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Article ; Online: Long-term impact of weight loss for people with overweight but not obesity, and with type 2 diabetes: 10-year outcomes of a randomized trial of gastric band surgery.

Qi, Qi Yang Damien / Playfair, Julie / Brown, Wendy A / Burton, Paul / O'Brien, Paul E / Wentworth, John M

2023 Volume 25, Issue 6, Page(s) 1464–1472

Abstract: Aim: Randomized trials reporting 5-year outcomes have shown bariatric surgery to induce diabetes remission and improve cardiovascular risk. However, the longer-term effects of surgery are uncertain, with only one randomized trial reporting 10-year ... ...

Abstract	Aim: Randomized trials reporting 5-year outcomes have shown bariatric surgery to induce diabetes remission and improve cardiovascular risk. However, the longer-term effects of surgery are uncertain, with only one randomized trial reporting 10-year diabetes outcomes in people with obesity. We aimed to compare 10-year diabetes outcomes of people who are overweight but not obese, randomly assigned to receive either multidisciplinary diabetes care, or multidisciplinary diabetes care combined with gastric band (GB) surgery. Methods: Between 2009 and 2011, 51 adults were randomized. After 5 years, they were discharged to receive community care and reassessed after 10 years. The primary outcome was diabetes remission, defined as glycated haemoglobin (HbA1c) <6.5% (48 mmol/mol) without glucose-lowering medication. Results: Forty-one participants (20 medical and 21 GB) completed the 10-year assessment. The median (Q1, Q3) weight loss in the GB group was 9.8 (6.7, 16.3)% at 10 years compared with 5.6 (3.4, 7.6)% in the medical group (median difference 4.2%; p = .008). Diabetes remission occurred in five GB participants and no medical participants (relative risk 0.76, 95% CI: 0.55-0.93, p = .048). GB participants used fewer glucose-lowering medications at 10 years but HbA1c, fasting glucose, calculated cardiovascular risk, quality-of-life and incident diabetes complications did not differ significantly between the groups. Conclusion: When compared with medical care, GB surgery achieved greater weight loss and modestly increased the likelihood of diabetes remission. However, it did not improve HbA1c, cardiovascular risk or quality of life.
MeSH term(s)	Adult ; Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/therapy ; Overweight/complications ; Overweight/therapy ; Glycated Hemoglobin ; Quality of Life ; Treatment Outcome ; Obesity/complications ; Obesity/epidemiology ; Obesity/surgery ; Bariatric Surgery ; Glucose ; Weight Loss
Chemical Substances	Glycated Hemoglobin ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14992
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Zs.A 5442: Show issues

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Article ; Online: Metyrapone abolishes spike-wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones.

Dezsi, Gabi / Ozturk, Ezgi / Harris, Georgia / Paul, Cornelius / O'Brien, Terence J / Jones, Nigel C

Epilepsia

2023 Volume 64, Issue 6, Page(s) 1684–1693

Abstract: Objective: Stress is one of the most commonly reported triggers for seizures in patients with epilepsy, although the mechanisms that mediate this effect are not established. The clinical evidence supporting this is derived from patients' subjective ... ...

Abstract	Objective: Stress is one of the most commonly reported triggers for seizures in patients with epilepsy, although the mechanisms that mediate this effect are not established. The clinical evidence supporting this is derived from patients' subjective experience of stress, and how this influences their own seizures. Animal models can be used to explore this phenomenon in controlled environments, free from subjective bias. Here, we used genetic absence epilepsy rats from Strasbourg (GAERS), a genetic rat model of absence epilepsy, to explore the influence of stress and stress hormones on spontaneous seizures. Methods: Adult male GAERS (n = 38) and nonepileptic control (NEC) rats (n = 4) were used. First, rats were subjected to 30-min restraint stress to assess hypothalamic-pituitary-adrenal axis function. Next, we assessed the effects of 30-min noise stress, and cage tilt stress, on spike-wave discharge seizures in GAERS. We then performed pharmacological experiments to assess the direct effects of stress hormones on seizures, including corticosterone, metyrapone, and deoxycorticosterone. Results: GAERS exhibited elevated baseline corticosterone levels, compared to NEC rats. Noise stress and cage tilt stress significantly enhanced seizure incidence (p < .05), but only during stress periods. Exogenous corticosterone administration also significantly increased seizure occurrence (p < .05). Metyrapone, an inhibitor of corticosterone synthesis, completely abolished seizures in GAERS, and seizures remained suppressed for >2 h. However, deoxycorticosterone, the precursor of corticosterone, increased seizures. Significance: These results suggest that GAERS exhibit elevations in stress hormones, and this may contribute to seizures. Inhibiting corticosterone synthesis with metyrapone prevents seizures in GAERS, and shows potential for repurposing this drug as a future antiseizure medication.
MeSH term(s)	Humans ; Rats ; Male ; Animals ; Epilepsy, Absence/genetics ; Metyrapone/pharmacology ; Corticosterone ; Hypothalamo-Hypophyseal System ; Patient Discharge ; Electroencephalography ; Pituitary-Adrenal System ; Seizures ; Desoxycorticosterone ; Disease Models, Animal
Chemical Substances	Metyrapone (ZS9KD92H6V) ; Corticosterone (W980KJ009P) ; Desoxycorticosterone (40GP35YQ49)
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	216382-2
ISSN	1528-1167 ; 0013-9580
ISSN (online)	1528-1167
ISSN	0013-9580
DOI	10.1111/epi.17584
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Zs.A 517: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 475: Show issues

