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Article ; Online: Conformation of K

Tainaka, Sota / Ujihira, Tomoyuki / Kubo, Mayuko / Kida, Motoki / Shimoyama, Daisuke / Muramatsu, Satoru / Abe, Manabu / Haino, Takeharu / Ebata, Takayuki / Misaizu, Fuminori / Ohshimo, Keijiro / Inokuchi, Yoshiya

The journal of physical chemistry. A

2020 Volume 124, Issue 48, Page(s) 9980–9990

Abstract: The conformation and electronic structure of dibenzo-24-crown-8 (DB24C8) complexes with K ...

Abstract	The conformation and electronic structure of dibenzo-24-crown-8 (DB24C8) complexes with K
Language	English
Publishing date	2020-11-18
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.0c09068
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Article ; Online: Structural properties determining low K

Tsukamoto, Hisao / Higashi, Masahiro / Motoki, Hideyoshi / Watanabe, Hiroki / Ganser, Christian / Nakajo, Koichi / Kubo, Yoshihiro / Uchihashi, Takayuki / Furutani, Yuji

The Journal of biological chemistry

2018 Volume 293, Issue 18, Page(s) 6969–6984

Abstract: Canonical K ...

Abstract	Canonical K
MeSH term(s)	Animals ; Biophysical Phenomena ; Cations ; Hydrogen Bonding ; Liposomes ; Mice ; Microscopy, Atomic Force ; Molecular Dynamics Simulation ; Potassium/metabolism ; Potassium Channels, Tandem Pore Domain/chemistry ; Potassium Channels, Tandem Pore Domain/metabolism ; Protein Conformation ; Quantum Theory ; Sodium/metabolism ; Spectrophotometry, Infrared ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Cations ; Kcnk1 protein, mouse ; Liposomes ; Potassium Channels, Tandem Pore Domain ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2018-03-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.001817
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Article ; Online: Deexcitation Dynamics of Muonic Atoms Revealed by High-Precision Spectroscopy of Electronic K X Rays.

Okumura, T / Azuma, T / Bennett, D A / Caradonna, P / Chiu, I / Doriese, W B / Durkin, M S / Fowler, J W / Gard, J D / Hashimoto, T / Hayakawa, R / Hilton, G C / Ichinohe, Y / Indelicato, P / Isobe, T / Kanda, S / Kato, D / Katsuragawa, M / Kawamura, N /

Kino, Y / Kubo, M K / Mine, K / Miyake, Y / Morgan, K M / Ninomiya, K / Noda, H / O'Neil, G C / Okada, S / Okutsu, K / Osawa, T / Paul, N / Reintsema, C D / Schmidt, D R / Shimomura, K / Strasser, P / Suda, H / Swetz, D S / Takahashi, T / Takeda, S / Takeshita, S / Tampo, M / Tatsuno, H / Tong, X M / Ueno, Y / Ullom, J N / Watanabe, S / Yamada, S

Physical review letters

2021 Volume 127, Issue 5, Page(s) 53001

Abstract: We observed electronic K x rays emitted from muonic iron atoms using superconducting transition ... by a simulation, these data clearly reveal the electronic K- and L-shell hole production and their temporal ... K^{h}α x rays around 6 keV. This signature reflects the time-dependent screening of the nuclear ...

Abstract	We observed electronic K x rays emitted from muonic iron atoms using superconducting transition-edge sensor microcalorimeters. The energy resolution of 5.2 eV in FWHM allowed us to observe the asymmetric broad profile of the electronic characteristic Kα and Kβ x rays together with the hypersatellite K^{h}α x rays around 6 keV. This signature reflects the time-dependent screening of the nuclear charge by the negative muon and the L-shell electrons, accompanied by electron side feeding. Assisted by a simulation, these data clearly reveal the electronic K- and L-shell hole production and their temporal evolution on the 10-20 fs scale during the muon cascade process.
Language	English
Publishing date	2021-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.053001
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Article ; Online: A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K

Chen, I-Shan / Eldstrom, Jodene / Fedida, David / Kubo, Yoshihiro

The Journal of physiology

2021 Volume 600, Issue 3, Page(s) 603–622

Abstract: G-protein-gated inwardly rectifying K ...

