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Article ; Online: Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells.

Lodge, Mareca / Scheidemantle, Grace / Adams, Victoria R / Cottam, Matthew A / Richard, Daniel / Breuer, Denitra / Thompson, Peter / Shrestha, Kritika / Liu, Xiaojing / Kennedy, Arion

Scientific reports

2024 Volume 14, Issue 1, Page(s) 4020

Abstract: Over-consumption of fructose in adults and children has been linked to increased risk of non-alcoholic fatty liver disease (NAFLD). Recent studies have highlighted the effect of fructose on liver inflammation, fibrosis, and immune cell activation. ... ...

Abstract	Over-consumption of fructose in adults and children has been linked to increased risk of non-alcoholic fatty liver disease (NAFLD). Recent studies have highlighted the effect of fructose on liver inflammation, fibrosis, and immune cell activation. However, little work summarizes the direct impact of fructose on macrophage infiltration, phenotype, and function within the liver. We demonstrate that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes. In addition, fructose increased fibrotic gene expression of collagen 1 alpha 1 (Col1a1) and tissue metallopeptidase inhibitor 1 (Timp1) as well as inflammatory gene expression of tumor necrosis factor alpha (Tnfa) and expression of transmembrane glycoprotein NMB (Gpnmb) in liver tissue compared to glucose and control diets. Single cell RNA sequencing (scRNAseq) revealed fructose elevated expression of matrix metallopeptidase 12 (Mmp12), interleukin 1 receptor antagonist (Il1rn), and radical S-adenosyl methionine domain (Rsad2) in liver and hepatic macrophages. In vitro studies using IMKC and J774.1 cells demonstrated decreased viability when exposed to fructose. Additionally, fructose increased Gpnmb, Tnfa, Mmp12, Il1rn, and Rsad2 in unpolarized IMKC. By mass spectrometry, C13 fructose tracing detected fructose metabolites in glycolysis and the pentose phosphate pathway (PPP). Inhibition of the PPP further increased fructose induced Il6, Gpnmb, Mmp12, Il1rn, and Rsad2 in nonpolarized IMKC. Taken together, fructose decreases cell viability while upregulating resolution and anti-inflammatory associated genes in Kupffer cells.
MeSH term(s)	Child ; Humans ; Kupffer Cells/metabolism ; Fructose/metabolism ; Pentose Phosphate Pathway ; Matrix Metalloproteinase 12/metabolism ; Liver/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Fibrosis ; Phenotype
Chemical Substances	Fructose (30237-26-4) ; Matrix Metalloproteinase 12 (EC 3.4.24.65)
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54272-w
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Article ; Online: Laparoscopic Single Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy: Surgical Technique.

Surve, Amit / Rao, Ravi / Cottam, Daniel

Obesity surgery

2020 Volume 30, Issue 11, Page(s) 4684–4686

Abstract: This video shows a case of a 57-year-old female patient with morbid obesity who underwent a laparoscopic single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S). ...

Abstract	This video shows a case of a 57-year-old female patient with morbid obesity who underwent a laparoscopic single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S).
MeSH term(s)	Anastomosis, Surgical ; Duodenum/surgery ; Female ; Gastrectomy ; Gastric Bypass ; Humans ; Laparoscopy ; Middle Aged ; Obesity, Morbid/surgery
Language	English
Publishing date	2020-07-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-020-04847-z
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Article ; Online: Weight Loss Outcomes of Laparoscopic Adjustable Gastric Band with Plication: a Single Center Experience of 66 Patients with 18-Month Follow-Up.

Billy, Helmuth / Surve, Amit / Fairley, Ryan / Cottam, Daniel / Cottam, Austin / Zaveri, Hinali / Cottam, Samuel

Obesity surgery

2018 Volume 29, Issue 1, Page(s) 246–251

Abstract: Background: Laparoscopic adjustable gastric band with plication (LAGBP) is a novel bariatric procedure, which combines the adjustability of the laparoscopic adjustable gastric band (LAGB) with the restrictive nature of the vertical sleeve gastrectomy ( ... ...

