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  1. Article ; Online: A rare case of ectopic retrosternal goiter

    Shen Leong Oh / Clement L. K. Chia / Oon Cheong Ooi / Vikram Sonawane / Anil D. Rao / Reyaz Singaporewalla

    Clinical Case Reports, Vol 9, Iss 4, Pp 1849-

    2021  Volume 1852

    Abstract: Abstract It is important for the clinician to be familiar with interpreting a variety of radiological modalities that provide vital information that will aid in the preoperative planning, counseling, and subsequent management of patients with ... ...

    Abstract Abstract It is important for the clinician to be familiar with interpreting a variety of radiological modalities that provide vital information that will aid in the preoperative planning, counseling, and subsequent management of patients with retrosternal goiter.
    Keywords ectopic ; intrathoracic ; retrosternal goiter ; thyroid ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: A rare case of ectopic retrosternal goiter.

    Oh, Shen Leong / Chia, Clement L K / Ooi, Oon Cheong / Sonawane, Vikram / Rao, Anil D / Singaporewalla, Reyaz

    Clinical case reports

    2020  Volume 9, Issue 4, Page(s) 1849–1852

    Abstract: It is important for the clinician to be familiar with interpreting a variety of radiological modalities that provide vital information that will aid in the preoperative planning, counseling, and subsequent management of patients with retrosternal goiter. ...

    Abstract It is important for the clinician to be familiar with interpreting a variety of radiological modalities that provide vital information that will aid in the preoperative planning, counseling, and subsequent management of patients with retrosternal goiter.
    Language English
    Publishing date 2020-12-14
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.3610
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  3. Article: Laparoscopic surgery in a patient with atypical presentation of COVID-19: salient points to reduce the perils of surgery.

    Oh, Shen Leong / Chia, Clement Luck Khng / Chen, Yanlin Rachel / Goo, Tiong Thye Jerry / Rao, Anil Dinkar / Tan, Kok Yang / Ong, Marc Weijie

    Singapore medical journal

    2020  Volume 61, Issue 8, Page(s) 443–444

    MeSH term(s) Aged ; COVID-19 ; COVID-19 Testing ; Cholecystectomy, Laparoscopic/methods ; Cholelithiasis/complications ; Cholelithiasis/diagnosis ; Cholelithiasis/surgery ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Elective Surgical Procedures/methods ; Follow-Up Studies ; Humans ; Infection Control/methods ; Male ; Pandemics ; Patient Safety ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Postoperative Care/methods ; Risk Assessment ; Singapore ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country Singapore
    Document type Case Reports ; Letter ; Review
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2020086
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  4. Article: Laparoscopic surgery in a patient with atypical presentation of COVID-19: salient points to reduce the perils of surgery

    Oh, Shen Leong / Chia, Clement Luck Khng / Chen, Yanlin Rachel / Goo, Tiong Thye Jerry / Rao, Anil Dinkar / Tan, Kok Yang / Ong, Marc Weijie

    Singapore Med J

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #459057
    Database COVID19

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  5. Article ; Online: FDA Approval Summary: Selumetinib for Plexiform Neurofibroma.

    Casey, Denise / Demko, Suzanne / Sinha, Arup / Mishra-Kalyani, Pallavi S / Shen, Yuan-Li / Khasar, Sachia / Goheer, M Anwar / Helms, Whitney S / Pan, Lili / Xu, Yuan / Fan, Jianghong / Leong, Ruby / Liu, Jiang / Yang, Yuching / Windsor, Katherine / Ou, Mei / Stephens, Olen / Oh, Byeongtaek / Reaman, Gregory H /
    Nair, Abhilasha / Shord, Stacy S / Bhatnagar, Vishal / Daniels, Selena R / Sickafuse, Sharon / Goldberg, Kirsten B / Theoret, Marc R / Pazdur, Richard / Singh, Harpreet

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2021  Volume 27, Issue 15, Page(s) 4142–4146

    Abstract: On April 10, 2020, the FDA approved selumetinib (KOSELUGO, AstraZeneca) for the treatment of pediatric patients 2 years of age and older with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. Approval was based on ... ...

    Abstract On April 10, 2020, the FDA approved selumetinib (KOSELUGO, AstraZeneca) for the treatment of pediatric patients 2 years of age and older with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. Approval was based on demonstration of a durable overall response rate per Response Evaluation in Neurofibromatosis and Schwannomatosis criteria and supported by observed clinical improvements in plexiform neurofibroma-related symptoms and functional impairments in 50 pediatric patients with inoperable plexiform neurofibromas in a single-arm, multicenter trial. The overall reponse rate per NCI investigator assessment was 66% (95% confidence interval, 51-79) with at least 12 months of follow-up. The median duration of response was not reached, and 82% of responding patients experienced duration of response ≥12 months. Clinical outcome assessment endpoints provided supportive efficacy data. Risks of selumetinib are consistent with MAPK (MEK) inhibitor class effects, including ocular, cardiac, musculoskeletal, gastrointestinal, and dermatologic toxicities. Safety was assessed across a pooled database of 74 pediatric patients with plexiform neurofibromas and supported by adult and pediatric selumetinib clinical trial data in cancer indications. The benefit-risk assessment for selumetinib in patients with inoperable plexiform neurofibromas was considered favorable.
    MeSH term(s) Adolescent ; Benzimidazoles/therapeutic use ; Child ; Child, Preschool ; Drug Approval ; Female ; Humans ; Male ; Neurofibroma, Plexiform/drug therapy ; United States
    Chemical Substances AZD 6244 ; Benzimidazoles
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-20-5032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Paradoxical motion in L5-S1 adult spondylolytic spondylolisthesis.

    Oh, Jacob Yoong-Leong / Liang, Shen / Louange, Danny / Rahmat, Razmi / Hee, Hwan-Tak / Kumar, V P

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2011  Volume 21, Issue 2, Page(s) 262–267

    Abstract: Introduction: In patients with spondylolisthesis, it is assumed that flexion accentuates anterior displacement, whereas extension causes some reduction. Paradoxical movement-where flexion causes reduction of spondylolisthesis and extension increases the ...

    Abstract Introduction: In patients with spondylolisthesis, it is assumed that flexion accentuates anterior displacement, whereas extension causes some reduction. Paradoxical movement-where flexion causes reduction of spondylolisthesis and extension increases the anterior translation, is rarely described. In this study, we investigate the prevalence of paradoxical motion in patients with L5-S1 spondylolytic spondylolisthesis and why this abnormal motion occurs.
    Materials and methods: Flexion and extension radiographs of 41 patients with grade I and II spondylolytic spondylolisthesis of the L5-S1 segment were analysed. Patients who had previous lumbar spine surgery, recent lumbar spine trauma, those more than 50 years of age and those with poor quality radiographs were excluded.
    Results: There were 24 male and 17 female patients. The average age was 32.7 years. Of the 41 patients, 29 (70.7%) showed no significant instability. Six (15%) patients showed anterolisthesis, where flexion accentuated the forward displacement, while further six (15%) patients showed paradoxical motion. Statistical analyses found that patients with paradoxical motion had a significantly higher slip angle.
    Conclusion: In this study, we have demonstrated that: (1) paradoxical motion in spondylolytic spondylolisthesis is more common than previously thought. (2) Patients without anterolisthesis during flexion in dynamic radiographs may still have (paradoxical) instability. (3) Paradoxical motion may be more common in patients with a low sacral slope and increased lumbosacral lordosis.
    MeSH term(s) Adult ; Female ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/physiopathology ; Male ; Radiography ; Retrospective Studies ; Sacrum/diagnostic imaging ; Sacrum/physiopathology ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/physiopathology ; Statistics, Nonparametric
    Language English
    Publishing date 2011-06-15
    Publishing country Germany
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-011-1880-9
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  7. Article ; Online: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.

