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Article ; Online: Acute to long-term characteristics of impedance recordings during neurostimulation in humans.

Cui, Jie / Mivalt, Filip / Sladky, Vladimir / Kim, Jiwon / Richner, Thomas J / Lundstrom, Brian N / Van Gompel, Jamie J / Wang, Hai-Long / Miller, Kai J / Gregg, Nicholas / Wu, Long Jun / Denison, Timothy / Winter, Bailey / Brinkmann, Benjamin H / Kremen, Vaclav / Worrell, Gregory A

Journal of neural engineering

2024 Volume 21, Issue 2

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Humans ; Electric Impedance ; Brain/physiology ; Electrodes, Implanted ; Deep Brain Stimulation/methods ; Foreign Bodies
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ad3416
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Article: Acute to long-term characteristics of impedance recordings during neurostimulation in humans.

medRxiv : the preprint server for health sciences

2024

Abstract: ... month recording, with circadian variation in impedance dominating the long-term measures ...

Abstract	Objective: This study aims to characterize the time course of impedance, a crucial electrophysiological property of brain tissue, in the human thalamus (THL), amygdala-hippocampus (AMG-HPC), and posterior hippocampus (post-HPC) over an extended period. Approach: Impedance was periodically sampled every 5-15 minutes over several months in five subjects with drug-resistant epilepsy using an experimental neuromodulation device. Initially, we employed descriptive piecewise and continuous mathematical models to characterize the impedance response for approximately three weeks post-electrode implantation. We then explored the temporal dynamics of impedance during periods when electrical stimulation was temporarily halted, observing a monotonic increase (rebound) in impedance before it stabilized at a higher value. Lastly, we assessed the stability of amplitude and phase over the 24-hour impedance cycle throughout the multi-month recording. Main results: Immediately post-implantation, the impedance decreased, reaching a minimum value in all brain regions within approximately two days, and then increased monotonically over about 14 days to a stable value. The models accounted for the variance in short-term impedance changes. Notably, the minimum impedance of the THL in the most epileptogenic hemisphere was significantly lower than in other regions. During the gaps in electrical stimulation, the impedance rebound decreased over time and stabilized around 200 days post-implant, likely indicative of the foreign body response and fibrous tissue encapsulation around the electrodes. The amplitude and phase of the 24-hour impedance oscillation remained stable throughout the multi-month recording, with circadian variation in impedance dominating the long-term measures. Significance: Our findings illustrate the complex temporal dynamics of impedance in implanted electrodes and the impact of electrical stimulation. We discuss these dynamics in the context of the known biological foreign body response of the brain to implanted electrodes. The data suggest that the temporal dynamics of impedance are dependent on the anatomical location and tissue epileptogenicity. These insights may offer additional guidance for the delivery of therapeutic stimulation at various time points post-implantation for neuromodulation therapy.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.23.24301672
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Article ; Online: Identification of long noncoding RNA

Chen, Ting / Sun, Zhengxu / Cui, Yunqi / Ji, Jiamei / Li, Yating / Qu, Xiaoyan

Hematology (Amsterdam, Netherlands)

2023 Volume 28, Issue 1, Page(s) 2164449

Abstract: Objective: Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and play a key role ...

