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Article: Fahr's disease: A rare neuropsychiatric disorder.

Sipra, Zeshan Shabbir / Din, Islah Ud / Awais, Muhammad Arqam / Tariq, Taimoor Ali

JPMA. The Journal of the Pakistan Medical Association

2022 Volume 72, Issue 2, Page(s) 383

Abstract: Fahr's disease is a rare clinical neurodegenerative entity, occurring mainly in 4th or 5th decade, showing gradually progressive bilateral symmetric calcifications in basal ganglia, subcortical white matter, thalami or cerebellum, which can lead to ... ...

Abstract	Fahr's disease is a rare clinical neurodegenerative entity, occurring mainly in 4th or 5th decade, showing gradually progressive bilateral symmetric calcifications in basal ganglia, subcortical white matter, thalami or cerebellum, which can lead to movement disorder and/or neuropsychiatric manifestations. We present two cases in the same family; a 68-year-old brother had involuntary jerky movements of hand and dysarthria for 10 years while the 44-year-old sister had right lower limb spasticity and decreased vision for 2 years. The serial MRI scans showed slow progression in the bilateral subcortical white matter and cerebellar dentate nuclei calcifications along with surrounding reactive gliosis.
MeSH term(s)	Aged ; Basal Ganglia Diseases/diagnostic imaging ; Calcinosis/diagnosis ; Calcinosis/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/diagnostic imaging
Language	English
Publishing date	2022-03-23
Publishing country	Pakistan
Document type	Case Reports ; Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.22-40
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Article ; Online: Mycorrhizosphere bacteria inhibit greenhouse gas emissions from microplastics contaminated soil by regulating soil enzyme activities and microbial community structure.

Khan, Zeeshan / Shah, Tariq / Haider, Ghulam / Adnan, Fazal / Sheikh, Zeshan / El-Sheikh, Mohamed A / Bhatti, Muhammad Faraz / Ahmad, Parvaiz

Journal of environmental management

2024 Volume 356, Page(s) 120673

Abstract: Microplastics (MPs) accumulation in terrestrial ecosystems can affect greenhouse gases (GHGs) production by altering microbial and soil structure. Presently, research on the MPs effect on plants is not consistent, and underlying molecular mechanisms ... ...

Abstract	Microplastics (MPs) accumulation in terrestrial ecosystems can affect greenhouse gases (GHGs) production by altering microbial and soil structure. Presently, research on the MPs effect on plants is not consistent, and underlying molecular mechanisms associated with GHGs are yet unknown. For the first time, we conducted a microcosm study to explore the impact of MPs addition (Raw vs. aged) and Trichoderma longibrachiatum and Bacillus subtilis inoculation (Sole vs. combination) on GHGs emission, soil community structure, physiochemical properties, and enzyme activities. Our results indicated that the addition of aged MPs considerably enhanced the GHGs emissions (N
MeSH term(s)	Greenhouse Gases/analysis ; Soil/chemistry ; Microplastics ; Plastics ; Carbon Dioxide/analysis ; Carbon ; Microbiota ; Bacteria ; Nitrous Oxide/analysis
Chemical Substances	Greenhouse Gases ; Soil ; Microplastics ; Plastics ; Carbon Dioxide (142M471B3J) ; Carbon (7440-44-0) ; Nitrous Oxide (K50XQU1029)
Language	English
Publishing date	2024-03-19
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2024.120673
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Article ; Online: Corrigendum to "Epstein-Barr virus (EBV) hyperimmune globulin isolated from donors with high gp350 antibody titers protect humanized mice from challenge with EBV" [Virology 561 (2021) 80-86].

Kim, JungHyun / Bu, Wei / Mine, Sohtaro / Tariq, Zeshan / Nguyen, Hanh / Wang, Yanmei / Tolman, Cynthia / Mond, James / Cohen, Jeffrey I

Virology

2022 Volume 568, Page(s) 12

Language	English
Publishing date	2022-01-20
Publishing country	United States
Document type	Published Erratum
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2022.01.007
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Article ; Online: Eye Disease Prevalence and VF-14 Validation Among Patients Experiencing Homelessness and Presenting for Ophthalmic Examination in Baltimore, Maryland.

