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Article: Pediatric Ectopic Cushing Syndrome Caused by Hepatic Neoplasms: A Case Report and Systematic Review.

Jevalikar, Ganesh / Ravindra, Shruthi / Reddy, Pavan Kumar / S L, Sagar Reddy / Sarathi, Vijaya

2023 Volume 15, Issue 3, Page(s) e36852

Abstract: Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is rare in children, and localizing the source of EAS is often challenging. Here, we report EAS in an adolescent boy who presented with Cushingoid features and had endogenous ACTH-dependent ... ...

Abstract	Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is rare in children, and localizing the source of EAS is often challenging. Here, we report EAS in an adolescent boy who presented with Cushingoid features and had endogenous ACTH-dependent hypercortisolism on hormonal evaluation. Abdominal ultrasound and CT revealed a hepatic lesion with characteristics suggestive of hemangioma, whereas the lesion was tracer non-avid on
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.36852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Video Consultation Versus In-Person Clinic Visit for Glycemic Control in Type 2 Diabetes during COVID-19 Pandemic (VIP-CD Study).

Dutta, Aditya / Mahendru, Shama / Sharma, Rutuja / Singh, Anshu / Jain, Anjali / Jevalikar, Ganesh / Mithal, Ambrish

Indian journal of endocrinology and metabolism

2022 Volume 25, Issue 5, Page(s) 427–431

Abstract: Objectives: To compare the efficacy of video consultation (VC) for prospective glycemic control against that of in-person clinic visit (IPV) in individuals with type 2 diabetes.: Materials and methods: This is a retrospective, cohort study of 96 ... ...

Abstract	Objectives: To compare the efficacy of video consultation (VC) for prospective glycemic control against that of in-person clinic visit (IPV) in individuals with type 2 diabetes. Materials and methods: This is a retrospective, cohort study of 96 individuals with type 2 diabetes followed up for a period of ≤6 months. The cohort was divided into two groups depending on the mode of consultation, namely IPV ( Results: The cohort had a mean age of 55.4 ± 13.8 years, median diabetes duration of 8 (0.3-70) years, a mean body mass index (BMI) of 28.8 ± 5.8 kg/m Conclusions: Telemedicine is an effective mode of consultation for attaining glycemic control during COVID-19 pandemic, possibly owing to the quicker follow-up without the risk of potential in-clinic/hospital exposure to COVID-19.
Language	English
Publishing date	2022-01-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2600211-5
ISSN	2230-9500 ; 2230-8210
ISSN (online)	2230-9500
ISSN	2230-8210
DOI	10.4103/ijem.ijem_347_21
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Article ; Online: Exogenous Cushing Syndrome due to Topical Clobetasone use for Diaper Rash.

Jevalikar, Ganesh / Sharma, Ojasvini

Indian pediatrics

2016 Volume 53, Issue 1, Page(s) 76–77

MeSH term(s)	Anti-Inflammatory Agents/adverse effects ; Anti-Inflammatory Agents/therapeutic use ; Clobetasol/adverse effects ; Clobetasol/analogs & derivatives ; Clobetasol/therapeutic use ; Cushing Syndrome/chemically induced ; Cushing Syndrome/diagnosis ; Cushing Syndrome/pathology ; Diaper Rash/drug therapy ; Female ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Infant
Chemical Substances	Anti-Inflammatory Agents ; Glucocorticoids ; clobetasone butyrate (8U0H6XI6EO) ; Clobetasol (ADN79D536H)
Language	English
Publishing date	2016-01
Publishing country	India
Document type	Case Reports ; Letter
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article: Risk Factors for Cerebral Edema and Acute Kidney Injury in Children with Diabetic Ketoacidosis.

Raghunathan, Veena / Jevalikar, Ganesh / Dhaliwal, Maninder / Singh, Dhirendra / Sethi, Sidharth K / Kaur, Parjeet / Singhi, Sunit C

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

2022 Volume 25, Issue 12, Page(s) 1446–1451

Abstract: ... this article: Raghunathan V, Jevalikar G, Dhaliwal M, Singh D, Sethi SK, Kaur P, ...

