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  1. Article ; Online: Hindered Gamow-Teller decay to the odd-odd N=Z (62)Ga: absence of proton-neutron T=0 condensate in A=62.

    Grodner, E / Gadea, A / Sarriguren, P / Lenzi, S M / Grebosz, J / Valiente-Dobón, J J / Algora, A / Górska, M / Regan, P H / Rudolph, D / de Angelis, G / Agramunt, J / Alkhomashi, N / Amon Susam, L / Bazzacco, D / Benlliure, J / Benzoni, G / Boutachkov, P / Bracco, A /
    Caceres, L / Cakirli, R B / Crespi, F C L / Domingo-Pardo, C / Doncel, M / Dombrádi, Zs / Doornenbal, P / Farnea, E / Ganioğlu, E / Gelletly, W / Gerl, J / Gottardo, A / Hüyük, T / Kurz, N / Leoni, S / Mengoni, D / Molina, F / Morales, A I / Orlandi, R / Oktem, Y / Page, R D / Perez, D / Pietri, S / Podolyák, Zs / Poves, A / Quintana, B / Rinta-Antila, S / Rubio, B / Nara Singh, B S / Steer, A N / Verma, S / Wadsworth, R / Wieland, O / Wollersheim, H J

    Physical review letters

    2014  Volume 113, Issue 9, Page(s) 92501

    Abstract: ... is performed studying the Gamow-Teller decay of the T=1, J(π)=0+ ground state of (62)Ge into excited ... states of the odd-odd N=Z nucleus (62)Ga. The experiment is performed at GSI Helmholtzzentrum für ... of coherent T=0 proton-neutron correlations in (62)Ga. ...

    Abstract Search for a new kind of superfluidity built on collective proton-neutron pairs with aligned spin is performed studying the Gamow-Teller decay of the T=1, J(π)=0+ ground state of (62)Ge into excited states of the odd-odd N=Z nucleus (62)Ga. The experiment is performed at GSI Helmholtzzentrum für Shwerionenforshung with the (62)Ge ions selected by the fragment separator and implanted in a stack of Si-strip detectors, surrounded by the RISING Ge array. A half-life of T1/2=82.9(14)  ms is measured for the (62)Ge ground state. Six excited states of (62)Ga, populated below 2.5 MeV through Gamow-Teller transitions, are identified. Individual Gamow-Teller transition strengths agree well with theoretical predictions of the interacting shell model and the quasiparticle random phase approximation. The absence of any sizable low-lying Gamow-Teller strength in the reported beta-decay experiment supports the hypothesis of a negligible role of coherent T=0 proton-neutron correlations in (62)Ga.
    Language English
    Publishing date 2014-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.113.092501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The cathepsin B inhibitor, z-FA-FMK, inhibits human T cell proliferation in vitro and modulates host response to pneumococcal infection in vivo.

    Lawrence, Clare P / Kadioglu, Aras / Yang, Ai-Li / Coward, William R / Chow, Sek C

    Journal of immunology (Baltimore, Md. : 1950)

    2006  Volume 177, Issue 6, Page(s) 3827–3836

    Abstract: ... cell marker, CD69, was unaffected. Furthermore, z-FA-FMK blocks NF-kappaB activation, inhibits T cell ... in proliferating T cells. When administered in vivo, z-FA-FMK significantly increased pneumococcal growth ... The cathepsin B inhibitor, benzyloxycarbonyl-phenyl-alanyl-fluoromethylketone (z-FA-FMK ...

    Abstract The cathepsin B inhibitor, benzyloxycarbonyl-phenyl-alanyl-fluoromethylketone (z-FA-FMK) at nontoxic doses was found to be immunosuppressive and repressed human T cell proliferation induced by mitogens and IL-2 in vitro. We showed that z-FA-FMK suppresses the secretion of IL-2 and IFN-gamma as well as the expression of IL-2R alpha-chain (CD25) in activated T cells, whereas the expression of the early activated T cell marker, CD69, was unaffected. Furthermore, z-FA-FMK blocks NF-kappaB activation, inhibits T cell blast formation, and prevents cells from entering and leaving the cell cycle. z-FA-FMK inhibits the processing of caspase-8 and caspase-3 to their respective subunits in resting T cells stimulated through the Ag receptor, but has no effect on the activation of these caspases during Fas-induced apoptosis in proliferating T cells. When administered in vivo, z-FA-FMK significantly increased pneumococcal growth in both lungs and blood, compared with controls, in a mouse model of intranasal pneumococcal infection. Because host response to bronchopneumonia in mice is T cell dependent, our collective results demonstrated that z-FA-FMK is immunosuppressive in vitro and in vivo.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Apoptosis/immunology ; Cathepsin B/antagonists & inhibitors ; Cell Proliferation/drug effects ; Cells, Cultured ; Cysteine Proteinase Inhibitors/pharmacology ; Dipeptides/administration & dosage ; Dipeptides/pharmacology ; Female ; Growth Inhibitors/pharmacology ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/pharmacology ; Ketones/administration & dosage ; Ketones/pharmacology ; Mice ; Pneumococcal Infections/enzymology ; Pneumococcal Infections/immunology ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/growth & development ; T-Lymphocytes/drug effects ; T-Lymphocytes/enzymology ; T-Lymphocytes/immunology
    Chemical Substances Cysteine Proteinase Inhibitors ; Dipeptides ; Growth Inhibitors ; Immunosuppressive Agents ; Ketones ; MDL 201053 (1Q2Z3U96CG) ; Cathepsin B (EC 3.4.22.1)
    Language English
    Publishing date 2006-09-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.177.6.3827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Extracorporeal shock wave therapy for low back pain: A systematic review and meta-analysis.