    Suzuki, Ken / Hatzikotoulas, Konstantinos / Southam, Lorraine / Taylor, Henry J / Yin, Xianyong / Lorenz, Kim M / Mandla, Ravi / Huerta-Chagoya, Alicia / Melloni, Giorgio E M / Kanoni, Stavroula / Rayner, Nigel W / Bocher, Ozvan / Arruda, Ana Luiza / Sonehara, Kyuto / Namba, Shinichi / Lee, Simon S K / Preuss, Michael H / Petty, Lauren E / Schroeder, Philip /
    Vanderwerff, Brett / Kals, Mart / Bragg, Fiona / Lin, Kuang / Guo, Xiuqing / Zhang, Weihua / Yao, Jie / Kim, Young Jin / Graff, Mariaelisa / Takeuchi, Fumihiko / Nano, Jana / Lamri, Amel / Nakatochi, Masahiro / Moon, Sanghoon / Scott, Robert A / Cook, James P / Lee, Jung-Jin / Pan, Ian / Taliun, Daniel / Parra, Esteban J / Chai, Jin-Fang / Bielak, Lawrence F / Tabara, Yasuharu / Hai, Yang / Thorleifsson, Gudmar / Grarup, Niels / Sofer, Tamar / Wuttke, Matthias / Sarnowski, Chloé / Gieger, Christian / Nousome, Darryl / Trompet, Stella / Kwak, Soo-Heon / Long, Jirong / Sun, Meng / Tong, Lin / Chen, Wei-Min / Nongmaithem, Suraj S / Noordam, Raymond / Lim, Victor J Y / Tam, Claudia H T / Joo, Yoonjung Yoonie / Chen, Chien-Hsiun / Raffield, Laura M / Prins, Bram Peter / Nicolas, Aude / Yanek, Lisa R / Chen, Guanjie / Brody, Jennifer A / Kabagambe, Edmond / An, Ping / Xiang, Anny H / Choi, Hyeok Sun / Cade, Brian E / Tan, Jingyi / Broadaway, K Alaine / Williamson, Alice / Kamali, Zoha / Cui, Jinrui / Thangam, Manonanthini / Adair, Linda S / Adeyemo, Adebowale / Aguilar-Salinas, Carlos A / Ahluwalia, Tarunveer S / Anand, Sonia S / Bertoni, Alain / Bork-Jensen, Jette / Brandslund, Ivan / Buchanan, Thomas A / Burant, Charles F / Butterworth, Adam S / Canouil, Mickaël / Chan, Juliana C N / Chang, Li-Ching / Chee, Miao-Li / Chen, Ji / Chen, Shyh-Huei / Chen, Yuan-Tsong / Chen, Zhengming / Chuang, Lee-Ming / Cushman, Mary / Danesh, John / Das, Swapan K / de Silva, H Janaka / Dedoussis, George / Dimitrov, Latchezar / Doumatey, Ayo P / Du, Shufa / Duan, Qing / Eckardt, Kai-Uwe / Emery, Leslie S / Evans, Daniel S / Evans, Michele K / Fischer, Krista / Floyd, James S / Ford, Ian / Franco, Oscar H / Frayling, Timothy M / Freedman, Barry I / Genter, Pauline / Gerstein, Hertzel C / Giedraitis, Vilmantas / González-Villalpando, Clicerio / González-Villalpando, Maria Elena / Gordon-Larsen, Penny / Gross, Myron / Guare, Lindsay A / Hackinger, Sophie / Hakaste, Liisa / Han, Sohee / Hattersley, Andrew T / Herder, Christian / Horikoshi, Momoko / Howard, Annie-Green / Hsueh, Willa / Huang, Mengna / Huang, Wei / Hung, Yi-Jen / Hwang, Mi Yeong / Hwu, Chii-Min / Ichihara, Sahoko / Ikram, Mohammad Arfan / Ingelsson, Martin / Islam, Md Tariqul / Isono, Masato / Jang, Hye-Mi / Jasmine, Farzana / Jiang, Guozhi / Jonas, Jost B / Jørgensen, Torben / Kamanu, Frederick K / Kandeel, Fouad R / Kasturiratne, Anuradhani / Katsuya, Tomohiro / Kaur, Varinderpal / Kawaguchi, Takahisa / Keaton, Jacob M / Kho, Abel N / Khor, Chiea-Chuen / Kibriya, Muhammad G / Kim, Duk-Hwan / Kronenberg, Florian / Kuusisto, Johanna / Läll, Kristi / Lange, Leslie A / Lee, Kyung Min / Lee, Myung-Shik / Lee, Nanette R / Leong, Aaron / Li, Liming / Li, Yun / Li-Gao, Ruifang / Ligthart, Symen / Lindgren, Cecilia M / Linneberg, Allan / Liu, Ching-Ti / Liu, Jianjun / Locke, Adam E / Louie, Tin / Luan, Jian'an / Luk, Andrea O / Luo, Xi / Lv, Jun / Lynch, Julie A / Lyssenko, Valeriya / Maeda, Shiro / Mamakou, Vasiliki / Mansuri, Sohail Rafik / Matsuda, Koichi / Meitinger, Thomas / Melander, Olle / Metspalu, Andres / Mo, Huan / Morris, Andrew D / Moura, Filipe A / Nadler, Jerry L / Nalls, Michael A / Nayak, Uma / Ntalla, Ioanna / Okada, Yukinori / Orozco, Lorena / Patel, Sanjay R / Patil, Snehal / Pei, Pei / Pereira, Mark A / Peters, Annette / Pirie, Fraser J / Polikowsky, Hannah G / Porneala, Bianca / Prasad, Gauri / Rasmussen-Torvik, Laura J / Reiner, Alexander P / Roden, Michael / Rohde, Rebecca / Roll, Katheryn / Sabanayagam, Charumathi / Sandow, Kevin / Sankareswaran, Alagu / Sattar, Naveed / Schönherr, Sebastian / Shahriar, Mohammad / Shen, Botong / Shi, Jinxiu / Shin, Dong Mun / Shojima, Nobuhiro / Smith, Jennifer A / So, Wing Yee / Stančáková, Alena / Steinthorsdottir, Valgerdur / Stilp, Adrienne M / Strauch, Konstantin / Taylor, Kent D / Thorand, Barbara / Thorsteinsdottir, Unnur / Tomlinson, Brian / Tran, Tam C / Tsai, Fuu-Jen / Tuomilehto, Jaakko / Tusie-Luna, Teresa / Udler, Miriam S / Valladares-Salgado, Adan / van Dam, Rob M / van Klinken, Jan B / Varma, Rohit / Wacher-Rodarte, Niels / Wheeler, Eleanor / Wickremasinghe, Ananda R / van Dijk, Ko Willems / Witte, Daniel R / Yajnik, Chittaranjan S / Yamamoto, Ken / Yamamoto, Kenichi / Yoon, Kyungheon / Yu, Canqing / Yuan, Jian-Min / Yusuf, Salim / Zawistowski, Matthew / Zhang, Liang / Zheng, Wei / Raffel, Leslie J / Igase, Michiya / Ipp, Eli / Redline, Susan / Cho, Yoon Shin / Lind, Lars / Province, Michael A / Fornage, Myriam / Hanis, Craig L / Ingelsson, Erik / Zonderman, Alan B / Psaty, Bruce M / Wang, Ya-Xing / Rotimi, Charles N / Becker, Diane M / Matsuda, Fumihiko / Liu, Yongmei / Yokota, Mitsuhiro / Kardia, Sharon L R / Peyser, Patricia A / Pankow, James S / Engert, James C / Bonnefond, Amélie / Froguel, Philippe / Wilson, James G / Sheu, Wayne H H / Wu, Jer-Yuarn / Hayes, M Geoffrey / Ma, Ronald C W / Wong, Tien-Yin / Mook-Kanamori, Dennis O / Tuomi, Tiinamaija / Chandak, Giriraj R / Collins, Francis 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Chambers, John C / Ng, Maggie C Y / Sim, Xueling / Below, Jennifer E / Tsao, Philip S / Chang, Kyong-Mi / McCarthy, Mark I / Meigs, James B / Mahajan, Anubha / Spracklen, Cassandra N / Mercader, Josep M / Boehnke, Michael / Rotter, Jerome I / Vujkovic, Marijana / Voight, Benjamin F / Morris, Andrew P / Zeggini, Eleftheria

    Nature

    2024  Volume 627, Issue 8003, Page(s) 347–357

    Abstract: Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological ... ...

    Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes
    MeSH term(s) Humans ; Adipocytes/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Coronary Artery Disease/complications ; Coronary Artery Disease/genetics ; Diabetes Mellitus, Type 2/classification ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/pathology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/genetics ; Disease Progression ; Endothelial Cells/metabolism ; Enteroendocrine Cells ; Epigenomics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Islets of Langerhans/metabolism ; Multifactorial Inheritance/genetics ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/genetics ; Single-Cell Analysis
    Chemical Substances Chromatin
    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-024-07019-6
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  8. Article: Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.

    Suzuki, Ken / Hatzikotoulas, Konstantinos / Southam, Lorraine / Taylor, Henry J / Yin, Xianyong / Lorenz, Kim M / Mandla, Ravi / Huerta-Chagoya, Alicia / Rayner, Nigel W / Bocher, Ozvan / Arruda, Ana Luiza de S V / Sonehara, Kyuto / Namba, Shinichi / Lee, Simon S K / Preuss, Michael H / Petty, Lauren E / Schroeder, Philip / Vanderwerff, Brett / Kals, Mart /
    Bragg, Fiona / Lin, Kuang / Guo, Xiuqing / Zhang, Weihua / Yao, Jie / Kim, Young Jin / Graff, Mariaelisa / Takeuchi, Fumihiko / Nano, Jana / Lamri, Amel / Nakatochi, Masahiro / Moon, Sanghoon / Scott, Robert A / Cook, James P / Lee, Jung-Jin / Pan, Ian / Taliun, Daniel / Parra, Esteban J / Chai, Jin-Fang / Bielak, Lawrence F / Tabara, Yasuharu / Hai, Yang / Thorleifsson, Gudmar / Grarup, Niels / Sofer, Tamar / Wuttke, Matthias / Sarnowski, Chloé / Gieger, Christian / Nousome, Darryl / Trompet, Stella / Kwak, Soo-Heon / Long, Jirong / Sun, Meng / Tong, Lin / Chen, Wei-Min / Nongmaithem, Suraj S / Noordam, Raymond / Lim, Victor J Y / Tam, Claudia H T / Joo, Yoonjung Yoonie / Chen, Chien-Hsiun / Raffield, Laura M / Prins, Bram Peter / Nicolas, Aude / Yanek, Lisa R / Chen, Guanjie / Brody, Jennifer A / Kabagambe, Edmond / An, Ping / Xiang, Anny H / Choi, Hyeok Sun / Cade, Brian E / Tan, Jingyi / Broadaway, K Alaine / Williamson, Alice / Kamali, Zoha / Cui, Jinrui / Adair, Linda S / Adeyemo, Adebowale / Aguilar-Salinas, Carlos A / Ahluwalia, Tarunveer S / Anand, Sonia S / Bertoni, Alain / Bork-Jensen, Jette / Brandslund, Ivan / Buchanan, Thomas A / Burant, Charles F / Butterworth, Adam S / Canouil, Mickaël / Chan, Juliana C N / Chang, Li-Ching / Chee, Miao-Li / Chen, Ji / Chen, Shyh-Huei / Chen, Yuan-Tsong / Chen, Zhengming / Chuang, Lee-Ming / Cushman, Mary / Danesh, John / Das, Swapan K / de Silva, H Janaka / Dedoussis, George / Dimitrov, Latchezar / Doumatey, Ayo P / Du, Shufa / Duan, Qing / Eckardt, Kai-Uwe / Emery, Leslie S / Evans, Daniel S / Evans, Michele K / Fischer, Krista / Floyd, James S / Ford, Ian / Franco, Oscar H / Frayling, Timothy M / Freedman, Barry I / Genter, Pauline / Gerstein, Hertzel C / Giedraitis, Vilmantas / González-Villalpando, Clicerio / González-Villalpando, Maria Elena / Gordon-Larsen, Penny / Gross, Myron / Guare, Lindsay A / Hackinger, Sophie / Han, Sohee / Hattersley, Andrew T / Herder, Christian / Horikoshi, Momoko / Howard, Annie-Green / Hsueh, Willa / Huang, Mengna / Huang, Wei / Hung, Yi-Jen / Hwang, Mi Yeong / Hwu, Chii-Min / Ichihara, Sahoko / Ikram, Mohammad Arfan / Ingelsson, Martin / Islam, Md Tariqul / Isono, Masato / Jang, Hye-Mi / Jasmine, Farzana / Jiang, Guozhi / Jonas, Jost B / Jørgensen, Torben / Kandeel, Fouad R / Kasturiratne, Anuradhani / Katsuya, Tomohiro / Kaur, Varinderpal / Kawaguchi, Takahisa / Keaton, Jacob M / Kho, Abel N / Khor, Chiea-Chuen / Kibriya, Muhammad G / Kim, Duk-Hwan / Kronenberg, Florian / Kuusisto, Johanna / Läll, Kristi / Lange, Leslie A / Lee, Kyung Min / Lee, Myung-Shik / Lee, Nanette R / Leong, Aaron / Li, Liming / Li, Yun / Li-Gao, Ruifang / Lithgart, Symen / Lindgren, Cecilia M / Linneberg, Allan / Liu, Ching-Ti / Liu, Jianjun / Locke, Adam E / Louie, Tin / Luan, Jian'an / Luk, Andrea O / Luo, Xi / Lv, Jun / Lynch, Julie A / Lyssenko, Valeriya / Maeda, Shiro / Mamakou, Vasiliki / Mansuri, Sohail Rafik / Matsuda, Koichi / Meitinger, Thomas / Metspalu, Andres / Mo, Huan / Morris, Andrew D / Nadler, Jerry L / Nalls, Michael A / Nayak, Uma / Ntalla, Ioanna / Okada, Yukinori / Orozco, Lorena / Patel, Sanjay R / Patil, Snehal / Pei, Pei / Pereira, Mark A / Peters, Annette / Pirie, Fraser J / Polikowsky, Hannah G / Porneala, Bianca / Prasad, Gauri / Rasmussen-Torvik, Laura J / Reiner, Alexander P / Roden, Michael / Rohde, Rebecca / Roll, Katheryn / Sabanayagam, Charumathi / Sandow, Kevin / Sankareswaran, Alagu / Sattar, Naveed / Schönherr, Sebastian / Shahriar, Mohammad / Shen, Botong / Shi, Jinxiu / Shin, Dong Mun / Shojima, Nobuhiro / Smith, Jennifer A / So, Wing Yee / Stančáková, Alena / Steinthorsdottir, Valgerdur / Stilp, Adrienne M / Strauch, Konstantin / Taylor, Kent D / Thorand, Barbara / Thorsteinsdottir, Unnur / Tomlinson, Brian / Tran, Tam C / Tsai, Fuu-Jen / Tuomilehto, Jaakko / Tusie-Luna, Teresa / Udler, Miriam S / Valladares-Salgado, Adan / van Dam, Rob M / van Klinken, Jan B / Varma, Rohit / Wacher-Rodarte, Niels / Wheeler, Eleanor / Wickremasinghe, Ananda R / van Dijk, Ko Willems / Witte, Daniel R / Yajnik, Chittaranjan S / Yamamoto, Ken / Yamamoto, Kenichi / Yoon, Kyungheon / Yu, Canqing / Yuan, Jian-Min / Yusuf, Salim / Zawistowski, Matthew / Zhang, Liang / Zheng, Wei / Raffel, Leslie J / Igase, Michiya / Ipp, Eli / Redline, Susan / Cho, Yoon Shin / Lind, Lars / Province, Michael A / Fornage, Myriam / Hanis, Craig L / Ingelsson, Erik / Zonderman, Alan B / Psaty, Bruce M / Wang, Ya-Xing / Rotimi, Charles N / Becker, Diane M / Matsuda, Fumihiko / Liu, Yongmei / Yokota, Mitsuhiro / Kardia, Sharon L R / Peyser, Patricia A / Pankow, James S / Engert, James C / Bonnefond, Amélie / Froguel, Philippe / Wilson, James G / Sheu, Wayne H H / Wu, Jer-Yuarn / Hayes, M Geoffrey / Ma, Ronald C W / Wong, Tien-Yin / Mook-Kanamori, Dennis O / Tuomi, Tiinamaija / Chandak, Giriraj R / Collins, Francis S / Bharadwaj, Dwaipayan / Paré, Guillaume / Sale, Michèle M / Ahsan, Habibul / Motala, Ayesha A / Shu, Xiao-Ou / Park, Kyong-Soo / Jukema, J Wouter / Cruz, Miguel / Chen, Yii-Der Ida / Rich, Stephen S / McKean-Cowdin, Roberta / Grallert, Harald / Cheng, Ching-Yu / Ghanbari, Mohsen / Tai, E-Shyong / Dupuis, Josee / Kato, Norihiro / Laakso, Markku / Köttgen, Anna / Koh, Woon-Puay / Bowden, Donald W / Palmer, Colin N A / Kooner, Jaspal S / Kooperberg, Charles / Liu, Simin / North, Kari E / Saleheen, Danish / Hansen, Torben / Pedersen, Oluf / Wareham, Nicholas J / Lee, Juyoung / Kim, Bong-Jo / Millwood, Iona Y / Walters, Robin G / Stefansson, Kari / Goodarzi, Mark O / Mohlke, Karen L / Langenberg, Claudia / Haiman, Christopher A / Loos, Ruth J F / Florez, Jose C / Rader, Daniel J / Ritchie, Marylyn D / Zöllner, Sebastian / Mägi, Reedik / Denny, Joshua C / Yamauchi, Toshimasa / Kadowaki, Takashi / Chambers, John C / Ng, Maggie C Y / Sim, Xueling / Below, Jennifer E / Tsao, Philip S / Chang, Kyong-Mi / McCarthy, Mark I / Meigs, James B / Mahajan, Anubha / Spracklen, Cassandra N / Mercader, Josep M / Boehnke, Michael / Rotter, Jerome I / Vujkovic, Marijana / Voight, Benjamin F / Morris, Andrew P / Zeggini, Eleftheria

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2, ...

    Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological processes. To characterise the genetic contribution to these processes across ancestry groups, we aggregate genome-wide association study (GWAS) data from 2,535,601 individuals (39.7% non-European ancestry), including 428,452 T2D cases. We identify 1,289 independent association signals at genome-wide significance (
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.31.23287839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Klionsky, Daniel J / Abdel-Aziz, Amal Kamal / Abdelfatah, Sara / Abdellatif, Mahmoud / Abdoli, Asghar / Abel, Steffen / Abeliovich, Hagai / Abildgaard, Marie H / Abudu, Yakubu Princely / Acevedo-Arozena, Abraham / Adamopoulos, Iannis E / Adeli, Khosrow / Adolph, Timon E / Adornetto, Annagrazia / Aflaki, Elma / Agam, Galila / Agarwal, Anupam / Aggarwal, Bharat B / Agnello, Maria /
    Agostinis, Patrizia / Agrewala, Javed N / Agrotis, Alexander / Aguilar, Patricia V / Ahmad, S Tariq / Ahmed, Zubair M / Ahumada-Castro, Ulises / Aits, Sonja / Aizawa, Shu / Akkoc, Yunus / Akoumianaki, Tonia / Akpinar, Hafize Aysin / Al-Abd, Ahmed M / Al-Akra, Lina / Al-Gharaibeh, Abeer / Alaoui-Jamali, Moulay A / Alberti, Simon / Alcocer-Gómez, Elísabet / Alessandri, Cristiano / Ali, Muhammad / Alim Al-Bari, M Abdul / Aliwaini, Saeb / Alizadeh, Javad / Almacellas, Eugènia / Almasan, Alexandru / Alonso, Alicia / Alonso, Guillermo D / Altan-Bonnet, Nihal / Altieri, Dario C / Álvarez, Élida M C / Alves, Sara / Alves da Costa, Cristine / Alzaharna, Mazen M / Amadio, Marialaura / Amantini, Consuelo / Amaral, Cristina / Ambrosio, Susanna / Amer, Amal O / Ammanathan, Veena / An, Zhenyi / Andersen, Stig U / Andrabi, Shaida A / Andrade-Silva, Magaiver / Andres, Allen M / Angelini, Sabrina / Ann, David / Anozie, Uche C / Ansari, Mohammad Y / Antas, Pedro / Antebi, Adam / Antón, Zuriñe / Anwar, Tahira / Apetoh, Lionel / Apostolova, Nadezda / Araki, Toshiyuki / Araki, Yasuhiro / Arasaki, Kohei / Araújo, Wagner L / Araya, Jun / Arden, Catherine / Arévalo, Maria-Angeles / Arguelles, Sandro / Arias, Esperanza / Arikkath, Jyothi / Arimoto, Hirokazu / Ariosa, Aileen R / Armstrong-James, Darius / Arnauné-Pelloquin, Laetitia / Aroca, Angeles / Arroyo, Daniela S / Arsov, Ivica / Artero, Rubén / Asaro, Dalia Maria Lucia / Aschner, Michael / Ashrafizadeh, Milad / Ashur-Fabian, Osnat / Atanasov, Atanas G / Au, Alicia K / Auberger, Patrick / Auner, Holger W / Aurelian, Laure / Autelli, Riccardo / Avagliano, Laura / Ávalos, Yenniffer / Aveic, Sanja / Aveleira, Célia Alexandra / Avin-Wittenberg, Tamar / Aydin, Yucel / Ayton, Scott / Ayyadevara, Srinivas / Azzopardi, Maria / Baba, Misuzu / Backer, Jonathan M / Backues, Steven K / Bae, Dong-Hun / Bae, Ok-Nam / Bae, Soo Han / Baehrecke, Eric H / Baek, Ahruem / Baek, Seung-Hoon / Baek, Sung Hee / Bagetta, Giacinto / Bagniewska-Zadworna, Agnieszka / Bai, Hua / Bai, Jie / Bai, Xiyuan / Bai, Yidong / Bairagi, Nandadulal / Baksi, Shounak / Balbi, Teresa / Baldari, Cosima T / Balduini, Walter / Ballabio, Andrea / Ballester, Maria / Balazadeh, Salma / Balzan, Rena / Bandopadhyay, Rina / Banerjee, Sreeparna / Banerjee, Sulagna / Bánréti, Ágnes / Bao, Yan / Baptista, Mauricio S / Baracca, Alessandra / Barbati, Cristiana / Bargiela, Ariadna / Barilà, Daniela / Barlow, Peter G / Barmada, Sami J / Barreiro, Esther / Barreto, George E / Bartek, Jiri / Bartel, Bonnie / Bartolome, Alberto / Barve, Gaurav R / Basagoudanavar, Suresh H / Bassham, Diane C / Bast, Robert C / Basu, Alakananda / Batoko, Henri / Batten, Isabella / Baulieu, Etienne E / Baumgarner, Bradley L / Bayry, Jagadeesh / Beale, Rupert / Beau, Isabelle / Beaumatin, Florian / Bechara, Luiz R G / Beck, George R / Beers, Michael F / Begun, Jakob / Behrends, Christian / Behrens, Georg M N / Bei, Roberto / Bejarano, Eloy / Bel, Shai / Behl, Christian / Belaid, Amine / Belgareh-Touzé, Naïma / Bellarosa, Cristina / Belleudi, Francesca / Belló Pérez, Melissa / Bello-Morales, Raquel / Beltran, Jackeline Soares de Oliveira / Beltran, Sebastián / Benbrook, Doris Mangiaracina / Bendorius, Mykolas / Benitez, Bruno A / Benito-Cuesta, Irene / Bensalem, Julien / Berchtold, Martin W / Berezowska, Sabina / Bergamaschi, Daniele / Bergami, Matteo / Bergmann, Andreas / Berliocchi, Laura / Berlioz-Torrent, Clarisse / Bernard, Amélie / Berthoux, Lionel / Besirli, Cagri G / Besteiro, Sebastien / Betin, Virginie M / Beyaert, Rudi / Bezbradica, Jelena S / Bhaskar, Kiran / Bhatia-Kissova, Ingrid / Bhattacharya, Resham / Bhattacharya, Sujoy / Bhattacharyya, Shalmoli / Bhuiyan, Md Shenuarin / Bhutia, Sujit Kumar / Bi, Lanrong / Bi, Xiaolin / Biden, Trevor J / Bijian, Krikor / Billes, Viktor A / Binart, Nadine / Bincoletto, Claudia / Birgisdottir, Asa B / Bjorkoy, Geir / Blanco, Gonzalo / Blas-Garcia, Ana / Blasiak, Janusz / Blomgran, Robert / Blomgren, Klas / Blum, Janice S / Boada-Romero, Emilio / Boban, Mirta / Boesze-Battaglia, Kathleen / Boeuf, Philippe / Boland, Barry / Bomont, Pascale / Bonaldo, Paolo / Bonam, Srinivasa Reddy / Bonfili, Laura / Bonifacino, Juan S / Boone, Brian A / Bootman, Martin D / Bordi, Matteo / Borner, Christoph / Bornhauser, Beat C / Borthakur, Gautam / Bosch, Jürgen / Bose, Santanu / Botana, Luis M / Botas, Juan / Boulanger, Chantal M / Boulton, Michael E / Bourdenx, Mathieu / Bourgeois, Benjamin / Bourke, Nollaig M / Bousquet, Guilhem / Boya, Patricia / Bozhkov, Peter V / Bozi, Luiz H M / Bozkurt, Tolga O / Brackney, Doug E / Brandts, Christian H / Braun, Ralf J / Braus, Gerhard H / Bravo-Sagua, Roberto / Bravo-San Pedro, José M / Brest, Patrick / Bringer, Marie-Agnès / Briones-Herrera, Alfredo / Broaddus, V Courtney / Brodersen, Peter / Brodsky, Jeffrey L / Brody, Steven L / Bronson, Paola G / Bronstein, Jeff M / Brown, Carolyn N / Brown, Rhoderick E / Brum, Patricia C / Brumell, John H / Brunetti-Pierri, Nicola / Bruno, Daniele / Bryson-Richardson, Robert J / Bucci, Cecilia / Buchrieser, Carmen / Bueno, Marta / Buitrago-Molina, Laura Elisa / Buraschi, Simone / Buch, Shilpa / Buchan, J Ross / Buckingham, Erin M / Budak, Hikmet / Budini, Mauricio / Bultynck, Geert / Burada, Florin / Burgoyne, Joseph R / Burón, M Isabel / Bustos, Victor / Büttner, Sabrina / Butturini, Elena / Byrd, Aaron / Cabas, Isabel / Cabrera-Benitez, Sandra / Cadwell, Ken / Cai, Jingjing / Cai, Lu / Cai, Qian / Cairó, Montserrat / Calbet, Jose A / Caldwell, Guy A / Caldwell, Kim A / Call, Jarrod A / Calvani, Riccardo / Calvo, Ana C / Calvo-Rubio Barrera, Miguel / Camara, Niels Os / Camonis, Jacques H / Camougrand, Nadine / Campanella, Michelangelo / Campbell, Edward M / Campbell-Valois, François-Xavier / Campello, Silvia / Campesi, Ilaria / Campos, Juliane C / Camuzard, Olivier / Cancino, Jorge / Candido de Almeida, Danilo / Canesi, Laura / Caniggia, Isabella / Canonico, Barbara / Cantí, Carles / Cao, Bin / Caraglia, Michele / Caramés, Beatriz / Carchman, Evie H / Cardenal-Muñoz, Elena / Cardenas, Cesar / Cardenas, Luis / Cardoso, Sandra M / Carew, Jennifer S / Carle, Georges F / Carleton, Gillian / Carloni, Silvia / Carmona-Gutierrez, Didac / Carneiro, Leticia A / Carnevali, Oliana / Carosi, Julian M / Carra, Serena / Carrier, Alice / Carrier, Lucie / Carroll, Bernadette / Carter, A Brent / Carvalho, Andreia Neves / Casanova, Magali / Casas, Caty / Casas, Josefina / Cassioli, Chiara / Castillo, Eliseo F / Castillo, Karen / Castillo-Lluva, Sonia / Castoldi, Francesca / Castori, Marco / Castro, Ariel F / Castro-Caldas, Margarida / Castro-Hernandez, Javier / Castro-Obregon, Susana / Catz, Sergio D / Cavadas, Claudia / Cavaliere, Federica / Cavallini, Gabriella / Cavinato, Maria / Cayuela, Maria L / Cebollada Rica, Paula / Cecarini, Valentina / Cecconi, Francesco / Cechowska-Pasko, Marzanna / Cenci, Simone / Ceperuelo-Mallafré, Victòria / Cerqueira, João J / Cerutti, Janete M / Cervia, Davide / Cetintas, Vildan Bozok / Cetrullo, Silvia / Chae, Han-Jung / Chagin, Andrei S / Chai, Chee-Yin / Chakrabarti, Gopal / Chakrabarti, Oishee / Chakraborty, Tapas / Chakraborty, Trinad / Chami, Mounia / Chamilos, Georgios / Chan, David W / Chan, Edmond Y W / Chan, Edward D / Chan, H Y Edwin / Chan, Helen H / Chan, Hung / Chan, Matthew T V / Chan, Yau Sang / Chandra, Partha K / Chang, Chih-Peng / Chang, Chunmei / Chang, Hao-Chun / Chang, Kai / Chao, Jie / Chapman, Tracey / Charlet-Berguerand, Nicolas / Chatterjee, Samrat / Chaube, Shail K / Chaudhary, Anu / Chauhan, Santosh / Chaum, Edward / Checler, Frédéric / Cheetham, Michael E / Chen, Chang-Shi / Chen, Guang-Chao / Chen, Jian-Fu / Chen, Liam L / Chen, Leilei / Chen, Lin / Chen, Mingliang / Chen, Mu-Kuan / Chen, Ning / Chen, Quan / Chen, Ruey-Hwa / Chen, Shi / Chen, Wei / Chen, Weiqiang / Chen, Xin-Ming / Chen, Xiong-Wen / Chen, Xu / Chen, Yan / Chen, Ye-Guang / Chen, Yingyu / Chen, Yongqiang / Chen, Yu-Jen / Chen, Yue-Qin / Chen, Zhefan Stephen / Chen, 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Clementi, Emilio / Coccia, Eliana M / Codogno, Patrice / Cohen, Ehud / Cohen, Mickael M / Colasanti, Tania / Colasuonno, Fiorella / Colbert, Robert A / Colell, Anna / Čolić, Miodrag / Coll, Nuria S / Collins, Mark O / Colombo, María I / Colón-Ramos, Daniel A / Combaret, Lydie / Comincini, Sergio / Cominetti, Márcia R / Consiglio, Antonella / Conte, Andrea / Conti, Fabrizio / Contu, Viorica Raluca / Cookson, Mark R / Coombs, Kevin M / Coppens, Isabelle / Corasaniti, Maria Tiziana / Corkery, Dale P / Cordes, Nils / Cortese, Katia / Costa, Maria do Carmo / Costantino, Sarah / Costelli, Paola / Coto-Montes, Ana / Crack, Peter J / Crespo, Jose L / Criollo, Alfredo / Crippa, Valeria / Cristofani, Riccardo / Csizmadia, Tamas / Cuadrado, Antonio / Cui, Bing / Cui, Jun / Cui, Yixian / Cui, Yong / Culetto, Emmanuel / Cumino, Andrea C / Cybulsky, Andrey V / Czaja, Mark J / Czuczwar, Stanislaw J / D'Adamo, Stefania / D'Amelio, Marcello / D'Arcangelo, Daniela / D'Lugos, Andrew C / D'Orazi, 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M D / Delorme-Axford, Elizabeth / Delpino, M Victoria / Demarchi, Francesca / Dembitz, Vilma / Demers, Nicholas D / Deng, Hongbin / Deng, Zhiqiang / Dengjel, Joern / Dent, Paul / Denton, Donna / DePamphilis, Melvin L / Der, Channing J / Deretic, Vojo / Descoteaux, Albert / Devis, Laura / Devkota, Sushil / Devuyst, Olivier / Dewson, Grant / Dharmasivam, Mahendiran / Dhiman, Rohan / di Bernardo, Diego / Di Cristina, Manlio / Di Domenico, Fabio / Di Fazio, Pietro / Di Fonzo, Alessio / Di Guardo, Giovanni / Di Guglielmo, Gianni M / Di Leo, Luca / Di Malta, Chiara / Di Nardo, Alessia / Di Rienzo, Martina / Di Sano, Federica / Diallinas, George / Diao, Jiajie / Diaz-Araya, Guillermo / Díaz-Laviada, Inés / Dickinson, Jared M / Diederich, Marc / Dieudé, Mélanie / Dikic, Ivan / Ding, Shiping / Ding, Wen-Xing / Dini, Luciana / Dinić, Jelena / Dinic, Miroslav / Dinkova-Kostova, Albena T / Dionne, Marc S / Distler, Jörg H W / Diwan, Abhinav / Dixon, Ian M C / Djavaheri-Mergny, Mojgan / Dobrinski, Ina / Dobrovinskaya, Oxana / Dobrowolski, Radek / Dobson, Renwick C J / Đokić, Jelena / Dokmeci Emre, Serap / Donadelli, Massimo / Dong, Bo / Dong, Xiaonan / Dong, Zhiwu / Dorn Ii, Gerald W / Dotsch, Volker / Dou, Huan / Dou, Juan / Dowaidar, Moataz / Dridi, Sami / Drucker, Liat / Du, Ailian / Du, Caigan / Du, Guangwei / Du, Hai-Ning / Du, Li-Lin / du Toit, André / Duan, Shao-Bin / Duan, Xiaoqiong / Duarte, Sónia P / Dubrovska, Anna / Dunlop, Elaine A / Dupont, Nicolas / Durán, Raúl V / Dwarakanath, Bilikere S / Dyshlovoy, Sergey A / Ebrahimi-Fakhari, Darius / Eckhart, Leopold / Edelstein, Charles L / Efferth, Thomas / Eftekharpour, Eftekhar / Eichinger, Ludwig / Eid, Nabil / Eisenberg, Tobias / Eissa, N Tony / Eissa, Sanaa / Ejarque, Miriam / El Andaloussi, Abdeljabar / El-Hage, Nazira / El-Naggar, Shahenda / Eleuteri, Anna Maria / El-Shafey, Eman S / Elgendy, Mohamed / Eliopoulos, Aristides G / Elizalde, María M / Elks, Philip M / Elsasser, Hans-Peter / Elsherbiny, Eslam S / Emerling, Brooke M / Emre, N C Tolga / Eng, Christina H / Engedal, Nikolai / Engelbrecht, Anna-Mart / Engelsen, Agnete S T / Enserink, Jorrit M / Escalante, Ricardo / Esclatine, Audrey / Escobar-Henriques, Mafalda / Eskelinen, Eeva-Liisa / Espert, Lucile / Eusebio, Makandjou-Ola / Fabrias, Gemma / Fabrizi, Cinzia / Facchiano, Antonio / Facchiano, Francesco / Fadeel, Bengt / Fader, Claudio / Faesen, Alex C / Fairlie, W Douglas / Falcó, Alberto / Falkenburger, Bjorn H / Fan, Daping / Fan, Jie / Fan, Yanbo / Fang, Evandro F / Fang, Yanshan / Fang, Yognqi / Fanto, Manolis / Farfel-Becker, Tamar / Faure, Mathias / Fazeli, Gholamreza / Fedele, Anthony O / Feldman, Arthur M / Feng, Du / Feng, Jiachun / Feng, Lifeng / Feng, Yibin / Feng, Yuchen / Feng, Wei / Fenz Araujo, Thais / Ferguson, Thomas A / Fernández, Álvaro F / Fernandez-Checa, Jose C / Fernández-Veledo, Sonia / Fernie, Alisdair R / Ferrante, Anthony W / Ferraresi, Alessandra / Ferrari, Merari F / Ferreira, Julio C B / Ferro-Novick, Susan / Figueras, Antonio / Filadi, Riccardo / Filigheddu, Nicoletta / Filippi-Chiela, Eduardo / Filomeni, Giuseppe / Fimia, Gian Maria / Fineschi, Vittorio / Finetti, Francesca / Finkbeiner, Steven / Fisher, Edward A / Fisher, Paul B / Flamigni, Flavio / Fliesler, Steven J / Flo, Trude H / Florance, Ida / Florey, Oliver / Florio, Tullio / Fodor, Erika / Follo, Carlo / Fon, Edward A / Forlino, Antonella / Fornai, Francesco / Fortini, Paola / Fracassi, Anna / Fraldi, Alessandro / Franco, Brunella / Franco, Rodrigo / Franconi, Flavia / Frankel, Lisa B / Friedman, Scott L / Fröhlich, Leopold F / Frühbeck, Gema / Fuentes, Jose M / Fujiki, Yukio / Fujita, Naonobu / Fujiwara, Yuuki / Fukuda, Mitsunori / Fulda, Simone / Furic, Luc / Furuya, Norihiko / Fusco, Carmela / Gack, Michaela U / Gaffke, Lidia / Galadari, Sehamuddin / Galasso, Alessia / Galindo, Maria F / Gallolu Kankanamalage, Sachith / Galluzzi, Lorenzo / Galy, Vincent / Gammoh, Noor / Gan, Boyi / Ganley, Ian G / Gao, Feng / Gao, Hui / Gao, Minghui / Gao, Ping / Gao, Shou-Jiang / Gao, Wentao / Gao, Xiaobo / Garcera, Ana / Garcia, Maria Noé / Garcia, Verónica E / García-Del Portillo, Francisco / Garcia-Escudero, Vega / Garcia-Garcia, Aracely / Garcia-Macia, Marina / García-Moreno, Diana / Garcia-Ruiz, Carmen / García-Sanz, Patricia / Garg, Abhishek D / Gargini, Ricardo / Garofalo, Tina / Garry, Robert F / Gassen, Nils C / Gatica, Damian / Ge, Liang / Ge, Wanzhong / Geiss-Friedlander, Ruth / Gelfi, Cecilia / Genschik, Pascal / Gentle, Ian E / Gerbino, Valeria / Gerhardt, Christoph / Germain, Kyla / Germain, Marc / Gewirtz, David A / Ghasemipour Afshar, Elham / Ghavami, Saeid / Ghigo, Alessandra / Ghosh, Manosij / Giamas, Georgios / Giampietri, Claudia / Giatromanolaki, Alexandra / Gibson, Gary E / Gibson, Spencer B / Ginet, Vanessa / Giniger, Edward / Giorgi, Carlotta / Girao, Henrique / Girardin, Stephen E / Giridharan, Mridhula / Giuliano, Sandy / Giulivi, Cecilia / Giuriato, Sylvie / Giustiniani, Julien / Gluschko, Alexander / Goder, Veit / Goginashvili, Alexander / Golab, Jakub / Goldstone, David C / Golebiewska, Anna / Gomes, Luciana R / Gomez, Rodrigo / Gómez-Sánchez, Rubén / Gomez-Puerto, Maria Catalina / Gomez-Sintes, Raquel / Gong, Qingqiu / Goni, Felix M / González-Gallego, Javier / Gonzalez-Hernandez, Tomas / Gonzalez-Polo, Rosa A / Gonzalez-Reyes, Jose A / González-Rodríguez, Patricia / Goping, Ing Swie / Gorbatyuk, Marina S / Gorbunov, Nikolai V / Görgülü, Kıvanç / Gorojod, Roxana M / Gorski, Sharon M / Goruppi, Sandro / Gotor, Cecilia / Gottlieb, Roberta A / Gozes, Illana / Gozuacik, Devrim / Graef, Martin / Gräler, Markus H / Granatiero, Veronica / Grasso, Daniel / Gray, Joshua P / Green, Douglas R / Greenhough, Alexander / Gregory, Stephen L / Griffin, Edward F / Grinstaff, Mark W / Gros, Frederic / Grose, Charles / Gross, Angelina S / Gruber, Florian / Grumati, Paolo / Grune, Tilman / Gu, Xueyan / Guan, Jun-Lin / Guardia, Carlos M / Guda, Kishore / Guerra, Flora / Guerri, Consuelo / Guha, Prasun / Guillén, Carlos / Gujar, Shashi / Gukovskaya, Anna / Gukovsky, Ilya / Gunst, Jan / Günther, Andreas / Guntur, Anyonya R / Guo, Chuanyong / Guo, Chun / Guo, Hongqing / Guo, Lian-Wang / Guo, Ming / Gupta, Pawan / Gupta, Shashi Kumar / Gupta, Swapnil / Gupta, Veer Bala / Gupta, Vivek / Gustafsson, Asa B / Gutterman, David D / H B, Ranjitha / Haapasalo, Annakaisa / Haber, James E / Hać, Aleksandra / Hadano, Shinji / Hafrén, Anders J / Haidar, Mansour / Hall, Belinda S / Halldén, Gunnel / Hamacher-Brady, Anne / Hamann, Andrea / Hamasaki, Maho / Han, Weidong / Hansen, Malene / Hanson, Phyllis I / Hao, Zijian / Harada, Masaru / Harhaji-Trajkovic, Ljubica / Hariharan, Nirmala / Haroon, Nigil / Harris, James / Hasegawa, Takafumi / Hasima Nagoor, Noor / Haspel, Jeffrey A / Haucke, Volker / Hawkins, Wayne D / Hay, Bruce A / Haynes, Cole M / Hayrabedyan, Soren B / Hays, Thomas S / He, Congcong / He, Qin / He, Rong-Rong / He, You-Wen / He, Yu-Ying / Heakal, Yasser / Heberle, Alexander M / Hejtmancik, J