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Article ; Online: Molekulargenetik der humanen Hypertonie.

Luft, F C

2021 Volume 62, Issue 3, Page(s) 223–235

Abstract: A genetic influence on blood pressure was demonstrated more than 100 years ago and a simple Mendelian inheritance was initially presumed. Platt and Pickering conducted a lively debate on this topic. Platt favored the idea that a single gene or only a few ...

Title translation	Molecular genetics of human hypertension.
Abstract	A genetic influence on blood pressure was demonstrated more than 100 years ago and a simple Mendelian inheritance was initially presumed. Platt and Pickering conducted a lively debate on this topic. Platt favored the idea that a single gene or only a few genes were responsible for high blood pressure. Pickering presented research results, which supported the assumption that many genes exerted an influence on blood pressure. This was all in a period when it was not even known what genes were. Genome-wide association studies (GWAS) according to the Pickering model have identified > 500 blood pressure relevant gene loci, which are distributed over the whole genome. Each individual gene exerts only a small effect on blood pressure. The dark horses of hypertension research are the secondary causes. In pheochromocytoma, primary aldosteronism, Cushing's syndrome and even fibromuscular dysplasia (renovascular hypertension) the results indicate that a genetic cause regularly underlies secondary hypertension. This would therefore also partially confirm Platt's theory. In the meantime, a multitude of forms of hypertension have been described with a genetic inheritance according to Mendel. Each of these genetic variants exerts a considerable influence on blood pressure. A multitude of novel physiological mechanisms were explained by this. These findings will become therapeutically important. Therefore, it is incumbent upon clinicians to be optimally informed about these research results.
MeSH term(s)	Blood Pressure/genetics ; Genome-Wide Association Study ; Humans ; Hypertension/genetics ; Polymorphism, Single Nucleotide
Language	German
Publishing date	2021-02-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-021-00979-1
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Article ; Online: Resistente Hypertonie : Was ist das?

Luft, F C

Der Internist

2015 Volume 56, Issue 3, Page(s) 224–229

Abstract: When blood pressure is poorly controlled despite treatment with a diuretic and two antihypertensive drugs at adequate doses, the hypertension is termed resistant. The prevalence of resistant hypertension is increasing. Once pseudo-resistance due to poor ... ...

Title translation	Resistant hypertension : What is it?.
Abstract	When blood pressure is poorly controlled despite treatment with a diuretic and two antihypertensive drugs at adequate doses, the hypertension is termed resistant. The prevalence of resistant hypertension is increasing. Once pseudo-resistance due to poor compliance, secondary forms of hypertension, and massive salt consumption have been excluded, some authorities maintain that blood pressure can be invariably lowered using minoxidil or mineralocorticoid receptor blockade. I also adhered to this belief until we encountered a patient who despite treatment with seven antihypertensive agents, electrical carotid sinus stimulation, and catheter-based renal denervation continued to exhibit extraordinarily high blood pressure values. I am now convinced that resistant hypertension does indeed exist. The prevalence of such patients can be substantially reduced by means of a thorough history and physical examination, determining drug serum concentrations, and excluding secondary causes.
MeSH term(s)	Antihypertensive Agents/administration & dosage ; Diuretics/administration & dosage ; Electric Stimulation Therapy/methods ; Humans ; Hypertension/diagnosis ; Hypertension/therapy ; Treatment Failure
Chemical Substances	Antihypertensive Agents ; Diuretics
Language	German
Publishing date	2015-03
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-014-3568-9
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Article ; Online: The value of an action: Impact of motor behaviour on outcome processing and stimulus preference.

Bikute, Kotryna / Di Bernardi Luft, Caroline / Beyer, Frederike

The European journal of neuroscience

2022 Volume 56, Issue 10, Page(s) 5823–5835

Abstract: While influences of Pavlovian associations on instrumental behaviour are well established, we still do not know how motor actions affect the formation of Pavlovian associations. To address this question, we designed a task in which participants were ... ...

Abstract	While influences of Pavlovian associations on instrumental behaviour are well established, we still do not know how motor actions affect the formation of Pavlovian associations. To address this question, we designed a task in which participants were presented with neutral stimuli, half of which were paired with an active response, half with a passive waiting period. Stimuli had an 80% chance of predicting either a monetary gain or loss. We compared the feedback-related negativity (FRN) in response to predictive stimuli and outcomes, as well as directed phase synchronization before and after outcome presentation between trials with versus without a motor response. We found a larger FRN amplitude in response to outcomes presented after a motor response (active trials). This effect was driven by a positive deflection in active reward trials, which was absent in passive reward trials. Connectivity analysis revealed that the motor action reversed the direction of the phase synchronization at the time of the feedback presentation: Top-down information flow during the outcome anticipation phase in active trials, but bottom-up information flow in passive trials. This main effect of action was mirrored in behavioural data showing that participants preferred stimuli associated with an active response. Our findings suggest an influence of neural systems that initiate motor actions on neural systems involved in reward processing. We suggest that motor actions might modulate the brain responses to feedback by affecting the dynamics of brain activity towards optimizing the processing of the resulting action outcome.
MeSH term(s)	Humans ; Reward ; Brain/physiology ; Choice Behavior/physiology ; Electroencephalography ; Evoked Potentials/physiology
Language	English
Publishing date	2022-09-27
Publishing country	France
Document type	Journal Article
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.15826
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Article ; Online: Where Does Some of the Ingested Sodium Chloride Hide without Exerting Osmotic Pressure?: Internal Sodium Balance in DOCA-Salt Rats: A Body Composition Study. Am J Renal Physiol 289: F793-F802, 2005.

