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  1. Article ; Online: Understanding Developmental Cell Death Using

    Umargamwala, Ruchi / Manning, Jantina / Dorstyn, Loretta / Denton, Donna / Kumar, Sharad

    Cells

    2024  Volume 13, Issue 4

    Abstract: Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the most conserved type of cell death in metazoans and the most ... ...

    Abstract Cell death plays an essential function in organismal development, wellbeing, and ageing. Many types of cell deaths have been described in the past 30 years. Among these, apoptosis remains the most conserved type of cell death in metazoans and the most common mechanism for deleting unwanted cells. Other types of cell deaths that often play roles in specific contexts or upon pathological insults can be classed under variant forms of cell death and programmed necrosis. Studies in
    MeSH term(s) Animals ; Drosophila/metabolism ; Cell Death ; Apoptosis/genetics ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Autophagic Cell Death
    Chemical Substances Drosophila Proteins
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pharmacogenomics for Prader-Willi syndrome: caregiver interest and planned utilization.

    Bar-Peled, Yael / Denton, Jessica J / Richards, Jaimie L / Brown, Donna / Worthey, Elizabeth / Strong, Theresa V

    Pharmacogenomics

    2024  Volume 25, Issue 4, Page(s) 207–216

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Child ; Humans ; Pharmacogenetics/methods ; Caregivers ; Prader-Willi Syndrome/drug therapy ; Prader-Willi Syndrome/genetics ; Surveys and Questionnaires ; Pharmacogenomic Testing
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2019513-8
    ISSN 1744-8042 ; 1462-2416
    ISSN (online) 1744-8042
    ISSN 1462-2416
    DOI 10.2217/pgs-2023-0189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5247: Show issues Location:
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  3. Article ; Online: Receptor Recycling by Retromer.

    Carosi, Julian M / Denton, Donna / Kumar, Sharad / Sargeant, Timothy J

    Molecular and cellular biology

    2023  Volume 43, Issue 7, Page(s) 317–334

    Abstract: The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as an essential ... ...

    Abstract The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as an essential regulator of endosome-to-Golgi transport in yeast; since then, significant progress has been made to characterize how metazoan retromer components assemble to enable its engagement with endosomal membranes, where it sorts cargo receptors from endosomes to the
    MeSH term(s) Animals ; Golgi Apparatus/metabolism ; trans-Golgi Network/metabolism ; Protein Transport/physiology ; Cell Membrane/metabolism ; Endosomes/metabolism ; Saccharomyces cerevisiae
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1080/10985549.2023.2222053
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  4. Article ; Online: Sport-related concussion in para athletes: A scoping review of concussion incidence, assessment, and management.

    Smetana, Racheal M / Kaplan, Danielle T / Magill, Robbie T / Denton, Andrea H / Ahmed, Osman Hassan / Broshek, Donna K

    American journal of physical medicine & rehabilitation

    2024  

    Abstract: Abstract: Although research on sport-related concussion has grown substantially in the last decade, research on concussion in para sports remains limited. The aim of this scoping review is to synthesize and describe the current literature on the ... ...

    Abstract Abstract: Although research on sport-related concussion has grown substantially in the last decade, research on concussion in para sports remains limited. The aim of this scoping review is to synthesize and describe the current literature on the incidence, assessment, and management of sport-related concussion in para athletes. The literature search was conducted in CINAHL, Google Scholar, MEDLINE, SPORTDiscus, and Web of Science databases and identified 22 studies that addressed one of our research questions. A majority of studies addressed concussion in elite athletes; youth and collegiate para athletes were largely under-represented. Fewer studies addressed concussion assessment and management, in part due to limitations in accessibility of current assessment tools for athletes with varying disabilities. Moving forward, there is a need to capture a larger range of incidence data, create modified assessment tools with para-specific normative data, and develop risk prevention strategies for para athletes.
    Language English
    Publishing date 2024-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000002451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ribophagy: new receptor discovered.

    Denton, Donna / Kumar, Sharad

    Cell research

    2018  Volume 28, Issue 7, Page(s) 699–700

    MeSH term(s) Autophagy ; Receptors, Cytoplasmic and Nuclear
    Chemical Substances Receptors, Cytoplasmic and Nuclear ; ribosome receptor
    Language English
    Publishing date 2018-06-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-018-0054-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5283: Show issues Location:
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  6. Article ; Online: Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling.

    Carosi, Julian M / Hein, Leanne K / Sandow, Jarrod J / Dang, Linh V P / Hattersley, Kathryn / Denton, Donna / Kumar, Sharad / Sargeant, Timothy J

    Autophagy

    2023  , Page(s) 1–20

    Abstract: Retromer prevents the destruction of numerous receptors by recycling them from endosomes to ... ...

    Abstract Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2281126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Using

    O'Keefe, Louise / Denton, Donna

    BioMed research international

    2018  Volume 2018, Page(s) 5195416

    Abstract: Autophagy is a conserved catabolic pathway that involves the engulfment of cytoplasmic components such as large protein aggregates and organelles that are delivered to the lysosome for degradation. This process is important in maintaining neuronal ... ...