Fielding / Helgason, Gudmundur Vignir / Henkel, Vanessa / Herb, Marc / Hergovich, Alexander / Herman-Antosiewicz, Anna / Hernández, Agustín / Hernandez, Carlos / Hernandez-Diaz, Sergio / Hernandez-Gea, Virginia / Herpin, Amaury / Herreros, Judit / Hervás, Javier H / Hesselson, Daniel / Hetz, Claudio / Heussler, Volker T / Higuchi, Yujiro / Hilfiker, Sabine / Hill, Joseph A / Hlavacek, William S / Ho, Emmanuel A / Ho, Idy H T / Ho, Philip Wing-Lok / Ho, Shu-Leong / Ho, Wan Yun / Hobbs, G Aaron / Hochstrasser, Mark / Hoet, Peter H M / Hofius, Daniel / Hofman, Paul / Höhn, Annika / Holmberg, Carina I / Hombrebueno, Jose R / Yi-Ren Hong, Chang-Won Hong / Hooper, Lora V / Hoppe, Thorsten / Horos, Rastislav / Hoshida, Yujin / Hsin, I-Lun / Hsu, Hsin-Yun / Hu, Bing / Hu, Dong / Hu, Li-Fang / Hu, Ming Chang / Hu, Ronggui / Hu, Wei / Hu, Yu-Chen / Hu, Zhuo-Wei / Hua, Fang / Hua, Jinlian / Hua, Yingqi / Huan, Chongmin / Huang, Canhua / Huang, Chuanshu / Huang, Chuanxin / Huang, Chunling / Huang, Haishan / Huang, Kun / Huang, Michael L H / Huang, Rui / Huang, Shan / Huang, Tianzhi / Huang, Xing / Huang, Yuxiang Jack / Huber, Tobias B / Hubert, Virginie / Hubner, Christian A / Hughes, Stephanie M / Hughes, William E / Humbert, Magali / Hummer, Gerhard / Hurley, James H / Hussain, Sabah / Hussain, Salik / Hussey, Patrick J / Hutabarat, Martina / Hwang, Hui-Yun / Hwang, Seungmin / Ieni, Antonio / Ikeda, Fumiyo / Imagawa, Yusuke / Imai, Yuzuru / Imbriano, Carol / Imoto, Masaya / Inman, Denise M / Inoki, Ken / Iovanna, Juan / Iozzo, Renato V / Ippolito, Giuseppe / Irazoqui, Javier E / Iribarren, Pablo / Ishaq, Mohd / Ishikawa, Makoto / Ishimwe, Nestor / Isidoro, Ciro / Ismail, Nahed / Issazadeh-Navikas, Shohreh / Itakura, Eisuke / Ito, Daisuke / Ivankovic, Davor / Ivanova, Saška / Iyer, Anand Krishnan V / Izquierdo, José M / Izumi, Masanori / Jäättelä, Marja / Jabir, Majid Sakhi / Jackson, William T / Jacobo-Herrera, Nadia / Jacomin, Anne-Claire / Jacquin, Elise / Jadiya, Pooja / Jaeschke, Hartmut / Jagannath, Chinnaswamy / Jakobi, Arjen J / Jakobsson, Johan / Janji, Bassam / Jansen-Dürr, Pidder / Jansson, Patric J / Jantsch, Jonathan / Januszewski, Sławomir / Jassey, Alagie / Jean, Steve / Jeltsch-David, Hélène / Jendelova, Pavla / Jenny, Andreas / Jensen, Thomas E / Jessen, Niels / Jewell, Jenna L / Ji, Jing / Jia, Lijun / Jia, Rui / Jiang, Liwen / Jiang, Qing / Jiang, Richeng / Jiang, Teng / Jiang, Xuejun / Jiang, Yu / Jimenez-Sanchez, Maria / Jin, Eun-Jung / Jin, Fengyan / Jin, Hongchuan / Jin, Li / Jin, Luqi / Jin, Meiyan / Jin, Si / Jo, Eun-Kyeong / Joffre, Carine / Johansen, Terje / Johnson, Gail V W / Johnston, Simon A / Jokitalo, Eija / Jolly, Mohit Kumar / Joosten, Leo A B / Jordan, Joaquin / Joseph, Bertrand / Ju, Dianwen / Ju, Jeong-Sun / Ju, Jingfang / Juárez, Esmeralda / Judith, Delphine / Juhász, Gábor / Jun, Youngsoo / Jung, Chang Hwa / Jung, Sung-Chul / Jung, Yong Keun / Jungbluth, Heinz / Jungverdorben, Johannes / Just, Steffen / Kaarniranta, Kai / Kaasik, Allen / Kabuta, Tomohiro / Kaganovich, Daniel / Kahana, Alon / Kain, Renate / Kajimura, Shinjo / Kalamvoki, Maria / Kalia, Manjula / Kalinowski, Danuta S / Kaludercic, Nina / Kalvari, Ioanna / Kaminska, Joanna / Kaminskyy, Vitaliy O / Kanamori, Hiromitsu / Kanasaki, Keizo / Kang, Chanhee / Kang, Rui / Kang, Sang Sun / Kaniyappan, Senthilvelrajan / Kanki, Tomotake / Kanneganti, Thirumala-Devi / Kanthasamy, Anumantha G / Kanthasamy, Arthi / Kantorow, Marc / Kapuy, Orsolya / Karamouzis, Michalis V / Karim, Md Razaul / Karmakar, Parimal / Katare, Rajesh G / Kato, Masaru / Kaufmann, Stefan H E / Kauppinen, Anu / Kaushal, Gur P / Kaushik, Susmita / Kawasaki, Kiyoshi / Kazan, Kemal / Ke, Po-Yuan / Keating, Damien J / Keber, Ursula / Kehrl, John H / Keller, Kate E / Keller, Christian W / Kemper, Jongsook Kim / Kenific, Candia M / Kepp, Oliver / Kermorgant, Stephanie / Kern, Andreas / Ketteler, Robin / Keulers, Tom G / Khalfin, Boris / Khalil, Hany / Khambu, Bilon / Khan, Shahid Y / Khandelwal, Vinoth Kumar Megraj / Khandia, Rekha / Kho, Widuri / Khobrekar, Noopur V / Khuansuwan, Sataree / Khundadze, Mukhran / Killackey, Samuel A / Kim, Dasol / Kim, Deok Ryong / Kim, Do-Hyung / Kim, Dong-Eun / Kim, Eun Young / Kim, Eun-Kyoung / Kim, Hak-Rim / Kim, Hee-Sik / Hyung-Ryong Kim / Kim, Jeong Hun / Kim, Jin Kyung / Kim, Jin-Hoi / Kim, Joungmok / Kim, Ju Hwan / Kim, Keun Il / Kim, Peter K / Kim, Seong-Jun / Kimball, Scot R / Kimchi, Adi / Kimmelman, Alec C / Kimura, Tomonori / King, Matthew A / Kinghorn, Kerri J / Kinsey, Conan G / Kirkin, Vladimir / Kirshenbaum, Lorrie A / Kiselev, Sergey L / Kishi, Shuji / Kitamoto, Katsuhiko / Kitaoka, Yasushi / Kitazato, Kaio / Kitsis, Richard N / Kittler, Josef T / Kjaerulff, Ole / Klein, Peter S / Klopstock, Thomas / Klucken, Jochen / Knævelsrud, Helene / Knorr, Roland L / Ko, Ben C B / Ko, Fred / Ko, Jiunn-Liang / Kobayashi, Hotaka / Kobayashi, Satoru / Koch, Ina / Koch, Jan C / Koenig, Ulrich / Kögel, Donat / Koh, Young Ho / Koike, Masato / Kohlwein, Sepp D / Kocaturk, Nur M / Komatsu, Masaaki / König, Jeannette / Kono, Toru / Kopp, Benjamin T / Korcsmaros, Tamas / Korkmaz, Gözde / Korolchuk, Viktor I / Korsnes, Mónica Suárez / Koskela, Ali / Kota, Janaiah / Kotake, Yaichiro / Kotler, Monica L / Kou, Yanjun / Koukourakis, Michael I / Koustas, Evangelos / Kovacs, Attila L / Kovács, Tibor / Koya, Daisuke / Kozako, Tomohiro / Kraft, Claudine / Krainc, Dimitri / Krämer, Helmut / Krasnodembskaya, Anna D / Kretz-Remy, Carole / Kroemer, Guido / Ktistakis, Nicholas T / Kuchitsu, Kazuyuki / Kuenen, Sabine / Kuerschner, Lars / Kukar, Thomas / Kumar, Ajay / Kumar, Ashok / Kumar, Deepak / Kumar, Dhiraj / Kumar, Sharad / Kume, Shinji / Kumsta, Caroline / Kundu, Chanakya N / Kundu, Mondira / Kunnumakkara, Ajaikumar B / Kurgan, Lukasz / Kutateladze, Tatiana G / Kutlu, Ozlem / Kwak, SeongAe / Kwon, Ho Jeong / Kwon, Taeg Kyu / Kwon, Yong Tae / Kyrmizi, Irene / La Spada, Albert / Labonté, Patrick / Ladoire, Sylvain / Laface, Ilaria / Lafont, Frank / Lagace, Diane C / Lahiri, Vikramjit / Lai, Zhibing / Laird, Angela S / Lakkaraju, Aparna / Lamark, Trond / Lan, Sheng-Hui / Landajuela, Ane / Lane, Darius J R / Lane, Jon D / Lang, Charles H / Lange, Carsten / Langel, Ülo / Langer, Rupert / Lapaquette, Pierre / Laporte, Jocelyn / LaRusso, Nicholas F / Lastres-Becker, Isabel / Lau, Wilson Chun Yu / Laurie, Gordon W / Lavandero, Sergio / Law, Betty Yuen Kwan / Law, Helen Ka-Wai / Layfield, Rob / Le, Weidong / Le Stunff, Herve / Leary, Alexandre Y / Lebrun, Jean-Jacques / Leck, Lionel Y W / Leduc-Gaudet, Jean-Philippe / Lee, Changwook / Lee, Chung-Pei / Lee, Da-Hye / Lee, Edward B / Lee, Erinna F / Lee, Gyun Min / Lee, He-Jin / Lee, Heung Kyu / Lee, Jae Man / Lee, Jason S / Lee, Jin-A / Lee, Joo-Yong / Lee, Jun Hee / Lee, Michael / Lee, Min Goo / Lee, Min Jae / Lee, Myung-Shik / Lee, Sang Yoon / Lee, Seung-Jae / Lee, Stella Y / Lee, Sung Bae / Lee, Won Hee / Lee, Ying-Ray / Lee, Yong-Ho / Lee, Youngil / Lefebvre, Christophe / Legouis, Renaud / Lei, Yu L / Lei, Yuchen / Leikin, Sergey / Leitinger, Gerd / Lemus, Leticia / Leng, Shuilong / Lenoir, Olivia / Lenz, Guido / Lenz, Heinz Josef / Lenzi, Paola / León, Yolanda / Leopoldino, Andréia M / Leschczyk, Christoph / Leskelä, Stina / Letellier, Elisabeth / Leung, Chi-Ting / Leung, Po Sing / Leventhal, Jeremy S / Levine, Beth / Lewis, Patrick A / Ley, Klaus / Li, Bin / Li, Da-Qiang / Li, Jianming / Li, Jing / Li, Jiong / Li, Ke / Li, Liwu / Li, Mei / Li, Min / Li, Ming / Li, Mingchuan / Li, Pin-Lan / Li, Ming-Qing / Li, Qing / Li, Sheng / Li, Tiangang / Li, Wei / Li, Wenming / Li, Xue / Li, Yi-Ping / Li, Yuan / Li, Zhiqiang / Li, Zhiyong / Li, Zhiyuan / Lian, Jiqin / Liang, Chengyu / Liang, Qiangrong / Liang, Weicheng / Liang, Yongheng / Liang, YongTian / Liao, Guanghong / Liao, Lujian / Liao, Mingzhi / Liao, Yung-Feng / Librizzi, Mariangela / Lie, Pearl P Y / Lilly, Mary A / Lim, Hyunjung J / Lima, Thania R R / Limana, Federica / Lin, Chao / Lin, Chih-Wen / Lin, Dar-Shong / Lin, Fu-Cheng / Lin, Jiandie D / Lin, Kurt M / Lin, Kwang-Huei / Lin, Liang-Tzung / Lin, Pei-Hui / Lin, Qiong / Lin, Shaofeng / Lin, Su-Ju / Lin, Wenyu / Lin, Xueying / Lin, Yao-Xin / Lin, Yee-Shin / Linden, Rafael / Lindner, Paula / Ling, Shuo-Chien / Lingor, Paul / Linnemann, Amelia K / Liou, Yih-Cherng / Lipinski, Marta M / Lipovšek, Saška / Lira, Vitor A / Lisiak, Natalia / Liton, Paloma B / Liu, Chao / Liu, Ching-Hsuan / Liu, Chun-Feng / Liu, Cui Hua / Liu, Fang / Liu, Hao / Liu, Hsiao-Sheng / Liu, Hua-Feng / Liu, Huifang / Liu, Jia / Liu, Jing / Liu, Julia / Liu, Leyuan / Liu, Longhua / Liu, Meilian / Liu, Qin / Liu, Wei / Liu, Wende / Liu, Xiao-Hong / Liu, Xiaodong / Liu, Xingguo / Liu, Xu / Liu, Xuedong / Liu, Yanfen / Liu, Yang / Liu, Yueyang / Liu, Yule / Livingston, J Andrew / Lizard, Gerard / Lizcano, Jose M / Ljubojevic-Holzer, Senka / LLeonart, Matilde E / Llobet-Navàs, David / Llorente, Alicia / Lo, Chih Hung / Lobato-Márquez, Damián / Long, Qi / Long, Yun Chau / Loos, Ben / Loos, Julia A / López, Manuela G / López-Doménech, Guillermo / López-Guerrero, José Antonio / López-Jiménez, Ana T / López-Pérez, Óscar / López-Valero, Israel / Lorenowicz, Magdalena J / Lorente, Mar / Lorincz, Peter / Lossi, Laura / Lotersztajn, Sophie / Lovat, Penny E / Lovell, Jonathan F / Lovy, Alenka / Lőw, Péter / Lu, Guang / Lu, Haocheng / Lu, Jia-Hong / Lu, Jin-Jian / Lu, Mengji / Lu, Shuyan / Luciani, Alessandro / Lucocq, John M / Ludovico, Paula / Luftig, Micah A / Luhr, Morten / Luis-Ravelo, Diego / Lum, Julian J / Luna-Dulcey, Liany / Lund, Anders H / Lund, Viktor K / Lünemann, Jan D / Lüningschrör, Patrick / Luo, Honglin / Luo, Rongcan / Luo, Shouqing / Luo, Zhi / Luparello, Claudio / Lüscher, Bernhard / Luu, Luan / Lyakhovich, Alex / Lyamzaev, Konstantin G / Lystad, Alf Håkon / Lytvynchuk, Lyubomyr / Ma, Alvin C / Ma, Changle / Ma, Mengxiao / Ma, Ning-Fang / Ma, Quan-Hong / Ma, Xinliang / Ma, Yueyun / Ma, Zhenyi / MacDougald, Ormond A / Macian, Fernando / MacIntosh, Gustavo C / MacKeigan, Jeffrey P / Macleod, Kay F / Maday, Sandra / Madeo, Frank / Madesh, Muniswamy / Madl, Tobias / Madrigal-Matute, Julio / Maeda, Akiko / Maejima, Yasuhiro / Magarinos, Marta / Mahavadi, Poornima / Maiani, Emiliano / Maiese, Kenneth / Maiti, Panchanan / Maiuri, Maria Chiara / Majello, Barbara / Major, Michael B / Makareeva, Elena / Malik, Fayaz / Mallilankaraman, Karthik / Malorni, Walter / Maloyan, Alina / Mammadova, Najiba / Man, Gene Chi Wai / Manai, Federico / Mancias, Joseph D / Mandelkow, Eva-Maria / Mandell, Michael A / Manfredi, Angelo A / Manjili, Masoud H / Manjithaya, Ravi / Manque, Patricio / Manshian, Bella B / Manzano, Raquel / Manzoni, Claudia / Mao, Kai / Marchese, Cinzia / Marchetti, Sandrine / Marconi, Anna Maria / Marcucci, Fabrizio / Mardente, Stefania / Mareninova, Olga A / Margeta, Marta / Mari, Muriel / Marinelli, Sara / Marinelli, Oliviero / Mariño, Guillermo / Mariotto, Sofia / Marshall, Richard S / Marten, Mark R / Martens, Sascha / Martin, Alexandre P J / Martin, Katie R / Martin, Sara / Martin, Shaun / Martín-Segura, Adrián / Martín-Acebes, Miguel A / Martin-Burriel, Inmaculada / Martin-Rincon, Marcos / Martin-Sanz, Paloma / Martina, José A / Martinet, Wim / Martinez, Aitor / Martinez, Ana / Martinez, Jennifer / Martinez Velazquez, Moises / Martinez-Lopez, Nuria / Martinez-Vicente, Marta / Martins, Daniel O / Martins, Joilson O / Martins, Waleska K / Martins-Marques, Tania / Marzetti, Emanuele / Masaldan, Shashank / Masclaux-Daubresse, Celine / Mashek, Douglas G / Massa, Valentina / Massieu, Lourdes / Masson, Glenn R / Masuelli, Laura / Masyuk, Anatoliy I / Masyuk, Tetyana V / Matarrese, Paola / Matheu, Ander / Matoba, Satoaki / Matsuzaki, Sachiko / Mattar, Pamela / Matte, Alessandro / Mattoscio, Domenico / Mauriz, José L / Mauthe, Mario / Mauvezin, Caroline / Maverakis, Emanual / Maycotte, Paola / Mayer, Johanna / Mazzoccoli, Gianluigi / Mazzoni, Cristina / Mazzulli, Joseph R / McCarty, Nami / McDonald, Christine / McGill, Mitchell R / McKenna, Sharon L / McLaughlin, BethAnn / McLoughlin, Fionn / McNiven, Mark A / McWilliams, Thomas G / Mechta-Grigoriou, Fatima / Medeiros, Tania Catarina / Medina, Diego L / Megeney, Lynn A / Megyeri, Klara / Mehrpour, Maryam / Mehta, Jawahar L / Meijer, Alfred J / Meijer, Annemarie H / Mejlvang, Jakob / Meléndez, Alicia / Melk, Annette / Memisoglu, Gonen / Mendes, Alexandrina F / Meng, Delong / Meng, Fei / Meng, Tian / Menna-Barreto, Rubem / Menon, Manoj B / Mercer, Carol / Mercier, Anne E / Mergny, Jean-Louis / Merighi, Adalberto / Merkley, Seth D / Merla, Giuseppe / Meske, Volker / Mestre, Ana Cecilia / Metur, Shree Padma / Meyer, Christian / Meyer, Hemmo / Mi, Wenyi / Mialet-Perez, Jeanne / Miao, Junying / Micale, Lucia / Miki, Yasuo / Milan, Enrico / Milczarek, Małgorzata / Miller, Dana L / Miller, Samuel I / Miller, Silke / Millward, Steven W / Milosevic, Ira / Minina, Elena A / Mirzaei, Hamed / Mirzaei, Hamid Reza / Mirzaei, Mehdi / Mishra, Amit / Mishra, Nandita / Mishra, Paras Kumar / Misirkic Marjanovic, Maja / Misasi, Roberta / Misra, Amit / Misso, Gabriella / Mitchell, Claire / Mitou, Geraldine / Miura, Tetsuji / Miyamoto, Shigeki / Miyazaki, Makoto / Miyazaki, Mitsunori / Miyazaki, Taiga / Miyazawa, Keisuke / Mizushima, Noboru / Mogensen, Trine H / Mograbi, Baharia / Mohammadinejad, Reza / Mohamud, Yasir / Mohanty, Abhishek / Mohapatra, Sipra / Möhlmann, Torsten / Mohmmed, Asif / Moles, Anna / Moley, Kelle H / Molinari, Maurizio / Mollace, Vincenzo / Møller, Andreas Buch / Mollereau, Bertrand / Mollinedo, Faustino / Montagna, Costanza / Monteiro, Mervyn J / Montella, Andrea / Montes, L Ruth / Montico, Barbara / Mony, Vinod K / Monzio Compagnoni, Giacomo / Moore, Michael N / Moosavi, Mohammad A / Mora, Ana L / Mora, Marina / Morales-Alamo, David / Moratalla, Rosario / Moreira, Paula I / Morelli, Elena / Moreno, Sandra / Moreno-Blas, Daniel / Moresi, Viviana / Morga, Benjamin / Morgan, Alwena H / Morin, Fabrice / Morishita, Hideaki / Moritz, Orson L / Moriyama, Mariko / Moriyasu, Yuji / Morleo, Manuela / Morselli, Eugenia / Moruno-Manchon, Jose F / Moscat, Jorge / Mostowy, Serge / Motori, Elisa / Moura, Andrea Felinto / Moustaid-Moussa, Naima / Mrakovcic, Maria / Muciño-Hernández, Gabriel / Mukherjee, Anupam / Mukhopadhyay, Subhadip / Mulcahy Levy, Jean M / Mulero, Victoriano / Muller, Sylviane / Münch, Christian / Munjal, Ashok / Munoz-Canoves, Pura / Muñoz-Galdeano, Teresa / Münz, Christian / Murakawa, Tomokazu / Muratori, Claudia / Murphy, Brona M / Murphy, J Patrick / Murthy, Aditya / Myöhänen, Timo T / Mysorekar, Indira U / Mytych, Jennifer / Nabavi, Seyed Mohammad / Nabissi, Massimo / Nagy, Péter / Nah, Jihoon / Nahimana, Aimable / Nakagawa, Ichiro / Nakamura, Ken / Nakatogawa, Hitoshi / Nandi, Shyam S / Nanjundan, Meera / Nanni, Monica / Napolitano, Gennaro / Nardacci, Roberta / Narita, Masashi / Nassif, Melissa / Nathan, Ilana / Natsumeda, Manabu / Naude, Ryno J / Naumann, Christin / Naveiras, Olaia / Navid, Fatemeh / Nawrocki, Steffan T / Nazarko, Taras Y / Nazio, Francesca / Negoita, Florentina / Neill, Thomas / Neisch, Amanda L / Neri, Luca M / Netea, Mihai G / Neubert, Patrick / Neufeld, Thomas P / Neumann, Dietbert / Neutzner, Albert / Newton, Phillip T / Ney, Paul A / Nezis, Ioannis P / Ng, Charlene C W / Ng, Tzi Bun / Nguyen, Hang T T / Nguyen, Long T / Ni, Hong-Min / Ní Cheallaigh, Clíona / Ni, Zhenhong / Nicolao, M Celeste / Nicoli, Francesco / Nieto-Diaz, Manuel / Nilsson, Per / Ning, Shunbin / Niranjan, Rituraj / Nishimune, Hiroshi / Niso-Santano, Mireia / Nixon, Ralph A / Nobili, Annalisa / Nobrega, Clevio / Noda, Takeshi / Nogueira-Recalde, Uxía / Nolan, Trevor M / Nombela, Ivan / Novak, Ivana / Novoa, Beatriz / Nozawa, Takashi / Nukina, Nobuyuki / Nussbaum-Krammer, Carmen / Nylandsted, Jesper / O'Donovan, Tracey R / O'Leary, Seónadh M / O'Rourke, Eyleen J / O'Sullivan, Mary P / O'Sullivan, Timothy E / Oddo, Salvatore / Oehme, Ina / Ogawa, Michinaga / Ogier-Denis, Eric / Ogmundsdottir, Margret H / Ogretmen, Besim / Oh, Goo Taeg / Oh, Seon-Hee / Oh, Young J / Ohama, Takashi / Ohashi, Yohei / Ohmuraya, Masaki / Oikonomou, Vasileios / Ojha, Rani / Okamoto, Koji / Okazawa, Hitoshi / Oku, Masahide / Oliván, Sara / Oliveira, Jorge M A / Ollmann, Michael / Olzmann, James A / Omari, Shakib / Omary, M Bishr / Önal, Gizem / Ondrej, Martin / Ong, Sang-Bing / Ong, Sang-Ging / Onnis, Anna / Orellana, Juan A / Orellana-Muñoz, Sara / Ortega-Villaizan, Maria Del Mar / Ortiz-Gonzalez, Xilma R / Ortona, Elena / Osiewacz, Heinz D / Osman, Abdel-Hamid K / Osta, Rosario / Otegui, Marisa S / Otsu, Kinya / Ott, Christiane / Ottobrini, Luisa / Ou, Jing-Hsiung James / Outeiro, Tiago F / Oynebraten, Inger / Ozturk, Melek / Pagès, Gilles / Pahari, Susanta / Pajares, Marta / Pajvani, Utpal B / Pal, Rituraj / Paladino, Simona / Pallet, Nicolas / Palmieri, Michela / Palmisano, Giuseppe / 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    Autophagy

