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Article ; Online: Diastolic Function Assessment with 4D Flow CMR using Automatic Deep Learning EA Ratio Analysis.

Viola, Federica / Bustamante, Mariana / Bolger, Ann / Engvall, Jan / Ebbers, Tino

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

2024 , Page(s) 101042

Abstract: ... EA ratio (R: Discussion and conclusion: Peak E, peak A and EA ratio are integral to the assessment ... While underestimation of absolute peak E and A velocities was noted, the EA ratio measured with all three 4D Flow ...

Abstract	Background: Diastolic left ventricular dysfunction is a powerful contributor to the symptoms and prognosis of patients with heart failure. In patients with depressed left ventricular systolic function the EA ratio is the first step to defining the grade of diastolic dysfunction. Doppler echocardiography is the preferred imaging technique for diastolic function assessment, while CMR is less established as a method. Previous 4D Flow-based studies have looked at the EA ratio proximally to the mitral valve, requiring manual interaction. In this study we compare an automated, deep learning-based, and two semiautomated approaches for 4D Flow CMR-based EA ratio assessment to conventional, gold standard echo-based methods. Methods: Ninety-seven subjects with chronic ischemic heart disease underwent a cardiac echo followed by an MRI investigation. 4D Flow-based EA ratio values were computed using three different approaches; two semi-automated, assessing the EA ratio by measuring the inflow velocity (MVvel) and the inflow volume (MVflow) at the mitral valve plane, and one fully automated, creating a full LV segmentation using a deep learning-based method within which the EA ratio could be assessed without constraint to the mitral plane (LVvel). Results: MVvel, MVflow, and LVvel EA ratios were strongly associated with Echo EA ratio (R Discussion and conclusion: Peak E, peak A and EA ratio are integral to the assessment of diastolic dysfunction and may expand the utility of CMR studies in patients with cardiovascular disease. While underestimation of absolute peak E and A velocities was noted, the EA ratio measured with all three 4D Flow methods was strongly associated with the gold standard Doppler echocardiography. The automatic, deep learning-based method performed best, with the most favorable runtime of ~40seconds. As both semiautomatic methods associated very strongly to LVvel, they could be employed as an alternative for estimation of EA ratio.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1458034-2
ISSN	1532-429X ; 1097-6647
ISSN (online)	1532-429X
ISSN	1097-6647
DOI	10.1016/j.jocmr.2024.101042
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Article ; Online: Potassium-Induced Phenomena and Their Effects on the Intrinsic Reactivity of Biomass-Derived Char during Steam Gasification.

Ding, Saiman / Kantarelis, Efthymios / Engvall, Klas

ACS omega

2023 Volume 8, Issue 32, Page(s) 29131–29142

Abstract: The mineral content of biomass plays an important role in the gasification rate of biomass-derived char. The understanding and quantification of mineral-related phenomena are thus of importance when considering gasification reactor design. In the present ...

Abstract	The mineral content of biomass plays an important role in the gasification rate of biomass-derived char. The understanding and quantification of mineral-related phenomena are thus of importance when considering gasification reactor design. In the present work, the potassium-induced catalytic phenomena during gasification of biomass-derived char have been studied. Char samples with similar structure and different intrinsic potassium content were gasified in a steam atmosphere at a temperature range of 700-800 °C. It was found that for all the samples, irrespective of the temperature and the initial potassium content, there is a critical K/C ratio (5 × 10
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c02234
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Article: Lack of association between schizophrenia and the apolipoprotein E epsilon 4 allele.

Jönsson, E / Lannfelt, L / Engvall, B / Sedvall, G

European archives of psychiatry and clinical neuroscience

1996 Volume 246, Issue 4, Page(s) 182–184

Abstract: The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and ...

Abstract	The association between the epsilon 4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the epsilon 4 allele may play a role also in schizophrenia, another mental disorder, patients (n = 87) and control subjects (n = 57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.
MeSH term(s)	Adult ; Alleles ; Apolipoproteins E/genetics ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Schizophrenia/genetics ; Schizophrenic Psychology
Chemical Substances	Apolipoproteins E
Language	English
Publishing date	1996
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1045583-8
ISSN	1433-8491 ; 0940-1334 ; 0175-758X
ISSN (online)	1433-8491
ISSN	0940-1334 ; 0175-758X
DOI	10.1007/bf02188951
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Article ; Online: Right ventricular function in severe aortic stenosis assessed by echocardiography and MRI.