Abstract	G-protein-gated inwardly rectifying K
MeSH term(s)	Animals ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; GTP-Binding Proteins ; Mice ; Mutation ; Oocytes/physiology
Chemical Substances	G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Kcnj6 protein, mouse ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	2021-12-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/JP282430
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Article: [Association of the combined estimated 24-h urinary Na/K ratio and body mass index with blood pressure: Cross-sectional data from the KOBE study].

Nozawa, Miki / Kuwabara, Kazuyo / Kubota, Yoshimi / Nishida, Yoko / Kubo, Sachimi / Hirata, Takumi / Higashiyama, Aya / Hirata, Aya / Hattori, Hiroko / Sata, Mizuki / Kadota, Aya / Sugiyama, Daisuke / Miyamatsu, Naomi / Miyamoto, Yoshihiro / Okamura, Tomonori

Nihon koshu eisei zasshi] Japanese journal of public health

2020 Volume 67, Issue 10, Page(s) 722–733

Abstract: Objective　Several studies have suggested that high dietary Na/K ratio and body mass index (BMI ... of the combined estimated 24-h urinary Na/K ratio (24h-u-Na/K) (high or low) and BMI (high or low) with the risk ... cardiovascular diseases or current anti-hypertensive medications. Sex-specific analyses were performed. The 24h-u-Na/K ...

Abstract	Objective　Several studies have suggested that high dietary Na/K ratio and body mass index (BMI) increase the prevalence of hypertension. However, there have been a few reports on the combination of these two factors and their relationship with hypertension. This study aimed to examine the association of the combined estimated 24-h urinary Na/K ratio (24h-u-Na/K) (high or low) and BMI (high or low) with the risk of high blood pressure.Method　We performed a cross-sectional study involving 1,112 participants (340 men and 772 women) of the Kobe Orthopedic and Biomedical Epidemiological study (KOBE study) who had no cardiovascular diseases or current anti-hypertensive medications. Sex-specific analyses were performed. The 24h-u-Na/K ratio was calculated from an estimation formula using collected spot urine. Participants were divided into four groups based on their 24h-u-Na/K ratio (low or high) and BMI (low or high), with the cutoff points being the median and 25 kg/m
MeSH term(s)	Blood Pressure ; Body Mass Index ; Cross-Sectional Studies ; Diet, Sodium-Restricted ; Female ; Fruit ; Humans ; Hypertension/diagnosis ; Hypertension/etiology ; Hypertension/prevention & control ; Japan ; Male ; Potassium/urine ; Risk Assessment/methods ; Sodium/urine ; Vegetables
Chemical Substances	Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	Japanese
Publishing date	2020-12-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	45044-3
ISSN	0546-1766
ISSN	0546-1766
DOI	10.11236/jph.67.10_722
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Article ; Online: Non-sedating antihistamines block G-protein-gated inwardly rectifying K

Chen, I-Shan / Liu, Chang / Tateyama, Michihiro / Karbat, Izhar / Uesugi, Motonari / Reuveny, Eitan / Kubo, Yoshihiro

British journal of pharmacology

2019 Volume 176, Issue 17, Page(s) 3161–3179

Abstract: ... the activity of G-protein-gated inwardly rectifying K: Experimental approach: Electrophysiological ... on various GIRK subunits (K: Key results: GIRK channels containing K: Conclusion and implications ... The Phe137 residue in K ...

Abstract	Background and purpose: A second-generation antihistamine, terfenadine, is known to induce arrhythmia by blocking hERG channels. In this study, we have shown that terfenadine also inhibits the activity of G-protein-gated inwardly rectifying K Experimental approach: Electrophysiological recordings were made in Xenopus oocytes and rat atrial myocytes to analyse the effects of antihistamines on various GIRK subunits (K Key results: GIRK channels containing K Conclusion and implications: The Phe137 residue in K
MeSH term(s)	Animals ; Dose-Response Relationship, Drug ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/antagonists & inhibitors ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/genetics ; G Protein-Coupled Inwardly-Rectifying Potassium Channels/metabolism ; Histamine Antagonists/chemistry ; Histamine Antagonists/pharmacology ; Male ; Molecular Docking Simulation ; Mutation ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Oocytes/drug effects ; Oocytes/metabolism ; Rats ; Rats, Wistar ; Structure-Activity Relationship ; Xenopus laevis
Chemical Substances	G Protein-Coupled Inwardly-Rectifying Potassium Channels ; Histamine Antagonists
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.14717
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Article: [Clinical significance of neutrophil to lymphocyte ratio in colorectal cancer patients receiving adjuvant chemotherapy combined with polysaccharide-K].