Abstract	Background: Laparoscopic adjustable gastric band with plication (LAGBP) is a novel bariatric procedure, which combines the adjustability of the laparoscopic adjustable gastric band (LAGB) with the restrictive nature of the vertical sleeve gastrectomy (VSG). The addition of plication of the stomach to LAGB should provide better appetite control, more effective weight loss, and greater weight loss potential. The purpose of the study was to analyze the outcomes of LAGBP at 18 months. Methods: Data from all patients who underwent a primary LAGBP procedure from December 2011 through June 2016 were retrospectively analyzed. Data collected from each patient included age, gender, weight, body mass index (BMI), and excess weight loss (EWL). Results: Sixty-six patients underwent LAGBP. The mean age and BMI were 44.6 ± 12.7 years and 42.1 ± 5.1 kg/m Conclusions: LAGBP is a relatively safe and effective bariatric procedure. In light of recent studies demonstrating poor outcomes following LAGB, LAGBP may prove to be the future for patients desiring a bariatric procedure without resection of the stomach.
MeSH term(s)	Adult ; Body Mass Index ; Female ; Follow-Up Studies ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Gastrectomy/statistics & numerical data ; Gastroplasty/adverse effects ; Gastroplasty/methods ; Gastroplasty/statistics & numerical data ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Laparoscopy/statistics & numerical data ; Male ; Middle Aged ; Obesity, Morbid/epidemiology ; Obesity, Morbid/surgery ; Retrospective Studies ; Treatment Outcome ; Weight Loss/physiology
Keywords	covid19
Language	English
Publishing date	2018-09-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-018-3512-5
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Article ; Online: Stomach Intestinal Pylorus-Sparing Surgery for Morbid Obesity.

Neichoy, Bo T / Schniederjan, Bleu / Cottam, Daniel R / Surve, Amit K / Zaveri, Hinali M / Cottam, Austin / Cottam, Samuel

JSLS : Journal of the Society of Laparoendoscopic Surgeons

2018 Volume 22, Issue 1

Abstract: Background and objective: The Roux-en-Y duodenal switch (RYDS) is one of the most efficient forms of bariatric surgery. However, diarrhea, malnutrition, ulcers, and internal hernias have hampered its widespread adoption. The stomach intestinal pylorus- ... ...

Abstract	Background and objective: The Roux-en-Y duodenal switch (RYDS) is one of the most efficient forms of bariatric surgery. However, diarrhea, malnutrition, ulcers, and internal hernias have hampered its widespread adoption. The stomach intestinal pylorus-sparing (SIPS) procedure was developed to alleviate these sequelae while retaining the same weight loss as the RYDS. In this study, we report our midterm experience with this novel technique. Methods: Retrospective analysis was performed on data from 225 patients who underwent a primary SIPS procedure by 2 surgeons at a single center from October 2013 through December 2016. Results: Two hundred twenty-five patients were identified for analysis. The mean preoperative body mass index (BMI) was 52.4 ± 9.1 kg/m Conclusion: In conclusion, SIPS surgery is a safe procedure with favorable weight loss outcomes at 2 years.
MeSH term(s)	Body Mass Index ; Duodenum/surgery ; Female ; Gastric Bypass/methods ; Humans ; Laparoscopy/methods ; Male ; Middle Aged ; Obesity, Morbid/physiopathology ; Obesity, Morbid/surgery ; Pylorus/surgery ; Retrospective Studies ; Weight Loss/physiology
Language	English
Publishing date	2018-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2011211-7
ISSN	1938-3797 ; 1086-8089
ISSN (online)	1938-3797
ISSN	1086-8089
DOI	10.4293/JSLS.2017.00063
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Zs.A 5183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure.

Smart, Charles Duncan / Fehrenbach, Daniel J / Wassenaar, Jean W / Agrawal, Vineet / Fortune, Niki L / Dixon, Debra D / Cottam, Matthew A / Hasty, Alyssa H / Hemnes, Anna R / Doran, Amanda C / Gupta, Deepak K / Madhur, Meena S

Cardiovascular research

2023 Volume 119, Issue 13, Page(s) 2312–2328

Abstract: Aims: Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, microvascular dysfunction, and myocardial fibrosis with recent evidence implicating the immune system in orchestrating cardiac remodelling.: ... ...

