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  1. Article ; Online: Experimental Models to Study the Pathogenesis and Treatment of Mucormycosis.

    Ben-Ami, Ronen

    Journal of fungi (Basel, Switzerland)

    2024  Volume 10, Issue 1

    Abstract: Mucormycosis presents a formidable challenge to clinicians and researchers. Animal models are an essential part of the effort to decipher the pathogenesis of mucormycosis and to develop novel pharmacotherapeutics against it. Diverse model systems have ... ...

    Abstract Mucormycosis presents a formidable challenge to clinicians and researchers. Animal models are an essential part of the effort to decipher the pathogenesis of mucormycosis and to develop novel pharmacotherapeutics against it. Diverse model systems have been established, using a range of animal hosts, immune and metabolic perturbations, and infection routes. An understanding of the characteristics, strengths, and drawbacks of these models is needed to optimize their use for specific research aims.
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof10010085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Systemic Antifungal Therapy for Invasive Pulmonary Infections.

    Ben-Ami, Ronen

    Journal of fungi (Basel, Switzerland)

    2023  Volume 9, Issue 2

    Abstract: Antifungal therapy for pulmonary fungal diseases is in a state of flux. Amphotericin B, the time-honored standard of care for many years, has been replaced by agents demonstrating superior efficacy and safety, including extended-spectrum triazoles and ... ...

    Abstract Antifungal therapy for pulmonary fungal diseases is in a state of flux. Amphotericin B, the time-honored standard of care for many years, has been replaced by agents demonstrating superior efficacy and safety, including extended-spectrum triazoles and liposomal amphotericin B. Voriconazole, which became the treatment of choice for most pulmonary mold diseases, has been compared with posaconazole and itraconazole, both of which have shown clinical efficacy similar to that of voriconazole, with fewer adverse events. With the worldwide expansion of azole-resistant
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof9020144
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The changing landscape of azole-resistant invasive candidiasis.

    Ben-Ami, Ronen

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2022  Volume 28, Issue 8, Page(s) 1055–1056

    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Azoles/pharmacology ; Azoles/therapeutic use ; Candidiasis ; Candidiasis, Invasive/diagnosis ; Candidiasis, Invasive/drug therapy ; Candidiasis, Invasive/microbiology ; Drug Resistance, Fungal ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Azoles
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2022.04.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  4. Article ; Online: Comparison of pregnancy rates in antagonist cycles after luteal support with GnRH-agonist versus progesterone: prospective randomized study.

    Buhbut, Eadit / Nabulsi, Rinad / Avigdor, Gilad / Ben-Ami, Ido

    Archives of gynecology and obstetrics

    2023  Volume 308, Issue 1, Page(s) 255–263

    Abstract: Purpose: To compare pregnancy rates in GnRH-antagonist cycles triggered with hCG after luteal phase support with intranasal GnRH-agonist as sole luteal phase support versus standard vaginal progesterone preparation.: Methods: Prospective randomized ... ...

    Abstract Purpose: To compare pregnancy rates in GnRH-antagonist cycles triggered with hCG after luteal phase support with intranasal GnRH-agonist as sole luteal phase support versus standard vaginal progesterone preparation.
    Methods: Prospective randomized controlled study of patients who underwent antagonist-based IVF cycles triggered with hCG at university-affiliated tertiary medical center between 2020 and 2022. Patients meeting the inclusion criteria were randomly assigned to either intranasal GnRH-agonist or vaginal progesterone for luteal phase support. Pregnancy rates were the main outcome compared between the two study groups.
    Results: A total of 150 patients underwent 164 cycles, 127 cycles of which were included in the study cohort. Of them, 64 (50.4%) and 63 (49.6%) cycles were treated with GnRH-agonist or progesterone, respectively, as sole luteal phase support. A significantly higher pregnancy rate was demonstrated in the GnRH-agonist group compared with the progesterone group. After adjustment of several potential confounders such as age, body mass index, past obstetric history, number of IVF cycles, oocyte retrieved and embryos transferred, GnRH-agonist was still associated with a higher pregnancy rate (odds ratio 3.4, 95% confidence interval 1.4-8.3). Ovarian hyperstimulation syndrome rates were similar between the groups.
    Conclusions: This prospective study suggests that nasal GnRH-agonist for luteal phase support is associated with higher pregnancy rates compared with standard progesterone support in an antagonist-based protocol triggered with hCG, while maintaining a similar safety profile.
    Trial registration: Clinicaltrials.gov NCT05484193. Date of registration: August 02 2022. The trial was retrospectively registered.
    MeSH term(s) Pregnancy ; Female ; Humans ; Progesterone ; Pregnancy Rate ; Prospective Studies ; Fertilization in Vitro/methods ; Gonadotropin-Releasing Hormone ; Luteal Phase/physiology ; Ovulation Induction/methods ; Chorionic Gonadotropin
    Chemical Substances Progesterone (4G7DS2Q64Y) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Chorionic Gonadotropin
    Language English
    Publishing date 2023-04-25
    Publishing country Germany
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 896455-5
    ISSN 1432-0711 ; 0932-0067
    ISSN (online) 1432-0711
    ISSN 0932-0067
    DOI 10.1007/s00404-023-07017-5
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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.55: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Corynebacterium bovis surgical site infection and brain abscess: The first case report and literature review.

    Gabay, Segev / Tene, Yael / Ben-Ami, Ronen / Shapira, Yuval

    IDCases

    2023  Volume 33, Page(s) e01782

    Abstract: Corynebacterium ... ...