Abstract	Objective: Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and play a key role in cancer progression. To determine whether lncRNAs are involved in extramedullary disease of multiple myeloma (EMD), we analyzed the expression profile of lncRNAs in EMD. Methods: Three pairs of EMD patients and their intramedullary MM cells were screened by microarray first. We extracted data from gene chips and made an identification of lncRNAs and mRNAs with significant differences between EMD group and non EMD group. WGCNA confirmed the EMD related gene module and drew a heat map to further determine the key gene lncRNA-NEAT1. In the meantime, bone marrow and extramedullary samples (hydrothorax and ascites) were collected from 2 MM patients and subjected to single-cell RNA-seq. Single cell Transcriptome analysis was conducted to verify the gene expression difference of malignant plasma cells derived from intramedullary and extramedullary. Then we verified high expression level of lncRNA-NEAT1 in EMD patients by using quantitative real-time PCR (qRT-PCR) and analyzed the correlation between expression patterns and survival and molecular genetics analysis of the LncRNA (NEAT1) involved in MM patients. At last, cell experiments were conducted to observe the effects of down-regulation of NEAT1on the proliferation, cell cycle and PTEN pathway related proteins of multiple myeloma cell lines U266 and RPMI8226. Results: We identified one of the EMD related key gene is lncRNA-NEAT1. Compared with patients without extramedullary lesions, intramedullary MM cells in EMD patients expressed NEAT1 highly. The outcome of parallel single-cell RNA sequencing (RNA-seq) revealed NEAT1 level of plasma cells came from pleural effusion /ascites increased significantly compared with myeloma-stricken bone marrow. By survival and molecular genetic analysis, NEAT1 gene expression was not associated with OS and PFS in MM patients. However, the expression of NEAT1 is related to adverse therapeutic reactions and the progression of MM. We found that the expressions of NEAT1 were negatively associated with albumin levels and were positively associated with gain of chromosome 1q, IGH-CCND1, IGH@-FGFR3/WHSC1,and IGH-MAF gene fusion, respectively. At the level of cell experiment, CCK-8, soft agar clone formation experiment and CFSE staining showed that down regulating NEAT1 could inhibit the proliferation of U266 and RPMI8226 cells; Cell cycle detection showed that down-regulation of NEAT1 would interfere with the cell cycle process, and RPMI 8226 cells were blocked in G1 phase. Western blot analysis showed that when the expression of NEAT1 was down regulated in U266 and RPMI 8226 cells, the expression of PTEN and p-PTEN (phosphorylated phosphatase and tensin homologue) was up-regulated, and the expression of PI3K, p-PI3K (human phosphorylated inositol 3 kinase), Akt, p-Akt (phosphorylated protein kinase B). Discuccion and conclusion: This study provides novel insights into the lncRNA-NEAT1 and reveals that NEAT1 maybe a potential lncRNA biomarkers in EMD.
MeSH term(s)	Humans ; Ascites/genetics ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; Multiple Myeloma/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	MicroRNAs ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; RNA, Long Noncoding ; NEAT1 long non-coding RNA, human
Language	English
Publishing date	2023-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1341428-8
ISSN	1607-8454 ; 1024-5332 ; 1024-5340
ISSN (online)	1607-8454
ISSN	1024-5332 ; 1024-5340
DOI	10.1080/16078454.2022.2164449
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Article ; Online: Osteitis in long bones of SAPHO syndrome mimicking osteosarcoma.

Cui, Ran / Dai, Sheng-Ming

Rheumatology (Oxford, England)

2024

Language	English
Publishing date	2024-04-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keae241
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Article ; Online: High-Energy and Long-Lived Zn-MnO

Cui, Yang-Feng / Zhuang, Zhen-Bang / Xie, Zi-Long / Cao, Ren-Fei / Hao, Qi / Zhang, Ning / Liu, Wan-Qiang / Zhu, Yun-Hai / Huang, Gang

ACS nano

2022

Abstract: Alkaline Zn- ... ...

Abstract	Alkaline Zn-MnO
Language	English
Publishing date	2022-12-12
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.2c07792
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Article ; Online: Long-term oncological outcomes of robotic versus laparoscopic gastrectomy for gastric cancer: multicentre cohort study.

The British journal of surgery

2024 Volume 111, Issue 1

Abstract: Background: The aim of this multicentre cohort study was to compare the long-term oncological ...

Abstract	Background: The aim of this multicentre cohort study was to compare the long-term oncological outcomes of robotic gastrectomy (RG) and laparoscopic gastrectomy (LG) for patients with gastric cancer. Methods: Patients with gastric cancer who underwent radical gastrectomy by robotic or laparoscopic approaches from 1 March 2010 to 31 December 2018 at 10 high-volume centres in China were selected from institutional databases. Patients receiving RG were matched 1 : 1 by propensity score with patients undergoing LG. The primary outcome was 3-year disease-free survival. Secondary outcomes were overall survival and disease recurrence. Results: Some 2055 patients who underwent RG and 4309 patients who had LG were included. The propensity score-matched cohort comprised 2026 RGs and 2026 LGs. Median follow-up was 41 (i.q.r. 39-58) months for the RG group and 39 (38-56) months for the LG group. The 3-year disease-free survival rates were 80.8% in the RG group and 79.5% in the LG group (log rank P = 0.240; HR 0.92, 95% c.i. 0.80 to 1.06; P = 0.242). Three-year OS rates were 83.9 and 81.8% respectively (log rank P = 0.068; HR 0.87, 0.75 to 1.01; P = 0.068) and the cumulative incidence of recurrence over 3 years was 19.3% versus 20.8% (HR 0.95, 0.88 to 1.03; P = 0.219), with no difference between groups. Conclusion: RG and LG in patients with gastric cancer are associated with comparable disease-free and overall survival.
MeSH term(s)	Humans ; Robotic Surgical Procedures ; Treatment Outcome ; Cohort Studies ; Stomach Neoplasms/surgery ; Gastrectomy ; Laparoscopy ; Propensity Score ; Retrospective Studies ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Levamisole/analogs & derivatives
Chemical Substances	3-aminolevamisole (43081-63-6) ; Levamisole (2880D3468G)
Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znad435
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Article ; Online: Biochar amendment reassembles microbial community in a long-term phosphorus fertilization paddy soil.