Abstract	Objectives: To study the clinical profile and risk factors of cerebral edema and acute kidney injury in children with diabetic ketoacidosis. Design: Retrospective review of medical records. Patients: Fifty consecutive patients (age <18 years) admitted to our pediatric intensive care unit with a diagnosis of diabetic ketoacidosis over 5 years. Materials and methods: Retrospective analysis of medical records was done, and data including patients' age, sex, presenting features, biochemical profile including blood glucose, osmolality, urea, creatinine, and venous blood gas, electrolytes were recorded at admission, at 12 and 24 hours. Treatment details including fluid administration, rate of fall of glucose, time to resolution of diabetic ketoacidosis were noted. Complications such as cerebral edema and acute kidney injury were recorded. Patients with and without cerebral edema and acute kidney injury were compared. Variables that were significant on univariate analysis were entered in a multiple logistic regression analysis to determine the independent predictors for cerebral edema and acute kidney injury. Odds ratio and 95% confidence interval were calculated using SPSS version 22. Measurements and main results: Between November 2015 and 2020, 48 patients were admitted for a total of 50 episodes of diabetic ketoacidosis. Two patients had recurrent diabetic ketoacidosis. Median age was 9.5 years (range 1-17). Thirty-one patients (62%) had new-onset type I diabetes mellitus. Twenty-two patients (44%) presented with severe diabetic ketoacidosis. Cerebral edema and acute kidney injury were seen in 11 (22%) and 15 (30%) patients, respectively. On multiple logistic regression analysis, higher blood urea level, lower serum bicarbonate level, and higher corrected sodium levels at admission were identified to be variables independently associated with risk of cerebral edema. Conclusions: Higher corrected sodium, higher urea level, and lower serum bicarbonate levels at admission are predictive of cerebral edema in patients presenting with diabetic ketoacidosis. The severity of dehydration and acidosis in DKA appears to be a common factor responsible for the development of dysfunction of both brain and kidney. How to cite this article: Raghunathan V, Jevalikar G, Dhaliwal M, Singh D, Sethi SK, Kaur P,
Language	English
Publishing date	2022-01-14
Publishing country	India
Document type	Case Reports
ZDB-ID	2121263-6
ISSN	1998-359X ; 0972-5229
ISSN (online)	1998-359X
ISSN	0972-5229
DOI	10.5005/jp-journals-10071-24038
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Article: Low FT3 is an independent marker of disease severity in patients hospitalized for COVID-19.

Dutta, Aditya / Jevalikar, Ganesh / Sharma, Rutuja / Farooqui, Khalid J / Mahendru, Shama / Dewan, Arun / Bhudiraja, Sandeep / Mithal, Ambrish

Endocrine connections

2021 Volume 10, Issue 11, Page(s) 1455–1462

Abstract: Aim: To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients of coronavirus disease-19 (COVID-19).: Methods: In this retrospective cohort study, thyroid function tests (TFT) of 236 ... ...

Abstract	Aim: To study the prevalence of thyroid dysfunction and its association with disease severity in hospitalized patients of coronavirus disease-19 (COVID-19). Methods: In this retrospective cohort study, thyroid function tests (TFT) of 236 hospitalized patients of COVID-19 along with demographic, comorbid, clinical, biochemical and disease severity records were analysed. Patients were divided into previous euthyroid or hypothyroid status to observe the effect of prior hypothyroidism on the severity of COVID-19. Results: TFT abnormalities were common. Low free T3 (FT3), high thyroid-stimulating hormone (TSH) and low TSH were seen in 56 (23.7%), 15 (6.4%) and 9 (3.8%) patients, respectively. The median levels of TSH (2.06 vs 1.26 mIU/mL, P = 0.001) and FT3 (2.94 vs 2.47 pg/mL, P < 0.001) were significantly lower in severe disease. Previous hypothyroid status (n = 43) was associated with older age, higher frequency of comorbidities, higher FT4 and lower FT3. TFT did not correlate with markers of inflammation (except lactate dehydrogenase); however, FT3 and TSH negatively correlated with outcome severity score and duration of hospital stay. Cox regression analysis showed that low FT3 was associated with severe COVID-19 (P = 0.032, HR 0.302; CI 0.101-0.904), irrespective of prior hypothyroidism. Conclusions: Functional thyroid abnormalities (low FT3 and low TSH) are frequently seen in hospitalized patients of COVID-19. Although these abnormalities did not correlate with markers of inflammation, this study shows that low FT3 at admission independently predicts the severity of COVID-19.
Language	English
Publishing date	2021-11-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2668428-7
ISSN	2049-3614
ISSN	2049-3614
DOI	10.1530/EC-21-0362
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Article ; Online: Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19.

Jevalikar, Ganesh / Mithal, Ambrish / Singh, Anshu / Sharma, Rutuja / Farooqui, Khalid J / Mahendru, Shama / Dewan, Arun / Budhiraja, Sandeep

Scientific reports

2021 Volume 11, Issue 1, Page(s) 6258

Abstract: Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed to influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with COVID-19. Serum 25-OHD level < 20 ng/mL was considered VDD. ... ...