    Wu, Zhuorao / Zhou, Tianqi / Ai, Shuangchun

    Medicine

    2024  Volume 102, Issue 52, Page(s) e36596

    Abstract: Background: To provide high-quality evidence for extracorporeal shock wave therapy (ESWT) for low back pain (LBP).: Methods: A computerized search screened trials of ESWT for LBP, and the time range was from the establishment of databases to August ... ...

    Abstract Background: To provide high-quality evidence for extracorporeal shock wave therapy (ESWT) for low back pain (LBP).
    Methods: A computerized search screened trials of ESWT for LBP, and the time range was from the establishment of databases to August 2023, including CNKI, CBMdisc, Wanfang Data, VIP, PubMed, Web of Science, Embase, and Cochrane databases. The outcomes were extracted, including patients' pain, physical and psychological conditions, and adverse reactions. Meta-analysis was completed using Revman 5.4 and Stata 15 software, and GRADEpro software quantitated rate the evidence and assigned a recommendation strength.
    Results: This meta-analysis included 22 studies involving 1749 patients. After treatment, patients in the ESWT group had lower scores in the visual analog scale (VAS) (mean difference [MD] = -1.14, 95% confidence interval [CI] (-1.47, -0.80), P < .00001), Oswestry disability index (ODI) [MD = -6.01, 95%CI (-7.97, -4.05), P < .00001], and Beck depression inventory [MD = -3.89, 95%CI (-6.59, -1.20), P = .005]; finger-floor distance [MD = -3.71, 95%CI (-5.26, -2.17), P < .00001] was shorter; Japanese orthopedic association scores [MD = 3.20, 95%CI (1.56, 4.85), P = .0001] were higher; at the 3-month follow-up, the VAS [MD = -1.29, 95%CI (-2.39, -0.19), P = .02] and ODI [MD = -5.95, 95%CI (-10.06, -1.84), P = .005] remained lower; adverse reactions [odds ratio = 0.19, 95%CI (0.07, 0.52), P = .001] were less, and the valid cases [odds ratio = 3.84, 95%CI (2.47, 5.96), P < .00001] were more. Sensitivity analyses revealed that the results were stable; Egger test found no publication bias in VAS (P = .270) and valid cases (P = .747); the trim and fill analysis tested the robustness of ODI scores due to the publication bias (P = .029), and the effect sizes before and after the trim and fill were consistent, which means the result was robust.
    Conclusion: ESWT for LBP has efficacy and safety in improving pain, dysfunction, and psychological conditions compared to other therapies. ESWT has shown advantages in terms of long-term efficacy. Randomized controlled trials with larger sample sizes and more objective outcomes are required.
    MeSH term(s) Humans ; Extracorporeal Shockwave Therapy ; Low Back Pain/therapy ; Exercise Therapy/methods ; Mental Disorders/therapy ; Pain Measurement ; Treatment Outcome
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000036596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Abnormal blood concentration changes in a 71-year-old female who survived a 10,000mg overdose of clozapine: a case report.

    Wu, Yonghua / Zhou, Ziyan / Ai, Ziyi / Wang, Tiancheng / Cui, Liyan

    BMC psychiatry

    2024  Volume 24, Issue 1, Page(s) 123

    Abstract: Background: Clozapine is a highly effective second-generation antipsychotic with few extrapyramidal reactions, making it a preferred choice among clinicians. However, instances of acute clozapine poisoning resulting from suicide attempts and misuse have ...

