LIVIVO - Search results -

Search results

Result 1 - 10 of total 58

Search options

Article ; Online: Endocrine disruptors: Manmade and natural oestrogens: opposite effects on assisted reproduction.

vom Saal, Frederick S / Welshons, Wade V

2016 Volume 12, Issue 5, Page(s) 251–252

MeSH term(s)	Benzhydryl Compounds/urine ; Diet ; Female ; Humans ; Phenols/urine ; Pregnancy ; Pregnancy Outcome ; Reproductive Techniques, Assisted ; Soy Foods
Chemical Substances	Benzhydryl Compounds ; Phenols
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/nrendo.2016.38
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6336: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 93: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure.

vom Saal, Frederick S / Welshons, Wade V

Molecular and cellular endocrinology

2014 Volume 398, Issue 1-2, Page(s) 101–113

Abstract: There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels ...

Abstract	There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources.
MeSH term(s)	Animals ; Benzhydryl Compounds/blood ; Benzhydryl Compounds/toxicity ; Benzhydryl Compounds/urine ; Endocrine Disruptors/blood ; Endocrine Disruptors/toxicity ; Endocrine Disruptors/urine ; Environmental Exposure/analysis ; Environmental Monitoring/methods ; Humans ; Phenols/blood ; Phenols/toxicity ; Phenols/urine ; Risk Assessment
Chemical Substances	Benzhydryl Compounds ; Endocrine Disruptors ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2014-10-07
Publishing country	Ireland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2014.09.028
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1127: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

Vom Saal, Frederick S / Antoniou, Michael / Belcher, Scott M / Bergman, Ake / Bhandari, Ramji K / Birnbaum, Linda S / Cohen, Aly / Collins, Terrence J / Demeneix, Barbara / Fine, Anne Marie / Flaws, Jodi A / Gayrard, Veronique / Goodson, William H / Gore, Andrea C / Heindel, Jerrold J / Hunt, Patricia A / Iguchi, Taisen / Kassotis, Christopher D / Kortenkamp, Andreas /

Environmental health perspectives

2024 Volume 132, Issue 4, Page(s) 45001

Abstract: Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to : Objectives: We identify the flaws in the assumptions that the German BfR, as well as the ... ...

Abstract	Background: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for bisphenol A (BPA) 20,000-fold to Objectives: We identify the flaws in the assumptions that the German BfR, as well as the FDA, have used to justify maintaining the TDI for BPA at levels above what a vast amount of academic research shows to cause harm. We argue that regulatory agencies need to incorporate 21st century science into chemical hazard identifications using the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) nonguideline academic studies in a collaborative government-academic program model. Discussion: We strongly endorse EFSA's revised TDI for BPA and support the European Commission's (EC) apparent acceptance of this updated BPA risk assessment. We discuss challenges to current chemical risk assessment assumptions about EDCs that need to be addressed by regulatory agencies to, in our opinion, become truly protective of public health. Addressing these challenges will hopefully result in BPA, and eventually other structurally similar bisphenols (called regrettable substitutions) for which there are known adverse effects, being eliminated from all food-related and many other uses in the EU and elsewhere. https://doi.org/10.1289/EHP13812.
MeSH term(s)	Humans ; Benzhydryl Compounds ; Food Safety ; No-Observed-Adverse-Effect Level ; Phenols ; Systematic Reviews as Topic
Chemical Substances	Benzhydryl Compounds ; bisphenol A (MLT3645I99) ; Phenols
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/EHP13812
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Report of very low real-world exposure to bisphenol A is unwarranted based on a lack of data and flawed assumptions.

Vom Saal, Frederick S / Prins, Gail S / Welshons, Wade V

Toxicological sciences : an official journal of the Society of Toxicology

2012 Volume 125, Issue 1, Page(s) 318–20; author reply 321–5

MeSH term(s)	Environmental Monitoring/methods ; Environmental Pollutants/pharmacokinetics ; Estrogens, Non-Steroidal/pharmacokinetics ; Female ; Food Contamination/analysis ; Humans ; Male ; Phenols/pharmacokinetics
Chemical Substances	Environmental Pollutants ; Estrogens, Non-Steroidal ; Phenols
Language	English
Publishing date	2012-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfr273
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1709: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure

vom Saal, Frederick S / Wade V. Welshons

Molecular and Cellular Endocrinology. 2014 Dec., v. 398

2014

Abstract	There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources.
Keywords	adverse effects ; algorithms ; bisphenol A ; blood serum ; exposure pathways ; humans ; metabolites ; prediction ; urine
Language	English
Dates of publication	2014-12
Size	p. 101-113.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2014.09.028
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1127: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Comment on "Optimal Exposure Biomarkers for Nonpersistent Chemicals in Environmental Epidemiology".