Vinnett, Alfred / Tariq, Zeshan / Alvarez, Jason A / Andrews, Laura / Okezie, Nneoma / Levin, Moran R / Kaleem, Mona A

Translational vision science & technology

2023 Volume 12, Issue 11, Page(s) 7

Abstract: Purpose: The coronavirus disease 2019 (COVID-19) pandemic is projected to drive 1.5 million Americans toward homelessness, adding to the 3.5 million currently affected. Homelessness poses both socioeconomic and public health challenges because housing ... ...

Abstract	Purpose: The coronavirus disease 2019 (COVID-19) pandemic is projected to drive 1.5 million Americans toward homelessness, adding to the 3.5 million currently affected. Homelessness poses both socioeconomic and public health challenges because housing status is a social determinant of health. Given ophthalmic health's importance in daily functioning, we characterized ophthalmic disease and vision-related quality of life (VRQOL) among a population experiencing homelessness in Baltimore, Maryland. Methods: Questionnaires, including a Visual Function Index-14 (VF-14) for measuring VRQOL, were administered among patients seeking eye examinations at Health Care for the Homeless (HCH) from October 2018 to March 2020. Results: One hundred sixty-two participants were enrolled in this study. The average age was 53 years. Participants' most common vision concerns were blurry vision (70%) and desire for glasses (52%). Best corrected visual acuity (BCVA) measurements revealed significant vision loss (18%, P < 0.001). Physicians mostly diagnosed refractive error (77%), cataracts (36%), glaucoma/glaucoma suspect (25%), and dry eye (24%). Nearly half were referred to additional ophthalmic care (46%). VRQOL trends reflected functional vision categories (P = 0.042 and P = 0.021). The 1:1 VRQOL and BCVA comparison showed correlation (rho = -0.3, P < 0.001). Cronbach's alpha demonstrated VF-14 reliability (alpha = 0.92). Conclusions: We find high ophthalmic disease prevalence within a population experiencing homelessness. Comparison to studies worldwide reveals healthcare disparities despite healthcare system differences, suggesting a need for more targeted solutions. VF-14 is valid and reliable in assessing those experiencing homelessness. Intragroup VRQOL comparisons may reveal subgroup needs. It is imperative that future studies continue monitoring those experiencing homelessness. Translational relevance: Validation of VF-14 will allow future studies to utilize this patient-oriented metric within populations experiencing homelessness.
MeSH term(s)	Humans ; Middle Aged ; Quality of Life ; Prevalence ; Baltimore/epidemiology ; Reproducibility of Results ; Vision Disorders/diagnosis ; Vision Disorders/epidemiology ; Ocular Hypertension ; Ill-Housed Persons ; Glaucoma
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.12.11.7
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Article: Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine.

Tariq, Zeshan / Board, Nathan / Eftimiades, Alex / Ibrahim, Ronnie

SAGE open medical case reports

2019 Volume 7, Page(s) 2050313X19847804

Abstract: New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, ... ...

Abstract	New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT
Language	English
Publishing date	2019-05-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X19847804
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Article ; Online: Resolution of new daily persistent headache by a tumor necrosis factor alpha antagonist, Venlafaxine

Zeshan Tariq / Nathan Board / Alex Eftimiades / Ronnie Ibrahim

SAGE Open Medical Case Reports, Vol

2019 Volume 7

Abstract	New daily persistent headache is a continuous, unremitting headache, notorious for its unresponsiveness to aggressive medical interventions. The underlying pathophysiology of new daily persistent headache is poorly understood resulting in unending, chronic pain. However, a prior study identified elevated tumor necrosis factor alpha within the cerebral spinal fluid of new daily persistent headache patients. Herein, we report on a patient who suffered with headache for 6 years failing to respond to over 20 different medical treatments, but found drastic improvement and eventual resolution with Venlafaxine. This drug binds to the 5-HT 2A receptor inhibiting tumor necrosis factor alpha signaling. Therefore, we hypothesize a chronic inflammatory mechanism driving new daily persistent headache pathology.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2019-05-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
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Article ; Online: Elucidating molecular characterization of chlorpyrifos and profenofos degrading distinct bacterial strains for enhancing seed germination potential of Gossypium arboreum L.

