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  1. Article ; Online: Discovery of TIM-3: Beyond a Th1 Regulator.

    Anderson, Ana C

    Journal of immunology (Baltimore, Md. : 1950)

    2024  Volume 212, Issue 3, Page(s) 359–360

    MeSH term(s) Hepatitis A Virus Cellular Receptor 2 ; Th1 Cells ; Th2 Cells ; Receptors, Virus
    Chemical Substances Hepatitis A Virus Cellular Receptor 2 ; Receptors, Virus
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300682
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    Ud II Zs.37: Show issues Location:
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  2. Article ; Online: Decoding T cell state-specific regulomes in cancer.

    Escobar, Giulia / Anderson, Ana C

    Cell research

    2024  

    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-024-00926-3
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    Zs.A 5283: Show issues Location:
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  3. Article ; Online: LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation.

    Joller, Nicole / Anderson, Ana C / Kuchroo, Vijay K

    Immunity

    2024  Volume 57, Issue 2, Page(s) 206–222

    Abstract: LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic. Although initially studied for their roles in restraining T cell responses, intense investigation over the last several years has started ... ...

    Abstract LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic. Although initially studied for their roles in restraining T cell responses, intense investigation over the last several years has started to pinpoint the unique functions of these molecules in other immune cell types. Understanding the distinct processes that these receptors regulate across immune cells and tissues will inform the clinical development and application of therapies that either antagonize or agonize these receptors, as well as the profile of potential tissue toxicity associated with their targeting. Here, we discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and the implications for their targeting in the clinic.
    MeSH term(s) Hepatitis A Virus Cellular Receptor 2/metabolism ; Receptors, Immunologic/metabolism ; T-Lymphocytes
    Chemical Substances Hepatitis A Virus Cellular Receptor 2 ; Receptors, Immunologic
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.01.010
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    Zs.A 4227: Show issues Location:
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  4. Article ; Online: Introduction to the Special Issue: Immuno-oncology.

    Anderson, Ana C / Kuchroo, Vijay K

    Seminars in immunology

    2021  Volume 52, Page(s) 101483

    MeSH term(s) Humans ; Immunotherapy ; Medical Oncology ; Neoplasms/therapy
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2021.101483
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    Zs.A 2843: Show issues Location:
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  5. Article ; Online: Steroid hormone regulation of immune responses in cancer.

    Anderson, Ana C / Acharya, Nandini

    Immunometabolism (Cobham (Surrey, England))

    2022  Volume 4, Issue 4, Page(s) e00012

    Abstract: Steroid hormones are derived from cholesterol and can be classified into sex hormones (estrogens, androgens, progesterone) that are primarily synthesized in the gonads and adrenal hormones (glucocorticoids and mineralocorticoids) that are primarily ... ...

    Abstract Steroid hormones are derived from cholesterol and can be classified into sex hormones (estrogens, androgens, progesterone) that are primarily synthesized in the gonads and adrenal hormones (glucocorticoids and mineralocorticoids) that are primarily synthesized in the adrenal gland. Although, it has long been known that steroid hormones have potent effects on the immune system, recent studies have led to renewed interest in their role in regulating anti-tumor immunity. Extra-glandular cells, such as epithelial cells and immune cells, have been shown to synthesize glucocorticoids and thereby modulate immune responses in the tumor microenvironment. Additionally, new insight into the role of androgens on immune cell responses have shed light on mechanisms underpinning the observed sex bias in cancer survival outcomes. Here, we review the role of steroid hormones, specifically glucocorticoids and androgens, in regulating anti-tumor immunity and discuss how their modulation could pave the way for designing novel therapeutic strategies to improve anti-tumor immune responses.
    Language English
    Publishing date 2022-10-31
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2633-0407
    ISSN (online) 2633-0407
    DOI 10.1097/IN9.0000000000000012
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  6. Article ; Online: Learning from the nexus of autoimmunity and cancer.