Holmberg, Erica / Tamás, Éva / Nylander, Eva / Engvall, Jan / Granfeldt, Hans

Clinical physiology and functional imaging

2023 Volume 44, Issue 3, Page(s) 211–219

Abstract: Background: The prevalence of aortic valve stenosis (AS) is increasing due to an ageing population. Despite that right ventricular function has prognostic value for postoperative outcome, the right ventricle (RV) is not extensively studied and often not ...

Abstract	Background: The prevalence of aortic valve stenosis (AS) is increasing due to an ageing population. Despite that right ventricular function has prognostic value for postoperative outcome, the right ventricle (RV) is not extensively studied and often not routinely assessed in AS. Our aim was to explore the relation between severe AS and RV function in a surgical aortic valve replacement (SAVR) cohort, comparing two imaging modalities for RV evaluation. Methods: Patients with severe AS, underwent cardiovascular magnetic resonance imaging (CMR) and transthoracic echocardiography (TTE) before SAVR. RV dysfunction was defined as one or more of the following: tricuspid annular plane systolic excursion (TAPSE) < 17 mm, RV free wall strain (RVFWS) > -20% by TTE and RV ejection fraction (RVEF) <50% by CMR. Results: Sixteen (33%) patients were found to have RV dysfunction. Patients with RV dysfunction showed significantly lower indexed aortic valve area, left ventricular (LV) ejection fraction as well as RV and LV stroke volumes compared to patients with maintained RV function. All patients with reduced RVEF also had changes in TAPSE or RVFWS and a larger number of patients had a reduced longitudinal RV function despite a normal RVEF. Conclusion: In a SAVR cohort one-third of the patients had RV dysfunction, defined by RVEF, TAPSE or RVFW strain. Echocardiography detected subtle changes in RV function before RVEF was reduced. It is likely that the more pronounced the AS, the more frequent the occurrence of RV dysfunction.
MeSH term(s)	Humans ; Ventricular Function, Right ; Echocardiography/methods ; Magnetic Resonance Imaging ; Heart ; Stroke Volume ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/etiology
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2071203-0
ISSN	1475-097X ; 1475-0961
ISSN (online)	1475-097X
ISSN	1475-0961
DOI	10.1111/cpf.12867
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Article ; Online: Four- to seven-year follow-up of pharmacological postconditioning with mangafodipir as an adjunct to primary PCI in ST-segment elevation myocardial infarction.

El-Saadi, Walid / Engvall, Jan / Karlsson, Jan-Erik / Maret, Eva

Clinical physiology and functional imaging

2023 Volume 43, Issue 6, Page(s) 413–420

Abstract: Introduction: Adverse left ventricular remodelling (AR) develops over time in approximately 30% of patients with a history of coronary artery disease. AR manifests as a structural change in the left ventricle (LV) in terms of increased volumes and ... ...

Abstract	Introduction: Adverse left ventricular remodelling (AR) develops over time in approximately 30% of patients with a history of coronary artery disease. AR manifests as a structural change in the left ventricle (LV) in terms of increased volumes and reduced left ventricular ejection fraction (LVEF). Manganese dipyridoxyl diphosphate (mangafodipir) has demonstrated interesting cardioprotective features in acute myocardial ischaemia. Pharmacological postconditioning (PP) with mangafodipir as an adjunct to primary percutaneous coronary intervention may possibly reduce the development of AR over time in ST-elevation myocardial infarction (STEMI). The aim of this 4-7-year follow-up study is to investigate the potential benefits of PP with mangafodipir in STEMI patients. Method: Thirteen out of the initial 20 patients that were included in the primary study of Karlsson et al. were followed up between April and June 2017. The study group underwent review of the hospital records, a clinical examination with ECG and blood sample analysis before cardiac magnetic resonance examination of the patient. LVEF, left ventricular diastolic volume, left ventricular end systolic volume, LV mass and myocardial strain in all directions were computed. Results: The PP group showed a decrease in LV volume, mass and higher LVEF at follow-up (p < 0.05) while the individual response of the placebo group showed features that are seen in AR. Although there was no difference in myocardial strain, measurement for the PP-group was higher in absolute terms. Conclusion: Pharmacological postconditioning with mangafodipir in STEMI demonstrated cardioprotective features compared to the placebo group at follow-up. This article is protected by copyright. All rights reserved.
MeSH term(s)	Humans ; ST Elevation Myocardial Infarction/diagnostic imaging ; ST Elevation Myocardial Infarction/drug therapy ; Stroke Volume ; Ventricular Function, Left ; Follow-Up Studies ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome
Chemical Substances	N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid (P28BIW0UTB)
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2071203-0
ISSN	1475-097X ; 1475-0961
ISSN (online)	1475-097X
ISSN	1475-0961
DOI	10.1111/cpf.12839
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Article ; Online: An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries.