Yoshioka, Shinichi / Kubo, Masahiko / Yanagisawa, Kiminori / Hata, Tsuyoshi / Takiuchi, Daisuke / Hamano, Rie / Minohata, Junya / Kashiwazaki, Masaki / Miki, Hirofumi / Tsujie, Masaki / Konishi, Muneharu / Yano, Hiroshi

Gan to kagaku ryoho. Cancer & chemotherapy

2013 Volume 40, Issue 12, Page(s) 2086–2088

Abstract: ... polysaccharide-K (PSK). The patients were stratified into 2 groups according to the preoperative N/L ratio (cut ...

Abstract	The neutrophil to lymphocyte ratio (N/L ratio) has been reported to be related to the prognosis of various types of cancer. In particular, a high N/L ratio has been suggested to be associated with poor outcome. We investigated the changes in N/L ratio during treatment in 12 patients who had undergone surgery for colorectal cancer and were receiving postoperative adjuvant therapy with a combination of chemotherapy and polysaccharide-K (PSK). The patients were stratified into 2 groups according to the preoperative N/L ratio (cut-off ratio was 2.5): high N/L (≥2.5) and low N/L (<2.5). The changes in N/L ratio and other clinical parameters over time were investigated. In patients with a high preoperative N/L ratio, the use of postoperative PSK-chemotherapy controlled the N/L ratio at low levels. The N/L ratio tended to remain low in patients with low preoperative N/L ratios. No difference in outcome was observed between patients with high and low N/L ratios. In patients who underwent colorectal cancer surgery, postoperative adjuvant therapy with a combination of chemotherapy and PSK succeeded in controlling the N/L ratio at low levels. Further studies with more patients are required to explore the outcomes associated with changing N/L ratios.
MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/surgery ; Female ; Humans ; Leukocyte Count ; Lymphocytes ; Male ; Middle Aged ; Neutrophils ; Polysaccharides/administration & dosage ; Polysaccharides/adverse effects ; Treatment Outcome
Chemical Substances	Polysaccharides
Language	Japanese
Publishing date	2013-11
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.

Kitazawa, Masahiro / Kubo, Yoshihiro / Nakajo, Koichi

The Journal of biological chemistry

2014 Volume 289, Issue 25, Page(s) 17597–17609

Abstract: Kv4 is a voltage-gated K(+) channel, which underlies somatodendritic subthreshold A-type current ... ISA) and cardiac transient outward K(+) (Ito) current. Various ion channel properties of Kv4 are known ... to be modulated by its auxiliary subunits, such as K(+) channel-interacting protein (KChIP) or ...