Zhou, Tongtong / Tang, Sijia / Cui, Jie / Zhang, Yukai / Li, Xin / Qiao, Qicheng / Long, Xi-En

Applied microbiology and biotechnology

2023 Volume 107, Issue 19, Page(s) 6013–6028

Abstract: ... on sustainable agricultural practices. A 90-day incubation period revealed that biochar amendment, as opposed to long-term ... The microcosm experiment conducted using six treatments analyzed soil samples from a long-term rice ecosystem ...

Abstract	This study investigates the effect of biochar amendment on microbial community structure and soil nutrient status in paddy soil that has been fertilized for an extended period of time, shedding light on sustainable agricultural practices. A 90-day incubation period revealed that biochar amendment, as opposed to long-term fertilization, significantly influenced the physicochemical properties and microbial composition of the soil. The microcosm experiment conducted using six treatments analyzed soil samples from a long-term rice ecosystem. We employed microbial biomarkers (phospholipid fatty acids, PLFAs; isoprenoid and branched glycerol dialkyl glycerol tetraethers, iGDGTs and brGDGTs; DNA) to assess microbial biomass and community structure. Biochar addition led to a decrease in PLFA biomass (15-32%) and archaeal iGDGT abundance (14-43%), while enhancing bacterial brGDGT abundance by 15-77%. Intact biochar increased archaeal and bacterial diversity, though fungal diversity remained unchanged. However, acid-washed biochar did not result in a uniform microbial diversity response. The abundance of various microbial taxa was changed by biochar amendment, including Crenarchaeota, Proteobacteria, Nitrospira, Basidiomycota, Halobacterota, Chloroflexi, Planctomycetota, and Ascomycota. Soil NH
MeSH term(s)	Soil/chemistry ; Phosphorus ; Glycerol ; Charcoal ; Microbiota ; Bacteria/genetics ; Fatty Acids ; Archaea ; Phospholipids ; Oryza ; Soil Microbiology
Chemical Substances	Soil ; biochar ; Phosphorus (27YLU75U4W) ; Glycerol (PDC6A3C0OX) ; Charcoal (16291-96-6) ; Fatty Acids ; Phospholipids
Language	English
Publishing date	2023-08-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-023-12701-2
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Article: Long non-coding RNA

Feng, Xu-Dong / Zhou, Jia-Hang / Chen, Jun-Yao / Feng, Bing / Hu, Rui-Tian / Wu, Jian / Pan, Qiao-Ling / Yang, Jin-Feng / Yu, Jiong / Cao, Hong-Cui

World journal of stem cells

2022 Volume 14, Issue 9, Page(s) 714–728

Abstract: ... biology. Although long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) are reported to play ...

Abstract	Background: The effect of hypoxia on mesenchymal stem cells (MSCs) is an emerging topic in MSC biology. Although long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) are reported to play a critical role in regulating the biological characteristics of MSCs, their specific expression and co-expression profiles in human placenta-derived MSCs (hP-MSCs) under hypoxia and the underlying mech anisms of lncRNAs in hP-MSC biology are unknown. Aim: To reveal the specific expression profiles of lncRNAs in hP-MSCs under hypoxia and initially explored the possible mechanism of lncRNAs on hP-MSC biology. Methods: Here, we used a multigas incubator (92.5% N Results: We identified 289 differentially expressed lncRNAs and 240 differentially expressed mRNAs between the hypoxia and normoxia groups. Among them, the lncRNA Conclusion: Our results revealed the specific expression characteristics of lncRNAs and mRNAs in hypoxia-cultured hP-MSCs and that lncRNA
Language	English
Publishing date	2022-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2583482-4
ISSN	1948-0210
ISSN	1948-0210
DOI	10.4252/wjsc.v14.i9.714
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Article ; Online: Plant secondary metabolites involved in the stress tolerance of long-lived trees.