Paker, Najeeba Paree / Mehmood, Shehzad / Javed, Muhammad Tariq / Damalas, Christos A / Rehman, Fazal Ur / Chaudhary, Hassan Javed / Munir, Muhammad Zeshan / Malik, Mahrukh

Environmental science and pollution research international

2023 Volume 30, Issue 16, Page(s) 48120–48137

Abstract: Chlorpyrifos (CP) and profenofos (PF) are organophosphate pesticides (OPs) widely used in agriculture and are noxious to both fauna and flora. The presented work was designed to attenuate the toxicity of both pesticides in the growth parameters of a ... ...

Abstract	Chlorpyrifos (CP) and profenofos (PF) are organophosphate pesticides (OPs) widely used in agriculture and are noxious to both fauna and flora. The presented work was designed to attenuate the toxicity of both pesticides in the growth parameters of a cotton crop by applying plant growth-promoting rhizobacteria (PGPR), namely Pseudomonas aeruginosa PM36 and Bacillus sp. PM37. The multifarious biological activities of both strains include plant growth-promoting traits, including phosphate solubilization; indole-3-acetic acid (IAA), siderophore, and HCN production; nitrogen fixation; and enzymatic activity such as cellulase, protease, amylase, and catalase. Furthermore, the molecular profiling of multi-stress-responsive genes, including acdS, ituC, czcD, nifH, and sfp, also confirmed the plant growth regulation and abiotic stress tolerance potential of PM36 and PM37. Both strains (PM36 and PM37) revealed 92% and 89% of CP degradation at 50 ppm and 87% and 81% at 150 ppm within 7 days. Simultaneously 94% and 98% PF degradation was observed at 50 ppm and 90% and 92% at 150 ppm within 7 days at 35 °C and pH 7. Biodegradation was analyzed using HPLC and FTIR. The strains exhibited first-order reaction kinetics, indicating their reliance on CP and PF as energy and carbon sources. The presence of opd, mpd, and opdA genes in both strains also supported the CP and PF degradation potential of both strains. Inoculation of strains under normal and OP stress conditions resulted in a significant increase in seed germination, plant biomass, and chlorophyll contents of the cotton seedling. Our findings indicate that the strains PM36 and PM37 have abilities as biodegraders and plant growth promoters, with potential applications in crop sciences and bioremediation studies. These strains could serve as an environmentally friendly, sustainable, and socially acceptable solution to manage OP-contaminated sites.
MeSH term(s)	Bacteria/metabolism ; Chlorpyrifos/chemistry ; Chlorpyrifos/metabolism ; Germination ; Gossypium/metabolism ; Pesticides/chemistry ; Pesticides/metabolism ; Plants/metabolism ; Seeds/metabolism ; Soil Microbiology
Chemical Substances	Chlorpyrifos (JCS58I644W) ; Pesticides ; profenofos (7J04O7BS4W)
Language	English
Publishing date	2023-02-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-25343-8
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Article ; Online: CURRENT PRACTICES OF PERSONAL PROTECTIVE EQUIPMENT IN OPERATION THEATERS

Saira Mahboob / Tariq Mehmood / Amna Gulrez / Anum Sultan / Zeshan Nasir / Taimur Azam Khan

Pakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 83-

A CROSS SECTIONAL STUDY

2021 Volume 86

Abstract: Objective: To evaluate the prevailing practices regarding personal protective equipment in operation theaters. Study Design: Cross-sectional study. Place and Duration of Study: Pakistan Naval Ship Shifa Hospital, Karachi, from May to Jun 2020. ... ...

