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Book: [Yun chan fu bao jian zhi shi]

Sheng, Danqing

Yun chan fu bao jian zhi shi. [Health instruction for pregnant and lying-in women

1959

MeSH term(s)	Postpartum Period ; Pregnancy
Language	Chinese
Size	62 p., ill.
Publisher	Kexuejishuchubanshe
Publishing place	Shanghai
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Clinical Relevance of Xpert MRSA/SA in Guiding Therapeutic Decisions for Staphylococcal Infections: A Diagnostic Test Accuracy Analysis.

Ojha, Suvash Chandra / Chen, Ke / Sun, Changfeng / Ahmed, Sarfraz / Sheng, Yun-Jian / Deng, Cun-Liang

Infectious diseases and therapy

2022 Volume 11, Issue 3, Page(s) 1205–1227

Abstract: Introduction: Rapid identification of the causal organism and antibiotic resistance is crucial for guiding targeted therapy in patients with suspected staphylococcal infection. A meta-analysis was carried out to evaluate the diagnostic relevance of ... ...

Abstract	Introduction: Rapid identification of the causal organism and antibiotic resistance is crucial for guiding targeted therapy in patients with suspected staphylococcal infection. A meta-analysis was carried out to evaluate the diagnostic relevance of Xpert™ MRSA/SA (Xpert) from clinical samples of various origins for limiting the use of unnecessary empirical methicillin-resistant Staphylococcus aureus (MRSA) therapy. Methods: Five databases, including the Cochrane Library, Scopus, PubMed, Web of Science, and Embase, were comprehensively inspected from inception to October 12, 2021. The pooled summary estimates were evaluated using a bivariate random-effects model. Results: Our inclusion criteria were met by 49 publications containing 68 datasets out of 735 citations. A total of 21 studies (n = 4996) examined the accuracy of Xpert in detecting methicillin-sensitive S. aureus (MSSA), while 47 studies (n = 45,430) examined the accuracy of Xpert in detecting MRSA. As compared to MRSA, Xpert's diagnostic performance for MSSA detection was markedly higher [sensitivity: 0.97 (0.96-0.98), specificity: 0.97 (0.97-0.98), area under curve (AUC): 0.99 (0.99-1.0)]. Xpert's pooled sensitivity and specificity differed marginally across sample types, including screening of colonization, lower respiratory tract (LRT), osteoarticular, and bloodstream samples. Notably, the Xpert pooled specificity was consistently ≥ 92% against microbiological culture across all sample types. The diagnostic efficiency heterogeneity was not explained by a meta-regression and subgroup analysis of research design, sample conditions, and sampling methods (P > 0.05). Conclusion: Our findings suggest that Xpert could be used as the favoured screening test for the early detection of staphylococcal infection in a variety of sample types, with the goal of guiding therapeutic decisions.
Language	English
Publishing date	2022-04-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2701611-0
ISSN	2193-6382 ; 2193-8229
ISSN (online)	2193-6382
ISSN	2193-8229
DOI	10.1007/s40121-022-00632-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling

Wang, Yun / Fu, Qiang / Tao, Yun-jian / Ying, Sheng-nan / Zhong, Heng-gao / Zhu, Yue / Qian, Xiao-han / Miao, Lin / Yang, Lihua

Funct Integr Genomics. 2023 Mar., v. 23, no. 1 p.29-29

2023

Abstract: ThE present work focused on exploring Girdin expression within gastric cancer (GC), examining the effect of Girdin on the cell phenotype of GC, and clarifying the underlying mechanisms. Girdin expression in GC samples was identified by ... ...

