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  1. Article ; Online: Oxygen therapy attenuates neuroinflammation after spinal cord injury.

    Sunshine, Michael D / Bindi, Victoria E / Nguyen, Branden L / Doerr, Vivian / Boeno, Franccesco P / Chandran, Vijayendran / Smuder, Ashley J / Fuller, David D

    Journal of neuroinflammation

    2023  Volume 20, Issue 1, Page(s) 303

    Abstract: Acute hyperbaric ... ...

    Abstract Acute hyperbaric O
    MeSH term(s) Rats ; Male ; Female ; Animals ; Hyperbaric Oxygenation ; Neuroinflammatory Diseases ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/therapy ; Spinal Cord Injuries/metabolism ; Spinal Cord/pathology ; Inflammation/metabolism ; Oxygen/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-023-02985-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hyperbaric Oxygen Therapy after Mid-Cervical Spinal Contusion Injury.

    Turner, Sara M F / Sunshine, Michael D / Chandran, Vijayendran / Smuder, Ashley J / Fuller, David D

    Journal of neurotrauma

    2022  Volume 39, Issue 9-10, Page(s) 715–723

    Abstract: Hyperbaric oxygen (HBO) therapy is frequently used to treat peripheral wounds or decompression sickness. Evidence suggests that HBO therapy can provide neuroprotection and has an anti-inflammatory impact after neurological injury, including spinal cord ... ...

    Abstract Hyperbaric oxygen (HBO) therapy is frequently used to treat peripheral wounds or decompression sickness. Evidence suggests that HBO therapy can provide neuroprotection and has an anti-inflammatory impact after neurological injury, including spinal cord injury (SCI). Our primary purpose was to conduct a genome-wide screening of mRNA expression changes in the injured spinal cord after HBO therapy. An mRNA gene array was used to evaluate samples taken from the contused region of the spinal cord following a lateralized mid-cervical contusion injury in adult female rats. HBO therapy consisted of daily, 1-h sessions (3.0 ATA, 100% O
    MeSH term(s) Animals ; Contusions ; Female ; Humans ; Hyperbaric Oxygenation ; Neck Injuries ; RNA, Messenger/metabolism ; Rats ; Spinal Cord/metabolism ; Spinal Cord Injuries
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2021.0412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel roles of phentolamine in protecting axon myelination, muscle atrophy, and functional recovery following nerve injury.

    Zainul, Zarin / Ma, Bo / Koka, Mert / Wilkerson, Jenny L / Ortiz, Yuma T / Kerosuo, Laura / Chandran, Vijayendran

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 3344

    Abstract: Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery following ... ...

    Abstract Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery following PNI remains a challenge. This study demonstrates that phentolamine may hold a significant promise in treating nerve injuries and denervation induced muscle atrophy following PNI. In a sciatic nerve crush injury mouse model, we found that phentolamine treatment enhanced motor and functional recovery, protected axon myelination, and attenuated injury-induced muscle atrophy in mice at 14 days post-injury (dpi) compared to saline treatment. In the soleus of phentolamine treated animals, we observed the downregulation of phosphorylated signal transducer and activator of transcription factor 3 (p-STAT3) as well as muscle atrophy-related genes Myogenin, muscle ring finger 1 (MuRF-1), and Forkhead box O proteins (FoxO1, FoxO3). Our results show that both nerve and muscle recovery are integral components of phentolamine treatment-induced global functional recovery in mice at 14 dpi. Moreover, phentolamine treatment improved locomotor functional recovery in the mice after spinal cord crush (SCC) injury. The fact that phentolamine is an FDA approved non-selective alpha-adrenergic blocker, clinically prescribed for oral anesthesia reversal, hypertension, and erectile dysfunction makes this drug a promising candidate for repurposing in restoring behavioral recovery following PNI and SCC injuries, axonal neuropathy, and muscle wasting disorders.
    MeSH term(s) Animals ; Axons/metabolism ; Humans ; Male ; Mice ; Muscle, Skeletal/pathology ; Muscular Atrophy/pathology ; Nerve Regeneration ; Peripheral Nerve Injuries ; Phentolamine/therapeutic use ; Recovery of Function/physiology ; Sciatic Nerve/injuries ; Sciatic Neuropathy
    Chemical Substances Phentolamine (Z468598HBV)
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-07253-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel roles of phentolamine in protecting axon myelination, muscle atrophy, and functional recovery following nerve injury