Titze, J / Bauer, K / Schafflhuber, M / Dietsch, P / Lang, R / Schwind, K H / Luft, F C / Eckhardt, K U / Hilgers, K F

Journal of the American Society of Nephrology : JASN

2023 Volume 17, Issue 1, Page(s) 3–11

Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/01.asn.0000926772.62479.56
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Zs.A 3344: Show issues

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Article ; Online: Prevalence, recovery and phenotype of dysphagia in patients with ischaemic cerebellar stroke.

Schaefer, Jan Hendrik / Luft, Felix / Seiler, Alexander / Harborth, Elena / Kaffenberger, Sara / Polkowski, Christoph / Foerch, Christian / Lapa, Sriramya

European journal of neurology

2024 , Page(s) e16303

Abstract: Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the ... ...

Abstract	Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the cerebellum are associated with dysphagia. Therefore, the aim of the study was to evaluate dysphagia prevalence, recovery and dysphagia pattern in patients with ischaemic cerebellar stroke. Methods: A retrospective analysis of patients consecutively admitted to an academic stroke centre with ischaemic stroke found only in the cerebellum was performed. The presence of dysphagia was the primary end-point and was assessed by a speech-language pathologist, according to defined criteria. Dysphagia pattern was evaluated by analysing the videos of the flexible endoscopic evaluation of swallowing. Brain imaging was used to identify lesion size and location associated with dysphagia. Results: Between January 2016 and December 2021, 102 patients (35.3% female) with a mean age of 52.8 ± 17.3 years were included. Thirteen (12.7%) patients presented with dysphagia. The most frequently observed flexible endoscopic evaluation of swallowing phenotype was premature spillage (n = 7; 58.3%), whilst significant residues or aspiration did not occur. One patient died (7.7%); the other patients showed improvement of dysphagia and one patient (7.7%) was discharged with dietary restrictions. Conclusions: Although the involvement of the cerebellum in deglutition has become increasingly evident, isolated lesions to the cerebellum are less likely to cause clinically relevant and persisting dysphagia compared to other brain regions. The observed dysphagia pattern shows a lack of coordination and control, resulting in premature spillage or fragmented bolus transfer in some patients.
Language	English
Publishing date	2024-04-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1280785-0
ISSN	1468-1331 ; 1351-5101 ; 1471-0552
ISSN (online)	1468-1331
ISSN	1351-5101 ; 1471-0552
DOI	10.1111/ene.16303
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Zs.A 4738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 592: Show issues

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Article ; Online: Covid-19, ACE2, and the kidney

Hardenberg, J.H. / Luft, F.C.

2020

Abstract: We are confronted with the most dramatic pandemic world-wide for the past 100 years. We are armed "to-the-teeth" compared to 1918, we know the agent, the genomic sequence, the bodily entry, the proliferation rate, the damage pathogenesis, and the very ... ...

Abstract	We are confronted with the most dramatic pandemic world-wide for the past 100 years. We are armed "to-the-teeth" compared to 1918, we know the agent, the genomic sequence, the bodily entry, the proliferation rate, the damage pathogenesis, and the very nature of our enemy. We can identify its bodily presence and our resistance to it in terms of neutralizing antibody production. Nonetheless, the disease has laid lame the great nations of the current world and crippled the less fortunate countries. The primary disease features are not the kidney. However, the entry point has much to do with renal and cardiovascular disease. The kidney is a common target of corona-virus (SARS-CoV2) disease; the longer-term consequences could be as well.
Keywords	Cardiovascular and Metabolic Diseases ; covid19
Publisher	Wiley
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Corneal Manifestation in Patients with Infantile Nephropathic Cystinosis.

Kruse, Franziska / Keidel, Leonie Franziska / Priglinger, Siegfried / Luft, Nikolaus / Priglinger, Claudia

Klinische Monatsblatter fur Augenheilkunde

2023 Volume 240, Issue 3, Page(s) 260–265

Abstract: Nephropathic cystinosis is a rare autosomal recessive disease caused by mutations in the CTNS gene. This causes dysfunction of cystinosin, a protein that transports cystine out of lysosomes, causing cystine crystals to accumulate in cells in most organ ... ...

