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  1. Article: In silico

    Chaurasia, Reetika / Vinetz, Joseph M

    Frontiers in molecular biosciences

    2023  Volume 9, Page(s) 1092197

    Abstract: Mechanisms of leptospirosis pathogenesis remain unclear despite the identification of a number of potential leptospiral virulence factors. We recently demonstrated potential mechanisms by which the virulence-modifying (VM) proteins-defined as containing ... ...

    Abstract Mechanisms of leptospirosis pathogenesis remain unclear despite the identification of a number of potential leptospiral virulence factors. We recently demonstrated potential mechanisms by which the virulence-modifying (VM) proteins-defined as containing a Domain of Unknown function (DUF1561), encoded by the PF07598 gene family-found only in group 1 pathogenic
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.1092197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Lack of efficacy of hydroxychloroquine in covid-19.

    Vinetz, Joseph M

    BMJ (Clinical research ed.)

    2020  Volume 369, Page(s) m2018

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Hydroxychloroquine ; Oxygen ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Oxygen (S88TT14065)
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.10: Show issues Location:
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  4. Book ; Online: Lack of efficacy of hydroxychloroquine in covid-19

    Vinetz, Joseph M

    2020  

    Keywords EDITORIALS ; covid19
    Language English
    Publishing date 2020-05-19 07:56:19.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Lack of efficacy of hydroxychloroquine in covid-19

    Vinetz, Joseph M

    BMJ

    2020  , Page(s) m2018

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2018
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Transmission-Blocking Preventive Measures for Infectious Diseases: Altruism, Solidarity, and the Common Good.

    Garber, Laine / Vinetz, Joseph M

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 5, Page(s) 1609–1610

    Abstract: Aiming to prevent the spread of contagious diseases has long been a central tenet of public health. In the present time, divisive political responses to mask wearing to prevent SARS-CoV-2 transmission have competed with sound public health advice for ... ...

    Abstract Aiming to prevent the spread of contagious diseases has long been a central tenet of public health. In the present time, divisive political responses to mask wearing to prevent SARS-CoV-2 transmission have competed with sound public health advice for public attention. Here, we draw parallels in terms of individualism versus societal solidarity between the slow and ponderous development of transmission-blocking vaccines for malaria and advocacy for mask wearing to prevent COVID-19.
    MeSH term(s) Altruism ; COVID-19/prevention & control ; COVID-19/transmission ; Humans ; Infection Control/methods ; Masks ; Public Health ; SARS-CoV-2 ; Social Cohesion
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Next-Generation Sequencing Analysis of Pathogenic Leptospira: A Way Forward for Understanding Infectious Disease Dynamics in Low/Middle-Income, Disease-Endemic Settings.

    Agampodi, Suneth B / Vinetz, Joseph M

    The American journal of tropical medicine and hygiene

    2021  Volume 104, Issue 5, Page(s) 1625–1627

    Abstract: In the current genomic era, knowledge of diversity of Leptospira, the spirochetal agents of leptospirosis, is changing rapidly. Next-generation sequencing has decreased in price and increased in scale, with the potential to democratize large-scale ... ...

    Abstract In the current genomic era, knowledge of diversity of Leptospira, the spirochetal agents of leptospirosis, is changing rapidly. Next-generation sequencing has decreased in price and increased in scale, with the potential to democratize large-scale analysis of pathogens in resource-limited, low/middle-income (LMIC) regions. Consequently, the molecular classification of Leptospira, a pathogen disproportionately affecting LMIC countries, has changed dramatically over the last decade. Leptospira classification and molecular understandings of pathogen diversity have rapidly evolved, now most precisely based on core genome analysis supplemented by new insights provided by culture-independent methods directly using body fluids such as blood and urine. In places where leptospirosis disease burden is highest, genomic technologies have not been available, and serology-based methods remain the mainstay of leptospiral classification. Understanding the epidemiology, pathogenesis, and ultimately new approaches to treating and preventing leptospirosis requires detailed knowledge of regionally circulating Leptospira in highly endemic settings. Next-generation sequencing-based, culture-independent typing overcomes the limitation of culture isolation of Leptospira from clinical samples, with promise of providing public health-actionable information applicable to leptospirosis-endemic LMIC settings.
    MeSH term(s) Animals ; Endemic Diseases/prevention & control ; Genotype ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Leptospira/classification ; Leptospira/genetics ; Leptospira/pathogenicity ; Leptospirosis/epidemiology ; Leptospirosis/microbiology ; Phylogeny ; Poverty ; Sequence Analysis, DNA ; Serogroup ; Zoonoses/epidemiology ; Zoonoses/microbiology
    Language English
    Publishing date 2021-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.20-1518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of the PF07598-Encoded Virulence-Modifying Proteins of

    Vieira, Dielson S / Chaurasia, Reetika / Vinetz, Joseph M

    Tropical medicine and infectious disease

    2022  Volume 8, Issue 1

    Abstract: Leptospirosis is an emerging infectious disease, with increasing frequency and severity of outbreaks, a changing epidemiology of populations at risk, and the emergence of new strains, serovars, serogroups, and species. Virulence-modifying (VM) proteins ... ...

    Abstract Leptospirosis is an emerging infectious disease, with increasing frequency and severity of outbreaks, a changing epidemiology of populations at risk, and the emergence of new strains, serovars, serogroups, and species. Virulence-modifying (VM) proteins encoded by the PF07598 gene family are hypothesized to be
    Language English
    Publishing date 2022-12-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2414-6366
    ISSN (online) 2414-6366
    DOI 10.3390/tropicalmed8010014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dexamethasone in the management of covid -19.

    Johnson, Raymond M / Vinetz, Joseph M

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2648

    MeSH term(s) Age Factors ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Dexamethasone/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Editorial
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Whole genome sequencing data of

    Senavirathna, Indika / Jayasundara, Dinesha / Warnasekara, Janith / Matthias, Michael A / Vinetz, Joseph M / Agampodi, Suneth

    Data in brief

    2023  Volume 52, Page(s) 109840

    Abstract: Leptospirosis is a re-emerging zoonotic disease. This article reports the complete genome sequences of three novel strains of ... ...

    Abstract Leptospirosis is a re-emerging zoonotic disease. This article reports the complete genome sequences of three novel strains of Genus
    Language English
    Publishing date 2023-11-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2786545-9
    ISSN 2352-3409 ; 2352-3409
    ISSN (online) 2352-3409
    ISSN 2352-3409
    DOI 10.1016/j.dib.2023.109840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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