Abstract	Aims: Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, microvascular dysfunction, and myocardial fibrosis with recent evidence implicating the immune system in orchestrating cardiac remodelling. Methods and results: Here, we show the mouse model of deoxycorticosterone acetate (DOCA)-salt hypertension induces key elements of HFpEF, including diastolic dysfunction, exercise intolerance, and pulmonary congestion in the setting of preserved ejection fraction. A modified single-cell sequencing approach, cellular indexing of transcriptomes and epitopes by sequencing, of cardiac immune cells reveals an altered abundance and transcriptional signature in multiple cell types, most notably cardiac macrophages. The DOCA-salt model results in differential expression of several known and novel genes in cardiac macrophages, including up-regulation of Trem2, which has been recently implicated in obesity and atherosclerosis. The role of Trem2 in hypertensive heart failure, however, is unknown. We found that mice with genetic deletion of Trem2 exhibit increased cardiac hypertrophy, diastolic dysfunction, renal injury, and decreased cardiac capillary density after DOCA-salt treatment compared to wild-type controls. Moreover, Trem2-deficient macrophages have impaired expression of pro-angiogenic gene programmes and increased expression of pro-inflammatory cytokines. Furthermore, we found that plasma levels of soluble TREM2 are elevated in DOCA-salt treated mice and humans with heart failure. Conclusions: Together, our data provide an atlas of immunological alterations that can lead to improved diagnostic and therapeutic strategies for HFpEF. We provide our dataset in an easy to explore and freely accessible web application making it a useful resource for the community. Finally, our results suggest a novel cardioprotective role for Trem2 in hypertensive heart failure.
MeSH term(s)	Humans ; Mice ; Animals ; Heart Failure ; Desoxycorticosterone Acetate ; Stroke Volume/physiology ; Hypertension/chemically induced ; Hypertension/genetics ; Hypertension/metabolism ; Cardiomyopathies ; Myeloid Cells/metabolism ; Leukocytes/metabolism ; Membrane Glycoproteins/genetics ; Receptors, Immunologic/genetics
Chemical Substances	Desoxycorticosterone Acetate (6E0A168OB8) ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2023-02-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80340-6
ISSN	1755-3245 ; 0008-6363
ISSN (online)	1755-3245
ISSN	0008-6363
DOI	10.1093/cvr/cvad093
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Article ; Online: A Prospective Multicenter Standard of Care Study of Outpatient Laparoscopic Sleeve Gastrectomy.

Obesity surgery

2024 Volume 34, Issue 4, Page(s) 1122–1130

Abstract: A global shift is occurring as hospital procedures move to ambulatory surgical settings. Surgeons have performed outpatient sleeve gastrectomy (SG) in bariatric surgery since 2010. However, prospective trials are needed to ensure its safety before ... ...

Abstract	A global shift is occurring as hospital procedures move to ambulatory surgical settings. Surgeons have performed outpatient sleeve gastrectomy (SG) in bariatric surgery since 2010. However, prospective trials are needed to ensure its safety before widespread adoption. Purpose: The study aimed to present a comprehensive report on the prospective data collection of 30-day outcomes of outpatient primary laparoscopic SG (LSG). This trial seeks to assess whether outpatient LSG is non-inferior to hospital-based surgery in selected patients who meet the outpatient surgery criteria set by the American Society for Metabolic and Bariatric Surgery. Materials and methods: This study is funded by the Society of American Gastrointestinal and Endoscopic Surgeons and has been approved by the Advarra Institutional Review Board (Pro00055990). Cognizant of the necessity for a prospective approach, data collection commenced after patients underwent primary LSG procedures, spanning from August 2021 to September 2022, at six medical centers across the USA. Data centralization was facilitated through ArborMetrix. Each center has its own enhanced recovery protocols, and no attempt was made to standardize the protocols. Results: The analysis included 365 patients with a mean preoperative BMI of 43.7 ± 5.7 kg/m Conclusion: The prospective cohort study suggests that same-day discharge following LSG seems safe in highly selected patients at experienced US centers.
MeSH term(s)	Humans ; Obesity, Morbid/surgery ; Prospective Studies ; Outpatients ; Standard of Care ; Laparoscopy/methods ; Bariatric Surgery/methods ; Gastrectomy/methods ; Postoperative Complications/etiology ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2024-02-17
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-024-07094-8
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Article ; Online: Early Outcomes of Primary SADI-S: an Australian Experience.