Title translation	Hornhautmanifestation bei Patienten mit infantiler nephropathischer Cystinose.
Abstract	Nephropathic cystinosis is a rare autosomal recessive disease caused by mutations in the CTNS gene. This causes dysfunction of cystinosin, a protein that transports cystine out of lysosomes, causing cystine crystals to accumulate in cells in most organ systems. While renal complications predominate in the early forms of cystinosis, corneal crystal accumulation will inevitably manifest in all patients. The main symptoms are photophobia along with glare sensitivity and blepharospasm. In addition, corneal crystal accumulation can cause other complications, such as recurrent corneal erosions, punctate or filamentary keratopathy, and chronic dry eye. Eventually, peripheral corneal neovascularization and limbal stem cell deficiency may develop. Ophthalmologists play a key role in the early diagnosis of patients with cystinosis. This review aims to not only raise awareness of secondary complications of corneal crystal accumulation, but also to highlight current treatment options and challenges that ophthalmologists and pediatricians might face.
MeSH term(s)	Humans ; Cystinosis/complications ; Cystinosis/diagnosis ; Cystinosis/genetics ; Cystine/genetics ; Cystine/metabolism ; Mutation ; Cornea/metabolism
Chemical Substances	Cystine (48TCX9A1VT)
Language	English
Publishing date	2023-01-25
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	80175-6
ISSN	1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
ISSN (online)	1439-3999
ISSN	0344-6360 ; 0344-6387 ; 0023-2165
DOI	10.1055/a-2020-0926
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Article: Seltene Elektrolytstörungen

Kettritz, R. / Luft, F. C.

Der Nephrologe

2019 Volume 14, Issue 2, Page(s) 94

Language	German
Document type	Article
ZDB-ID	2274530-0
ISSN	1862-040X
Database	Current Contents Medicine

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Article ; Online: Pre-transplant EASIX and sepsis after allogeneic stem cell transplantation.

Korell, Felix / Schreck, Nicholas / Müller-Tidow, Carsten / Dreger, Peter / Luft, Thomas

Intensive care medicine

2022 Volume 48, Issue 6, Page(s) 753–755

MeSH term(s)	Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Retrospective Studies ; Sepsis/etiology ; Transplantation, Homologous/adverse effects
Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80387-x
ISSN	1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
ISSN (online)	1432-1238
ISSN	0340-0964 ; 0342-4642 ; 0935-1701
DOI	10.1007/s00134-022-06676-3
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Article ; Online: Consequences of post-weaning sleep deprivation on behaviour and oxidative stress parameters in rat plasma and brain.

Wearick-Silva, Luis Eduardo / Nunes, Magda Lahorgue / Luft, Carolina / Camargo, Nathalia F / Fernandes, Nathalia F / Taurisano, Melissa R G / de Oliveira, Jarbas R

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

2023 Volume 83, Issue 2, Page(s) 216–223

Abstract: Sleep is essential for health: Adequate sleep is essential for healthy development and sleep deprivation results in several consequences. Indeed, sleep deprivation early in life is associated with poor behaviour and cognition, as well as impaired mental ... ...

Abstract	Sleep is essential for health: Adequate sleep is essential for healthy development and sleep deprivation results in several consequences. Indeed, sleep deprivation early in life is associated with poor behaviour and cognition, as well as impaired mental and physical health. Preclinical studies have shown that sleep deprivation alters several physiological functions later in life such as the cardiovascular, immune and endocrine systems, resulting in altered oxidative states. Most of the preclinical literature is focused on adult animals, and little is known about oxidative alterations during development, especially in the context of sleep deprivation. Hence, we adapted a classic and well-documented model of sleep deprivation, paradoxical sleep deprivation using multiple platforms, for juvenile rats and explored central and peripheral oxidative parameters, as well as the behavioural consequences of sleep deprivation post-weaning. We showed that 96 h of paradoxical sleep deprivation induced a significant reduction in body weight, decreased sucrose preference-a behaviour suggestive of anhedonia-and increased glucose and decreased cholesterol in the plasma. In the brain, we observed a decrease in reduced glutathione levels in the medial prefrontal cortex and an increase in thiobarbituric acid reactive substance levels in the hypothalamus, indicating oxidative damage in these regions. Taken together, our findings suggest that paradoxical sleep deprivation during development induces anhedonic behaviour and promotes central and peripheral alterations in oxidative parameters.
MeSH term(s)	Rats ; Animals ; Sleep Deprivation/complications ; Weaning ; Brain/metabolism ; Oxidative Stress ; Glutathione/metabolism
Chemical Substances	Glutathione (GAN16C9B8O)
Language	English
Publishing date	2023-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	605533-3
ISSN	1873-474X ; 0736-5748
ISSN (online)	1873-474X
ISSN	0736-5748
DOI	10.1002/jdn.10249
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