    Abstract Autophagy is a conserved catabolic pathway that involves the engulfment of cytoplasmic components such as large protein aggregates and organelles that are delivered to the lysosome for degradation. This process is important in maintaining neuronal function and raises the possibility of a role for autophagy in neurodegenerative diseases. Alzheimer's disease (AD) is the most prevalent form of these diseases and is characterized by the accumulation of amyloid plaques in the brain which arise due to the misfolding and aggregation of toxic peptides, including amyloid beta (A
    MeSH term(s) Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/toxicity ; Amyloidogenic Proteins/genetics ; Amyloidogenic Proteins/metabolism ; Animals ; Autophagy/genetics ; Brain/metabolism ; Brain/pathology ; Disease Models, Animal ; Drosophila melanogaster/genetics ; Drosophila melanogaster/physiology ; Endosomes/metabolism ; Endosomes/pathology ; Humans ; Lysosomes/genetics ; Lysosomes/physiology
    Chemical Substances Amyloid beta-Peptides ; Amyloidogenic Proteins
    Language English
    Publishing date 2018-05-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2018/5195416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Drosophila as a model to understand autophagy deregulation in human disorders.

    Denton, Donna / O'Keefe, Louise / Kumar, Sharad

    Progress in molecular biology and translational science

    2020  Volume 172, Page(s) 375–409

    Abstract: Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of ... ...

    Abstract Autophagy has important functions in normal physiology to maintain homeostasis and protect against cellular stresses by the removal of harmful cargos such as dysfunctional organelles, protein aggregates and invading pathogens. The deregulation of autophagy is a hallmark of many diseases and therapeutic targeting of autophagy is highly topical. With the complex role of autophagy in disease it is essential to understand the genetic and molecular basis of the contribution of autophagy to pathogenesis. The model organism, Drosophila, provides a genetically amenable system to dissect out the contribution of autophagy to human disease models. Here we review the roles of autophagy in human disease and how autophagy studies in Drosophila have contributed to the understanding of pathophysiology.
    Language English
    Publishing date 2020-02-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2020.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    Uc I Zs 357: Show issues Location:
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  9. Article ; Online: Autophagy-dependent cell death.

    Denton, Donna / Kumar, Sharad

    Cell death and differentiation

    2018  Volume 26, Issue 4, Page(s) 605–616

    Abstract: Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death following many toxic insults, the requirement of autophagic machinery for cell death execution, as ... ...

    Abstract Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death following many toxic insults, the requirement of autophagic machinery for cell death execution, as established through specific genetic or chemical inhibition of the process, is highly contextual. During animal development, perhaps the best validated model of autophagy-dependent cell death is the degradation of the larval midgut during larval-pupal metamorphosis, where a number of key autophagy genes are required for the removal of the tissues. Surprisingly though, even in the midgut, not all of the 'canonical' autophagic machinery appears to be required. In other organisms and cancer cells many variations of autophagy-dependent cell death are apparent, pointing to the lack of a unifying cell death pathway. It is thus possible that components of the autophagy machinery are selectively utilised or repurposed for this type of cell death. In this review, we discuss examples of cell death that utilise autophagy machinery (or part thereof), the current knowledge of the complexity of autophagy-dependent cellular demise and the potential mechanisms and regulatory pathways involved in such cell death.
    MeSH term(s) Animals ; Apoptosis/genetics ; Apoptosis/physiology ; Autophagic Cell Death/genetics ; Autophagy/genetics ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila/metabolism ; Humans ; Metamorphosis, Biological/genetics ; Metamorphosis, Biological/physiology ; Signal Transduction/genetics
    Language English
    Publishing date 2018-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-018-0252-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4230: Show issues Location:
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  10. Article ; Online: Receptor Recycling by Retromer

    Carosi, Julian M. / Denton, Donna / Kumar, Sharad / Sargeant, Timothy J.

    Molecular and Cellular Biology. 2023 July 3, v. 43, no. 7 p.317-334

    2023  

    Abstract: The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as an essential ... ...

    Abstract The highly conserved retromer complex controls the fate of hundreds of receptors that pass through the endolysosomal system and is a central regulatory node for diverse metabolic programs. More than 20 years ago, retromer was discovered as an essential regulator of endosome-to-Golgi transport in yeast; since then, significant progress has been made to characterize how metazoan retromer components assemble to enable its engagement with endosomal membranes, where it sorts cargo receptors from endosomes to the trans-Golgi network or plasma membrane through recognition of sorting motifs in their cytoplasmic tails. In this review, we examine retromer regulation by exploring its assembled structure with an emphasis on how a range of adaptor proteins shape the process of receptor trafficking. Specifically, we focus on how retromer is recruited to endosomes, selects cargoes, and generates tubulovesicular carriers that deliver cargoes to target membranes. We also examine how cells adapt to distinct metabolic states by coordinating retromer expression and function. We contrast similarities and differences between retromer and its related complexes: retriever and commander/CCC, as well as their interplay in receptor trafficking. We elucidate how loss of retromer regulation is central to the pathology of various neurogenerative and metabolic diseases, as well as microbial infections, and highlight both opportunities and cautions for therapeutics that target retromer. Finally, with a focus on understanding the mechanisms that govern retromer regulation, we outline new directions for the field moving forward.
    Keywords Animalia ; endosomes ; plasma membrane ; therapeutics ; yeasts ; retromer ; VPS35 ; endosome ; neurodegeneration ; cell trafficking
    Language English
    Dates of publication 2023-0703
    Size p. 317-334.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 779397-2
    ISSN 1098-5549 ; 0270-7306
    ISSN (online) 1098-5549
    ISSN 0270-7306
    DOI 10.1080/10985549.2023.2222053
    Database NAL-Catalogue (AGRICOLA)

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