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Article ; Online: Correction: Tian et al. The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease.

Tian, Yu / Zhao, Mengxi / Chen, Yiyi / Yang, Mo / Wang, Yilong

2023 Volume 13, Issue 4

Abstract: In the published publication [ ... ]. ...

Abstract	In the published publication [...].
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13040705
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Article: [The "jīvanīya class of herbs" (Shi Tian Yao) in

Shi, S Y / Wang, X Y / Duan, Y S

Zhonghua yi shi za zhi (Beijing, China : 1980)

2022 Volume 52, Issue 2, Page(s) 67–74

Abstract: The Bower ... ...

Abstract	The Bower Manuscript
MeSH term(s)	Books ; Child ; Fritillaria ; Humans ; Medicine, Ayurvedic/history ; Medicine, Chinese Traditional/history ; Medicine, Traditional
Language	Chinese
Publishing date	2022-05-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20210319-00043
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Zs.A 4688: Show issues

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Article ; Online: Tian et al. reply.

Tian, Yongjun / Xu, Bo / Yu, Dongli / Ma, Yanming / Wang, Yanbin / Jiang, Yingbing / Hu, Wentao / Tang, Chengchun / Gao, Yufei / Luo, Kun / Zhao, Zhisheng / Wang, Li-Min / Wen, Bin / He, Julong / Liu, Zhongyuan

Nature

2013 Volume 502, Issue 7472, Page(s) E2–3

Language	English
Publishing date	2013-10-23
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/nature12621
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Article: Does the "Tian-Ren-He-Yi" Belief System Promote Corporate Environmental Performance?

Lai, Jieji / Liu, Bin / Wang, Hong

Frontiers in psychology

2022 Volume 13, Page(s) 886114

Abstract: Buddhism and Taoism are among two of the major religions in China. Their "Tian-ren-he-yi" belief ... Furthermore, mechanism tests show that the "Tian-ren-he-yi" belief system promotes corporate environmental ...

Abstract	Buddhism and Taoism are among two of the major religions in China. Their "Tian-ren-he-yi" belief system promotes a conception of harmony between man and nature, which is an important guide for the construction of ecological civilization in China. Using data from Chinese listed manufacturing companies, this paper explores the impact and mechanism of Chinese local religious beliefs on corporate environmental governance. The results indicate that this belief system can improve corporate environmental performance. Furthermore, mechanism tests show that the "Tian-ren-he-yi" belief system promotes corporate environmental practices by reducing the pressure on management to achieve economic performance goals and increasing investment in environmental protection. Finally, the impact of the belief system on corporate environmental performance is more efficacious when the enterprises are under weak external supervision. Our results imply that the traditional religious culture is an important factor that influences corporate environmental performance in Chinese business practices.
Language	English
Publishing date	2022-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.886114
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Article ; Online: Optimization of the Zhou Tian Formula extraction technology based on AHP-CRITIC method and analysis of transfer efficiency of key components based on HPLC fingerprinting.

Ma, Yi-Feng / Feng, Yang / Yao, Li-Li / Feng, Pei-Shi / Zhou, Wei-Kang / Fang, Le-Xuan / Tao, Yi / Wang, Ping

Phytochemical analysis : PCA

2024

Abstract: Introduction: Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized ...

Abstract	Introduction: Zhou Tian Formula (ZTF) is an antidepressant traditional Chinese medicine utilized widely in clinical settings for the treatment of patients with depression. However, shortcomings persist in its extraction technology and quality control. Objective: This study aimed to propose a methodology for ZTF extraction technology based on the analytic hierarchy process (AHP)-criteria importance through intercriteria correlation (CRITIC) method and to establish a quality control framework for the efficient transfer of index components. Method: Firstly, we analyzed the chemical components of ZTF and determined the optimal extraction technology. Secondly, we calculated the transfer efficiency of the index components during the conversion of water decoction to extract powder and subsequently to granules. Thirdly, we established HPLC fingerprints for 15 batches of ZTF water decoction, extract powder, and granules. We employed SIMCA software to analyze the chemicals responsible for variations in quality among different batches of ZTF granules. Results: We determined the optimal extraction process. The average transfer efficiency of ferulic acid, puerarin, mirificin, isoferulic acid, and calycosin during the conversion of water decoction to extract powder and subsequently to granules exceeded 41%. The HPLC fingerprints of ZTF exhibited a similarity exceeding 0.890. Variable importance in projection values indicated that calycosin, ferulic acid, and puerarin were the primary contributors to quality variations. Conclusions: The AHP-CRITIC method, coupled with an orthogonal array design, could be used for exploring extraction technology. In addition, the rules governing the transfer of index components from water decoction to extract powder, and subsequently to granules, could be applied for the evaluation and quality assessment of ZTF.
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1073576-8
ISSN	1099-1565 ; 0958-0344
ISSN (online)	1099-1565
ISSN	0958-0344
DOI	10.1002/pca.3334
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Zs.A 4608: Show issues