Surve, Amit / Rao, Ravi / Cottam, Daniel / Rao, Aditya / Ide, Leila / Cottam, Samuel / Horsley, Benjamin

Obesity surgery

2019 Volume 30, Issue 4, Page(s) 1429–1436

Abstract: Introduction: Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) surgery is a modification of the traditional duodenal switch (DS) surgery. SADI-S is relatively a new bariatric surgical procedure and has gone by many names ... ...

Abstract	Introduction: Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) surgery is a modification of the traditional duodenal switch (DS) surgery. SADI-S is relatively a new bariatric surgical procedure and has gone by many names depending on the length of the common channel. In this study, we report our initial experience with this novel technique in the Australian population. Methods: The medical records of 91 patients who underwent laparoscopic primary SADI-S surgery by one surgeon at a single Australian center from January 2017 through May 2019 were retrospectively studied. Results: Ninety-one patients were identified for analysis. The mean age and preoperative body mass index (BMI) was 46.2 ± 9 years and 43.2 ± 5.7 kg/m Conclusions: SADI-S appears to be a safe bariatric surgical procedure with favorable outcomes at 2 years in the Australian population.
MeSH term(s)	Australia/epidemiology ; Diabetes Mellitus, Type 2/surgery ; Gastrectomy ; Humans ; Laparoscopy ; Obesity, Morbid/surgery ; Retrospective Studies ; Weight Loss
Language	English
Publishing date	2019-12-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-019-04312-6
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Article ; Online: Single anastomosis duodenal switch versus Roux-en-Y gastric bypass in patients with BMI ≥ 50 kg/m

Hage, Karl / Teixeira, Andre F / Surve, Amit / Lind, Romulo / Jawad, Muhammad A / Ghanem, Muhammad / Abi Mosleh, Kamal / Kendrick, Michael L / Cottam, Daniel / Ghanem, Omar M

Surgical endoscopy

2024

Abstract: Background: Roux-en-Y gastric bypass (RYGB) has consistently demonstrated excellent weight loss and comorbidity resolution. However, outcomes vary based on patient's BMI. Single anastomosis duodeno-ileostomy with sleeve (SADI-S) is a novel procedure ... ...

Abstract	Background: Roux-en-Y gastric bypass (RYGB) has consistently demonstrated excellent weight loss and comorbidity resolution. However, outcomes vary based on patient's BMI. Single anastomosis duodeno-ileostomy with sleeve (SADI-S) is a novel procedure with promising short-term results. The long-term outcomes of SADI-S in patients with BMI ≥ 50 kg/m Methods: We performed a multicenter retrospective study of patients with a BMI ≥ 50 kg/m Results: A total of 968 patients (343 RYGB and 625 SADI-S; 68.3% female, age 42.9 ± 12.1 years; BMI 57.3 ± 6.7 kg/m Conclusions: In our cohort, SADI-S was associated with higher and sustained weight-loss results compared to RYGB. Comorbidity resolution was also higher after SADI-S. Both procedures demonstrate a similar safety profile. Further studies are required to validate the long-term safety of SADI-S compared to other bariatric procedures.
Language	English
Publishing date	2024-03-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-024-10765-3
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Zs.A 2214: Show issues

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Article ; Online: Randomized double-blinded trial of laparoscopic gastric imbrication v laparoscopic sleeve gastrectomy at a single Indian institution.