Abstract	Objective: To evaluate the prevailing practices regarding personal protective equipment in operation theaters. Study Design: Cross-sectional study. Place and Duration of Study: Pakistan Naval Ship Shifa Hospital, Karachi, from May to Jun 2020. Methodology: After the approval of the approval of the hospital ethical committee, 300 online forms were send. A total of 227 respondents returned the 22 questions survey forms. Data was collected and analyzed using online site www.surveyplanet.com. Results: A total of 203 forms were included in our final analysis. Most 128 (63.1%) were males with 90 (44.3%) common aged between 31-40 years and 168 (82.8%) working in tertiary care hospitals. One hundred and fifty eight (77.8%) were routinely managing known Covid cases per-operatively. One hundred and seventy four (85.7%) reported that personal protective equipment was being provided by the hospital administration; 55 (27.1%) have bought part of full protective equipment at their own expense; 72 (35.5%) re-using protective equipment; 167 (82.3%) being provided with N-95 masks and 120 (59.1%) re-using N-95 masks. One hundred and twenty one (59.6%) wearing level III protective gear during all surgeries. 192 (94.6%) respondents reported maintaining hand hygiene after each patient. Only 65 (32%) taking shower at the hospital at the end of their shift. Conclusion: Most of the operation theaters were providing protective equipment to their staff with nearly half reusing protective gear and N-95 masks.
Keywords	hand hygiene ; hand washm n-95 mask ; personal protective equipment ; re-use ; covid-19 ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Army Medical College Rawalpindi
Document type	Article ; Online
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Article ; Online: Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.

Saleem, Saira / Aleem, Iffat / Zeshan, Muhammad / Bakar, Muhammad Abu / Atiq, Aribah / Tahseen, Muhammad / Mahmood, Mohammad Tariq / Hassan, Sadia / Syed, Aamir Ali / Hussain, Mudassar / Ahmad, Asad Hayat / Khattak, Shahid / Yusuf, Muhammed Aasim

Journal of cancer & allied specialties

2022 Volume 8, Issue 2, Page(s) 477

Abstract: Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction) and body ... ...

Abstract	Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction) and body mass index (BMI) to the occurrence and progression of colon cancer (CC). Methods: A cohort of non-cancer (NC) and CC patients of South-Central Asian origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan, from 2015 to 2020 was identified. BMI (Kg/m Results: Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC Overall, participants included 74 women and 162 men aged 20-85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0% of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer. Conclusion: Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.
Language	English
Publishing date	2022-08-08
Publishing country	Pakistan
Document type	Journal Article
ISSN	2411-989X
ISSN (online)	2411-989X
DOI	10.37029/jcas.v8i2.477
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Article: Expression of cornulin in tongue squamous cell carcinoma.

Saleem, Saira / Aleem, Iffat / Atiq, Aribah / Tariq, Sahrish / Babar, Amna / Bakar, Muhammad Abu / Syed, Madiha / Maruf, Maheen / Mahmood, Mohammad Tariq / Zeshan, Muhammad / Tahseen, Muhammad / Hussain, Raza / Loya, Asif / Sutton, Chris

Ecancermedicalscience

2021 Volume 15, Page(s) 1197

Abstract: The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement of tongue squamous cell carcinoma (TSCC). A comparison of addictive (containing potential carcinogens) versus non-addiction causative agents was expected ... ...

Abstract	The aim of the study is to identify cornulin (CRNN) protein expression associated with advancement of tongue squamous cell carcinoma (TSCC). A comparison of addictive (containing potential carcinogens) versus non-addiction causative agents was expected to allow detection of differences in CRNN expression associated with TSCC. Bespoke tissue microarrays (TMAs) were prepared and immunohistochemistry (IHC) performed to determine the changes in CRNN expression in epithelial cells of node-negative (pN-), node-positive (pN+) TSCC and non-cancer patients' oral tissues. TMAs were validated by performing IHC on whole diagnostic tissues. Chi-square test or Fisher's-exact tests were used to establish significant expression differences. Analogous analyses were performed for biomarkers previously associated with TSCC, namely collagen I alpha 2 (COL1A2) and decorin (DCN) to compare the significance of CRNN. Keratinisation and its level (low, extensive) were studied in relation to CRNN so that the extent of squamous differentiation could better be assessed. IHC immunoreactive score (IRS) clustered the patients based on weak/moderate (Low (IRS ≤ +3)) or strong (High (IRS ≥ +4)) expression groups. A low expression was observed in a larger number of patients in control proteins COL1A2 (77.3%), DCN (87.5%) and target protein CRNN (52.3%), respectively. Low CRNN expression was observed in TSCC where nodes were involved (pN+: mean 1.4 ± 2.1) (
Language	English
Publishing date	2021-03-04
Publishing country	England
Document type	Journal Article
ISSN	1754-6605
ISSN	1754-6605
DOI	10.3332/ecancer.2021.1197
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