Cornvik, Tobias / Dahlroth, Sue-Li / Magnusdottir, Audur / Flodin, Susanne / Engvall, Benita / Lieu, Victoria / Ekberg, Monica / Nordlund, Pär

Proteins

2006 Volume 65, Issue 2, Page(s) 266–273

Abstract: ... developed a new method for rapid identification of soluble protein expression in E. coli, the colony ... the success rate (from 34 to 68%) of producing soluble and readily purifiable proteins in E. coli. Most ...

Abstract	The implementation of generic and efficient technologies for the production of recombinant eukaryotic proteins remains an outstanding challenge in structural genomics programs. We have recently developed a new method for rapid identification of soluble protein expression in E. coli, the colony filtration blot (CoFi blot). In this study, the CoFi blot was used to screen libraries where the N-terminal translation start point was randomized. To investigate the efficiency of this strategy, we have attributed a large number of proteins to this process. In a set of 32 mammalian proteins, we were able to double the success rate (from 34 to 68%) of producing soluble and readily purifiable proteins in E. coli. Most of the selected constructs had their N-termini close to predicted domain borders and the method therefore provides a mean for experimental "domain foot printing." Surprisingly, for most of the targets, we also observed expressing constructs that were close to full-length. In summary this strategy constitutes a generic and efficient method for producing mammalian proteins for structural and functional studies.
MeSH term(s)	Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Library ; Humans ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Solubility
Chemical Substances	Recombinant Proteins
Language	English
Publishing date	2006-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	806683-8
ISSN	1097-0134 ; 0887-3585
ISSN (online)	1097-0134
ISSN	0887-3585
DOI	10.1002/prot.21090
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Article: Leptospira

Strand, Tanja M / Olsson Engvall, Eva / Lahti, Elina / Hjertqvist, Marika / Lundkvist, Åke

Microorganisms

2023 Volume 11, Issue 8

Abstract: We compiled data on notified cases of leptospirosis in animals and humans in Sweden. Published studies on leptospirosis in humans and animals from the beginning of the 20th century onwards are summarized. During the Second World War, hundreds of ... ...

Abstract	We compiled data on notified cases of leptospirosis in animals and humans in Sweden. Published studies on leptospirosis in humans and animals from the beginning of the 20th century onwards are summarized. During the Second World War, hundreds of leptospirosis cases in humans were reported in Sweden, but since then, there have been only a few severe cases. Surveillance of leptospirosis in domestic animals demonstrates that the pathogen is still occurring. The occurrence of
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11081991
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Article ; Online: Prevalence and determinants of dilated ascending aorta in a Swedish population: a case-control study.

Swahn, Eva / Lekedal, Hanna / Engvall, Jan / Nyström, Fredrik H / Jonasson, Lena

European heart journal open

2023 Volume 3, Issue 5, Page(s) oead085

Abstract: Aims: Dilation of the ascending aorta (AA) is often asymptomatic until a life-threatening dissection or rupture occurs. An overall increase in the use of thoracic imaging has enabled early and sometimes incidental identification of AA dilation. Still, ... ...

