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  1. Article ; Online: Interstitial lung abnormalities: Real-world evidence.

    Rôlo Silvestre, Carina / Custódio, Catarina / Clemente, Susana / Rodrigues, Silvia / Furtado, Sofia Tello / Maio, Rui

    Health science reports

    2023  Volume 6, Issue 4, Page(s) e1216

    Language English
    Publishing date 2023-04-21
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.1216
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  2. Article: Risk Biomarkers for Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer Using Clinical and MRI-Derived Semantic Features.

    Guerra, Adalgisa / Alves, Filipe Caseiro / Maes, Kris / Maio, Rui / Villeirs, Geert / Mouriño, Helena

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Objectives: This study aimed to assess the impact of the covariates derived from a predictive model for detecting extracapsular extension on pathology (pECE+) on biochemical recurrence-free survival (BCRFS) within 4 years after robotic-assisted radical ... ...

    Abstract Objectives: This study aimed to assess the impact of the covariates derived from a predictive model for detecting extracapsular extension on pathology (pECE+) on biochemical recurrence-free survival (BCRFS) within 4 years after robotic-assisted radical prostatectomy (RARP).
    Methods: Retrospective data analysis was conducted from a single center between 2015 and 2022. Variables under consideration included prostate-specific antigen (PSA) levels, patient age, prostate volume, MRI semantic features, and Grade Group (GG). We also assessed the influence of pECE+ and positive surgical margins on BCRFS. To attain these goals, we used the Kaplan-Meier survival function and the multivariable Cox regression model. Additionally, we analyzed the MRI features on BCR (biochemical recurrence) in low/intermediate risk patients.
    Results: A total of 177 participants with a follow-up exceeding 6 months post-RARP were included. The 1-year, 2-year, and 4-year risks of BCR after radical prostatectomy were 5%, 13%, and 21%, respectively. The non-parametric approach for the survival analysis showed that adverse MRI features such as macroscopic ECE on MRI (mECE+), capsular disruption, high tumor capsular contact length (TCCL), GG ≥ 4, positive surgical margins (PSM), and pECE+ on pathology were risk factors for BCR. In low/intermediate-risk patients (pECE- and GG < 4), the presence of adverse MRI features has been shown to increase the risk of BCR.
    Conclusions: The study highlights the importance of incorporating predictive MRI features for detecting extracapsular extension pre-surgery in influencing early outcomes and clinical decision making; mECE+, TCCL, capsular disruption, and GG ≥ 4 based on pre-surgical biopsy were independent prognostic factors for early BCR. The presence of adverse features on MRI can assist in identifying low/intermediate-risk patients who will benefit from closer monitoring.
    Language English
    Publishing date 2023-11-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215296
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  3. Article ; Online: Predictive Value for Increased Red Blood Cell Distribution Width in Unprovoked Acute Venous Thromboembolism at the Emergency Department.

    Febra, Cláudia / Spinu, Verónica / Ferreira, Filipa / Gil, Victor / Maio, Rui / Penque, Deborah / Macedo, Ana

    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

    2023  Volume 29, Page(s) 10760296231193397

    Abstract: Acute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic ... ...

    Abstract Acute venous thromboembolism (VTE) is a common worldwide disease admitted to emergency departments (ED), usually presenting as pulmonary embolism or lower limb deep vein thrombosis (DVT). Due to the lack of typical clinical and biomarker diagnostic features of unprovoked VTE, early identification is challenging and has direct consequences on correct treatment delay. Longitudinal, prospective, observational study. Patients admitted to ED with a suspicion of unprovoked acute VTE between October 2020 and January 2021 were included. Clinical and laboratorial variables were compared between VTE positive and negative diagnoses. Red cell distribution width (RDW) cut point was determinate through a receiver operating characteristic analysis. RDW accuracy, sensitivity, and specificity were calculated. Fifty-eight patients were analyzed. And 82.8% of suspected patients with VTE were diagnosed with an acute thrombotic event confirmed by imaging examination. In patients with VTE, RDW at admission in ED was higher than with other diagnosis, respectively, 14.3% (13.2-15.1) and 13.5% (13.0-13.8). Platelet count was the only additional characteristic that revealed difference between the 2 groups (264×10
    MeSH term(s) Adult ; Humans ; Venous Thromboembolism/diagnosis ; Prospective Studies ; Risk Factors ; Venous Thrombosis ; Emergency Service, Hospital ; Erythrocytes
    Language English
    Publishing date 2023-09-04
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 1237357-6
    ISSN 1938-2723 ; 1076-0296
    ISSN (online) 1938-2723
    ISSN 1076-0296
    DOI 10.1177/10760296231193397
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4370: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Correction: Early biomarkers of extracapsular extension of prostate cancer using MRI-derived semantic features.