Stahlhut, Richard W / van Breemen, Richard B / Gerona, Roy R / Taylor, Julia A / Welshons, Wade V / vom Saal, Frederick S

Environmental health perspectives

2016 Volume 124, Issue 4, Page(s) A66

MeSH term(s)	Biomarkers/blood ; Biomarkers/urine ; Environmental Exposure/analysis ; Environmental Monitoring/methods ; Environmental Pollutants/blood ; Environmental Pollutants/urine ; Humans
Chemical Substances	Biomarkers ; Environmental Pollutants
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.1511057
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾

Article ; Online: Should oral gavage be abandoned in toxicity testing of endocrine disruptors?

Vandenberg, Laura N / Welshons, Wade V / Vom Saal, Frederick S / Toutain, Pierre-Louis / Myers, John Peterson

Environmental health : a global access science source

2014 Volume 13, Issue 1, Page(s) 46

Abstract: For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine ... ...

Abstract	For decades, hazard assessments for environmental chemicals have used intra-gastric gavage to assess the effects of 'oral' exposures. It is now widely used--and in some cases required--by US federal agencies to assess potential toxicity of endocrine disrupting chemicals (EDCs). In this review we enumerate several reasons why gavage is not appropriate for the assessment of EDCs using bisphenol A (BPA) as a main example. First, whereas human dietary exposures interact with the oral mucosa, gavage exposures avoid these interactions, leading to dramatic differences in absorption, bioavailability and metabolism with implications for toxicokinetic assumptions and models. Additionally, there are well acknowledged complications associated with gavage, such as perforation of the esophagus that diminish its value in toxicological experiments. Finally, the gavage protocol itself can induce stress responses by the endocrine system and confound the assessment of EDCs. These serious flaws have not been taken into account in interpreting results of EDC research. We propose the exploration of alternatives to mimic human exposures when there are multiple exposure routes/sources and when exposures are chronic. We conclude that gavage may be preferred over other routes for some environmental chemicals in some circumstances, but it does not appropriately model human dietary exposures for many chemicals. Because it avoids exposure pathways, is stressful, and thus interferes with endocrine responses, gavage should be abandoned as the default route of administration for hazard assessments of EDCs.
MeSH term(s)	Administration, Oral ; Animals ; Diet ; Endocrine Disruptors/administration & dosage ; Endocrine Disruptors/pharmacokinetics ; Endocrine Disruptors/toxicity ; Environmental Pollutants/administration & dosage ; Environmental Pollutants/pharmacokinetics ; Environmental Pollutants/toxicity ; Humans ; Stress, Psychological ; Toxicity Tests/methods
Chemical Substances	Endocrine Disruptors ; Environmental Pollutants
Language	English
Publishing date	2014-06-25
Publishing country	England
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ISSN	1476-069X
ISSN (online)	1476-069X
DOI	10.1186/1476-069X-13-46
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both.

Stahlhut, Richard W / Welshons, Wade V / Swan, Shanna H

Environmental health perspectives

2009 Volume 117, Issue 5, Page(s) 784–789

Abstract: Background: It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels in fasting ... ...

Abstract	Background: It is commonly stated in the literature on human exposure to bisphenol A (BPA) that food is the predominant BPA exposure source, and that BPA is rapidly and completely cleared from the body. If this is correct, BPA levels in fasting individuals should decrease with increased fasting time. Objectives: We set out to investigate the relationship between urine BPA concentration and fasting time in a population-based sample. Methods: We modeled log BPA urine concentration as a function of fasting time, adjusted for urine creatinine and other confounders, in 1,469 adult participants in the 2003-2004 National Health and Nutrition Examination Survey. We estimated the BPA "population-based half-life" (pop(1/2)) for a fasting time of 0-24 hr, < 4.5 hr, 4.5-8.5 hr, and > 8.5 hr. Results: The overall pop(1/2) for the 0- to 24-hr interval was 43 hr [95% confidence interval (CI), 26-119 hr]. Among those reporting fasting times of 4.5-8.5 hr (n = 441), BPA declined significantly with fasting time, with a pop(1/2) of 4.1 hr (95% CI, 2.6-10.6 hr). However, within the fasting time intervals of 0-4.5 hr (n = 129) and 8.5-24 hr (n = 899), we saw no appreciable decline. Fasting time did not significantly predict highest (> 12 ng/mL) or lowest (below limit of detection) BPA levels. Conclusions: Overall, BPA levels did not decline rapidly with fasting time in this sample. This suggests substantial nonfood exposure, accumulation in body tissues such as fat, or both. Explaining these findings may require experimental pharmacokinetic studies of chronic BPA exposure, further examination of BPA levels and effects in fat, and a search for important nonfood sources.
MeSH term(s)	Adult ; Aged ; Benzhydryl Compounds ; Environmental Exposure ; Environmental Monitoring ; Fasting ; Female ; Half-Life ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Phenols/analysis ; Phenols/pharmacokinetics ; Phenols/urine ; Young Adult
Chemical Substances	Benzhydryl Compounds ; Phenols ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2009-01-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	195189-0
ISSN	1552-9924 ; 0091-6765 ; 1078-0475
ISSN (online)	1552-9924
ISSN	0091-6765 ; 1078-0475
DOI	10.1289/ehp.0800376
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1360: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 379: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A.