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Article ; Online: Nerve-myeloid cell interactions in persistent human pain: a reappraisal using updated cell subset classifications.

O'Brien, Jayden A / Karrasch, Jackson F / Huang, Yun / Vine, Erica E / Cunningham, Anthony L / Harman, Andrew N / Austin, Paul J

Pain

2023 Volume 165, Issue 4, Page(s) 753–771

Abstract: Abstract: The past 20 years have seen a dramatic shift in our understanding of the role of the immune system in initiating and maintaining pain. Myeloid cells, including macrophages, dendritic cells, Langerhans cells, and mast cells, are increasingly ... ...

Abstract	Abstract: The past 20 years have seen a dramatic shift in our understanding of the role of the immune system in initiating and maintaining pain. Myeloid cells, including macrophages, dendritic cells, Langerhans cells, and mast cells, are increasingly implicated in bidirectional interactions with nerve fibres in rodent pain models. However, our understanding of the human setting is still poor. High-dimensional functional analyses have substantially changed myeloid cell classifications, with recently described subsets such as epidermal dendritic cells and DC3s unveiling new insight into how myeloid cells interact with nerve fibres. However, it is unclear whether this new understanding has informed the study of human chronic pain. In this article, we perform a scoping review investigating neuroimmune interactions between myeloid cells and peripheral nerve fibres in human chronic pain conditions. We found 37 papers from multiple pain states addressing this aim in skin, cornea, peripheral nerve, endometrium, and tumour, with macrophages, Langerhans cells, and mast cells the most investigated. The directionality of results between studies was inconsistent, although the clearest pattern was an increase in macrophage frequency across conditions, phases, and tissues. Myeloid cell definitions were often outdated and lacked correspondence with the stated cell types of interest; overreliance on morphology and traditional structural markers gave limited insight into the functional characteristics of investigated cells. We therefore critically reappraise the existing literature considering contemporary myeloid cell biology and advocate for the application of established and emerging high-dimensional proteomic and transcriptomic single-cell technologies to clarify the role of specific neuroimmune interactions in chronic pain.
MeSH term(s)	Female ; Humans ; Chronic Pain/metabolism ; Proteomics ; Macrophages ; Myeloid Cells/metabolism ; Cell Communication
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	193153-2
ISSN	1872-6623 ; 0304-3959
ISSN (online)	1872-6623
ISSN	0304-3959
DOI	10.1097/j.pain.0000000000003106
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Zs.A 1158: Show issues

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Article ; Online: Use of hare bone for the manufacture of a Clovis bead.

Surovell, Todd A / Litynski, McKenna L / Allaun, Sarah A / Buckley, Michael / Schoborg, Todd A / Govaerts, Jack A / O'Brien, Matthew J / Pelton, Spencer R / Sanders, Paul H / Mackie, Madeline E / Kelly, Robert L

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2937

Abstract: A tubular bone bead dating to ~ 12,940 BP was recovered from a hearth-centered activity area at the La Prele Mammoth site in Converse County, Wyoming, USA. This is the oldest known bead from the Western Hemisphere. To determine the taxonomic origin of ... ...