    Abstract Background: Clozapine is a highly effective second-generation antipsychotic with few extrapyramidal reactions, making it a preferred choice among clinicians. However, instances of acute clozapine poisoning resulting from suicide attempts and misuse have been reported. Through our review of existing literature, we identified that we believe to be the highest recorded overdose of clozapine in elderly patients, resulting in a nonfatal outcome.
    Case presentation: The case report involves a 71-year-old female with a history of depression who ingested a dose of 10,000 mg of clozapine. Approximately 6 h after the overdose, the clozapine level was 5,200 μg/L, significantly surpassing the recommended therapeutic concentration range of 350-600 μg/L. After gastric lavage and hemoperfusion, the blood level dropped to 1847.11 μg/L. Notably, during therapeutic drugs monitoring (TDM), we found a perplexing spike in the patient's blood level to 5554.15 μg/L after the second hemoperfusion.
    Conclusion: In this case we mainly focused on the abnormal fluctuations in the concentration of clozapine. We conducted a comprehensive analysis of potential factors contributing to this abnormal phenomenon in terms of the patient's age, clinical symptoms, various laboratory test indexes, and the pharmacokinetics of clozapine. Our findings underscore the importance of timely TDM and the precision of results in managing elderly patients experiencing high-dose clozapine poisoning.
    MeSH term(s) Aged ; Female ; Humans ; Antipsychotic Agents/poisoning ; Clozapine/poisoning ; Drug Monitoring/methods ; Drug Overdose ; Suicide, Attempted
    Chemical Substances Antipsychotic Agents ; Clozapine (J60AR2IKIC)
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Case Reports ; Review ; Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-024-05582-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardamonin-loaded liposomal formulation for improving percutaneous penetration and follicular delivery for androgenetic alopecia.

    Liu, Zhenda / He, Zehui / Ai, Xinyi / Guo, Teng / Feng, Nianping

    Drug delivery and translational research

    2024  

    Abstract: Androgenic alopecia (AGA) has a considerable impact on the physical and mental health of patients. Nano preparations have apparent advantages and high feasibility in the treatment of AGA. Cardamonin (CAR) has a wide range of pharmacological activities, ... ...

    Abstract Androgenic alopecia (AGA) has a considerable impact on the physical and mental health of patients. Nano preparations have apparent advantages and high feasibility in the treatment of AGA. Cardamonin (CAR) has a wide range of pharmacological activities, but it has the problems of poor solubility in water and low bioavailability. There are few, if any, researches on the use of nano-loaded CAR to improve topical skin delivery of AGA. In this study, a CAR-loaded liposomal formulation (CAR@Lip and CAR@Lip Gel) was developed and characterized. The prepared CAR@Lip exhibited a uniform and rounded vesicle in size. CAR@Lip and CAR@Lip Gel can significantly improve the cumulative release of CAR. Additionally, CAR@Lip can obviously promote the proliferation and migration of human dermal papilla cells (hDPCs). Cell uptake revealed that the uptake of CAR@Lip significantly increased compared with the free drug. Furthermore, both CAR@Lip and CAR@Lip Gel groups could markedly improve the transdermal performance of CAR, and increase the topical content of the drug in the hair follicle compared with CAR. The ratchet effect of hair follicles could improve the skin penetration depth of nanoformulations. Notably, Anti-AGA tests in the mice showed that CAR@Lip and CAR@Lip Gel groups could promote hair growth, and accelerate the transition of hair follicles to the growth stage. The anti-androgen effect was revealed by regulating the expression of IGF-1, VEGF, KGF, and TGF-β, participating in SHH/Gli and Wnt/β-catenin pathways. Importantly, the nanoformulations had no obvious skin irritation. Thus, our study showed that CAR-loaded liposomal formulation has potential application in the treatment of AGA.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-024-01519-8
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  6. Article ; Online: An Improved Nested U-Net Network for Fluorescence In Situ Hybridization Cell Image Segmentation.

    Jian, Zini / Song, Tianxiang / Zhang, Zhihui / Ai, Zhao / Zhao, Heng / Tang, Man / Liu, Kan

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 3

    Abstract: Fluorescence in situ hybridization (FISH) is a powerful cytogenetic method used to precisely detect and localize nucleic acid sequences. This technique is proving to be an invaluable tool in medical diagnostics and has made significant contributions to ... ...