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Article ; Online: Neuroprotective effect of the traditional decoction Tian-Si-Yin against Alzheimer's disease via suppression of neuroinflammation.

Zhou, Ling / Yang, Chunqing / Liu, Zhiqiang / Chen, Linlin / Wang, Ping / Zhou, Yuan / Yuan, Mei / Zhou, Lan-Ting / Wang, Xueren / Zhu, Ling-Qiang

Journal of ethnopharmacology

2023 Volume 321, Page(s) 117569

Abstract: ... neurodegenerative disease among old adults. As a traditional Chinese medicine, the herbal decoction Tian-Si-Yin consists ... Interestingly, Tian-Si-Yin has also been used to treat dementia, depression and other neurological conditions ... Aim of the study: To evaluate the therapeutic effect of the herbal formula Tian-Si-Yin against AD and ...

Abstract	Ethnopharmacological relevance: Alzheimer's disease (AD) is the most prevalent neurodegenerative disease among old adults. As a traditional Chinese medicine, the herbal decoction Tian-Si-Yin consists of Morinda officinalis How. and Cuscuta chinensis Lam., which has been widely used to nourish kidney. Interestingly, Tian-Si-Yin has also been used to treat dementia, depression and other neurological conditions. However, its therapeutic potential for neurodegenerative diseases such as AD and the underlying mechanisms remain unclear. Aim of the study: To evaluate the therapeutic effect of the herbal formula Tian-Si-Yin against AD and to explore the underlying mechanisms. Materials and methods: The N2a cells treated with amyloid β (Aβ) peptide or overexpressing amyloid precursor protein (APP) were used to establish cellular models of AD. The in vivo anti-AD effects were evaluated by using Caenorhabditis elegans and 3 × Tg-AD mouse models. Tian-Si-Yin was orally administered to the mice for 8 weeks at a dose of 10, 15 or 20 mg/kg/day, respectively. Its protective role on memory deficits of mice was examined using the Morris water maze and fear conditioning tests. Network pharmacology, proteomic analysis and ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UHPLC-MS/MS) were used to explore the underlying molecular mechanisms, which were further investigated by Western blotting and immunohistochemistry. Results: Tian-Si-Yin was shown to improve cell viability of Aβ-treated N2a cells and APP-expressing N2a-APP cells. Tian-Si-Yin was also found to reduce ROS level and extend lifespan of transgenic AD-like C. elegans model. Oral administration of Tian-Si-Yin at medium dose was able to effectively rescue memory impairment in 3 × Tg mice. Tian-Si-Yin was further shown to suppress neuroinflammation by inhibition of glia cell activation and downregulation of inflammatory cytokines, diminishing tau phosphoralytion and Aβ deposition in the mice. Using UHPLC-MS/MS and network pharmacology technologies, 17 phytochemicals from 68 components of Tian-Si-Yin were identified as potential anti-AD components. MAPK1, BRAF, TTR and Fyn were identified as anti-AD targets of Tian-Si-Yin from network pharmacology and mass spectrum. Conclusions: This study has established the protective effect of Tian-Si-Yin against AD and demonstrates that Tian-Si-Yin is capable of improving Aβ level, tau pathology and synaptic disorder by regulating inflammatory response.
MeSH term(s)	Mice ; Animals ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Neuroinflammatory Diseases ; Neurodegenerative Diseases/drug therapy ; Caenorhabditis elegans/metabolism ; Proteomics ; Tandem Mass Spectrometry ; Mice, Transgenic ; Maze Learning ; Amyloid beta-Protein Precursor/metabolism ; Memory Disorders/drug therapy ; Disease Models, Animal
Chemical Substances	Amyloid beta-Peptides ; Neuroprotective Agents ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2023-12-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117569
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Zs.A 1494: Show issues

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Article ; Online: Cross-reactive antibodies against monkeypox virus exist in the population immunized with vaccinia Tian Tan strain in China.