Abstract	Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed to influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with COVID-19. Serum 25-OHD level < 20 ng/mL was considered VDD. Patients were classified as having mild and severe disease on basis of the WHO ordinal scale for clinical improvement (OSCI). Of the 410 patients recruited, patients with VDD (197,48.2%) were significantly younger and had lesser comorbidities. The levels of PTH were significantly higher in the VDD group (63.5 ± 54.4 vs. 47.5 ± 42.9 pg/mL). The proportion of severe cases (13.2% vs.14.6%), mortality (2% vs. 5.2%), oxygen requirement (34.5% vs.43.4%), ICU admission (14.7% vs.19.8%) was not significantly different between patients with or without VDD. There was no significant correlation between serum 25-OHD levels and inflammatory markers studied. Serum parathormone levels correlated with D-dimer (r 0.117, p- 0.019), ferritin (r 0.132, p-0.010), and LDH (r 0.124, p-0.018). Amongst VDD patients, 128(64.9%) were treated with oral cholecalciferol (median dose of 60,000 IU). The proportion of severe cases, oxygen, or ICU admission was not significantly different in the treated vs. untreated group. In conclusion, serum 25-OHD levels at admission did not correlate with inflammatory markers, clinical outcomes, or mortality in hospitalized COVID-19 patients. Treatment of VDD with cholecalciferol did not make any difference to the outcomes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Child ; Cholecalciferol/therapeutic use ; Cross-Sectional Studies ; Female ; Humans ; India/epidemiology ; Male ; Middle Aged ; Parathyroid Hormone/blood ; Prevalence ; Prospective Studies ; Severity of Illness Index ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/therapy ; Young Adult
Chemical Substances	Parathyroid Hormone ; Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-85809-y
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Article ; Online: Intestinal mucormycosis complicated by iliac artery aneurysm and ureteric rupture in a child with new-onset type 1 diabetes mellitus.

Jevalikar, Ganesh / Sharma, Rajni / Raghunathan, Veena / Luthra, Meera / Dhaliwal, Maninder S / Jain, Vandana / Mithal, Ambrish

Journal of paediatrics and child health

2020 Volume 57, Issue 7, Page(s) 1117–1119

MeSH term(s)	Aneurysm ; Child ; Diabetes Mellitus, Type 1/complications ; Humans ; Iliac Artery ; Mucormycosis/complications ; Mucormycosis/diagnosis ; Rupture
Language	English
Publishing date	2020-08-20
Publishing country	Australia
Document type	Case Reports
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/jpc.15126
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Article ; Online: High prevalence of diabetes and other comorbidities in hospitalized patients with COVID-19 in Delhi, India, and their association with outcomes.

Mithal, Ambrish / Jevalikar, Ganesh / Sharma, Rutuja / Singh, Anshu / Farooqui, Khalid J / Mahendru, Shama / Krishnamurthy, Aishwarya / Dewan, Arun / Budhiraja, Sandeep

Diabetes & metabolic syndrome

2020 Volume 15, Issue 1, Page(s) 169–175

Abstract: Background and aims: To study the prevalence and impact of diabetes mellitus and other comorbidities among hospitalized patients with COVID-19.: Methods: In a prospective, observational study including consecutive adults hospitalized with COVID-19, ... ...

Abstract	Background and aims: To study the prevalence and impact of diabetes mellitus and other comorbidities among hospitalized patients with COVID-19. Methods: In a prospective, observational study including consecutive adults hospitalized with COVID-19, clinical outcomes and inflammatory markers were compared in those with and without diabetes. Participants were classified as having mild or severe COVID-19 disease using the WHO ordinal scale. Results: 401 patients (125 females) with median age of 54 years (range 19-92) were evaluated. Of them 189 (47.1%) had pre-existing diabetes and21 (5.2%) had new-onset hyperglycaemia. Overall, 344 (85.8%) and 57 (14.2%) cases had mild and severe COVID-19 disease respectively. The group with diabetes had a higher proportion of severe cases (20.1% vs 9%, p-0.002), mortality (6.3 vs 1.4%, p-0.015), ICU admission (24.3 vs 12.3%, p-0.002), and oxygen requirement (53.4 vs 28.3%, p < 0.001). Baseline Hba1c (n = 331) correlated significantly with outcome severity scores (r 0.136, p-0.013) and 12/15 (80%) of those who succumbed had diabetes. Hypertension, coronary artery disease, and chronic kidney disease were present in 164 (40.9%), 35 (8.7%) and 12 (2.99%) patients respectively. Hypertension was associated with a higher proportion of severe cases, mortality, ICU admission and oxygen administration. Conclusions: We report a high prevalence of diabetes in a hospitalized COVID-19 population. Patients with diabetes or hypertension had more severe disease and greater mortality.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; Comorbidity ; Cross-Sectional Studies ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Female ; Hospitalization/trends ; Humans ; Hyperglycemia/blood ; Hyperglycemia/diagnosis ; Hyperglycemia/epidemiology ; Hypertension/blood ; Hypertension/diagnosis ; Hypertension/epidemiology ; India/epidemiology ; Inflammation Mediators/blood ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Treatment Outcome ; Young Adult
Chemical Substances	Inflammation Mediators
Language	English
Publishing date	2020-12-17
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2020.12.029
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Article ; Online: Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19