    Mangani, Davide / Yang, Dandan / Anderson, Ana C

    Immunity

    2023  Volume 56, Issue 2, Page(s) 256–271

    Abstract: The immune system plays critical roles in both autoimmunity and cancer, diseases at opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against self, while in cancer, poor immunity against transformed self fails to ... ...

    Abstract The immune system plays critical roles in both autoimmunity and cancer, diseases at opposite ends of the immune spectrum. Autoimmunity arises from loss of T cell tolerance against self, while in cancer, poor immunity against transformed self fails to control tumor growth. Blockade of pathways that preserve self-tolerance is being leveraged to unleash immunity against many tumors; however, widespread success is hindered by the autoimmune-like toxicities that arise in treated patients. Knowledge gained from the treatment of autoimmunity can be leveraged to treat these toxicities in patients. Further, the understanding of how T cell dysfunction arises in cancer can be leveraged to induce a similar state in autoreactive T cells. Here, we review what is known about the T cell response in autoimmunity and cancer and highlight ways in which we can learn from the nexus of these two diseases to improve the application, efficacy, and management of immunotherapies.
    MeSH term(s) Humans ; Autoimmunity ; T-Lymphocytes ; Neoplasms/therapy ; Immune Tolerance ; Self Tolerance ; Autoimmune Diseases/therapy
    Language English
    Publishing date 2023-03-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.01.022
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  7. Article ; Online: Spatial determinants of CD8

    Tooley, Katherine A / Escobar, Giulia / Anderson, Ana C

    Trends in cancer

    2022  Volume 8, Issue 8, Page(s) 642–654

    Abstract: Uncovering the mechanisms that control ... ...

    Abstract Uncovering the mechanisms that control CD8
    MeSH term(s) CD8-Positive T-Lymphocytes ; Cell Communication ; Cell Differentiation/genetics ; Humans ; Lymphocyte Activation ; Neoplasms/genetics ; Neoplasms/pathology
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.04.003
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  8. Article ; Online: NRP1 cripples immunological memory.

    Acharya, Nandini / Anderson, Ana C

    Nature immunology

    2020  Volume 21, Issue 9, Page(s) 972–973

    MeSH term(s) Immunologic Memory ; Neuropilin-1 ; T-Lymphocytes
    Chemical Substances Neuropilin-1 (144713-63-3)
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-0759-5
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    Zs.A 5294: Show issues Location:
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  9. Article ; Online: Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression.

    Swatler, Julian / Ju, Young-Jun / Anderson, Ana C / Lugli, Enrico

    The Journal of clinical investigation

    2023  Volume 133, Issue 18

    Abstract: Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can ...

    Abstract Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can be reconverted from their inactive form to active metabolites via the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme expressed by murine tumor cell lines. In the tumor microenvironment, GCs acted on CD4+ regulatory T cells to enhance their immunosuppressive function and promote tumor growth. The findings suggest that targeting GC recycling as a strategy for modulating tumor immunosuppression has the potential to improve therapeutic efficacy of immune checkpoint blockade.
    MeSH term(s) Animals ; Mice ; Glucocorticoids/pharmacology ; T-Lymphocytes, Regulatory ; Immunosuppression Therapy ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; 11-beta-Hydroxysteroid Dehydrogenase Type 1
    Chemical Substances Glucocorticoids ; Immunosuppressive Agents ; 11-beta-Hydroxysteroid Dehydrogenase Type 1 (EC 1.1.1.146)
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI173141
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  10. Article ; Online: Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression

    Julian Swatler / Young-Jun Ju / Ana C. Anderson / Enrico Lugli

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 18

    Abstract: Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can ...

    Abstract Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can be reconverted from their inactive form to active metabolites via the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme expressed by murine tumor cell lines. In the tumor microenvironment, GCs acted on CD4+ regulatory T cells to enhance their immunosuppressive function and promote tumor growth. The findings suggest that targeting GC recycling as a strategy for modulating tumor immunosuppression has the potential to improve therapeutic efficacy of immune checkpoint blockade.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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