    Abstract Fluorescence in situ hybridization (FISH) is a powerful cytogenetic method used to precisely detect and localize nucleic acid sequences. This technique is proving to be an invaluable tool in medical diagnostics and has made significant contributions to biology and the life sciences. However, the number of cells is large and the nucleic acid sequences are disorganized in the FISH images taken using the microscope. Processing and analyzing images is a time-consuming and laborious task for researchers, as it can easily tire the human eyes and lead to errors in judgment. In recent years, deep learning has made significant progress in the field of medical imaging, especially the successful application of introducing the attention mechanism. The attention mechanism, as a key component of deep learning, improves the understanding and interpretation of medical images by giving different weights to different regions of the image, enabling the model to focus more on important features. To address the challenges in FISH image analysis, we combined medical imaging with deep learning to develop the SEAM-Unet++ automated cell contour segmentation algorithm with integrated attention mechanism. The significant advantage of this algorithm is that it improves the accuracy of cell contours in FISH images. Experiments have demonstrated that by introducing the attention mechanism, our method is able to segment cells that are adherent to each other more efficiently.
    MeSH term(s) Humans ; In Situ Hybridization, Fluorescence ; Algorithms ; Eye ; Image Processing, Computer-Assisted ; Nucleic Acids
    Chemical Substances Nucleic Acids
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24030928
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  7. Article ; Online: Airborne spread of expiratory droplet nuclei between the occupants of indoor environments: A review.

    Ai, Z T / Melikov, A K

    Indoor air

    2018  Volume 28, Issue 4, Page(s) 500–524

    Abstract: This article reviews past studies of airborne transmission between occupants in indoor environments, focusing on the spread of expiratory droplet nuclei from mouth/nose to mouth/nose for non-specific diseases. Special attention is paid to summarizing ... ...

    Abstract This article reviews past studies of airborne transmission between occupants in indoor environments, focusing on the spread of expiratory droplet nuclei from mouth/nose to mouth/nose for non-specific diseases. Special attention is paid to summarizing what is known about the influential factors, the inappropriate simplifications of the thermofluid boundary conditions of thermal manikins, the challenges facing the available experimental techniques, and the limitations of available evaluation methods. Secondary issues are highlighted, and some new ways to improve our understanding of airborne transmission indoors are provided. The characteristics of airborne spread of expiratory droplet nuclei between occupants, which are influenced correlatively by both environmental and personal factors, were widely revealed under steady-state conditions. Owing to the different boundary conditions used, some inconsistent findings on specific influential factors have been published. The available instrumentation was too slow to provide accurate concentration profiles for time-dependent evaluations of events with obvious time characteristics, while computational fluid dynamics (CFD) studies were mainly performed in the framework of inherently steady Reynolds-averaged Navier-Stokes modeling. Future research needs in 3 areas are identified: the importance of the direction of indoor airflow patterns, the dynamics of airborne transmission, and the application of CFD simulations.
    MeSH term(s) Air Microbiology ; Air Movements ; Air Pollution, Indoor/analysis ; Computer Simulation ; Exhalation ; Humans ; Hydrodynamics ; Manikins
    Language English
    Publishing date 2018-05-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1081722-0
    ISSN 1600-0668 ; 0905-6947
    ISSN (online) 1600-0668
    ISSN 0905-6947
    DOI 10.1111/ina.12465
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  8. Article ; Online: Intermittent occupancy combined with ventilation: An efficient strategy for the reduction of airborne transmission indoors.

    Melikov, A K / Ai, Z T / Markov, D G

    The Science of the total environment

    2020  Volume 744, Page(s) 140908

    Abstract: It is important that efficient measures to reduce the airborne transmission of respiratory infectious diseases (including COVID-19) should be formulated as soon as possible to ensure a safe easing of lockdown. Ventilation has been widely recognized as an ...

    Abstract It is important that efficient measures to reduce the airborne transmission of respiratory infectious diseases (including COVID-19) should be formulated as soon as possible to ensure a safe easing of lockdown. Ventilation has been widely recognized as an efficient engineering control measure for airborne transmission. Room ventilation with an increased supply of clean outdoor air could dilute the expiratory airborne aerosols to a lower concentration level. However, sufficient increase is beyond the capacity of most of the existing mechanical ventilation systems that were designed to be energy efficient under non-pandemic conditions. We propose an improved control strategy based on source control, which would be achieved by implementing intermittent breaks in room occupancy, specifically that all occupants should leave the room periodically and the room occupancy time should be reduced as much as possible. Under the assumption of good mixing of clean outdoor supply air with room air, the evolution of the concentration in the room of aerosols exhaled by infected person(s) is predicted. The risk of airborne cross-infection is then evaluated by calculating the time-averaged intake fraction. The effectiveness of the strategy is demonstrated for a case study of a typical classroom. This strategy, together with other control measures such as continuous supply of maximum clean air, distancing, face-to-back layout of workstations and reducing activities that increase aerosol generation (e.g., loudly talking and singing), is applicable in classrooms, offices, meeting rooms, conference rooms, etc.
    MeSH term(s) Air Pollution, Indoor ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Ventilation
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.140908
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  9. Article ; Online: Metabolomics analysis of the yolk of Zhijin white goose during the embryogenesis based on LC-MS/MS.