Ganesh Jevalikar / Ambrish Mithal / Anshu Singh / Rutuja Sharma / Khalid J. Farooqui / Shama Mahendru / Arun Dewan / Sandeep Budhiraja

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 8

Abstract: Abstract Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed to influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with COVID-19. Serum 25-OHD level < 20 ng/mL was considered ...

Abstract	Abstract Vitamin D deficiency (VDD) owing to its immunomodulatory effects is believed to influence outcomes in COVID-19. We conducted a prospective, observational study of patients, hospitalized with COVID-19. Serum 25-OHD level < 20 ng/mL was considered VDD. Patients were classified as having mild and severe disease on basis of the WHO ordinal scale for clinical improvement (OSCI). Of the 410 patients recruited, patients with VDD (197,48.2%) were significantly younger and had lesser comorbidities. The levels of PTH were significantly higher in the VDD group (63.5 ± 54.4 vs. 47.5 ± 42.9 pg/mL). The proportion of severe cases (13.2% vs.14.6%), mortality (2% vs. 5.2%), oxygen requirement (34.5% vs.43.4%), ICU admission (14.7% vs.19.8%) was not significantly different between patients with or without VDD. There was no significant correlation between serum 25-OHD levels and inflammatory markers studied. Serum parathormone levels correlated with D-dimer (r 0.117, p- 0.019), ferritin (r 0.132, p-0.010), and LDH (r 0.124, p-0.018). Amongst VDD patients, 128(64.9%) were treated with oral cholecalciferol (median dose of 60,000 IU). The proportion of severe cases, oxygen, or ICU admission was not significantly different in the treated vs. untreated group. In conclusion, serum 25-OHD levels at admission did not correlate with inflammatory markers, clinical outcomes, or mortality in hospitalized COVID-19 patients. Treatment of VDD with cholecalciferol did not make any difference to the outcomes.
Keywords	Medicine ; R ; Science ; Q
Subject code	610 ; 616
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Cutaneous mucormycosis as a presenting feature of type 1 diabetes in a boy - case report and review of the literature.

Jevalikar, Ganesh / Sudhanshu, Siddhnath / Mahendru, Sanjay / Sarma, Smita / Farooqui, Khalid J / Mithal, Ambrish

Journal of pediatric endocrinology & metabolism : JPEM

2018 Volume 31, Issue 6, Page(s) 689–692

Abstract: Background: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen.: Case presentation: We describe the case of a 4½ -year-old boy not ...

Abstract	Background: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen. Case presentation: We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. After the diagnosis of diabetes and initial treatment, pus from the wound showed broad aseptate hyphae suggestive of mucormycosis which was further confirmed on culture. Aggressive surgical debridement including amputation, antifungal treatment and glycemic control achieved a complete cure. Conclusions: Cutaneous mucormycosis is a rare complication of type 1 diabetes mellitus and can even be seen at the onset of diabetes. High index of suspicion, timely antifungal treatment and aggressive surgical debridement usually lead to recovery in the localized form of the disease.
MeSH term(s)	Amputation ; Antifungal Agents/therapeutic use ; Child, Preschool ; Debridement ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/surgery ; Diagnosis, Differential ; Fingers/microbiology ; Fingers/pathology ; Fingers/surgery ; Hand Deformities, Acquired/drug therapy ; Hand Deformities, Acquired/microbiology ; Hand Deformities, Acquired/pathology ; Hand Deformities, Acquired/surgery ; Humans ; Male ; Mucormycosis/diagnosis ; Mucormycosis/drug therapy ; Mucormycosis/etiology ; Mucormycosis/surgery
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2018-03-21
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1231070-0
ISSN	2191-0251 ; 0334-018X
ISSN (online)	2191-0251
ISSN	0334-018X
DOI	10.1515/jpem-2017-0404
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