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  1. Article ; Online: ICANS prophylaxis: potentially transformative but elusive.

    Dowling, Mark R / Turtle, Cameron J

    Blood advances

    2023  Volume 7, Issue 21, Page(s) 6782–6784

    MeSH term(s) Humans ; Interleukin 1 Receptor Antagonist Protein ; Lymphoma, B-Cell
    Chemical Substances Interleukin 1 Receptor Antagonist Protein
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023011027
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7153: Show issues Location:
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  2. Article ; Online: Response.

    Cameron, Rory A / Rowley, Mark / Simmonds, Nicholas J / Whitty, Jennifer A / Carr, Siobhán B

    Chest

    2023  Volume 163, Issue 4, Page(s) e194–e195

    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.01.006
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    Ui III Zs.45: Show issues Location:
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    Zs.MO 349: Show issues

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  3. Article ; Online: Adjuvant AS01 activates human monocytes for costimulation and systemic inflammation.

    Smith, Carson L / Richardson, Brian / Rubsamen, Michael / Cameron, Mark J / Cameron, Cheryl M / Canaday, David H

    Vaccine

    2023  Volume 42, Issue 2, Page(s) 229–238

    Abstract: Background: The adjuvanted recombinant zoster vaccine (RZV) is highly effective even in adults over 80 years old. The high efficacy of RZV is attributed to its highly reactogenic adjuvant, AS01, but limited studies have been done on AS01's activation of ...

    Abstract Background: The adjuvanted recombinant zoster vaccine (RZV) is highly effective even in adults over 80 years old. The high efficacy of RZV is attributed to its highly reactogenic adjuvant, AS01, but limited studies have been done on AS01's activation of human immune cells.
    Methods: We stimulated peripheral blood mononuclear cells (PBMC) with AS01 and used flow cytometry and RNA Sequencing (RNAseq) to analyze the impacts on human primary cells.
    Results: We found that incubation of PBMC with AS01 activated monocytes to a greater extent than any other cell population, including dendritic cells. Both classical and non-classical monocytes demonstrated this activation. RNASeq showed that TNF-ɑ and IL1R pathways were highly upregulated in response to AS01 exposure, even in older adults.
    Conclusions: In a PBMC co-culture, AS01 strongly activates human monocytes to upregulate costimulation markers and induce cytokines that mediate systemic inflammation. Understanding AS01's impacts on human cells opens possibilities to further address the reduced vaccine response associated with aging.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Leukocytes, Mononuclear ; Monocytes ; Adjuvants, Immunologic/pharmacology ; Herpes Zoster/prevention & control ; Vaccines, Synthetic ; Herpes Zoster Vaccine ; Inflammation
    Chemical Substances Adjuvants, Immunologic ; Vaccines, Synthetic ; Herpes Zoster Vaccine
    Language English
    Publishing date 2023-12-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2023.12.010
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    Zs.A 1930: Show issues Location:
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    Zs.MO 458: Show issues

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  4. Article ; Online: Is it Time to Change the Peer Review Process?

    Lambrechts, Mark J / Schroeder, Gregory D / Kia, Cameron / Makanji, Heeren S

    Clinical spine surgery

    2023  Volume 36, Issue 6, Page(s) 221–223

    MeSH term(s) Humans ; Peer Review
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001420
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    Zs.A 2427: Show issues Location:
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  5. Article: Estimating Excreted Nutrients to Improve Nutrient Management for Grazing System Dairy Farms.

    Aarons, Sharon R / Gourley, Cameron J P / Powell, J Mark

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 8

    Abstract: Improving nutrient management in grazing system dairy farms requires determining nutrient flows through animals, the placement of cows within farms and potential for collection, and the re-use and loss of nutrients. We applied a model incorporating data ... ...