Abstract	Aims: Dilation of the ascending aorta (AA) is often asymptomatic until a life-threatening dissection or rupture occurs. An overall increase in the use of thoracic imaging has enabled early and sometimes incidental identification of AA dilation. Still, the prevalence and determinants of AA dilation remain to be clarified. The aim was to identify and characterize persons with AA dilation in a middle-aged Swedish population. Methods and results: We used the Swedish CardioPulmonary BioImage Study Linköping ( Conclusion: The prevalence of dilated AA was 1.4% and showed positive associations with male gender, aortic valve pathology, and diastolic BP, though not with subclinical atherosclerosis.
Language	English
Publishing date	2023-08-25
Publishing country	England
Document type	Journal Article
ISSN	2752-4191
ISSN (online)	2752-4191
DOI	10.1093/ehjopen/oead085
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Article ; Online: Experimental and Numerical Investigation of Flow Field and Soot Particle Size Distribution of Methane-Containing Gas Mixtures in a Swirling Burner.

Musavi, Zari / Zhang, Yao / Robert, Etienne / Engvall, Klas

ACS omega

2021 Volume 7, Issue 1, Page(s) 469–479

Abstract: The formation of soot in a swirling flow is investigated experimentally and numerically in the context of biogas combustion using a ... ...

Abstract	The formation of soot in a swirling flow is investigated experimentally and numerically in the context of biogas combustion using a CO
Language	English
Publishing date	2021-12-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c04895
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Article: Essential elements of the capsid protein for self-assembly into empty virus-like particles of hepatitis E virus.

Li, Tian-Cheng / Takeda, Naokazu / Miyamura, Tatsuo / Matsuura, Yoshiharu / Wang, Joseph C Y / Engvall, Helena / Hammar, Lena / Xing, Li / Cheng, R Holland

Journal of virology

2005 Volume 79, Issue 20, Page(s) 12999–13006

Abstract: Hepatitis E virus (HEV) is a noncultivable virus that causes acute liver failure in humans ...

Abstract	Hepatitis E virus (HEV) is a noncultivable virus that causes acute liver failure in humans. The virus's major capsid protein is encoded by an open reading frame 2 (ORF2) gene. When the recombinant protein consisting of amino acid (aa) residues 112 to 660 of ORF2 is expressed with a recombinant baculovirus, the protein self-assembles into virus-like particles (VLPs) (T.-C. Li, Y. Yamakawa, K. Suzuki, M. Tatsumi, M. A. Razak, T. Uchida, N. Takeda, and T. Miyamura, J. Virol. 71:7207-7213, 1997). VLPs can be found in the culture medium of infected Tn5 cells but not in that of Sf9 cells, and the major VLPs have lost the C-terminal 52 aa. To investigate the protein requirement for HEV VLP formation, we prepared 14 baculovirus recombinants to express the capsid proteins truncated at the N terminus, the C terminus, or both. The capsid protein consisting of aa residues 112 to 608 formed VLPs in Sf9 cells, suggesting that particle formation is dependent on the modification process of the ORF2 protein. In the present study, electron cryomicroscopy and image processing of VLPs produced in Sf9 and Tn5 cells indicated that they possess the same configurations and structures. Empty VLPs were found in both Tn5 and Sf9 cells infected with the recombinant containing an N-terminal truncation up to aa residue 125 and C-terminal to aa residue 601, demonstrating that the aa residues 126 to 601 are the essential elements required for the initiation of VLP assembly. The recombinant HEV VLPs are potential mucosal vaccine carrier vehicles for the presentation of foreign antigenic epitopes and may also serve as vectors for the delivery of genes to mucosal tissue for DNA vaccination and gene therapy. The results of the present study provide useful information for constructing recombinant HEV VLPs having novel functions.
MeSH term(s)	Animals ; Baculoviridae/metabolism ; Capsid Proteins/chemistry ; Capsid Proteins/genetics ; Capsid Proteins/metabolism ; Cell Line ; Hepatitis E virus/chemistry ; Hepatitis E virus/physiology ; Models, Molecular ; Open Reading Frames ; Recombinant Proteins/biosynthesis ; Virus Assembly
Chemical Substances	Capsid Proteins ; Recombinant Proteins
Language	English
Publishing date	2005-10
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.79.20.12999-13006.2005
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