Abstract	A tubular bone bead dating to ~ 12,940 BP was recovered from a hearth-centered activity area at the La Prele Mammoth site in Converse County, Wyoming, USA. This is the oldest known bead from the Western Hemisphere. To determine the taxonomic origin of the bead, we extracted collagen for zooarchaeology by mass spectrometry (ZooMS). We also used micro-CT scanning for morphological analysis to determine likely skeletal elements used for its production. We conclude that the bead was made from a metapodial or proximal phalanx of a hare (Lepus sp.). This find represents the first secure evidence for the use of hares during the Clovis period. While the use of hare bone for the manufacture of beads was a common practice in western North America during the Holocene, its origins can now be traced back to at least the terminal Pleistocene.
MeSH term(s)	Animals ; Phylogeny ; Hares ; Mass Spectrometry ; North America ; Lagomorpha
Language	English
Publishing date	2024-02-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53390-9
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Article ; Online: Respiratory sinus arrhythmia predicts perceived therapy process of a group-based acceptance and commitment therapy intervention.

O'Brien, William H / Goetz, Paul / O'Brien, Aaron T / McCarren, Heather / Delaney, Eileen

Bulletin of the Menninger Clinic

2021 Volume 85, Issue 1, Page(s) 9–22

Abstract: Engagement in psychotherapy is partially contingent on present-moment focus, mindfulness, and emotion regulation skills. These skills can be linked to parasympathetic functioning with theoretical explanations provided by polyvagal and neurovisceral ... ...

Abstract	Engagement in psychotherapy is partially contingent on present-moment focus, mindfulness, and emotion regulation skills. These skills can be linked to parasympathetic functioning with theoretical explanations provided by polyvagal and neurovisceral integration theories. The specific aims of this project were to evaluate relationships between a measure of parasympathetic functioning (respiratory sinus arrythmia [RSA]) and measures of client reports of engagement in an experiential and emotionally evocative group-based intervention. Twenty-one community residents received group-based acceptance and commitment therapy (ACT) for work stress. RSA was measured 1 week before the intervention. Client ratings of relationship support, task focus, and hindering experiences were assessed after each session. Results indicated that clients perceived the ACT intervention to be supportive, task-focused, and without significant therapy-hindering experiences. Higher levels of RSA were significantly associated with higher levels of relationship support. These results support predictions derived from the polyvagal and neurovisceral integration theories.
MeSH term(s)	Acceptance and Commitment Therapy ; Arrhythmia, Sinus ; Humans ; Mindfulness ; Respiratory Sinus Arrhythmia
Language	English
Publishing date	2021-03-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	390416-7
ISSN	1943-2828 ; 0025-9284
ISSN (online)	1943-2828
ISSN	0025-9284
DOI	10.1521/bumc.2021.85.1.9
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Zs.B 77: Show issues

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Article ; Online: An Integrative Review of Recovery Services to Improve the Lives of Adults Living with Severe Mental Illness.

Badu, Eric / O'Brien, Anthony Paul / Mitchell, Rebecca

International journal of environmental research and public health

2021 Volume 18, Issue 16

Abstract: There is an increasing call for recovery-oriented services but few reviews have been undertaken regarding such interventions. This review aims to synthesize evidence on recovery services to improve the lives of adults living with severe mental illness. ... ...

Abstract	There is an increasing call for recovery-oriented services but few reviews have been undertaken regarding such interventions. This review aims to synthesize evidence on recovery services to improve the lives of adults living with severe mental illness. An integrative review methodology was used. We searched published literature from seven databases: Medline, EMBASE, PsycINFO, CINAHL, Google Scholar, Web of Science, and Scopus. Mixed-methods synthesis was used to analyse the data. Out of 40 included papers, 62.5% (25/40) used quantitative data, 32.5% used qualitative and 5% (2/40) used mixed methods. The participants in the included papers were mostly adults with schizophrenia and schizoaffective disorder. This review identified three recovery-oriented services-integrated recovery services, individual placement services and recovery narrative photovoice and art making. The recovery-oriented services are effective in areas such as medication and treatment adherence, improving functionality, symptoms reduction, physical health and social behaviour, self-efficacy, economic empowerment, social inclusion and household integration. We conclude that mental health professionals are encouraged to implement the identified recovery services to improve the recovery goals of consumers.
MeSH term(s)	Adult ; Health Personnel ; Humans ; Mental Disorders/therapy
Language	English
Publishing date	2021-08-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph18168873
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply to Hoad et al. Comment on White paper on pandemic preparedness in the blood supply.