Abstract	ThE present work focused on exploring Girdin expression within gastric cancer (GC), examining the effect of Girdin on the cell phenotype of GC, and clarifying the underlying mechanisms. Girdin expression in GC samples was identified by immunohistochemistry (IHC) and quantitative real-time PCR (qRT-PCR) assays. Girdin-targeting siRNAs were transfected into GC cells; later, we examined GC cell proliferation, migration, invasion, and apoptosis, respectively. Additionally, the protein expression was examined through Western blotting assay. Moreover, the tumor implantation experiment was conducted for examining Girdin knockdown in vivo. The results showed that Girdin expression elevated within GC samples, which was associated with the dismal prognostic outcome. Girdin knockdown suppressed GC cell proliferation, migration, and invasion, and enhanced apoptosis and cell cycle arrest. Girdin promoted the phosphorylation of AKT, GSK3β, and β-catenin. Moreover, Girdin inhibited the phosphorylation of β-catenin. Girdin suppressed cell apoptosis and stimulated cell migration and invasion, while AKT inhibitor (MK2206) treatment reversed the effect of Girdin overexpression, and GSK3β inhibitor (CHIR99021) treatment enhanced the effect of Girdin overexpression on GC cells. Besides, Girdin delayed tumor growth in vivo. In conclusion, Girdin was abnormally expressed in GC samples, which promoted the development of GC by regulating AKT/GSK3β/β-catenin signaling.
Keywords	apoptosis ; cell cycle checkpoints ; cell movement ; cell proliferation ; cell structures ; genomics ; immunohistochemistry ; oncogenes ; phosphorylation ; protein synthesis ; quantitative polymerase chain reaction ; stomach neoplasms
Language	English
Dates of publication	2023-03
Size	p. 29.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-022-00927-8
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: HKUST-1 nano metal-organic frameworks combined with ZnGa

Yu, Bin / Wang, Yun-Jian / Lin, Yuan-Ying / Feng, Yan / Wu, Juan / Liu, Wei-Sheng / Wang, Min / Gao, Xiu-Ping

Nanoscale

2022 Volume 14, Issue 25, Page(s) 8978–8985

Abstract: The multifunctional theranostic nanoplatform based on the combination of persistent luminescent nanoparticles (PLNPs) and metal-organic frameworks (MOFs) has ... ...

Abstract	The multifunctional theranostic nanoplatform based on the combination of persistent luminescent nanoparticles (PLNPs) and metal-organic frameworks (MOFs) has both
MeSH term(s)	Animals ; Cell Line, Tumor ; Hydrogen Peroxide/therapeutic use ; Luminescence ; Metal-Organic Frameworks ; Mice ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/therapy ; Phototherapy ; Photothermal Therapy ; Silicon Dioxide/pharmacology ; Theranostic Nanomedicine
Chemical Substances	Metal-Organic Frameworks ; bis(1,3,5-benzenetricarboxylate)tricopper(II) ; Silicon Dioxide (7631-86-9) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d1nr07927a
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Article: Molecular Tools for Guiding Therapy in Patients With Staphylococcal Bone and Joint Infections: A Diagnostic Test Accuracy Meta-analysis.

Chen, Ke / Wang, Yanqiu / Yuan, Yue / Qin, Wen / Sheng, Yun-Jian / Ahmed, Sarfraz / Sun, Changfeng / Deng, Cun-Liang / Ojha, Suvash Chandra

Frontiers in endocrinology

2022 Volume 13, Page(s) 792679

Abstract: Background: Timely detection of causative pathogens and their antimicrobial resistance are essential for guiding targeted therapies in bone and joint infections (BJI) patients. We performed a systematic review and meta-analysis to assess the diagnostic ... ...

Abstract	Background: Timely detection of causative pathogens and their antimicrobial resistance are essential for guiding targeted therapies in bone and joint infections (BJI) patients. We performed a systematic review and meta-analysis to assess the diagnostic value of testing osteoarticular samples with the nucleic acid amplification tests (NAAT) for effective staphylococcal strain identification and the administration of appropriately targeted antimicrobial agents in BJI patients. Methods: Five databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane Library, were searched for related publications from inception to July 24, 2021. Studies comparing the diagnostic accuracy of NAAT to a microbiological culture reference standard of osteoarticular specimens were eligible. Pooled summary values of sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) of NAAT compared to the microbiological culture reference standard were calculated using bivariate random-effects meta-analyses. Results: From 906 citations, 11 studies were included. Eleven studies comprising 13 datasets ( Conclusions: Our study suggested that NAAT can be applied as the preferred prescreening test for the timely diagnosis of staphylococcal strains associated with BJI in osteoarticular samples for successful antimicrobial therapy.
MeSH term(s)	Diagnostic Tests, Routine ; Humans ; Methicillin-Resistant Staphylococcus aureus ; Nucleic Acid Amplification Techniques ; Odds Ratio ; Sensitivity and Specificity
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.792679
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Article: Clinical Utility of Molecular Tests for Guiding Therapeutic Decisions in Bloodstream Staphylococcal Infections: A Meta-Analysis.

Chen, Ke / Malik, Aijaz Ahmad / Sheng, Yun-Jian / Ahmed, Sarfraz / Sun, Changfeng / Deng, Cun-Liang / Ojha, Suvash Chandra

Frontiers in pediatrics

2021 Volume 9, Page(s) 713447

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-05
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2021.713447
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Article ; Online: The relationship between NTCP gene varieties and the progress of liver disease after HBV infection: an updated systematic review and meta-analysis.

He, Chuan / He, Hong-Yan / Sun, Chang-Feng / Ojha, Suvash Chandra / Wang, Hang / Deng, Cun-Liang / Sheng, Yun-Jian

The American journal of the medical sciences

2022 Volume 364, Issue 2, Page(s) 207–219

Abstract: Background: The aim of this study was to analyze the relationship between sodium taurocholate cotransporting polypeptide (NTCP) gene varieties and hepatitis B virus (HBV) infection and the progress of HBV-related liver disease.: Methods: PubMed, ... ...

Abstract	Background: The aim of this study was to analyze the relationship between sodium taurocholate cotransporting polypeptide (NTCP) gene varieties and hepatitis B virus (HBV) infection and the progress of HBV-related liver disease. Methods: PubMed, EMBASE, Web of Science and Cochrane library were used to search eligible studies. STATA software was performed to combine results. Pooled odds ratios (OR) was used to assess the potential genetic relationships. Results: A total of 18 eligible case-control studies with 24960 cases and 28342 controls were included in this meta-analysis. The A allele of rs2296651 polymorphism was found to be significantly linked to a protection of HBV infection in the whole combined analysis (P = 0.000). Meanwhile, this allele was significantly associated with a decreased risk of hepatocellular carcinoma (HCC) (A vs. G: OR = 0.668, 95% CI: 0.571-0.782, P = 0.000), and was significantly associated with HBV nature clearance (A vs. G: OR = 0.744, 95% CI: 0.585-0.946, P = 0.016; AA+GA vs. GG: OR = 0.775, 95% CI: 0.613-0.980, P = 0.033; GA vs. GG: OR = 0.748, 95% CI: 0.588-0.952, P = 0.018). However, rs4646287 genetic varieties had no statistical differences in all models with HBV infection or HBV-related disease progress, liver cirrhosis, acute-on-chronic liver failure and HCC, as well as rs7154439, rs4646285, rs4646296. Conclusions: Rs2296651 polymorphism (A allele) may protect from HBV infection and the progress of HBV-related disease (HBV-related HCC). Future research about other single nucleotide polymorphisms (SNPs) (rs4646287, rs7154439, rs4646285, rs4646296) of NTCP may be needed to clarify the relationship of NTCP gene varieties with HBV infection and HBV-related disease.
MeSH term(s)	Carcinoma, Hepatocellular/genetics ; Genetic Predisposition to Disease ; Hepatitis B/complications ; Hepatitis B/genetics ; Hepatitis B virus ; Hepatitis B, Chronic ; Humans ; Liver Neoplasms/genetics ; Organic Anion Transporters, Sodium-Dependent/genetics ; Polymorphism, Single Nucleotide ; Symporters/genetics
Chemical Substances	Organic Anion Transporters, Sodium-Dependent ; Symporters ; sodium-bile acid cotransporter (145420-23-1)
Language	English
Publishing date	2022-04-06
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2022.03.014
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Article ; Online: Girdin acts as an oncogene in gastric cancer by regulating AKT/GSK3β/β-catenin signaling.

Wang, Yun / Fu, Qiang / Tao, Yun-Jian / Ying, Sheng-Nan / Zhong, Heng-Gao / Zhu, Yue / Qian, Xiao-Han / Miao, Lin / Yang, Li-Hua

Functional & integrative genomics

2023 Volume 23, Issue 1, Page(s) 29

Abstract	ThE present work focused on exploring Girdin expression within gastric cancer (GC), examining the effect of Girdin on the cell phenotype of GC, and clarifying the underlying mechanisms. Girdin expression in GC samples was identified by immunohistochemistry (IHC) and quantitative real-time PCR (qRT-PCR) assays. Girdin-targeting siRNAs were transfected into GC cells; later, we examined GC cell proliferation, migration, invasion, and apoptosis, respectively. Additionally, the protein expression was examined through Western blotting assay. Moreover, the tumor implantation experiment was conducted for examining Girdin knockdown in vivo. The results showed that Girdin expression elevated within GC samples, which was associated with the dismal prognostic outcome. Girdin knockdown suppressed GC cell proliferation, migration, and invasion, and enhanced apoptosis and cell cycle arrest. Girdin promoted the phosphorylation of AKT, GSK3β, and β-catenin. Moreover, Girdin inhibited the phosphorylation of β-catenin. Girdin suppressed cell apoptosis and stimulated cell migration and invasion, while AKT inhibitor (MK2206) treatment reversed the effect of Girdin overexpression, and GSK3β inhibitor (CHIR99021) treatment enhanced the effect of Girdin overexpression on GC cells. Besides, Girdin delayed tumor growth in vivo. In conclusion, Girdin was abnormally expressed in GC samples, which promoted the development of GC by regulating AKT/GSK3β/β-catenin signaling.
MeSH term(s)	Humans ; beta Catenin/genetics ; beta Catenin/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Glycogen Synthase Kinase 3 beta/genetics ; Glycogen Synthase Kinase 3 beta/metabolism ; Oncogenes ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Stomach Neoplasms/metabolism ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism
Chemical Substances	beta Catenin ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; CCDC88A protein, human ; Vesicular Transport Proteins ; Microfilament Proteins
Language	English
Publishing date	2023-01-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2014670-X
ISSN	1438-7948 ; 1438-793X
ISSN (online)	1438-7948
ISSN	1438-793X
DOI	10.1007/s10142-022-00927-8
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Article ; Online: Visual change as the presenting symptom of a suspected metastatic brain lesion in esophageal cancer: A case report.

Hsieh, Yun-Chen / Wu, Jian-Sheng

Medicine

2023 Volume 102, Issue 47, Page(s) e36014

Abstract: Introduction: Esophageal cancer is the seventh most common malignancy worldwide and the sixth leading cause of cancer mortality with an overall survival rate of <20%. Esophageal cancer frequently metastasizes to distant lymph nodes, lungs, liver, and ... ...

Abstract	Introduction: Esophageal cancer is the seventh most common malignancy worldwide and the sixth leading cause of cancer mortality with an overall survival rate of <20%. Esophageal cancer frequently metastasizes to distant lymph nodes, lungs, liver, and bones. Cerebral metastases originating from esophageal cancer are rare and often carry a poor prognosis as do most all metastatic lesions in esophageal cancer. Case presentation: In this report, we describe a 55-year-old patient with past history of esophageal carcinoma who presented with blurred vision after taking ethambutol for tuberculosis. Ethambutol-induced optic neuropathy was the lead diagnosis. Initial vision testing was normal so additional testing with visual field examination was warranted. The visual field examination revealed homonymous hemianopsia. Subsequent magnetic resonance imaging of his brain, demonstrated a focal lesion, consistent with but not diagnostic of a brain metastasis likely from his primary esophageal malignancy. Conclusion: We conclude that a careful review of the medical history and comprehensive assessment are essential in establishing an obscure clinical diagnosis especially in the event that an uncommon metastatic lesion is encountered.
MeSH term(s)	Humans ; Middle Aged ; Ethambutol ; Hemianopsia/etiology ; Visual Fields ; Brain/pathology ; Esophageal Neoplasms/pathology
Chemical Substances	Ethambutol (8G167061QZ)
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000036014
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Article ; Online: The effect of

Fu, Juan / Sun, Chang-Feng / He, Hong-Yan / Ojha, Suvash Chandra / Shi, Han / Deng, Cun-Liang / Sheng, Yun-Jian

Pharmacogenomics

2021 Volume 22, Issue 13, Page(s) 859–879

Abstract: Premise: ...

Abstract	Premise:
MeSH term(s)	Asians ; Cohort Studies ; Cytochrome P-450 CYP2C19/genetics ; Helicobacter Infections/drug therapy ; Helicobacter Infections/genetics ; Helicobacter pylori ; Humans ; Polymorphism, Genetic/genetics ; Proton Pump Inhibitors/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Proton Pump Inhibitors ; CYP2C19 protein, human (EC 1.14.14.1) ; Cytochrome P-450 CYP2C19 (EC 1.14.14.1)
Language	English
Publishing date	2021-08-20
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2019513-8
ISSN	1744-8042 ; 1462-2416
ISSN (online)	1744-8042
ISSN	1462-2416
DOI	10.2217/pgs-2020-0127
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