Abstract	Kv4 is a voltage-gated K(+) channel, which underlies somatodendritic subthreshold A-type current (ISA) and cardiac transient outward K(+) (Ito) current. Various ion channel properties of Kv4 are known to be modulated by its auxiliary subunits, such as K(+) channel-interacting protein (KChIP) or dipeptidyl peptidase-like protein. KChIP is a cytoplasmic protein and increases the current amplitude, decelerates the inactivation, and accelerates the recovery from inactivation of Kv4. Crystal structure analysis demonstrated that Kv4 and KChIP form an octameric complex with four Kv4 subunits and four KChIP subunits. However, it remains unknown whether the Kv4·KChIP complex can have a different stoichiometry other than 4:4. In this study, we expressed Kv4.2 and KChIP4 with various ratios in Xenopus oocytes and observed that the biophysical properties of Kv4.2 gradually changed with the increase in co-expressed KChIP4. The tandem repeat constructs of Kv4.2 and KChIP4 revealed that the 4:4 (Kv4.2/KChIP4) channel shows faster recovery than the 4:2 channel, suggesting that the biophysical properties of Kv4.2 change, depending on the number of bound KChIP4s. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2·KChIP4 complex was dependent on the expression level of KChIP4. Taken together, we conclude that the stoichiometry of Kv4·KChIP complex is variable, and the biophysical properties of Kv4 change depending on the number of bound KChIP subunits.
MeSH term(s)	Animals ; Humans ; Kv Channel-Interacting Proteins/genetics ; Kv Channel-Interacting Proteins/metabolism ; Multiprotein Complexes/genetics ; Multiprotein Complexes/metabolism ; Oocytes/cytology ; Oocytes/metabolism ; Rats ; Shal Potassium Channels/genetics ; Shal Potassium Channels/metabolism ; Xenopus laevis
Chemical Substances	Kcnip4 protein, rat ; Kv Channel-Interacting Proteins ; Multiprotein Complexes ; Shal Potassium Channels
Language	English
Publishing date	2014-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M114.563452
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Article ; Online: Impact of adjuvant immunochemotherapy using protein-bound polysaccharide-K on overall survival of patients with gastric cancer.

Tanaka, Hiroaki / Muguruma, Kazuya / Ohira, Masaichi / Kubo, Naoshi / Yamashita, Yoshito / Maeda, Kiyoshi / Sawada, Tetsuji / Hirakawa, Kosei

Anticancer research

2012 Volume 32, Issue 8, Page(s) 3427–3433

Abstract: Protein-bound polysaccharide K (PSK) is an anticancer agent used for adjuvant therapy against ...

Abstract	Protein-bound polysaccharide K (PSK) is an anticancer agent used for adjuvant therapy against gastric cancer. The aim of this study was to evaluate the effect of PSK on the overall survival of patients with gastric cancer. A total of 254 patients who underwent surgical curative resection were included in this retrospective study. We identified 138 patients who received antimetabolites alone (control group) and 115 patients who received antimetabolites plus PSK (PSK group). In patients with early tumor recurrence, overall survival was significantly better in the PSK group (p=0.023). In patients with pN3 lymph node metastasis, median overall survival was better in the PSK group compared with the control group (p=0.032). Our results suggest that adjuvant immunochemotherapy with PSK increased the overall survival for patients with pN3 and early tumor recurrence. Thus, the combination of PSK with oral chemotherapeutic agents might be suitable for postoperative adjuvant therapy against gastric cancer in patients with lymph node metastases.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Aged ; Antineoplastic Agents/therapeutic use ; Chemotherapy, Adjuvant/methods ; Female ; Humans ; Immunosuppression/methods ; Male ; Middle Aged ; Proteoglycans/therapeutic use ; Retrospective Studies ; Stomach Neoplasms/mortality ; Stomach Neoplasms/therapy ; Survival Analysis
Chemical Substances	Adjuvants, Immunologic ; Antineoplastic Agents ; Proteoglycans ; polysaccharide-K (3X48A86C8K)
Language	English
Publishing date	2012-08
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
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Article ; Online: Clinical significance of the K/DOQI bone guidelines in Japan.

Yokoyama, Keitaro / Katoh, Naohiko / Kubo, Hitoshi / Murai, Seizo / Imamura, Noritugu / Shoji, Ryo / Yamamoto, Hiroyasu / Shigematsu, Takashi / Nakayama, Masaaki / Takasu, Shinji / Kono, Takashi / Yoshida, Toyohiko / Hosoya, Tatsuo

American journal of kidney diseases : the official journal of the National Kidney Foundation

2004 Volume 44, Issue 2, Page(s) 383–4; author reply 384

MeSH term(s)	Blood Specimen Collection ; Bone Diseases, Metabolic/blood ; Bone Diseases, Metabolic/etiology ; Bone Diseases, Metabolic/prevention & control ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/etiology ; Japan ; Kidney Diseases/complications ; Kidney Diseases/metabolism ; Kidney Diseases/therapy ; Parathyroid Hormone/blood ; Phosphorus/blood ; Practice Guidelines as Topic ; Reference Values ; Time Factors ; United States ; Vitamin D/administration & dosage ; Vitamin D/therapeutic use
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2004-08
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2004.05.038
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