    Zarin Zainul / Bo Ma / Mert Koka / Jenny L. Wilkerson / Yuma T. Ortiz / Laura Kerosuo / Vijayendran Chandran

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 14

    Abstract: Abstract Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery ... ...

    Abstract Abstract Incomplete functional recovery after peripheral nerve injury (PNI) often results in devastating physical disabilities in human patients. Despite improved progress in surgical and non-surgical approaches, achieving complete functional recovery following PNI remains a challenge. This study demonstrates that phentolamine may hold a significant promise in treating nerve injuries and denervation induced muscle atrophy following PNI. In a sciatic nerve crush injury mouse model, we found that phentolamine treatment enhanced motor and functional recovery, protected axon myelination, and attenuated injury-induced muscle atrophy in mice at 14 days post-injury (dpi) compared to saline treatment. In the soleus of phentolamine treated animals, we observed the downregulation of phosphorylated signal transducer and activator of transcription factor 3 (p-STAT3) as well as muscle atrophy-related genes Myogenin, muscle ring finger 1 (MuRF-1), and Forkhead box O proteins (FoxO1, FoxO3). Our results show that both nerve and muscle recovery are integral components of phentolamine treatment-induced global functional recovery in mice at 14 dpi. Moreover, phentolamine treatment improved locomotor functional recovery in the mice after spinal cord crush (SCC) injury. The fact that phentolamine is an FDA approved non-selective alpha-adrenergic blocker, clinically prescribed for oral anesthesia reversal, hypertension, and erectile dysfunction makes this drug a promising candidate for repurposing in restoring behavioral recovery following PNI and SCC injuries, axonal neuropathy, and muscle wasting disorders.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Thesis: Proteome, transcriptome and metabolome plasticity in closely related strains of Escherichia coli-K12 and its diversity during molecular evolution processes

    Vijayendran, Chandran

    2007  

    Author's details Chandran Vijayendran
    Language English
    Size X, 124 Bl., graph. Darst, 30 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Bielefeld, 2007
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book ; Online ; Thesis: Proteome, transcriptome and metabolome plasticity in closely related strains of Escherichia coli- K12 and its diversity during molecular evolution processes

    Vijayendran, Chandran

    2007  

    Author's details Chandran Vijayendran
    Language English
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Bielefeld, 2007
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  7. Book ; Online ; Thesis: Proteome, transcriptome and metabolome plasticity in closely related strains of Escherichia coli- K12 and its diversity during molecular evolution processes

    Vijayendran, Chandran [Verfasser]

    2007  

    Author's details Chandran Vijayendran
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  8. Article: Impact of profiling technologies in the understanding of recombinant protein production.

    Vijayendran, Chandran / Flaschel, Erwin

    Advances in biochemical engineering/biotechnology

    2010  Volume 121, Page(s) 45–70

    Abstract: Since expression profiling methods have been available in a high throughput fashion, the implication of these technologies in the field of biotechnology has increased dramatically. Microarray technology is one such unique and efficient methodology for ... ...