    Zhao, Zhonglong / Yang, Hong / Wang, Zhiwei / Ai, Zhaobi / Yang, Runqian / Wang, Zhong / Wang, Tiansong / Fu, Kaibin / Zhang, Yong

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297429

    Abstract: The egg yolk of the goose is rich in lipids, proteins and minerals, which is the main source of nutrition during the goose embryogenesis. Actually, the magnitude and variety of nutrients in yolk are dynamically changed to satisfy the nutritional ... ...

    Abstract The egg yolk of the goose is rich in lipids, proteins and minerals, which is the main source of nutrition during the goose embryogenesis. Actually, the magnitude and variety of nutrients in yolk are dynamically changed to satisfy the nutritional requirements of different growth and development periods. The yolk sac membrane (YSM) plays a role in metabolizing and absorbing nutrients from the yolk, which are then consumed by the embryo or extra-fetal tissues. Therefore, identification of metabolites in egg yolk can help to reveal nutrient requirement in goose embryo. In this research, to explore the metabolite changes in egg yolk at embryonic day (E) 7, E12, E18, E23, and E28, we performed the assay using ultra-high performance liquid chromatography/tandem mass spectrometry (UHPLC-MS/MS). The findings showed that E7 and E12, E23 and E28 were grouped together, while E18 was significantly separated from other groups, indicating the changes of egg yolk development and metabolism. In total, 1472 metabolites were identified in the egg yolk of Zhijin white goose, and 636 differential metabolites (DMs) were screened, among which 264 were upregulated and 372 were downregulated. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the DMs were enriched in the biosynthesis and metabolism of amino acids, digestion and absorption of protein, citrate cycle (TCA cycle), aminoacyl-tRNA biosynthesis, phosphotransferase system (PTS), mineral absorption, cholesterol metabolism and pyrimidine metabolism. Our study may provide new ideas for improving prehatch embryonic health and nutrition.
    MeSH term(s) Animals ; Tandem Mass Spectrometry ; Liquid Chromatography-Mass Spectrometry ; Geese ; Chromatography, Liquid ; Embryonic Development ; Proteins/metabolism ; Metabolomics ; Egg Yolk/metabolism ; Minerals/analysis ; Yolk Sac
    Chemical Substances Proteins ; Minerals
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297429
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  10. Article ; Online: Multi-omics analyses uncover metabolic signatures and gene expression profiles of interstitial cystitis/bladder pain syndrome.

    Yi, Xianyanling / Li, Jin / Han, Zeyu / Zhang, Tianyi / Liao, Dazhou / Lv, Xiaoyan / Ai, Jianzhong

    Neurourology and urodynamics

    2024  Volume 43, Issue 3, Page(s) 767–778

    Abstract: Background and objective: We explore molecular and metabolic pathways involved in interstitial cystitis (IC) with integrating multi-omics analysis for identifying potential diagnostic and therapeutic targets.: Methods: Mouse models of IC/bladder pain ...

    Abstract Background and objective: We explore molecular and metabolic pathways involved in interstitial cystitis (IC) with integrating multi-omics analysis for identifying potential diagnostic and therapeutic targets.
    Methods: Mouse models of IC/bladder pain syndrome (BPS) were established by intraperitoneal injection of cyclophosphamide and bladder tissue samples were collected for metabolomics and transcriptome analysis.
    Results: We found a total of 82 and 145 differential metabolites in positive ion modes and negative ion modes, respectively. Glycerophospholipid metabolism, choline metabolism in cancer, and nucleotide metabolism pathways were significantly enriched in the IC/BPS group. Transcriptome analysis demonstrated that 1069 upregulated genes and 1087 downregulated genes were detected. Importantly, the stronger enrichment for cell cycle pathway was observed in IC/BPS than that in normal bladder tissue, which may be involved in the process of bladder remodeling. Moreover, the inflammatory response and inflammatory factors related pathways were enriched in the IC/BPS group.
    Conclusions: Our findings provide critical directions for further exploration of the molecular pathology underlying IC/BPS.
    MeSH term(s) Animals ; Mice ; Cystitis, Interstitial/diagnosis ; Transcriptome ; Multiomics ; Urinary Bladder/metabolism ; Gene Expression Profiling
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604904-7
    ISSN 1520-6777 ; 0733-2467
    ISSN (online) 1520-6777
    ISSN 0733-2467
    DOI 10.1002/nau.25418
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