    Abstract Improving nutrient management in grazing system dairy farms requires determining nutrient flows through animals, the placement of cows within farms and potential for collection, and the re-use and loss of nutrients. We applied a model incorporating data collected at a range of temporal and spatial scales to quantify nutrient excretion in all locations that lactating herds visited on five days over a year on 43 conventional and organic grazing system dairy farms. The calculated nutrient loads excreted by cows in different places were highly skewed; while N, P and K deposited loads were consistent across the year, S, Ca and Mg loads varied between sampling times and seasons. The greatest mean and range in nutrient loads were deposited in paddocks, with the smallest amounts deposited in dairy sheds. All excreted nutrient loads increased with farm and herd sizes and milk production. Mean daily loads of 112, 15, 85, 11, 22 and 13 kg of N, P, K, S, Ca and Mg were deposited by the herds which, when standardised to a 305-day lactation, amounted to 24, 4, 20, 3, 5 and 3 t excreted annually, respectively. In addition to routine manure collection in dairy sheds, ensuring collection and recycling of nutrients excreted on feed pads and holding areas would decrease potential nutrient losses by 29% on average. Non-collected, recycled nutrients were disproportionately returned to paddocks in which cows spent time overnight, and except for S and Ca, nutrient loading rates were greater than rates applied as fertilisers. These data demonstrate the extent of excreted nutrients in grazing dairy systems and indicate the need to account for these nutrients in nutrient management plans for Australian dairy farms. We propose incorporating excretion data in current budgeting tools using data currently collected on most Australian grazing system dairy farms.
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13081404
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  6. Article: Corrigendum to "Tracheostomy clinical practices and patient outcomes in three tertiary metropolitan hospitals in Australia" [Australian Critical Care 36 (2023) 327-335].

    Zaga, Charissa J / Berney, Sue / Hepworth, Graham / Cameron, Tanis S / Baker, Sonia / Giddings, Charles / Howard, Mark E / Bellomo, Rinaldo / Vogel, Adam P

    Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

    2024  Volume 37, Issue 2, Page(s) 380

    Language English
    Publishing date 2024-02-09
    Publishing country Australia
    Document type Published Erratum
    ZDB-ID 1159493-7
    ISSN 1878-1721 ; 1036-7314
    ISSN (online) 1878-1721
    ISSN 1036-7314
    DOI 10.1016/j.aucc.2024.02.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3762: Show issues Location:
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  7. Article ; Online: Molecular dynamics simulations of the dielectric constants of salt-free and salt-doped polar solvents.

    Shock, Cameron J / Stevens, Mark J / Frischknecht, Amalie L / Nakamura, Issei

    The Journal of chemical physics

    2023  Volume 159, Issue 13

    Abstract: We develop a Stockmayer fluid model that accounts for the dielectric responses of polar solvents (water, MeOH, EtOH, acetone, 1-propanol, DMSO, and DMF) and NaCl solutions. These solvent molecules are represented by Lennard-Jones (LJ) spheres with ... ...

    Abstract We develop a Stockmayer fluid model that accounts for the dielectric responses of polar solvents (water, MeOH, EtOH, acetone, 1-propanol, DMSO, and DMF) and NaCl solutions. These solvent molecules are represented by Lennard-Jones (LJ) spheres with permanent dipole moments and the ions by charged LJ spheres. The simulated dielectric constants of these liquids are comparable to experimental values, including the substantial decrease in the dielectric constant of water upon the addition of NaCl. Moreover, the simulations predict an increase in the dielectric constant when considering the influence of ion translations in addition to the orientation of permanent dipoles.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0165481
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    Z 4' 49/16: Show issues

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  8. Article ; Online: Do breast cancer patients have increased risk of complications after primary total hip and total knee arthroplasty?

    Ledford, Cameron K / Shirley, Matthew B / Spangehl, Mark J / Berry, Daniel J / Abdel, Matthew P

    The bone & joint journal

    2024  Volume 106-B, Issue 4, Page(s) 365–371

    Abstract: Aims: Breast cancer survivors have known risk factors that might influence the results of total hip arthroplasty (THA) or total knee arthroplasty (TKA). This study evaluated clinical outcomes of patients with breast cancer history after primary THA and ... ...