    Guerra, Adalgisa / Alves, Filipe Caseiro / Maes, Kris / Joniau, Steven / Cassis, João / Maio, Rui / Cravo, Marília / Mouriño, Helena

    Cancer imaging : the official publication of the International Cancer Imaging Society

    2023  Volume 23, Issue 1, Page(s) 32

    Language English
    Publishing date 2023-04-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2104862-9
    ISSN 1470-7330 ; 1470-7330
    ISSN (online) 1470-7330
    ISSN 1470-7330
    DOI 10.1186/s40644-023-00550-1
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  5. Article ; Online: Correction

    Adalgisa Guerra / Filipe Caseiro Alves / Kris Maes / Steven Joniau / João Cassis / Rui Maio / Marília Cravo / Helena Mouriño

    Cancer Imaging, Vol 23, Iss 1, Pp 1-

    Early biomarkers of extracapsular extension of prostate cancer using MRI-derived semantic features

    2023  Volume 2

    Keywords Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Loop ileostomy in rectal cancer surgery: factors predicting reversal and stoma related morbidity.

    Ourô, Susana / Ferreira, Marisa P / Albergaria, Diogo / Maio, Rui

    Langenbeck's archives of surgery

    2021  Volume 406, Issue 3, Page(s) 843–853

    Abstract: Purpose: Loop ileostomy is performed in rectal cancer surgery to decrease the impact of anastomotic leak but it is associated with a significant complication rate. This study aimed to analyze the morbidity related to diverting ileostomy and to identify ... ...

    Abstract Purpose: Loop ileostomy is performed in rectal cancer surgery to decrease the impact of anastomotic leak but it is associated with a significant complication rate. This study aimed to analyze the morbidity related to diverting ileostomy and to identify factors predictive of complications related to stoma management and reversal, as well as conversion into a permanent ileostomy.
    Methods: A retrospective study was conducted on 112 patients submitted to oncological rectal resection and defunctioning ileostomy in a Portuguese colorectal unit between March 2012 and March 2019.
    Results: Loop ileostomy was responsible for 13% of index surgery morbidity and 15% of patients' readmissions due to high output, stoma stenosis and parastomal hernia. Ileostomy was reversed in 89% cases with 7% Clavien-Dindo ≥ IIIb complications. An association was established between diabetes and higher stoma management morbidity (OR: 3.28 [95% CI: 1.039-10.426]. p = 0.041). Likewise, diabetes (OR: 0.17 [95% CI: 0.038; 6.90], p=0.015), oncological disease stage ≥ III (OR: 0.10 [95% CI: 0.005; 0.656], p=0.047) and index rectal surgery morbidity (OR: 0.23 [95% CI: 0.052; 0.955], p=0.041) were associated with less ileostomy closure. Complications of the index surgery also related to higher stoma reversal morbidity (OR: 5.11 [95% CI: 1.665; 16.346], p=0.005).
    Conclusions: Diabetes and complications of index rectal surgery were identified as predictive of ileostomy morbidity, closure rate and associated complications. It is essential to adjust treatment decisions to patient's morbidity risk and adopt a more selective approach concerning the use of an ileostomy.
    MeSH term(s) Anastomosis, Surgical ; Humans ; Ileostomy/adverse effects ; Morbidity ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Rectal Neoplasms/surgery ; Retrospective Studies
    Language English
    Publishing date 2021-04-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-021-02169-x
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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.10: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Acute venous thromboembolism plasma and red blood cell metabolomic profiling reveals potential new early diagnostic biomarkers: observational clinical study.

    Febra, Cláudia / Saraiva, Joana / Vaz, Fátima / Macedo, João / Al-Hroub, Hamza Mohammad / Semreen, Mohammad Harb / Maio, Rui / Gil, Vitor / Soares, Nelson / Penque, Deborah

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 200

    Abstract: Background: Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has contributed to the development of ... ...

    Abstract Background: Venous thromboembolism (VTE) is a leading cause of cardiovascular mortality. The diagnosis of acute VTE is based on complex imaging exams due to the lack of biomarkers. Recent multi-omics based research has contributed to the development of novel biomarkers in cardiovascular diseases. Our aim was to determine whether patients with acute VTE have differences in the metabolomic profile compared to non-acute VTE.
    Methods: This observational trial included 62 patients with clinical suspicion of acute deep vein thrombosis or pulmonary embolism, admitted to the emergency room. There were 50 patients diagnosed with acute VTE and 12 with non-acute VTE conditions and no significant differences were found between the two groups for clinical and demographic characteristics. Metabolomics assays identified and quantified a final number of 91 metabolites in plasma and 55 metabolites in red blood cells (RBCs). Plasma from acute VTE patients expressed tendency to a specific metabolomic signature, with univariate analyses revealing 23 significantly different molecules between acute VTE patients and controls (p < 0.05). The most relevant metabolic pathway with the strongest impact on the acute VTE phenotype was D-glutamine and D-glutamate (p = 0.001, false discovery rate = 0.06). RBCs revealed a specific metabolomic signature in patients with a confirmed diagnosis of DVT or PE that distinguished them from other acutely diseased patients, represented by 20 significantly higher metabolites and four lower metabolites. Three of those metabolites revealed high performant ROC curves, including adenosine 3',5'-diphosphate (AUC 0.983), glutathione (AUC 0.923), and adenine (AUC 0.91). Overall, the metabolic pathway most impacting to the differences observed in the RBCs was the purine metabolism (p = 0.000354, false discovery rate = 0.68).
    Conclusions: Our findings show that metabolite differences exist between acute VTE and nonacute VTE patients admitted to the ER in the early phases. Three potential biomarkers obtained from RBCs showed high performance for acute VTE diagnosis. Further studies should investigate accessible laboratory methods for the future daily practice usefulness of these metabolites for the early diagnosis of acute VTE in the ER.
    MeSH term(s) Humans ; Biomarkers ; Erythrocytes ; Pulmonary Embolism ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/etiology ; Venous Thrombosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Observational Study
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-04883-8
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  8. Article: Adenomyomatosis of the Common Bile Duct and Ampulla of Vater.