Zhen, Zida / Zhang, Linlin / Li, Qi / Zhu, Yun / Wang, Xiaohuan / Fu, Xiaoyan / Ai, Junhong / Wang, Ran / Xie, Zhengde / Ma, Shuxuan

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

2023 Volume 113, Page(s) 105477

Abstract: ... protection against reinfection by MPXV. The vaccinia Tian Tan (VTT) strain, which was widely inoculated ...

Abstract	Monkeypox virus (MPXV) belongs to the Orthopoxvirus genus. The worldwide outbreak of MPXV in 2022 has caused widespread concerns. Cross-reactive antibodies induced by vaccinia-inoculation can provide protection against reinfection by MPXV. The vaccinia Tian Tan (VTT) strain, which was widely inoculated in the Chinese population before the 1980s, has genomic differences from other vaccinia strains, although they all belong to the orthopoxviruses family. The current seroprevalence of VTT-vaccinated populations remains unclear more than four decades after the termination of vaccination campaigns in China. Our results showed that cross-reactive IgG antibodies against MPXV were present in 31.8% (75/236) of vaccinees four decades after VTT-vaccination, suggesting that vaccination with VTT may provide long-term protection against MPXV infection in some individuals.
MeSH term(s)	Humans ; Monkeypox virus/genetics ; Vaccinia/epidemiology ; Seroepidemiologic Studies ; Vaccinia virus/genetics ; Antibodies
Chemical Substances	Antibodies
Language	English
Publishing date	2023-06-29
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2037068-4
ISSN	1567-7257 ; 1567-1348
ISSN (online)	1567-7257
ISSN	1567-1348
DOI	10.1016/j.meegid.2023.105477
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Zs.A 5645: Show issues

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Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer.

Su, Lin / Zhang, Fei / Liu, Ming-Xi / Li, Hong / Li, Qiang / Zhu, Yang-Zhuangzhuang / Hou, Yi-Fei / Chen, Xiao / Wang, Xiao-Yu / Qian, Chun-Mei / Yao, Chao / Wang, Li-Xin / Jiao, Xiao-Ning / Zhu, Xian-Dan / Xu, Zi-Hang / Zou, Chun-Pu

Journal of ethnopharmacology

2023 Volume 313, Page(s) 116491

Abstract: Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD ...

Abstract	Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown. Aim of the study: This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs). Materials and methods: An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT-qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs. Results: TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8 Conclusion: This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
MeSH term(s)	Mice ; Animals ; Myeloid-Derived Suppressor Cells ; Mice, Nude ; NF-kappa B/metabolism ; Quality of Life ; Mice, Inbred C57BL ; Lung Neoplasms/metabolism ; Immunosuppressive Agents/pharmacology ; Tumor Microenvironment
Chemical Substances	NF-kappa B ; Immunosuppressive Agents
Language	English
Publishing date	2023-04-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116491
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Article ; Online: Quaternary Crustal Shortening of the Houyanshan Structure in the Eastern Chinese Tian Shan

Xue Yang / Zhigang Li / Weitao Wang / Peizhen Zhang / Chuanyong Wu / Gan Chen / Lei Duan / Xiancan Wu / Kang Liu

Remote Sensing, Vol 15, Iss 1603, p

Constrained from Geological and Geomorphological Analyses

2023 Volume 1603

Abstract: The Tian Shan is one of the most active intracontinental orogenic belts in the world. It has ... for understanding the tectonic propagation processes of the Tian Shan. Here, we gain insight into these crustal ... Chinese Tian Shan. We first describe a curved thrust ramp and related fold pairs of the structure using ...