    Abstract Aims: Breast cancer survivors have known risk factors that might influence the results of total hip arthroplasty (THA) or total knee arthroplasty (TKA). This study evaluated clinical outcomes of patients with breast cancer history after primary THA and TKA.
    Methods: Our total joint registry identified patients with breast cancer history undergoing primary THA (n = 423) and TKA (n = 540). Patients were matched 1:1 based upon age, sex, BMI, procedure (hip or knee), and surgical year to non-breast cancer controls. Mortality, implant survival, and complications were assessed via Kaplan-Meier methods. Clinical outcomes were evaluated via Harris Hip Scores (HHSs) or Knee Society Scores (KSSs). Mean follow-up was six years (2 to 15).
    Results: Breast cancer patient survival at five years was 92% (95% confidence interval (CI) 89% to 95%) after THA and 94% (95% CI 92% to 97%) after TKA. Breast and non-breast cancer patients had similar five-year implant survival free of any reoperation or revision after THA (p ≥ 0.412) and TKA (p ≥ 0.271). Breast cancer patients demonstrated significantly lower survival free of any complications after THA (91% vs 96%, respectively; hazard ratio = 2 (95% CI 1.1 to 3.4); p = 0.017). Specifically, the rate of intraoperative fracture was 2.4% vs 1.4%, and venous thromboembolism (VTE) was 1.4% and 0.5% for breast cancer and controls, respectively, after THA. No significant difference was noted in any complications after TKA (p ≥ 0.323). Both breast and non-breast cancer patients experienced similar improvements in HHSs (p = 0.514) and KSSs (p = 0.132).
    Conclusion: Breast cancer survivors did not have a significantly increased risk of mortality or reoperation after primary THA and TKA. However, there was a two-fold increased risk of complications after THA, including intraoperative fracture and VTE.
    MeSH term(s) Humans ; Female ; Arthroplasty, Replacement, Knee/adverse effects ; Breast Neoplasms/surgery ; Breast Neoplasms/etiology ; Venous Thromboembolism/etiology ; Retrospective Studies ; Knee Joint/surgery ; Arthroplasty, Replacement, Hip/adverse effects ; Risk Factors ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.106B4.BJJ-2023-0968.R1
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    Zs.A 6989: Show issues Location:
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  9. Article ; Online: Opioid Use and Driving Performance.

    Cameron-Burr, Keaton T / Conicella, Albert / Neavyn, Mark J

    Journal of medical toxicology : official journal of the American College of Medical Toxicology

    2021  Volume 17, Issue 3, Page(s) 289–308

    Abstract: Introduction: The USA is in an opioid epidemic, with an increased number of individuals taking psychoactive drugs while executing the tasks of everyday life, including operating a motor vehicle. The pharmacology of opioids has been widely studied, but ... ...

    Abstract Introduction: The USA is in an opioid epidemic, with an increased number of individuals taking psychoactive drugs while executing the tasks of everyday life, including operating a motor vehicle. The pharmacology of opioids has been widely studied, but the effects of opioids on psychomotor function, driving performance, and the risk of motor vehicle collision remain less clear. Clinicians are faced with the challenge of controlling patient pain while also reconciling conflicting messages from the literature about how safe it is for their patients taking opioids to engage in potentially dangerous routine tasks.
    Discussion: This review assesses the current literature regarding opioids as they relate to neurocognitive function, driving performance, and accident risk. Manuscripts are categorized by study context and subject matter: controlled experimental administration, illicit use, prescription use, retrospective forensic toxicology, and polydrug consumption.
    Conclusion: Illicit use, initiation of therapy, and opioid use in combination with other psychoactive medications are contexts most clearly associated with impairment of driving-related functions and/or operation of a motor vehicle. Clinicians should counsel patients on the risk of impairment when initiating therapy, when co-prescribing opioids and other psychoactive drugs, or when a patient is suspected of having an opioid use disorder.
    MeSH term(s) Accidents, Traffic/statistics & numerical data ; Adult ; Aged ; Aged, 80 and over ; Analgesics, Opioid/toxicity ; Female ; Humans ; Male ; Middle Aged ; Opioid-Related Disorders/epidemiology ; Psychomotor Disorders/chemically induced ; Retrospective Studies ; United States/epidemiology
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 2435016-3
    ISSN 1937-6995 ; 1556-9039
    ISSN (online) 1937-6995
    ISSN 1556-9039
    DOI 10.1007/s13181-020-00819-y
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    Zs.A 6682: Show issues Location:
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  10. Article ; Online: How the business practices of your antibody vendor could impact your ligand-binding assay.

    Cameron, Mark J

    Bioanalysis

    2014  Volume 6, Issue 12, Page(s) 1585–1589

    MeSH term(s) Animals ; Antibodies/economics ; Antibodies/immunology ; Commerce ; Humans ; Immunoassay/economics ; Immunoassay/methods ; Immunoassay/standards ; Ligands ; Quality Control ; Reproducibility of Results
    Chemical Substances Antibodies ; Ligands
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article
    ISSN 1757-6199
    ISSN (online) 1757-6199
    DOI 10.4155/bio.14.87
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