    Abstract Since expression profiling methods have been available in a high throughput fashion, the implication of these technologies in the field of biotechnology has increased dramatically. Microarray technology is one such unique and efficient methodology for simultaneous exploration of expression levels of numerous genes. Likewise, two-dimensional gel electrophoresis or multidimensional liquid chromatography coupled with mass spectrometry are extensively utilised for studying expression levels of numerous proteins. In the field of biotechnology these highly parallel analytical methods have paved the way to study and understand various biological phenomena depending on expression patterns. The next phenomenological level is represented by the metabolome and the (metabolic) fluxome. However, this chapter reviews gene and protein profiling and their impact on understanding recombinant protein production. We focus on the computational methods utilised for the analyses of data obtained from these profiling technologies as well as prominent results focusing on recombinant protein expression with Escherichia coli. Owing to the knowledge accumulated with respect to cellular signals triggered during recombinant protein production, this field is on the way to design strategies for developing improved processes. Both gene and protein profiling have exhibited a handful of functional categories to concentrate on in order to identify target genes and proteins, respectively, involved in the signalling network with major impact on recombinant protein production.
    MeSH term(s) Algorithms ; Computer Simulation ; Gene Expression Regulation/physiology ; Microarray Analysis/methods ; Models, Biological ; Peptide Mapping/methods ; Protein Interaction Mapping/methods ; Proteome/metabolism ; Recombinant Proteins/biosynthesis ; Signal Transduction/physiology
    Chemical Substances Proteome ; Recombinant Proteins
    Language English
    Publishing date 2010
    Publishing country Germany
    Document type Journal Article
    ISSN 0724-6145
    ISSN 0724-6145
    DOI 10.1007/10_2009_56
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat.

    Chandran, Vijayendran / Bermúdez, Mei-Ling / Koka, Mert / Chandran, Brindha / Pawale, Dhanashri / Vishnubhotla, Ramana / Alankar, Suresh / Maturi, Raj / Subramaniam, Balachundhar / Sadhasivam, Senthilkumar

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 51

    Abstract: The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with ... ...

    Abstract The positive impact of meditation on human well-being is well documented, yet its molecular mechanisms are incompletely understood. We applied a comprehensive systems biology approach starting with whole-blood gene expression profiling combined with multilevel bioinformatic analyses to characterize the coexpression, transcriptional, and protein-protein interaction networks to identify a meditation-specific core network after an advanced 8-d Inner Engineering retreat program. We found the response to oxidative stress, detoxification, and cell cycle regulation pathways were down-regulated after meditation. Strikingly, 220 genes directly associated with immune response, including 68 genes related to interferon signaling, were up-regulated, with no significant expression changes in the inflammatory genes. This robust meditation-specific immune response network is significantly dysregulated in multiple sclerosis and severe COVID-19 patients. The work provides a foundation for understanding the effect of meditation and suggests that meditation as a behavioral intervention can voluntarily and nonpharmacologically improve the immune response for treating various conditions associated with excessive or persistent inflammation with a dampened immune system profile.
    MeSH term(s) Adult ; COVID-19/immunology ; COVID-19/metabolism ; Diet, Vegan ; Female ; Genome, Human ; Humans ; Immune System/metabolism ; Male ; Meditation ; Multiple Sclerosis/immunology ; Multiple Sclerosis/metabolism ; Protein Interaction Maps ; Transcriptome
    Language English
    Publishing date 2021-12-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2110455118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  10. Article ; Online: Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia.

    Chandran, Vijayendran / Gao, Kun / Swarup, Vivek / Versano, Revital / Dong, Hongmei / Jordan, Maria C / Geschwind, Daniel H

    eLife

    2017  Volume 6

    Abstract: Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We developed an inducible mouse model ... ...

    Abstract Friedreich's ataxia (FRDA), the most common inherited ataxia, is caused by recessive mutations that reduce the levels of frataxin (FXN), a mitochondrial iron binding protein. We developed an inducible mouse model of
    MeSH term(s) Animals ; Disease Models, Animal ; Friedreich Ataxia/pathology ; Gene Expression Regulation ; Gene Knockdown Techniques ; Humans ; Iron-Binding Proteins/biosynthesis ; Iron-Binding Proteins/genetics ; Mice ; Phenotype ; Frataxin
    Chemical Substances Iron-Binding Proteins
    Language English
    Publishing date 2017-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.30054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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