Abstract	The Tian Shan is one of the most active intracontinental orogenic belts in the world. It has undergone complex deformation that has resulted in the formation of several fold-and-thrust belts (FTBs) in the piedmonts and intermontane basins. Investigating the deformation histories of these FTBs is important for understanding the tectonic propagation processes of the Tian Shan. Here, we gain insight into these crustal shortening processes by deciphering the Houyanshan structure, a typical fold-thrust belt in the eastern Chinese Tian Shan. We first describe a curved thrust ramp and related fold pairs of the structure using high-resolution remote sensing photography, deformation of fluvial terraces, and field-based geological cross-section. Combined with deformed terrace records and optically stimulated luminescence (OSL) dating results, the kinematic style allows us to yield a geologic shortening rate of 1.6 ± 0.2 mm/a since ~52 ka. Second, to reduce uncertainty in the seismic interpretation and quantify the amount and time of crustal shortening, we interpret three seismic reflection profiles by using the theory of quantitative fault-related fold, area-depth-strain (ADS), and reverse modeling analyses. These profiles provide direct evidence that this structure connects by means of a listric thrust ramp to a shallow detachment level. ADS analysis reveals that the maximum shortening of the Huoyanshan structure is ~4.5 km, which is consistent with the result of quantitative inverse modeling. Each of the structural analysis methods gives similar parameters, and the high consistency of results greatly improves the soundness of a given geologic interpretation. Finally, the shortening rate and total shortening amount suggest that the structure may have formed at 1.8–3.7 Ma, which is nearly synchronous around the Tibetan Plateau. Together, these results indicate that this combined geological and geomorphological analysis provides greater insight into deformation information than can be achieved by any individual technique ...
Keywords	eastern Chinese Tian Shan ; listric thrust ; crustal shortening ; area-depth-strain analysis ; inverse modeling ; Science ; Q
Subject code	550
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bu-Shen-Tian-Jing formulas alleviate the mitochondrial damage induced by oxidative stress in ovarian granulosa cells exposed to DEHP through the HDAC3-HSP90AA pathway.

Zhang, Hui / Wang, Huihua / Zhang, Qing / Wang, Hui / Zhu, Yuhang / Wang, Fangfang / Lin, Jun / Zhou, Jue / Qu, Fan

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1387–1400

Abstract: Context: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing ...

Abstract	Context: di-(2-Ethylhexyl) phthalate (DEHP) has potential reproductive toxicity. Bu-Shen-Tian-Jing formulations (BSTJFs) are beneficial for female reproductive capacity. However, BSTJF2 has much lower cytotoxicity than BSTJF1. Objective: To investigate the effects of BSTJFs on ovarian granulosa cells exposed to DEHP and determine the potential molecular mechanisms. Methods and materials: Human granulosa-like tumor cell line (KGN) cells were divided into control, DEHP, BSTJF1 and BSTJF2 groups. The DEHP group were given 1 μM DEHP for 24 h. They were then given BSTJF1 at 200 μg/mL or BSTJF2 at 100 μg/mL for 24 h. The control group was treated with the same concentration of DMSO (0.1%). Oxidative stress and mitochondrial function were measured. The mRNA and protein expression levels of HDAC3 and HSP90AA were determined. Integrative network pharmacology analysis of BSTJF2 was also performed. Results: DEHP (1 μM) significantly suppressed the proliferation of KGN cells by 17%, significantly increased ROS levels by 28% and MDA levels by 47%, significantly decreased MMP levels by 22% and mtDNA copy by 30%. DEHP significantly increased protein expression of HDAC3 by 21%and HSP90AA by 64%. All these changes were significantly reversed by BSTJFs. Integrative network pharmacology analysis revealed HSP90AA was a key target (degree = 8). Both RGFP966 and BSTJF2 significantly reversed the increased expression of HDAC3 and HSP90AA, attenuated oxidative stress, and mitochondrial damage which were induced by DEHP. Conclusion: BSTJFs might have therapeutic potential on oxidative stress and mitochondrial damage through the HDAC3/HSP90AA pathway which encourages further clinical trials.
MeSH term(s)	Humans ; Female ; Diethylhexyl Phthalate ; Oxidative Stress ; Granulosa Cells ; Busulfan ; Cell Line, Tumor
Chemical Substances	Diethylhexyl Phthalate (C42K0PH13C) ; Busulfan (G1LN9045DK)
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2249193
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