    Gouveia, Catarina / Fidalgo, Catarina / Loureiro, Rui / Oliveira, Helena / Maio, Rui / Cravo, Marília

    GE Portuguese journal of gastroenterology

    2020  Volume 28, Issue 2, Page(s) 121–133

    Abstract: Adenomyomatosis is a rare benign lesion that has been observed in different sites throughout the gastrointestinal tract, most frequently in the gallbladder. Few cases have been described in the stomach, small bowel, bile ducts, and ampullary region. ... ...

    Abstract Adenomyomatosis is a rare benign lesion that has been observed in different sites throughout the gastrointestinal tract, most frequently in the gallbladder. Few cases have been described in the stomach, small bowel, bile ducts, and ampullary region. Adenomyomas of the vaterian system (ampulla and common bile duct) have important clinical consequences, since the majority of these lesions present with biliary tract obstruction and mimic malignant behavior. As a consequence, considering the diagnostic difficulty of these lesions, patients are often treated with extensive surgery (pancreaticoduodenectomy). We report 2 cases of adenomyomatosis: one of the ampulla of Vater and the other of the common bile duct, as well as a review of reported cases in the literature. Both of our patients presented with epigastralgia and had laboratory or endoscopic evidence of biliary obstruction. Both patients underwent endoscopic ultrasound, one of them with fine-needle aspiration; however, it was not possible to exclude the possibility of cancer. The diagnosis of adenomyoma was only confirmed by the surgical specimen after pancreaticoduodenectomy.
    Language English
    Publishing date 2020-09-02
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2835774-7
    ISSN 2387-1954 ; 2341-4545
    ISSN (online) 2387-1954
    ISSN 2341-4545
    DOI 10.1159/000507788
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  9. Article: Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma.

    Ourô, Susana / Mourato, Cláudia / Velho, Sónia / Cardador, André / Ferreira, Marisa P / Albergaria, Diogo / Castro, Rui E / Maio, Rui / Rodrigues, Cecília M P

    Frontiers in oncology

    2020  Volume 10, Page(s) 577653

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-10-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2020.577653
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  10. Article ; Online: Walled-off pancreatic necrosis: a staged multidisciplinary step-up approach.

    Sousa, Débora / Freitas Ferreira, Ana Carolina / Raimundo, Pedro / Maio, Rui

    BMJ case reports

    2020  Volume 13, Issue 3

    Abstract: Walled-off pancreatic necrosis (WOPN) is a rare complication of pancreatitis. We present the case of a woman in her eighties admitted for diffuse abdominal pain. She had a palpable abdominal mass and the CT scan showed necrosis throughout the tail of the ...

    Abstract Walled-off pancreatic necrosis (WOPN) is a rare complication of pancreatitis. We present the case of a woman in her eighties admitted for diffuse abdominal pain. She had a palpable abdominal mass and the CT scan showed necrosis throughout the tail of the pancreas, a peripancreatic and retrogastric hydroaerial collection (19 cm of diameter) and a calculus in the main biliary duct, thus establishing a diagnosis of emphysematous necrotising obstructive pancreatitis. A step-up approach was decided, first with removal of the biliary calculus, followed by a waiting period of 4 weeks in which the patient was under intravenous antibiotics. At re-evaluation, the CT scan showed a smaller and more organised collection, bounded by a wall, defining WOPN. At this stage, transgastric drainage via echoendoscopy was attempted, without success, followed by percutaneous CT-guided drainage, also with little effect. Surgical necrosectomy was then executed, as a final step, with a successful outcome.
    MeSH term(s) Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Combined Modality Therapy ; Diagnosis, Differential ; Female ; Humans ; Pancreatitis, Acute Necrotizing/drug therapy ; Pancreatitis, Acute Necrotizing/surgery ; Piperacillin, Tazobactam Drug Combination/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Piperacillin, Tazobactam Drug Combination (157044-21-8)
    Language English
    Publishing date 2020-03-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2019-232952
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