Sharma, Sunil / Narwaria, Mahendra / Cottam, Daniel R / Cottam, Samuel

Obesity surgery

2015 Volume 25, Issue 5, Page(s) 800–804

Abstract: Background: Currently, there is a debate whether the laparoscopic gastric imbrication (LGI) offers similar weight loss when compared to the laparoscopic sleeve gastrectomy (LSG). On the surface, they seem to offer similar-sized stomachs after the ... ...

Abstract	Background: Currently, there is a debate whether the laparoscopic gastric imbrication (LGI) offers similar weight loss when compared to the laparoscopic sleeve gastrectomy (LSG). On the surface, they seem to offer similar-sized stomachs after the procedures are performed. We chose to perform a randomized double-blinded trial to see if similar-sized pouches result in similar types of weight loss. Our belief was that sleeve gastrectomy would offer at least a 10% better weight loss over a 3-year period. Methods: Thirty patients were randomized to one of two arms. The patients and the third party administrator following the patients were blinded as to which procedure was chosen. The surgeon had full knowledge of the patients' surgery throughout the treatment. The decision of which arm to place them was made by a single employee of the third party administrator and not shared with the employees following the patients. Patients were then followed for 3 years. Results: There were no differences in weight, age, or BMI preoperatively. There were no differences between the two groups at any follow-up time point from 6 months to 3 years. Follow-up was 100%. Conclusion: Due to the large standard deviations present in both groups, there was no statistical difference between either of the groups in terms of weight loss.
MeSH term(s)	Adult ; Body Mass Index ; Double-Blind Method ; Female ; Follow-Up Studies ; Gastrectomy/methods ; Gastroplasty/methods ; Humans ; India ; Laparoscopy/methods ; Male ; Middle Aged ; Obesity, Morbid/surgery ; Treatment Outcome ; Weight Loss
Keywords	covid19
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-014-1497-2
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Article ; Online: Healthcare cost and utilization of bariatric surgical patients with and without preoperative mental health diagnoses.

Kim, Jaewhan / Simper, Steven / McKinlay, Rodrick / Cottam, Daniel / Surve, Amit / Adams, Ted

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

2020 Volume 16, Issue 5, Page(s) 682–689

Abstract: Background: Postoperative healthcare cost and use among patients with and without preoperative mental health illness are not well known.: Objective: This study compared total healthcare spending and use (emergency department [ED] visits and inpatient ...

Abstract	Background: Postoperative healthcare cost and use among patients with and without preoperative mental health illness are not well known. Objective: This study compared total healthcare spending and use (emergency department [ED] visits and inpatient admissions) after 1 year post operation of those with and without preoperative mental health disorders. Setting: United States. Methods: Mental illness disorders were identified using International Classification of Disease-9/10 diagnosis codes in a statewide bariatric surgery registry and in claims databases that were linked to identify the study cohort. Generalized linear regression and zero-inflated negative binomial regression were used for the healthcare cost and use outcomes. Results: Among 3580 registry patients with private insurance, 1610 patients with continuous enrollment and without missing body mass index data were included. Among patients, 56.8% (n = 915) had diagnosed mental health disorders before surgery. Those with mental illness spent more in total cost than those without mental illness (unstandardized coefficient = $18,513, P value < .01) in the first year after surgery. Those with mental illness had a 73% higher rate in ED visits (P value < .01), 83% higher rate in preventable ED use (P value < .01), and a 101% higher rate in hospital admissions (P value < .01) than those without mental illness. Conclusions: Patients with mental health diagnoses before having bariatric surgery appear to have significant positive association with surgical outcomes relating to postsurgical healthcare cost and utilization. Greater postsurgical surveillance may be warranted for bariatric surgery patients with preoperative mental illness to reduce postoperative ED visits and inpatient admissions.
MeSH term(s)	Bariatric Surgery ; Emergency Service, Hospital ; Health Care Costs ; Humans ; Mental Disorders/epidemiology ; Mental Health ; United States/epidemiology
Language	English
Publishing date	2020-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2274243-8
ISSN	1878-7533 ; 1550-7289
ISSN (online)	1878-7533
ISSN	1550-7289
DOI	10.1016/j.soard.2020.01.035
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