Cui, Jiawen / Li, Xiang / Lu, Zhaogeng / Jin, Biao

Tree physiology

2024 Volume 44, Issue 2

Abstract: ... These long-lived trees have sophisticated defense mechanisms, such as the production of specialized ... plant metabolites (SPMs). In this review, we provide an overview of the major biotic and abiotic stresses that long ... a comparative genomic analysis of 17 long-lived tree species and discovered significant expansions of SPM ...

Abstract	Ancient trees are natural wonders because of their longevity, having lived for hundreds or thousands of years, and their ability to withstand changing environments and a variety of stresses. These long-lived trees have sophisticated defense mechanisms, such as the production of specialized plant metabolites (SPMs). In this review, we provide an overview of the major biotic and abiotic stresses that long-lived trees often face, as well as an analysis of renowned ancient tree species and their unique protective SPMs against environmental stressors. We also discuss the synthesis and accumulation of defensive SPMs induced by environmental factors and endophytes in these trees. Furthermore, we conducted a comparative genomic analysis of 17 long-lived tree species and discovered significant expansions of SPM biosynthesis gene families in these species. Our comprehensive review reveals the crucial role of SPMs in high resistance in long-lived trees, providing a novel natural resource for plant defense, crop improvement and even the pharmaceutical industry.
MeSH term(s)	Trees/metabolism ; Plants ; Longevity
Language	English
Publishing date	2024-01-09
Publishing country	Canada
Document type	Review ; Journal Article
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpae002
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Article ; Online: Impact of pre-ablation left appendage flow velocities on long term recurrence of catheter ablation for paroxysmal atrial fibrillation.

Cui, Jing / Du, Xin / He, Liu / Xia, Shi-Jun / Tang, Ri-Bo / Sang, Cai-Hua / Long, De-Yong / Dong, Jian-Zeng / Ma, Chang-Sheng

Pacing and clinical electrophysiology : PACE

2023 Volume 46, Issue 11, Page(s) 1412–1418

Abstract: Background: Despite undergoing a single ablation, many patients with paroxysmal atrial fibrillation (PAF) experience a gradually increasing recurrence rate. This study aims to examine the relationship between left atrial appendage emptying velocity ( ... ...

Abstract	Background: Despite undergoing a single ablation, many patients with paroxysmal atrial fibrillation (PAF) experience a gradually increasing recurrence rate. This study aims to examine the relationship between left atrial appendage emptying velocity (LAAeV) and filling velocity (LAAfV) profiles and 3-year recurrence of AF after ablation. Methods: We conducted a prospective study of 658 consecutive PAF patients who underwent their first ablation between January 2018 and December 2019. We collected the clinical and echocardiographic characteristics of the patients. LAAeV and LAAfV were obtained from a transesophageal echocardiogram (TEE) before catheter ablation. Patients were followed at regular intervals to monitor for the primary outcome of AF recurrence. Results: After a median follow-up period of 35.3 months (range, 10.7-36.3), 288 patients (43.8%) experienced AF recurrence after catheter ablation. Patients who experienced AF recurrence had decreased LAAeV and LAAfV (LAAeV: 56.5 ± 21.2 vs. 59.6 ± 20.7 cm/s, p = .052; LAAfV: 47.5 ± 17.9 vs. 51.7 ± 18.2, p = .003). Kaplan-Meier analysis showed that patients in the low LAAeV (<55 cm/s) group had a poorer event-free survival rate than those in the high LAAeV (≥55 cm/s) group (log-rank p = .012). Patients with LAAfV <48 cm/s had a significantly higher risk of AF recurrence than those with LAAfV ≥48 cm/s (log-rank p = .003). In the multivariable model, low LAAfV pre-ablation in TEE-guided was significantly independently associated with 3-year recurrence after single radiofrequency ablation in patients with PAF, along with LA dimension and duration of AF. Conclusion: This study found an independent association between low LAAfV pre-ablation in TEE-guided and 3-year recurrence after single radiofrequency ablation in patients with PAF.
MeSH term(s)	Humans ; Atrial Fibrillation/surgery ; Prospective Studies ; Atrial Appendage/diagnostic imaging ; Atrial Appendage/surgery ; Echocardiography/methods ; Catheter Ablation/methods ; Recurrence ; Treatment Outcome
Language	English
Publishing date	2023-09-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14828
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