vom Saal, Frederick S / Welshons, Wade V

Environmental research

2006 Volume 100, Issue 1, Page(s) 50–76

Abstract: Over six-billion pounds per year of the monomer bisphenol A (BPA) are used to manufacture polycarbonate plastic products, resins lining cans, dental sealants, and polyvinyl chloride plastic products. There are 109 published studies as of July 2005 that ... ...

Abstract	Over six-billion pounds per year of the monomer bisphenol A (BPA) are used to manufacture polycarbonate plastic products, resins lining cans, dental sealants, and polyvinyl chloride plastic products. There are 109 published studies as of July 2005 that report significant effects of low doses of BPA in experimental animals, with many adverse effects occurring at blood levels in animals within and below average blood levels in humans; 40 studies report effects below the current reference dose of 50 microg/kg/day that is still assumed to be safe by the US-FDA and US-EPA in complete disregard of the published findings. The extensive list of significant findings from government-funded studies is compared to the 11 published studies that were funded by the chemical industry, 100% of which conclude that BPA causes no significant effects. We discuss the importance of appropriate controls in toxicological research and that positive controls are required to determine whether conclusions from experiments that report no significant effects are valid or false.
MeSH term(s)	Animals ; Benzhydryl Compounds ; Diethylstilbestrol/toxicity ; Environmental Pollutants/toxicity ; Estrogens, Non-Steroidal/toxicity ; Female ; Humans ; Male ; Phenols/toxicity ; Research Design ; Risk Assessment ; Toxicity Tests/methods ; United States ; United States Environmental Protection Agency ; United States Food and Drug Administration
Chemical Substances	Benzhydryl Compounds ; Environmental Pollutants ; Estrogens, Non-Steroidal ; Phenols ; Diethylstilbestrol (731DCA35BT) ; bisphenol A (MLT3645I99)
Language	English
Publishing date	2006-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2005.09.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 726: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Cell cycle proteins in normal and chemically induced abnormal secondary palate development: a review.

Dhulipala, Vamsidhara C / Welshons, Wade V / Reddy, Chada S

Human & experimental toxicology

2006 Volume 25, Issue 11, Page(s) 675–682

Abstract: Cell cycle progression and thus proper cell number is essential for normal development of organs and organisms. Craniofacial tissues including the secondary palate are vulnerable to disruption of cell cycle progression and proliferation by many chemicals ...

Abstract	Cell cycle progression and thus proper cell number is essential for normal development of organs and organisms. Craniofacial tissues including the secondary palate are vulnerable to disruption of cell cycle progression and proliferation by many chemicals including mycotoxin, secalonic acid D (SAD), glucocorticoids, retinoic acid and 2,3,7,8-tetrachlorodibenzodioxin. Induction of cleft palate (CP) by SAD in mice occurs from a reduction in the size of developing palatal shelves. This is associated with an inhibition of proliferation of murine and human embryonic palatal mesenchymal (MEPM and HEPM) cells as well as a G1/S block of cell cycle. In murine embryonic palates and HEPM cells, SAD inhibited G1/S-phase-specific cyclin-dependent kinase (CDK)2 activity, reduced the level of cyclin E and increased the level of the CDK2 inhibitor, p21. These results, together with those from other laboratories, suggest that common cell cycle protein targets (biomarkers), relevant to the pathogenesis of CP by multiple chemical exposures, that can form the basis for the diagnosis and the development of preventive strategies, are likely to exist.
MeSH term(s)	Abnormalities, Drug-Induced/metabolism ; Animals ; Cell Cycle Proteins/metabolism ; Cleft Palate/etiology ; Cleft Palate/metabolism ; Embryonic Development/drug effects ; Embryonic Development/physiology ; Humans ; Palate/abnormalities ; Palate/embryology ; Palate/metabolism ; Teratogens/toxicity
Chemical Substances	Cell Cycle Proteins ; Teratogens
Language	English
Publishing date	2006-11
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1027454-6
ISSN	1477-0903 ; 0960-3271 ; 0144-5952
ISSN (online)	1477-0903
ISSN	0960-3271 ; 0144-5952
DOI	10.1177/0960327106070848
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1697: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito