Result 1 - 5 of total 5
hautnah dermatologie
| Keywords | covid19 |
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| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #824836 |
| Database | COVID19 |
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hautnah dermatologie
| Keywords | covid19 |
|---|---|
| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1007/s15012-020-4175-1 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Haut in Form
| Keywords | covid19 |
|---|---|
| Publisher | PMC |
| Document type | Article ; Online |
| DOI | 10.1007/s16022-020-0093-y |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Brain pathology (Zurich, Switzerland)
2017 Volume 28, Issue 5, Page(s) 595–602
Abstract: Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD). Experimental studies using animal models of AD have highlighted a ...
| Abstract | Mutation in the triggering receptor expressed on myeloid cells (TREM) 2 gene has been identified as a risk factor for several neurodegenerative diseases including Alzheimer's disease (AD). Experimental studies using animal models of AD have highlighted a number of functions associated with TREM2 and its expression by microglial cells. It has therefore been assumed that this is also the case in humans. However, there is very limited information concerning the cellular expression of TREM2 in the human brain. As part of investigations of microglia using post-mortem resources provided by the Medical Research Council Cognitive Function and Ageing Studies (MRC-CFAS), we immunostained the cerebral cortex of 299 participants for TREM2 using the Sigma antibody HPA010917 and compared with the macrophage/microglial markers Iba1 and CD68. As expected, Iba1 and CD68 labeled microglia and perivascular macrophages. However, in most cases (284/299), the TREM2 antibody labelled monocytes within vascular lumens, but not microglia or perivascular macrophages. In contrast, in 5 out of 6 cases with acute infarcts, TREM2 immunoreaction identified cells within the brain parenchyma interpreted as recruited monocytes. Six cases with old infarcts contained phagocytic foamy macrophages which were CD68-positive but TREM2 negative. Our observations, using the HPA010917 anti-TREM2 antibody, suggest that TREM2 is not expressed by microglia but instead seems to be a marker of recruited monocytes in the human brain. This finding has implications with regards to the role of TREM2 as a risk factor, emphasizing the importance of systemic immune responses in the development and progression of Alzheimer's disease. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Brain Infarction/metabolism ; Brain Infarction/pathology ; Calcium-Binding Proteins ; Cerebral Cortex/metabolism ; Cerebral Cortex/pathology ; Cohort Studies ; DNA-Binding Proteins/metabolism ; Dementia/metabolism ; Dementia/pathology ; Female ; Humans ; Immunohistochemistry ; Macrophages/metabolism ; Macrophages/pathology ; Male ; Membrane Glycoproteins/metabolism ; Microfilament Proteins ; Microglia/metabolism ; Microglia/pathology ; Monocytes/metabolism ; Monocytes/pathology ; Receptors, Immunologic/metabolism ; Spleen/metabolism ; Spleen/pathology |
| Chemical Substances | AIF1 protein, human ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD68 antigen, human ; Calcium-Binding Proteins ; DNA-Binding Proteins ; Membrane Glycoproteins ; Microfilament Proteins ; Receptors, Immunologic ; TREM2 protein, human |
| Language | English |
| Publishing date | 2017-10-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1051484-3 |
| ISSN | 1750-3639 ; 1015-6305 |
| ISSN (online) | 1750-3639 |
| ISSN | 1015-6305 |
| DOI | 10.1111/bpa.12564 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3585: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Journal of neuroinflammation
2016 Volume 13, Issue 1, Page(s) 135
Abstract: Background: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions, with their main role in ... ...
| Abstract | Background: Genetic risk factors for Alzheimer's disease imply that inflammation plays a causal role in development of the disease. Experimental studies suggest that microglia, as the brain macrophages, have diverse functions, with their main role in health being to survey the brain parenchyma through highly motile processes. Methods: Using the Medical Research Council Cognitive Function and Ageing Studies resources, we have immunophenotyped microglia to investigate their role in dementia with Alzheimer's pathology. Cerebral cortex obtained at post-mortem from 299 participants was analysed by immunohistochemistry for cluster of differentiation (CD)68 (phagocytosis), human leukocyte antigen (HLA)-DR (antigen-presenting function), ionized calcium-binding adaptor molecule (Iba1) (microglial motility), macrophage scavenger receptor (MSR)-A (plaque-related phagocytosis) and CD64 (immunoglobulin Fcγ receptor I). Results: The presence of dementia was associated positively with CD68 (P < 0.001), MSR-A (P = 0.010) and CD64 (P = 0.007) and negatively with Iba1 (P < 0.001). Among participants without dementia, the cognitive function according to the Mini-Mental State Examination was associated positively with Iba1 (P < 0.001) and negatively with CD68 (P = 0.033), and in participants with dementia and Alzheimer's pathology, positively with all microglial markers except Iba1. Overall, in participants without dementia, the relationship with Alzheimer's pathology was negative or not significant, and positive in participants with dementia and Alzheimer's pathology. Apolipoprotein E (APOE) ε2 allele was associated with expression of Iba1 (P = 0.001) and MSR-A (P < 0.001) and APOE ε4 with CD68, HLA-DR and CD64 (P < 0.001). Conclusions: Our findings raise the possibility that in dementia with Alzheimer's pathology, microglia lose motility (Iba-1) necessary to support neurons. Conversely, other microglial proteins (CD68, MSR-A), the role of which is clearance of damaged cellular material, are positively associated with Alzheimer's pathology and impaired cognitive function. In addition, our data imply that microglia may respond differently to Aβ and tau in participants with and without dementia so that the microglial activity could potentially influence the likelihood of developing dementia, as supported by genetic studies, highlighting the complexity and diversity of microglial responses. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Alzheimer Disease/pathology ; Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Calcium-Binding Proteins ; Cohort Studies ; Cytokines/metabolism ; DNA-Binding Proteins/metabolism ; Dementia/complications ; Dementia/pathology ; Diagnosis ; Female ; HLA-DR Antigens/metabolism ; Humans ; Male ; Mental Status Schedule ; Methionine Sulfoxide Reductases/metabolism ; Microfilament Proteins ; Microglia/metabolism ; Neuropsychological Tests ; Receptors, IgG/metabolism |
| Chemical Substances | AIF1 protein, human ; Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD68 antigen, human ; Calcium-Binding Proteins ; Cytokines ; DNA-Binding Proteins ; FCGR1A protein, human ; HLA-DR Antigens ; Microfilament Proteins ; Receptors, IgG ; Methionine Sulfoxide Reductases (EC 1.8.4.-) ; methionine sulfoxide reductase (EC 1.8.4.11) |
| Language | English |
| Publishing date | 2016-06-02 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 1742-2094 |
| ISSN (online) | 1742-2094 |
| DOI | 10.1186/s12974-016-0601-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.