Strengers, Paul / O'Brien, Sheila F / Politis, Constantina / Mayr, Wolfgang / Seifried, Erhard / Spencer, Bryan R

Vox sanguinis

2023 Volume 118, Issue 5, Page(s) 411–412

MeSH term(s)	Humans ; Pandemics/prevention & control ; Blood Banking/supply & distribution
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80313-3
ISSN	1423-0410 ; 0042-9007
ISSN (online)	1423-0410
ISSN	0042-9007
DOI	10.1111/vox.13424
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Zs.A 74: Show issues

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Article ; Online: Durable Learning Strategies in Nursing Education: State-of-the-Evidence Review.

Mechtel, Marci / Kitt-Lewis, Erin / Reaves, Crista / Sinacori, Barbara / O'Brien, Tara / Logan, Paul / Rimbey, Patrice / Streiff, Kimberly / Phillips, Kathleen

The Journal of nursing education

2024 Volume 63, Issue 1, Page(s) 24–31

Abstract: Background: Health professions (HP) students must achieve durable learning (DL) to transfer and apply knowledge from the classroom to the clinical setting. This review examines the state of the science of classroom-based DL in HP.: Method: The Joanna ...

Abstract	Background: Health professions (HP) students must achieve durable learning (DL) to transfer and apply knowledge from the classroom to the clinical setting. This review examines the state of the science of classroom-based DL in HP. Method: The Joanna Briggs Systematic Review Methodology was used. MEDLINE, CINAHL, PsycINFO, and ERIC databases were searched for articles published from 2006 to 2022. A total of 2,000 titles were identified for review, with 51 studies being selected for inclusion. Results: Multiple classroom-based learning strategies generally reported as being effective were identified, including flipped classroom, educational technology, spaced learning, team-based learning, concept mapping and schema, testing, and case study and problem-based learning. Conclusion: Although DL has been proven to be effective in the classroom setting for HP, no one type has been shown to be more effective than others. Additional research is needed within the context of transferring knowledge to clinical settings and in nursing education.
MeSH term(s)	Humans ; Education, Nursing ; Educational Technology ; Knowledge ; Learning ; Problem-Based Learning
Language	English
Publishing date	2024-01-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	410686-6
ISSN	1938-2421 ; 0148-4834
ISSN (online)	1938-2421
ISSN	0148-4834
DOI	10.3928/01484834-20231112-05
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Zs.B 616: Show issues

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Article ; Online: Physical and Electrochemical Analysis of

Stachurski, Christopher D / Davis, James H / Cosby, Tyler / Crowley, Margaret E / Larm, Nathaniel E / Ballentine, Mollie G / O'Brien, Richard A / Zeller, Matthias / Salter, E Alan / Wierzbicki, Andrzej / Trulove, Paul C / Durkin, David P

Inorganic chemistry

2023 Volume 62, Issue 44, Page(s) 18280–18289

Abstract: In this work, a series of novel boronium-bis(trifluoromethylsulfonyl)imide [ ... ...

Abstract	In this work, a series of novel boronium-bis(trifluoromethylsulfonyl)imide [TFSI
Language	English
Publishing date	2023-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c02971
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Article: Welfare Assessment for Captive Anseriformes: A Guide for Practitioners and Animal Keepers.

Rose, Paul / O'Brien, Michelle

Animals : an open access journal from MDPI

2020 Volume 10, Issue 7

Abstract: ... i.e., determination of aspects of the physical environment or the bird's physical appearance or ... activity) and animal-based (i.e., observations that equate to a bird's feelings or ...

Abstract	Welfare assessment is a tool to both identify welfare challenges and to evidence where current husbandry practices support positive welfare outcomes. Such tools are becoming more available and can be amended based on the nature of the facility and needs of taxonomic groups. Currently, welfare assessment has a strong mammalian theme, and some behavioural measures of welfare commonly applied to mammals do not translate well for other taxa. This paper provides a method for welfare assessment of Anseriformes; widely housed, diverse bird species kept under a range of management styles. A mixture of resource-based (i.e., determination of aspects of the physical environment or the bird's physical appearance or activity) and animal-based (i.e., observations that equate to a bird's feelings or personality characteristics) measures are integrated to enable a full review of potential predictors of welfare. The method provides a rapid and valid way for all personnel to collect information that evaluates quality-of-life experiences of the Anseriformes under their care. Explanations of key terminology are provided to enable repeatable and reliable assessment for all persons using the tool. Suggestions for follow-up actions are provided to emphasise why the welfare assessment process needs to be one of continual re-evaluation of animal care.
Language	English
Publishing date	2020-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani10071132
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