    2021  Volume 17, Issue 1, Page(s) 1–382

    Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also ... ...

    Abstract In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for
    MeSH term(s) Animals ; Autophagosomes ; Autophagy/physiology ; Autophagy-Related Proteins/metabolism ; Biological Assay/standards ; Biomarkers ; Humans ; Lysosomes
    Chemical Substances Autophagy-Related Proteins ; Biomarkers
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Guideline ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1797280
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: CD44-SLC1A2 gene fusions in gastric cancer.

    Tao, Jiong / Deng, Nian Tao / Ramnarayanan, Kalpana / Huang, Baohua / Oh, Hue Kian / Leong, Siew Hong / Lim, Seong Soo / Tan, Iain Beehuat / Ooi, Chia Huey / Wu, Jeanie / Lee, Minghui / Zhang, Shenli / Rha, Sun Young / Chung, Hyun Cheol / Smoot, Duane T / Ashktorab, Hassan / Kon, Oi Lian / Cacheux, Valere / Yap, Celestial /
    Palanisamy, Nallasivam / Tan, Patrick

    Science translational medicine

    2011  Volume 3, Issue 77, Page(s) 77ra30

    Abstract: Fusion genes are chimeric genes formed in cancers through genomic aberrations such as translocations, amplifications, and rearrangements. To identify fusion genes in gastric cancer, we analyzed regions of chromosomal imbalance in a cohort of 106 primary ... ...

    Abstract Fusion genes are chimeric genes formed in cancers through genomic aberrations such as translocations, amplifications, and rearrangements. To identify fusion genes in gastric cancer, we analyzed regions of chromosomal imbalance in a cohort of 106 primary gastric cancers and 27 cell lines derived from gastric cancers. Multiple samples exhibited genomic breakpoints in the 5' region of SLC1A2/EAAT2, a gene encoding a glutamate transporter. Analysis of a breakpoint-positive SNU16 cell line revealed expression of a CD44-SLC1A2 fusion transcript caused by a paracentric chromosomal inversion, which was predicted to produce a truncated but functional SLC1A2 protein. In primary tumors, CD44-SLC1A2 gene fusions were detected in 1 to 2% of gastric cancers, but not in adjacent matched normal gastric tissues. When we specifically silenced CD44-SLC1A2, cellular proliferation, invasion, and anchorage-independent growth were significantly reduced. Conversely, CD44-SLC1A2 overexpression in gastric cells stimulated these pro-oncogenic traits. CD44-SLC1A2 silencing caused significant reductions in intracellular glutamate concentrations and sensitized SNU16 cells to cisplatin, a commonly used chemotherapeutic agent in gastric cancer. We conclude that fusion of the SLC1A2 gene coding region to CD44 regulatory elements likely causes SLC1A2 transcriptional dysregulation, because tumors expressing high SLC1A2 levels also tended to be CD44-SLC1A2-positive. CD44-SLC1A2 may represent a class of gene fusions in cancers that establish a pro-oncogenic metabolic milieu favoring tumor growth and survival.
    MeSH term(s) Blotting, Western ; Cell Line, Tumor ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Gene Fusion/genetics ; Glutamate Plasma Membrane Transport Proteins/genetics ; Humans ; Hyaluronan Receptors/genetics ; In Situ Hybridization, Fluorescence ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Tumor Cells, Cultured
    Chemical Substances Glutamate Plasma Membrane Transport Proteins ; Hyaluronan Receptors ; Recombinant Fusion Proteins ; SLC1A2 protein, human
    Language English
    Publishing date 2011-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.3001423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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