    Abstract Corynebacterium bovis
    Language English
    Publishing date 2023-05-08
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2023.e01782
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  6. Article ; Online: Effectiveness and safety of an institutional aminoglycoside-based regimen as empirical treatment of patients with pyelonephritis-authors' response.

    Elbaz, Meital / Ben-Ami, Ronen

    The Journal of antimicrobial chemotherapy

    2020  Volume 75, Issue 12, Page(s) 3697–3698

    MeSH term(s) Aminoglycosides/adverse effects ; Anti-Bacterial Agents/adverse effects ; Humans ; Protein Synthesis Inhibitors ; Pyelonephritis/drug therapy
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Protein Synthesis Inhibitors
    Language English
    Publishing date 2020-10-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Show issues

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  7. Article ; Online: Treatment of Invasive Candidiasis: A Narrative Review.

    Ben-Ami, Ronen

    Journal of fungi (Basel, Switzerland)

    2018  Volume 4, Issue 3

    Abstract: Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals. Management of invasive candidiasis must take into account multiple host, ... ...

    Abstract Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals. Management of invasive candidiasis must take into account multiple host, pathogen, and drug-related factors, including the site of infection, host immune status, severity of sepsis, resistance and tolerance to antifungal agents, biofilm formation, and pharmacokinetic/pharmacodynamic considerations. Recent treatment directives have been shaped by the widespread introduction of echinocandins, highly potent and safe antifungals, into clinical use, as well as important changes in drug susceptibility patterns and the emergence of known and novel drug-resistant Candida species. Advances in molecular diagnostics have the potential to guide early targeted treatment of high-risk patients.
    Language English
    Publishing date 2018-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof4030097
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  8. Article ; Online: Frequency and Clinical Features of

    Elbaz, Meital / Chikly, Amanda / Meilik, Ronnie / Ben-Ami, Ronen

    Journal of fungi (Basel, Switzerland)

    2022  Volume 8, Issue 2

    Abstract: The urinary tract is considered an uncommon source ... ...

    Abstract The urinary tract is considered an uncommon source of
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof8020123
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  9. Article ; Online: Nocardia cyriacigeorgica brain abscess in a patient on low dose steroids: a case report and review of the literature.

    Gabay, Segev / Yakubovsky, Michal / Ben-Ami, Ronen / Grossman, Rachel

    BMC infectious diseases

    2022  Volume 22, Issue 1, Page(s) 635

    Abstract: Background: Nocardia cyriacigeorgica was first described in 2001. It is an emerging pathogen that mainly affects immunocompromised patients. A brain abscess caused by N. cyriacigeorgica has been reported only in immunocompromised hosts. We present a ... ...

    Abstract Background: Nocardia cyriacigeorgica was first described in 2001. It is an emerging pathogen that mainly affects immunocompromised patients. A brain abscess caused by N. cyriacigeorgica has been reported only in immunocompromised hosts. We present a rare case of brain abscess caused by N. cyriacigeorgica in an adult male receiving low dose steroids.
    Case presentation: A 75-year-old male weekend gardener without an immunocompromising condition presented with neurological complaints that were initially attributed to an ischemic stroke. Due to the unusual presentation and rapid progression, his condition was thought to be caused by a cerebral space-occupying lesion. He underwent an emergent right-sided parietal craniotomy and the histopathological report of the specimen was an abscess caused by N. cyriacigeorgica. The patient received appropriate antibiotic treatment and completely recovered without sequelae.
    Conclusions: Nocardia species are a rare cause of brain abscess in immunocompetent patients. Their clinical presentation can mimic other more common cerebral diseases, such as brain tumors (primary and secondary) and stroke. The possibility of an abscess caused by N. cyriacigeorgica should also be considered in the differential diagnosis in an immunocompetent patient.
    MeSH term(s) Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Brain Abscess/diagnosis ; Brain Abscess/drug therapy ; Brain Abscess/surgery ; Humans ; Male ; Nocardia ; Nocardia Infections/complications ; Nocardia Infections/diagnosis ; Nocardia Infections/drug therapy ; Steroids/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Steroids
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-022-07612-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Exposure to Non-Antimicrobial Drugs and Risk of Infection with Antibiotic-Resistant Enterobacteriaceae.

    Elbaz, Meital / Stein, Esther / Raykhshtat, Eli / Weiss-Meilik, Ahuva / Cohen, Regev / Ben-Ami, Ronen

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Antimicrobial resistance (AMR) has consistently been linked to antibiotic use. However, the roles of commonly prescribed non-antimicrobial drugs as drivers of AMR may be under-appreciated. Here, we studied a cohort of patients with community-acquired ... ...

    Abstract Antimicrobial resistance (AMR) has consistently been linked to antibiotic use. However, the roles of commonly prescribed non-antimicrobial drugs as drivers of AMR may be under-appreciated. Here, we studied a cohort of patients with community-acquired pyelonephritis and assessed the association of exposure to non-antimicrobial drugs at the time of hospital admission with infection with drug-resistant organisms (DRO). Associations identified on bivariate analyses were tested using a treatment effects estimator that models both outcome and treatment probability. Exposure to proton-pump inhibitors, beta-blockers, and antimetabolites was significantly associated with multiple resistance phenotypes. Clopidogrel, selective serotonin reuptake inhibitors, and anti-Xa agents were associated with single-drug resistance phenotypes. Antibiotic exposure and indwelling urinary catheters were covariates associated with AMR. Exposure to non-antimicrobial drugs significantly increased the probability of AMR in patients with no other risk factors for resistance. Non-antimicrobial drugs may affect the risk of infection with DRO through multiple mechanisms. If corroborated using additional datasets, these findings offer novel directions for predicting and mitigating AMR.
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12040789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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