmeyer, Jozefien / Omidinia-Anarkoli, Abdolrahman / Van Vlierberghe, Sandra / Daelemans, Lode / De Laporte, Laura / De Schauwer, Catharina / Hoogenboom, Richard / De Clerck, Karen

ACS applied materials & interfaces

2023 Volume 15, Issue 36, Page(s) 42241–42250

Abstract: Nanofibrous scaffolds are widely investigated for tendon tissue engineering due to their porous structure, high flexibility, and the ability to guide cells in a preferred direction. Previous research has shown that providing a microenvironment similar to ...

Abstract	Nanofibrous scaffolds are widely investigated for tendon tissue engineering due to their porous structure, high flexibility, and the ability to guide cells in a preferred direction. Previous research has shown that providing a microenvironment similar to in vivo settings improves tissue regeneration. Therefore, in this work, ingenious multicomponent nanoyarn scaffolds that mimic the fibrillar and tubular structures of tendons are developed for the first time through electrospinning and bundling nanoyarns followed by electrospinning of a nanofibrous shell around the bundle. Multicomponent nanoyarn scaffolds out of poly(ε-caprolactone) with varying porosity, density, and diameter were successfully produced by coelectrospinning with water-soluble poly(2-ethyl-2-oxazoline) as a sacrificial component. The diameter and fiber orientation of the nanoyarns were successfully tuned based on parameter-morphology models obtained by the design of experiments. Cyclic bending tests were performed, indicating that the flexibility of the multicomponent nanoyarn scaffolds depends on the morphology and can be tuned through controlling the number of nanoyarns in the bundle and the porosity. Indirect and direct cell culture tests using mouse and equine tendon cells revealed excellent cytocompatibility of the nanofibrous products and demonstrated the potential of the nanoyarns to guide the growing cells along the nanofiber direction, which is crucial for tendon tissue engineering.
MeSH term(s)	Animals ; Horses ; Mice ; Cell Culture Techniques ; Cytoskeleton ; Nanofibers ; Poly A ; Tendons
Chemical Substances	Poly A (24937-83-5)
Language	English
Publishing date	2023-08-31
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c08241
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Article ; Online: Astrocytes in Paper Chips and Their Interaction with Hybrid Vesicles.

Abild Meyer, Cathrine / De Dios Andres, Paula / Brodszkij, Edit / Westensee, Isabella N / Lyons, Joseph / Vaz, Sandra H / Städler, Brigitte

Advanced biology

2022 Volume 7, Issue 1, Page(s) e2200209

Abstract: The role of astrocytes in brain function has received increased attention lately due to their critical role in brain development and function under physiological and pathophysiological conditions. However, the biological evaluation of soft material ... ...

Abstract	The role of astrocytes in brain function has received increased attention lately due to their critical role in brain development and function under physiological and pathophysiological conditions. However, the biological evaluation of soft material nanoparticles in astrocytes remains unexplored. Here, the interaction of crosslinked hybrid vesicles (HVs) and either C8-D1A astrocytes or primary astrocytes cultured in polystyrene tissue culture or floatable paper-based chips is investigated. The amphiphilic block copolymer poly(cholesteryl methacrylate)-block-poly(2-carboxyethyl acrylate) (P1) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine lipids are used for the assembly of HVs with crosslinked membranes. The assemblies show no short-term toxicity towards the C8-D1A astrocytes and the primary astrocytes, and both cell types internalize the HVs when cultured in 2D cell culture. Further, it is demonstrated that both the C8-D1A astrocytes and the primary astrocytes could mature in paper-based chips with preserved calcium signaling and glial fibrillary acidic protein expression. Last, it is confirmed that both types of astrocytes could internalize the HVs when cultured in paper-based chips. These findings lay out a fundamental understanding of the interaction between soft material nanoparticles and astrocytes, even when primary astrocytes are cultured in paper-based chips offering a 3D environment.
MeSH term(s)	Astrocytes/metabolism ; Polymers/metabolism ; Paper ; Cell Culture Techniques
Chemical Substances	Polymers
Language	English
Publishing date	2022-11-03
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2701-0198
ISSN (online)	2701-0198
DOI	10.1002/adbi.202200209
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